Minimising harms of tight glycaemic control in older patients with type 2 diabetes by Wade Thompson

Subjects: Get full text

Identification of natural phytochemicals as AKT2 inhibitors using molecular docking and dynamics simulations as potential cancer therapeutics by Jibon Kumar Paul, Mahir Azmal, Md Naimul Haque Shohan, Mohua Mrinmoy, ANM Shah Newaz Been Haque, Omar Faruk Talukder, Ajit Ghosh

“…Dysregulation of this pathway, particularly in the AKT2 isoform, is commonly observed in cancers such as breast, ovarian, and pancreatic cancers, leading to enhanced tumor progression, metastasis, and therapeutic resistance. Therefore, targeting AKT2 for inhibition is a promising strategy for cancer therapy. …”
Get full text

Development of digital therapeutics in Hwa-byung treatment: exploring innovation potential in Korean medicine through practitioner survey by Chan-Young Kwon

Subjects: Get full text

Computer-assisted discovery of natural inhibitors for platelet-derived growth factor alpha as novel therapeutics for thyroid cancer by Hira Khalid, Farah Sattar, Iqra Ahmad, Valdir Ferreira de Paula Junior, Valdir Ferreira de Paula Junior, Umar Nishan, Umar Nishan, Riaz Ullah, Hanna Dib, Khaled W. Omari, Mohibullah Shah, Mohibullah Shah

“…This study necessitates the in-vitro and in-vivo studies to confirm the potential of our hits for the discovery of novel therapeutics against the thyroid cancer.…”
Get full text

Nanotechnology-driven electrochemical neurotransmitter sensing as a fundamental approach towards improving diagnostics and therapeutics: A review by Mehr Un Nisa, Asim Yaqub, Muhammad Hashim Khan, Fatima Yaseen, Shahaab Jilani, Huma Ajab, Noor S. Shah, Abdulaziz Al-Anazi

Get full text

Target-specific peptides for BK virus agnoprotein identified through phage display screening: advancing antiviral therapeutics by Xiaofei Xing, Jingxian Han, Keke Wang, Fuyun Tian, CuiXia Jiang, Wei Liang, Lin Qi, Xin Yue, Yinhang Wen, Yuwei Hu, Hui Qiao

Get full text

Lipid Nanoparticles With Fine‐Tuned Composition Show Enhanced Colon Targeting as a Platform for mRNA Therapeutics by Riccardo Rampado, Gonna Somu Naidu, Olga Karpov, Meir Goldsmith, Preeti Sharma, Assaf Ezra, Lior Stotsky, Dor Breier, Dan Peer

“…With many LNP‐based therapeutics in the pre‐clinical and clinical pipelines, there is extensive research dedicated to improving LNPs. …”
Get full text

The synergistic role of gut microbiota and RNA in metabolic diseases: mechanisms and therapeutic insights by Zhuo Huang, Zhuo Huang, Qinyan Yao, Qinyan Yao, Shuang Ma, Shuang Ma, Jinjie Zhou, Jinjie Zhou, Xiaoxuan Wang, Xiaoxuan Wang, Qingguo Meng, Qingguo Meng, Yaxin Liu, Yaxin Liu, Zihan Yu, Zihan Yu, Xin Chen, Xin Chen

“…By exploring the molecular mechanisms, particularly how gut microbiota-derived signals modulate RNA pathways, the review underscores the potential of targeting this axis for therapeutic interventions. Furthermore, it examines how dysbiosis leads to epigenetic changes such as m6A RNA methylation, contributing to disease pathogenesis. …”
Get full text

Crosstalk between the Gut and Brain in Ischemic Stroke: Mechanistic Insights and Therapeutic Options by Wenjing Huang, Luwen Zhu, Wenjing Song, Mei Zhang, Lili Teng, Minmin Wu

