The potential role of nanobodies in asthma therapy by Baraa Khalid Salah Al-Sheakly, Fatemeh Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Narjes Saheb Sharif-Askari, Narjes Saheb Sharif-Askari, Jennifer E. Hundt, Rabih Halwani, Rabih Halwani

“…This review discusses the key mediators involved in asthma, challenges in current treatments, and the potential of Nbs as a new therapeutic strategy. We also explore current studies and innovations in nanobody technology.…”
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Successful Treatment of Benign Insulinoma by Transcatheter Angioembolization by Maria Iriarte-Durán, MD, Jose Teleche-Loaiza, MD, Alberto Rosero-Guerrero, MD, Edgar Folleco-Pazmiño, MD, Andrés García-Trujillo, MD, Guillermo Guzmán-Gómez, MD

“…Therefore, it is important to be aware of the different therapeutic options in localized and metastatic disease. …”
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Translating Research into Clinical Scale Manufacturing of Mesenchymal Stromal Cells by Karen Bieback, Sven Kinzebach, Marianna Karagianni

“…The challenge relates to managing the expected therapeutic benefits with the potential risks and to balance the fast move to clinical trials with time-consuming cautious risk assessment. …”
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Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury by Ping Li, Zhao-Qian Teng, Chang-Mei Liu

“…This article reviews the role and mechanism of differentially expressed microRNAs in regulating axon regeneration and glial scar formation after spinal cord injury, as well as their therapeutic potential for promoting axonal regeneration and repair of the injured spinal cord.…”
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Mitochondrial KMT9 methylates DLAT to control pyruvate dehydrogenase activity and prostate cancer growth by Yanhan Jia, Sheng Wang, Sylvia Urban, Judith M. Müller, Manuela Sum, Qing Wang, Helena Bauer, Uwe Schulte, Heike Rampelt, Nikolaus Pfanner, Katrin M. Schüle, Axel Imhof, Ignasi Forné, Christopher Berlin, August Sigle, Christian Gratzke, Holger Greschik, Eric Metzger, Roland Schüle

“…The dependency of PCa cells on mitochondrial KMT9 allows to develop therapeutic strategies to selectively fight PCa.…”
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Protective Effects of Chicken Egg Yolk Immunoglobulins (IgYs) against Vibrio vulnificus Infections by Ruizhao Cai, Ning Liu, Penghao Guo, Kang Liao, Mengzhi Li, Junyou Zhu, Shouyi Chen, Lei Chen, Bin Shu, Shaohai Qi

“…Peritoneal cytokines, blood’s bacterial load, and survival curves were obtained from both prophylactic and therapeutic mouse models. The results showed that the specific IgYs (i) inhibited the growth of V. vulnificus in vitro, (ii) dramatically reduced the inflammatory response and blood’s bacterial load, and (iii) improved the survival rate of V. vulnificus-infected mice. …”
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Astrocytic heterogeneous nuclear ribonucleoprotein U is involved in scar formation after spinal cord injury by Lili Quan, Akiko Uyeda, Ichiro Manabe, Rieko Muramatsu

“…These findings uncover that modulation of endogenous astrocytic function would be a promising therapeutic avenue to restore neurological function after CNS injury.…”
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Optimization of Gentisides Extraction from Gentiana rigescens Franch. ex Hemsl. by Response Surface Methodology by Bowen Chu, Yao Shi, Zhimin Li, Hao Tian, Wanyi Li, Yuanzhong Wang

“…Gentisides are a class of chemical compounds which is considered as potential therapeutic substance for treatment of neurodegenerative disorders. …”
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Effects of low molecular weight polysaccharide from Sargassum thunbergii against palmitic acid-induced intracellular lipid accumulation in 3T3-L1 adipocyte and HepG2 cells by Hyo-Geun Lee, D.P. Nagahawatta, M.J.M.S. Kurera, Kyung-Mo Song, Yun-Sang Choi, You-Jin Jeon, Min-Cheol Kang

