The Role of Peroxisome Proliferator-Activated Receptors in Pulmonary Vascular Disease by Rachel E. Nisbet, Roy L. Sutliff, C. Michael Hart

“…Therefore, the following review will focus on selected mediators implicated in pulmonary vascular dysfunction and evidence that PPARs, in particular PPARγ, participate in their regulation and may provide a potential novel therapeutic target for the treatment of pulmonary hypertension.…”
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Craniomandibular Disorders and Mandibular Reference Position in Orthodontic Treatment by Farid Bourzgui, Hakima Aghoutan, Samir Diouny

“…The aim of this paper is to bring into focus the literature on the choice of the mandibular reference position in orthodontic treatment; of a particular reference to this paper is intercuspal position, centric relation position, or therapeutic position. To give a comprehensive account of the literature review on craniomandibular disorders (CMD), we have relied on books and articles using both Google Scholar and PubMed. …”
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The Efficacy and Safety of Lenalidomide plus Rituximab in an Orbital Relapse of Diffuse Large B-Cell Lymphoma by R. Palmieri, F. Esposito, F. Meconi, V. M. Rapisarda, L. Anemona, G. Paterno, S. Vaccarini, D. Nasso, L. Pupo, M. Cantonetti

“…In this experience, rituximab plus lenalidomide, without radiotherapy, was a safe and effective therapeutic combination in an elderly patient with a localized relapse of DLBCL who was unfit to receive more aggressive therapies.…”
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Boehmeria nivea Attenuates the Development of Dextran Sulfate Sodium-Induced Experimental Colitis by Eun Ju Shin, Mi Jeong Sung, Hye Jeong Yang, Myung Sunny Kim, Jin-Taek Hwang

“…We examined the therapeutic effect of an ethanol extract derived from Boehmeria nivea (Linn.) …”
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Role of RING-Type E3 Ubiquitin Ligases in Inflammatory Signalling and Inflammatory Bowel Disease by Liguo Zhu, Ying Li, Longyuan Zhou, Guang Yang, Ying Wang, Jing Han, Li Li, Shenghong Zhang

“…Owing to the limited data on the biology of RING-type ligases, there is an urgent need to analyse their potential as biomarkers and therapeutic targets in IBD in the future.…”
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Inflammatory Bowel Diseases: When Natural Friends Turn into Enemies—The Importance of CpG Motifs of Bacterial DNA in Intestinal Homeostasis and Chronic Intestinal Inflammation by Florian Obermeier, Claudia Hofmann, Werner Falk

“…In this review we suggest that regulators of TLR signaling may be interesting therapeutic targets in IBD aiming at the restoration of intestinal immune homeostasis.…”
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Decreased Count and Dysfunction of Circulating EPCs in Postmenopausal Hypercholesterolemic Females via Reducing NO Production by Ying Luo, Quan-Neng Yan, Wan-Zhou Wu, Fan-Yan Luo

“…Maintaining the EPC numbers and activity might be emerging as a potential therapeutic strategy to reduce the risk of cardiovascular injury in elder women.…”
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The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury by Xiaoling Zhong, Wenjiao Tai, Meng-Lu Liu, Shuaipeng Ma, Tianjin Shen, Yuhua Zou, Chun-Li Zhang

“…These findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.…”
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Functional abnormalities of the glymphatic system in cognitive disorders by Wuyue Shentu, Qi Kong, Yier Zhang, Wenyao Li, Qiulu Chen, Sicheng Yan, Junjun Wang, Qilun Lai, Qi Xu, Song Qiao

“…Various pathological mechanisms represent distinct therapeutic targets for cognitive disorders, but a balance between clearance and production is essential for maintaining the stability of the brain’s internal environment. …”
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Exploring the anti-aging potential of natural products and plant extracts in budding yeast Saccharomyces cerevisiae: A review [version 2; peer review: 1 approved, 2 approved with r... by Madhu Dyavaiah, Chella Perumal Palanisamy, Tewin Tencomnao, Siriporn Chuchawankul, Phaniendra Alugoju, Naga Venkata Anusha Anthikapalli, Anchalee Prasanskulab, Selvaraj Jayaraman

