Influenza Viral Manipulation of Sphingolipid Metabolism and Signaling to Modulate Host Defense System by Madhuvanthi Vijayan, Bumsuk Hahm

“…Therefore, investigating the sphingolipid metabolism and signaling in the context of virus replication could help us design innovative therapeutic approaches to improve human health.…”
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Role of the Renin-Angiotensin System and Aldosterone on Cardiometabolic Syndrome by P. Stiefel, A. J. Vallejo-Vaz, S. García Morillo, J. Villar

“…Further studies are needed to better establish therapeutic strategies that act on the blockade of mineralocorticoid receptor in the treatment and prevention of cardiovascular diseases related to the excess of aldosterone and the metabolic syndrome.…”
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Prognostic signature based on mitochondria- and angiogenesis-related genes associated with immune microenvironment of multiple myeloma by Dai Zhang, Yu Xing, Lu Liu, Xiaoqing Zhang, Cong Ma, MengYao Xu, Ruiqi Li, HanJing Wei, Yan Zhao, Bingxin Xu, Shuhao Mei

“…Biological function analysis revealed differences in cell cycle processes between risk groups, and immune microenvironment analysis showed distinct immune cell infiltration patterns.Conclusion: This mitochondria- and angiogenesis-related prognostic signature could enhance MM prognosis assessment and offer new therapeutic insights.…”
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Selective activation of SIGMAR1 in anterior cingulate cortex glutamatergic neurons facilitates comorbid pain in depression in male mice by Xianlei Wang, Shulin Wu, Junsheng Zuo, Keying Li, Yutong Chen, Zhijie Fan, Zhou Wu, Jun-Xia Yang, Weiyi Song, Jun-Li Cao, Mengqiao Cui

“…Moreover, we utilized translating ribosome affinity purification (TRAP) in combination with c-Fos-tTA strategy and pharmacological approaches and identified SIGMAR1 as a potential therapeutic molecular target. These results revealed a previously unknown neural mechanism for depression and pain comorbidity and provided new mechanistic insights into the antidepressive and analgesic effects of the disease.…”
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A Sweet Potion to Put Embryonic Stem Cells to Sleep by Kaushik D. Deb

“…Trehalose, a naturally occurring disaccharide with therapeutic properties, protects the integrity of cells against desiccation, dehydration, and extreme heat or cold, and has been successfully tested for some somatic stem cell types. …”
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Antiapoptotic Molecule Survivin in Transplantation: Helpful or Harmful? by Sara Assadiasl, Mohammad Javad Mousavi, Aliakbar Amirzargar

“…Survivin, an antiapoptotic molecule from inhibitor of apoptosis protein (IAP) family, is most known for its implication in cancer as there are some efforts to apply it for diagnostic as well as therapeutic purposes in oncology. On the other hand, it could be a useful molecule to be positively targeted when trying to save tissue and promote cells viability. …”
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Revolutionizing acute myeloid leukemia treatment: a systematic review of immune-based therapies by Ugochi Ebinama, Binsah George

“…In response to the necessity for more efficacious therapeutic modalities, targeted immunotherapy has emerged as a promising advancement in AML treatment. …”
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A SYSTEMATIC REVIEW OF THE USE OF TULATHROMYCIN IN VETERINARY MEDICINE by Carmen (Pop) Moldovan, Alexandra Dreancă, Oana Rotar, Mihai Madru, Ioan Marcus

“…The pharmacokinetic properties of tulathromycin, characterized by rapid absorption, extensive tissue distribution, and prolonged elimination half-life, contribute to its therapeutic advantages. Additionally, the review examines the dosage regimens, administration routes, and potential side effects reported in clinical trials. …”
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Robotic-Assisted Dissection of Bulky Lymph Nodes in Cervical Cancer by Ahmet Göçmen, Fatih Şanlıkan, Muhittin Eftal Avcı

“…The resection of bulky lymph node metastases, which may provide a therapeutic benefit, has been proposed in several studies based on laparotomy and laparoscopy. …”
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Recent Advances in Electrochemical Glycobiosensing by Germarie Sánchez-Pomales, Rebecca A. Zangmeister

“…These glyco-biosensors offer simple, rapid, sensitive, and economical approaches to the measurement need for rapid glycan analysis for biomarker detection, cancer and disease diagnostics, and bioprocess monitoring of therapeutic glycoproteins. Although the prevalent methods of glycan analysis (high-performance liquid chromatography, mass spectrometry, and nuclear magnetic resonance spectroscopy) provide detailed identification and structural analysis of glycan species, there are significantly few low-cost, rapid glycan assays available for diagnostic and screening applications. …”
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An Uncommon Case of Plasma Cell Mucositis of the Tongue in a Young Man by Alessandro Antonelli, Fiorella Averta, Federica Diodati, Danila Muraca, Ylenia Brancaccio, Chiara Mignogna, Amerigo Giudice

