Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through activating the... by Jiaochen Luan, Mengchi Yu, Qi Gu, Xuan Zhou, Yunqiang Shao, Tong Chen, Jiayi Zhang, Zheng Zhu, Ninghong Song, Jie Yang

“…BackgroundErectile dysfunction (ED) is a prevalent male sexual disorder, commonly associated with hypertension, though the underlying mechanisms remain poorly understood.ObjectiveThis study aims to explore the role of Fatty acid synthase (Fasn) in hypertension-induced ED and evaluate the therapeutic potential of the Fasn inhibitor C75.Materials and methodsErectile function was assessed by determining the intracavernous pressure/mean arterial pressure (ICP/MAP) ratio, followed by the collection of cavernous tissue for transcriptomic and non-targeted metabolomic analyses. …”
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Targeted ErbB4 receptor activation prevents D-galactose-induced neuronal senescence via inhibiting ferroptosis pathway by Ji-Ji Dao, Ji-Ji Dao, Wei Zhang, Wei Zhang, Chong Liu, Chong Liu, Qian Li, Qian Li, Chen-Meng Qiao, Chen-Meng Qiao, Chun Cui, Chun Cui, Yan-Qin Shen, Yan-Qin Shen, Shuang-Xi Chen, Shuang-Xi Chen, Wei-Jiang Zhao, Wei-Jiang Zhao

“…Behavioral assessments were conducted to evaluate therapeutic efficacy in memory and cognitive functions. …”
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AlphaFold-based AI docking reveals AMPK/SIRT1-TFEB pathway modulation by traditional Chinese medicine in metabolic-associated fatty liver disease by Lulu Zhang, Yi Zheng, Mingyan Shao, Aiping Chen, Meiyi Liu, Wenlong Sun, Tianxing Li, Yini Fang, Yang Dong, Shipeng Zhao, Hui Luo, Juan Feng, Qi Wang, Lingru Li, Yanfei Zheng

“…These findings suggest that QGJZF as a therapeutic agent in augmenting autophagy-facilitated lipid clearance for the management of MAFLD via AMPK/SIRT1-TFEB axis.…”
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NLRP3 inflammasome-modulated angiogenic function of EPC via PI3K/ Akt/mTOR pathway in diabetic myocardial infarction by Jia-Peng Li, Shu Qiu, Guang-Jie Tai, Yi-Ming Liu, Wei Wei, Meng-Meng Fu, Pan-Qi Fang, Joseph Nicolao Otieno, Tungalag Battulga, Xiao-Xue Li, Ming Xu

“…Methods A model was established combining high-fat diet (HFD)/streptozotocin (STZ)-induced diabetic mice with myocardial infarction. The therapeutic effects of transplanted wild-type EPC, Nlrp3 knockout EPC, and Nlrp3 overexpression EPC were evaluated. …”
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Hepatorenal syndrome in decompensated portal hypertension by M.I. Tutchenko, M.S. Besedinskyi, S.A. Aslanian, I.V. Kluzko, D.V. Rudyk, S.L. Chub

“…This study aimed to search for  optimal methods of early diagnostics, therapeutic approaches and establishment of lethality causes in hepatorenal syndrome. …”
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Patient centered medication treatment for opioid use disorder in rural Vermont: a qualitative study by Emily G. Hichborn, Owen B. Murray, Eilis I. Murphy, Tess E. Gallant, Sarah K. Moore, Bethany M. McLeman, John Saroyan, Anthony Folland, Megan Mitchell, Lisa A. Marsch

“…Emergent themes were deductively mapped to PCC domains of Therapeutic Alliance, Individualized Care, Shared Decision-Making, and Holistic Care. …”
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Peptide-based vaccine targeting IL17A attenuates experimental spondyloarthritis in HLA-B27 transgenic rats by Tetsuya Tomita, Hiromi Rakugi, Hiroki Hayashi, Ryuichi Morishita, Jiao Sun, Yuka Yanagida, Shota Yoshida, Satoshi Baba, Akiko Tenma, Masayoshi Toyoura, Sotaro Kawabata, Takako Ehara, Ryoko Asaki, Makoto Sakaguchi, Hideki Tomioka, Munehisa Shimamura, Hironori Nakagami

“…We also evaluated the effect of IL17A vaccine in SpA therapeutic model.Results The IL17A peptide-based vaccine with alum adjuvant successfully induced antibody production and suppressed the arthritis score and joint thickness. …”
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Metabolic reprogramming and macrophage expansion define ACPA-negative rheumatoid arthritis: insights from single-cell RNA sequencing by Yafeng Jiang, Zhaolan Hu, Roujie Huang, Kaying Ho, Pengfei Wang, Jin Kang, Jin Kang

“…By integrating single-cell RNA sequencing with machine learning, this study established a neural network model that robustly differentiates patients with ACPA− RA from healthy controls, highlighting promising diagnostic biomarkers and therapeutic targets centered on immune cell metabolism.…”
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A multi-omics strategy to understand PASC through the RECOVER cohorts: a paradigm for a systems biology approach to the study of chronic conditions by Jun Sun, Masanori Aikawa, Hassan Ashktorab, Noam D. Beckmann, Noam D. Beckmann, Michael L. Enger, Joaquin M. Espinosa, Xiaowu Gai, Xiaowu Gai, Benjamin D. Horne, Benjamin D. Horne, Paul Keim, Paul Keim, Paul Keim, Jessica Lasky-Su, Rebecca Letts, Cheryl L. Maier, Meisha Mandal, Lauren Nichols, Nadia R. Roan, Nadia R. Roan, Mark W. Russell, Jacqueline Rutter, George R. Saade, George R. Saade, Kumar Sharma, Kumar Sharma, Stephanie Shiau, Stephen N. Thibodeau, Samuel Yang, Lucio Miele, NIH Researching COVID to Enhance Recovery (RECOVER) Consortium