“…Given these constructive properties of LMPST2 from S. thunbergii, is a potential candidate for diminishing the intracellular lipids, and for a therapeutic agent in those conditions.…”
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Targeting to BMP9 to restrain flare-up of fibrodysplasia ossificans progressiva by Qiwen Li, Quan Yuan

“…In this issue of EMBO Molecular Medicine, Zhao et al, introduce bone morphogenetic protein 9 (BMP9) as a potential therapeutic target for FOP (Zhao et al, 2024).…”
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Application of Sequence-Dependent Electrophoresis Fingerprinting in Exploring Biodiversity and Population Dynamics of Human Intestinal Microbiota: What Can Be Revealed? by Geert Huys, Tom Vanhoutte, Peter Vandamme

“…In addition, the applicability of SDE analysis to monitor intestinal population changes upon nutritional or therapeutic interventions is critically evaluated.…”
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Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma by Odessa R Yabut, Jessica Arela, Hector G Gomez, Jesse Garcia Castillo, Thomas Ngo, Samuel J Pleasure

“…Thus, direct inhibition of FGF signaling may be a promising and novel therapeutic candidate for infantile MBSHH.…”
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Neratinib and the Role of Anti‐HER2 Therapy in Salivary Duct Carcinoma by Martina Napolitano, Lucia Trudu, Enrica Martinelli, Chiara Santini, Massimo Dominici, Federica Bertolini

“…Conclusions This case confirms the potential efficacy of neratinib in HER2‐positive SDC and underlines the need to define the best therapeutic sequence and potential biomarkers for these rare patients.…”
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Preventive Treatment with Methylprednisolone Paradoxically Exacerbates Experimental Autoimmune Encephalomyelitis by Simone Wüst, Jens van den Brandt, Holger M. Reichardt, Fred Lühder

“…Here, we compared the efficacy of therapeutic and preventive MP application in MOG35-55-induced experimental autoimmune encephalomyelitis (EAE) in C57Bl/6 mice. …”
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Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus: The Old and the New by Alessia Alunno, Elena Bartoloni, Onelia Bistoni, Giuseppe Nocentini, Simona Ronchetti, Sara Caterbi, Valentina Valentini, Carlo Riccardi, Roberto Gerli

“…In this setting, targeting Treg/Th17 balance for therapeutic purposes may represent an intriguing and useful tool for SLE treatment in the next future. …”
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TNPO1-Mediated Nuclear Import of FUBP1 Contributes to Tumor Immune Evasion by Increasing NRP1 Expression in Cervical Cancer by BiKang Yang, Jing Chen, YinCheng Teng

“…Collectively, this study revealed that FUBP1 might be a potential therapeutic target for the restriction of tumor progression.…”
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Dry Needling with Fascial Winding in Nontraumatic Medial Tibial Shin Pain by Manoj Kumar Sharma, Sarika Chaudhary

“…Dry needling with fascial winding can be a viable therapeutic option for the treatment of nontraumatic medial tibial shin pain.…”
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Mechanisms of Chronic State of Inflammation as Mediators That Link Obese Adipose Tissue and Metabolic Syndrome by Eduardo Fuentes, Francisco Fuentes, Gemma Vilahur, Lina Badimon, Iván Palomo

“…Therefore, the management of the metabolic syndrome requires the development of new therapeutic strategies aimed to alter the main genetic pathways involved in the regulation of adipose tissue metabolism.…”
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Hemiataxia: A Novel Presentation of Anti-NMDA Receptor Antibody Mediated Encephalitis in an Adolescent by Greg D. Phillips, Gillian N. Jones, Maureen Callaghan, Marc P. DiFazio

“…A personal and family history of preceding neuropsychiatric symptoms produced diagnostic confusion and resulted in a significant diagnostic and therapeutic delay. Our case confirms the unilateral movement manifestations that have been emphasized in recent reports. …”
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Recent Bacteriological Trends and Emerging Antimicrobial Resistance among Hospitalized Patients in a Tertiary Care Center, Central India by Ankita Dixit, Balvir Singh, Priyanka Chaubey, Ramesh Prasad Agrawal

“…Conclusion: Regular surveillance of MDRO helps in implementing better therapeutic strategies to reduce morbidity and mortality associated with them.…”
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