“…At 1-year follow-up, there was no recurrence of the disease. Many therapeutic treatments are able to stabilize but not able to induce a complete remission. …”
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Neuroprotective Transcription Factors in Animal Models of Parkinson Disease by François-Xavier Blaudin de Thé, Hocine Rekaik, Alain Prochiantz, Julia Fuchs, Rajiv L. Joshi

“…Therefore, the dissection of the mechanisms and survival signalling pathways engaged by these transcription factors to protect mDA neuron from degeneration can suggest novel therapeutic strategies. The work on En1/2-mediated neuroprotection also highlights the potential of protein transduction technology for neuroprotective approaches in PD.…”
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The Role of SGLT2 Inhibitor on the Treatment of Diabetic Retinopathy by Wenjun Sha, Song Wen, Lin Chen, Bilin Xu, Tao Lei, Ligang Zhou

“…Hence, this article reviewed the recent therapeutic and research progress of SGLT2 in the treatment of diabetic retinopathy.…”
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Molecular mechanisms of renal cell carcinoma metastasis and potential targets for therapy by Xinwei Li, Xinwei Li, Wei Xiong, Zhiyong Xiong, Zhiyong Xiong, Xiaoping Zhang, Xiaoping Zhang, Xiaoping Zhang

“…In this review, we present the definition and common molecular mechanisms of metastatic renal cell carcinoma and provide new insights on their potential link to targeted therapies, which may enlighten scientists to develop future targeted therapeutic agents to improve the prognosis of patients with metastatic renal cell carcinoma.…”
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Impact of Tat Genetic Variation on HIV-1 Disease by Luna Li, Satinder Dahiya, Sandhya Kortagere, Benjamas Aiamkitsumrit, David Cunningham, Vanessa Pirrone, Michael R. Nonnemacher, Brian Wigdahl

“…Consequently, the genetic variability within tat may impact the molecular architecture of functional domains of the Tat protein that may impact HIV pathogenesis and disease. Tat as a therapeutic target for anti-HIV drugs has also been discussed.…”
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Evaluation of free radical scavenging activity of various extracts of leaves from Kedrostis foetidissima (Jacq.) Cogn. by Kalaisezhiyen Pavithra, Sasikumar Vadivukkarasi

“…Thus the result suggests that the methanolic leaf extract of K. foetidissima could serve as a potential source of antioxidants and can be explored as a therapeutic agent in free radical induced diseases.…”
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Satellite Cells: Regenerative Mechanisms and Applicability in Muscular Dystrophy by Gustavo Torres de Souza, Rafaella de Souza Salomão Zanette, Danielle Luciana Aurora Soares do Amaral, Francisco Carlos da Guia, Claudinéia Pereira Maranduba, Camila Maurmann de Souza, Ernesto da Silveira Goulart Guimarães, João Vitor Paes Rettore, Natana Chaves Rabelo, Antônio Márcio Resende do Carmo, Fernando de Sá Silva, Carlos Magno da Costa Maranduba

“…There have been works on the application of precursors cells as a therapeutic alternative for Duchenne muscular dystrophy and initial attempts have proven the cells inefficient; however later endeavours have proposed solutions for the experiments improving significantly the results. …”
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Clinical Course of Methicillin Resistant Staphylococcus aureus in Pediatric Patients by Segundo Moisés San Lucas Coque, Sareli Anahi Aguilar Armendariz, Juan Diego Galarza López

“…This work analyzes 6 relevant studies for presenting a community infectious origin, patient age, treatment and the impact of signs and symptoms in contrast to mortality presented in the last 5 years to obtain an updated view of the course of the disease and the considerations therapeutic. The limitation of the spread of the infection is denoted mainly by hygiene control. …”
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Roles of perivascular adipose tissue in the pathogenesis of atherosclerosis ― an update on recent findings by Tomoya Hara, Masataka Sata

“…It is also expected to become a new diagnostic and therapeutic target for CVD.…”
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Oxidative stress and reactive oxygen species in otorhinolaryngological diseases: insights from pathophysiology to targeted antioxidant therapies by Linghui Meng, Shengyang Liu, Jinfeng Luo, Yanyi Tu, Tao Li, Ping Li, Jinzhuang Yu, Li Shi

“…This review provides an overview of the role of oxidative stress in otorhinolaryngological diseases and evaluates the therapeutic potential of antioxidant strategies.…”
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