“…This system biology strategy, coupled with modern data science approaches, will dramatically improve our prospects for accurate disease subtype identification, biomarker discovery and therapeutic target identification for precision treatment. …”
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Succinate supplementation alleviates liver cancer by inhibiting the FN1/SQLE axis-mediated cholesterol biosynthesis by Shuyuan Chang, Ayaka Tomii, Yunfei Zhou, Xun Yang, Yihong Dong, Jun Yan, Aodi Wu, Yumeng Wang, Qingxin Zhang, Hongxue Meng, Lei Yu, Wei Sun, Dabin Liu

“…Our study demonstrates that exogenous succinate acts as a cholesterol biosynthesis inhibitor to suppress HCC both in vitro and in vivo, highlighting its potential therapeutic applications.…”
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Asini Corii Colla (Ejiao) as a health-care food and traditional Chinese medicine: A review of its chemical composition, pharmacological activity, quality control, modern applicatio... by Xiao-jun Yu, Ling-mei Kong, Bin Wang, Chang-qi Zhai, Yong-zhen Lao, Long-jian Zhang, Yan Gao, Bo-Nian Zhao

“…It offers a range of therapeutic benefits, including anti-anemia properties, immune regulation, hemostasis, anti-inflammatory effects, antioxidant activity, and antibacterial properties. …”
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Magnetic Nanoparticles for Targeting and Imaging of Stem Cells in Myocardial Infarction by Michelle R. Santoso, Phillip C. Yang

“…Stem cells have emerged as a leading therapeutic option for many diseases and have broad applications in regenerative medicine. …”
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Characterization and evaluation of antioxidant properties of leaf extracts from Rhododendron arboreum by Shobha Mehra, Ufondu Maryann Afoma, Namrata Dudha, Shilpy Singh, Shweta Sharma, Ved Vrat Verma, Mohammad Zuhaib, Varun Kumar Sharma

“…In conclusion, the leaf extracts of R. arboretum can be one of the better natural source of antioxidant source and could be used for therapeutic purpose in the treatments of different diseases.…”
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Mitochondrial Ribosomal Proteins and Cancer by Huiyi Wu, Xiaowei Zhu, Huilin Zhou, Min Sha, Jun Ye, Hong Yu

“…Recent studies have underscored the importance of MRPs in cancer biology, revealing their altered expression patterns in various types of cancer and their potential as both prognostic biomarkers and therapeutic targets. Herein, we review the current knowledge regarding the multiple functions of MRPs in maintaining the structure of the mitochondrial ribosome and apoptosis, their implications for cancer susceptibility and progression, and the innovative strategies being developed to target MRPs and mitoribosome biogenesis in cancer therapy. …”
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The combination of a tyrosine kinase inhibitor and blinatumomab in patients with Philadelphia chromosome–positive acute lymphoblastic leukemia or Philadelphia chromosome‐like acute... by Xiaoxia Wu, Shenqi Lu, Xinhui Zhang, Zhen Yang, Aining Sun, Depei Wu, Huifen Zhou, Miao Miao

“…Blinatumomab in combination with TKIs is safe and effective and hence this combination therapy could be a viable therapeutic option in front‐line treatment of patients with Ph + ALL.…”
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Role of Acetylsalicylic Acid in Cytokine Stimulation of Macrophages in Antibody-Dependent Cellular Cytotoxicity (ADCC) by M. Jäpel, H. Lötzerich, K. Rogalla

“…The action of ASA on the activity of mouse peritoneal macrophages was therefore investigated in the present study. Therapeutically effective concentrations of ASA, which are known to decrease levels of prostaglandins, had neither a stimulating nor an inhibiting influence on antibody-dependent cellular cytotoxicity (ADCC) or on the binding capacity of macrophages with regard to SW 948 tumour cells. …”
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Two Venovenous Extracorporeal Membrane Oxygenation for One Gunshot by Louis Pot, Alizée Porto, Audrey Le Saux, Amandine Bichon, Emi Cauchois, Marc Gainnier, Julien Carvelli, Jeremy Bourenne

“…Contraindications to therapeutic anticoagulation must be ruled out prior to ECMO implementation. …”
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Application and development of biosensors in the detection of transfusion transmitted diseases markers：a review by CHEN Siyi, LIAO Deyu, ZHAO Lin, GAO Feiran, TAN Bin

“…Blood transfusion is a common therapeutic measure with indispensable role in clinical medicine. …”
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Breast Cancer Suspicion in a Transgender Male-to-Female Patient on Hormone Replacement Therapy Presenting with Right Breast Mass: Breast Cancer Risk Assessment and Presentation of... by Krystina Tongson, Victoria Konovalova, Naveen Dhawan, Steffi Sharma, Jaya Bahl, Mohammad Masri

“…While the number of reported cases of suspicious breast lesions in this population remains scarce, it presents both a diagnostic and therapeutic challenge due to the nature of the treatment course and the lack of research in this recently growing subgroup of patients.…”
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Modulating immune responses for enhanced cell therapies: The dual role of multi-scale biomaterials by Jia'nan Zeng, Yuhong Jin, Yanxiao Ao, Wenjing Li, Kaini Liang, Haoke Chen, Yi Long, Yanan Du

“…Herein, we summarize different methods used to engineer therapeutic cells with biomaterials across multiple spatial scales and review how biomaterials assist in immune activation or evasion in cell therapy based on a discussion of the effects of biomaterials on endogenous immune cells. …”
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