Statins as Modulators of Regulatory T-Cell Biology by David A. Forero-Peña, Fredy R. S. Gutierrez

“…Hence, strategies oriented towards the therapeutic expansion of Tregs are gaining special attention among biomedical researchers. …”
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Advances in personalized gastroenterology and hepatology 2016 by E. Blum Hubert

“…Such data increasingly allow to define the individual disease predisposition or risk and to predict disease prognosis as well as the efficacy of therapeutic strategies in the individual patient (‘personalized medicine’). …”
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Semi-Empirical Predictions on the Structure and Properties of ent-Kaurenoic Acid and Derivatives by Jose Isagani B. Janairo, Gerardo C. Janairo, Derrick Ethelbhert C. YU

“…The physicochemical properties of ent- kaurenoic acid model derivatives, which possibly influence its therapeutic application, were calculated. Results revealed that the molecule possess favourable attributes which renders it possible to be considered as a drug lead only that its very hydrophobic nature can result to poor bioavailabilty, low absorption and poor systemic circulation. …”
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Contemporary treatment of right ventricular failure by Bibhuti B. Das, MD, Shashi Raj, MD, FAAP, FACC

“…The pathophysiology of RVF involves complex interactions, such as maladaptive hypertrophy, metabolic reprogramming, inflammation, fibrosis, apoptosis, and endothelial dysfunction. Therapeutic strategies are limited for RVF, as basic and clinical research has historically focused mainly on the left ventricle. …”
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Interleukin-23 and Th17 Cells in the Control of Gut Inflammation by Ivan Monteleone, Francesco Pallone, Giovanni Monteleone

“…The demonstration that Th17-related cytokines cause pathology in many organs, including the gut, and that expansion and maintenance of Th17 cell responses require the activity of IL-23, a cytokine made in excess in the gut of IBD patients has contributed to elucidate new pathways of intestinal tissue damage as well as to design new therapeutic strategies. In this review, we discuss the available data supporting the role of the IL-23/Th17 axis in the modulation of intestinal tissue inflammation.…”
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Combined Pulmonary Fibrosis and Emphysema Syndrome: A New Phenotype within the Spectrum of Smoking-Related Interstitial Lung Disease by Karina Portillo, Josep Morera

“…Currently, there is no consensus about its treatment since those published to date on this issue are limited to well-characterised series of cases; hence, a better understanding of this entity may help in the development of future therapeutic approaches.…”
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Current developments in personalized treatment strategies for elderly acute myelogenous leukemia patients by Xueting Hou, Jizhang Bao

“…Acute myelogenous leukemia(AML) is a life-threatening hematologic malignancy that predominantly affects the elderly.Currently, chemotherapy and hematopoietic stem cell transplantation are the primary treatment modalities for AML, though their clinical application is limited in older patients.Recent years have seen the development of novel molecular targeted therapies, such as isocitrate dehydrogenase 1/2 (IDH1/2) and Feline macrophage stimulator-like tyrosine kinase 3 (FLT3) inhibitors, as well as individualized approaches like chimeric antigen receptor T-cell (CAR-T) therapy.However, due to patient heterogeneity and drug resistance, treatment outcomes for elderly AML remain unsatisfactory, underscoring the need for more precise and safer individualized treatment strategies.The combination of chemotherapy with novel targeted or immunotherapies shows promise as a future treatment direction.This research reviews the latest advances in the treatment of elderly AML, with a focus on achieving more individualized and safer therapeutic approaches.…”
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Innovative approaches to asthma treatment: harnessing nanoparticle technology by Vanshika Goswami, Kushneet Kaur Sodhi, Chandra Kant Singh

“…Nanoparticle drug delivery systems offer improved therapeutic efficacy compared to conventional administration techniques. …”
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Spatial heterogeneity of the hepatocellular carcinoma microenvironment determines the efficacy of immunotherapy by Minni Zhang, Kailin Huang, Qiushi Yin, Xueqin Wu, Mingyue Zhu, Mengsen Li