“…To effectively monitor and cure ischemic stroke, restoring a healthy microbial ecology in the gut may be a critical therapeutic focus. This review highlights mechanistic insights on the MGBA in disease pathophysiology. …”
Get full text

Therapeutic potential of cannabinoids in neurological conditions: a systematic review of clinical trials by Alqassem Y. Hakami, Alqassem Y. Hakami, Fahad S. Alshehri

“…OverviewCannabinoids have gained increasing attention for their therapeutic potential in treating several neurological conditions, including neurodegenerative diseases, chronic pain, and epilepsy. …”
Get full text

Interventions to Enhance Adaptive Plasticity after Stroke: From Mechanisms to Therapeutic Perspectives by Adriana Conforto, Annette Sterr, Ela Plow, Leonardo Cohen

Get full text

Unraveling the pathogenesis of bone marrow hematopoietic injury and the therapeutic potential of natural products by Jing Long, Hengzhou Lai, Yuqing Huang, Fengming You, Yifang Jiang, Qixuan Kuang

“…Natural products, particularly those derived from Chinese herbal medicines and other natural sources, have emerged as promising therapeutic options due to their distinctive mechanisms and minimal side effects. …”
Get full text

Exosome in Crosstalk between Inflammation and Angiogenesis: A Potential Therapeutic Strategy for Stroke by Yongdan Cun, Yaju Jin, Danli Wu, Li Zhou, Chengcai Zhang, Simei Zhang, Xicheng Yang, null Zuhong Wang, Pengyue Zhang

Get full text

Role of copper homeostasis and cuproptosis in heart failure pathogenesis: implications for therapeutic strategies by Zhichao Liu, Yongkang Gan, Zhen Shen, Siqi Cai, Xizhen Wang, Yong Li, Xiaofeng Li, Huanjie Fu, Jinhong Chen, Ningcen Li

“…Finally, we reviewed the therapeutic potential of current drugs that target copper metabolism for treating HF. …”
Get full text

Pollen–Food Allergy Syndrome: Allergens, Clinical Insights, Diagnostic and Therapeutic Challenges by Laura Haidar, Camelia Felicia Bănărescu, Cristina Uța, Sandra Iulia Moldovan, Elena-Larisa Zimbru, Răzvan-Ionuț Zimbru, Elena Ciurariu, Marius Georgescu, Carmen Panaitescu

“…Emerging diagnostic tools and biomarkers with potential to enhance accuracy are also examined. Therapeutic strategies for PFAS primarily focus on symptom management and avoidance of trigger foods. …”
Get full text

Dry eye syndrome, associated with the wearing of contact lenses. Features of the therapeutic approach by E.A. Egorov

“…Dry eye syndrome, associated with the wearing of contact lenses. Features of the therapeutic approach. RMJ “Clinical ophthalmology”. 2018;2:66–69.…”
Get full text

E3 Ubiquitin Ligases: Potential Therapeutic Targets for Skeletal Pathology and Degeneration by Ruiyin Zeng, Yuan Xiong, Ze Lin, Adriana C. Panayi, Yun Sun, Faqi Cao, Guohui Liu

Get full text

Macrophages in sepsis-induced acute lung injury: exosomal modulation and therapeutic potential by Kaiying Lv, Qun Liang

“…By understanding these mechanisms, it aims to uncover innovative therapeutic strategies for sepsis-induced ALI.…”
Get full text

Immunosuppressive Role of Myeloid-Derived Suppressor Cells and Therapeutic Targeting in Lung Cancer by Jie Ma, Huaxi Xu, Shengjun Wang

Get full text

Cancer-associated fibroblasts as therapeutic targets for cancer: advances, challenges, and future prospects by Zhipeng Cao, Sadia Quazi, Sakshi Arora, Laura D. Osellame, Ingrid J. Burvenich, Peter W. Janes, Andrew M. Scott

“…Encouraged by these compelling findings, therapeutic strategies have now advanced into clinical evaluation. …”
Get full text