“…Biogerontology research aims to explore the molecular basis of aging and discover new anti-aging therapeutic compounds or formulations to combat the detrimental effects of aging and promote a healthy life span. …”
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Lung transplantation for pulmonary chronic graft-versus-host disease: a missed opportunity? by Andrea Zajacova, MD, Hélène Schoemans, MD, PhD, Mark Greer, MD, MRCP, Hildegard Greinix, MD, Peter Jaksch, MD, Osnat Shtraichman, MD, Rayid Abdulqawi, MD, PhD, Are M. Holm, MD, PhD, Robin Vos, MD, PhD, Saskia Bos, MD, PhD

“…Lung transplantation (LuTx) is a final therapeutic option for well-selected patients affected by this condition. …”
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Molecular Mechanisms Regulating Hepcidin Revealed by Hepcidin Disorders by Clara Camaschella, Laura Silvestri

“…Studies of the hepcidin regulation by iron and inflammatory cytokines are revealing new pathways that might become targets of new therapeutic intervention in iron disorders.…”
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Restenosis and Therapy by Laszlo Denes, Laszlo Entz, Veronika Jancsik

“…Those could be useful markers of carotid restenosis after stent implantation. Gene therapy and therapeutic angiogenesis is proposed for therapy in restenosis. …”
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Mitochondrial Quality Control Orchestrates the Symphony of B Cells and Plays Critical Roles in B Cell-Related Diseases by Wuhao Li, Peiyang Cai, Ye Xu, Weihong Tian, Licong Jing, Qiaoyi Lv, Yangjing Zhao, Hui Wang, Qixiang Shao

“…In addition, we will discuss the physiological and pathological implications of MQC in B cells, providing new insights into potential therapeutic targets for diseases associated with B cell abnormalities.…”
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Novel Insights for Systemic Inflammation in Sepsis and Hemorrhage by Bolin Cai, Edwin A. Deitch, Luis Ulloa

“…In seeking potential anti-inflammatory strategies, we reported that ethyl pyruvate and alpha7 nicotinic acetylcholine receptor (alpha7nAChR) agonists effectively restrained cytokine production to provide therapeutic benefits in both experimental sepsis and hemorrhage. …”
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Focal Cryoablation of Prostate: A Review by Duke K. Bahn, Paul D. Silverman

“…Focal cryoablation may fill a void in the therapeutic options available to patients with unifocal or unilateral prostate cancer who have a strong desire to maintain their quality of life.…”
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Peculiarities of vitamin D metabolism in diabetic kidney disease by V.M. Yerokhovych, O.V. Karpenko, I.A. Paliienko, I.V. Dumka, O.A. Rudenko, Iu.I. Komisarenko

“…The mechanisms of glucose and vitamin D interaction at the level of the proximal tubules were analyzed, which emphasizes the need for further research to develop therapeutic strategies for correcting vitamin D deficiency in patients with diabetic kidney damage in order to improve their prognosis.…”
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Spatial distribution-based progression of spinal cord injury pathology: a key role for neuroimmune cells by Jian Li, Xiaolei Zhai, Chaochun Yu

“…Therefore, a comprehensive investigation into the spatial dynamics of immune cells following SCI is essential to uncover their mechanisms in neuroinflammation and repair, and to develop novel therapeutic strategies.…”
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Mesenchymal Stem Cells as Immunomodulators in a Vascularized Composite Allotransplantation by Yur-Ren Kuo, Chien-Chang Chen, Shigeru Goto, Pao-Yuan Lin, Fu-Chan Wei, Chao-Long Chen

“…Mesenchymal stem cells (MSCs) show promise as an immunomodulatory therapeutic agent and are currently being tested in preclinical and clinical settings as therapies for autoimmune disorders or transplant rejection. …”
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Spontaneous Retroperitoneal Hemorrhage in a Patient with Prolymphocytic Transformation of Chronic Lymphocytic Leukemia by Gwynivere A. Davies, Alejandro Lazo-Langner, Michael Shkrum, Leonard Minuk

“…This condition is rare and generally occurs in those receiving therapeutic anticoagulation or dialysis, with known bleeding disorders or vascular malformation, none of which were present in our patient. …”
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