“…As the efficacy of immunotherapy mainly depends on the spatial heterogeneity of the tumor immune microenvironment, it is necessary to elucidate the crosstalk between the composition of the liver cancer immune environment, from which potential therapeutic targets can be selected to provide more appropriate individualized treatment programs. …”
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Management of Ocular Diseases Using Lutein and Zeaxanthin: What Have We Learned from Experimental Animal Studies? by Chunyan Xue, Richard Rosen, Adrienne Jordan, Dan-Ning Hu

“…The results of these experimental animal studies may provide new preventive and therapeutic procedures for clinical management of various vision-threatening diseases.…”
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Clinical Aspects of Trace Elements: Zinc in Human Nutrition – Zinc Deficiency and Toxicity by Michelle M Pluhator, Alan Br Thomson, Richard N Fedorak

“…As the numerous challenges presented by the study of zinc in human nutrition are met, more appropriate recommendations for dietary and therapeutic zinc intake are being made.…”
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MICRO-FRAGMENTED ADIPOSE TISSUE IN THE KNEE OSTEOARTHRITIS UNDER LOCAL ANESTHESIA by Bruno Butturi Varone, Henrique Fuller, Daniel Perini, Daniel Peixoto Leal, Riccardo Gomes Gobbi, Marco Kawamura Demange

“…Level of Evidence IV; Therapeutic Study.…”
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Pityriasis rosea: a distinct entity or viral exanthem? by Natalia Dąbrowska, Piotr Węgrzyn, Konstancja Węgrzyn, Gustaw Laskowski, Anna Salińska, Marcin Wasilewski, Julia Skwara, Agnieszka Góra, Maciej Nowicki, Dawid Barański

“…Although the disease is typically not dangerous, it can be a therapeutic challenge, especially when its course is atypical or when it occurs during pregnancy and may pose a risk to the fetus. …”
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Cyclic Bicytopenia in a Patient with Shapiro Syndrome by Lindsey E. Roeker, Vinay Gupta, Wilson I. Gonsalves, Alexandra P. Wolanskyj, Naseema Gangat

“…Though accidental and therapeutic hypothermia have been associated with thrombocytopenia, this is, to our knowledge, the first reported case of periodic intrinsic hypothermia causing bicytopenia. …”
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Could flavonoid aglycones prevent the absorption of flavonoid glycosides by inhibiting sodium-dependent glucose transporter-1 in the small intestine? by Katrin Sak

“…However, the actual therapeutic use of these phytochemicals is impeded by their low oral bioavailability. …”
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Tumor venéreo transmissível canino com resistência quimioterápica e metástase esplênica. Relato de caso by A. P. Duzanski, A. D. Ortiz, H. B. Fêo, M. W. Fonseca, M. M. Flórez, L. T Rodrigues, F. Michelon, N. S. Rocha

“…After the cytological, histological and cytogenetic diagnostic, the primary tumor was still characterized in progression phase and showed low major histocompatibility complex expression MHC (4,4 ± 2% class I e 11 ± 4,1% class II. The dog underwent therapeutic splenectomy and ovariohysterectomy and did not present tumor recurrence within 12 months of clinical follow-up.…”
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Molecular Profiling: A Case of ZBTB16-RARA Acute Promyelocytic Leukemia by Stephen E. Langabeer, Lisa Preston, Johanna Kelly, Matt Goodyer, Ezzat Elhassadi, Amjad Hayat

“…Molecular profiling of additional mutations may provide a platform to individualise therapeutic management in patients with this rare form of APL.…”
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The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways by Wanqiong Yuan, Chunli Song

“…This review may provide some insights for our future research and novel therapeutic targets for diseases.…”
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Clinical Significance and Pathogenic Mechanisms of Long Non-Coding RNA TRPM2-AS in Cancers by Shichen Huang MS, Bowen Li MS, Huanyu Chen MD, Cheng Rong, Zheng Yang MD, Xianqin Zhang PhD

“…The current study highlights the potential of TRPM2-AS as a prognostic and therapeutic target in cancers.…”
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Cancer treatment comes to age: from one-size-fits-all to next-generation sequencing (NGS) technologies by Sepideh Parvizpour, Hanieh Beyrampour-Basmenj, Jafar Razmara, Farhad Farhadi, Mohd Shahir Shamsir

“…NGS is expected to lead the transition to precision medicine (PM), where the right therapeutic approach is chosen for each patient based on their characteristics and mutations. …”
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