Sympathetic Renal Innervation and Resistant Hypertension by Vito M. Campese, Elaine Ku, Jeanie Park

“…Understanding the pathogenic mechanisms responsible for hypertension in these conditions may lead to improved and more targeted therapeutic interventions. Several factors have been implicated in the pathogenesis of hypertension associated with renal disease and/or renal failure. …”
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Assembling Reading and Writing in the Face of Loss: Christa Couture’s How to Lose Everything and Dakshana Bascaramurty’s This Is Not the End of Me by Lola Artacho-Martín

“…In addition, the healing nature of this connection will be highlighted, which supports the idea of using reading and writing techniques as therapeutical strategies in the coping with emotional turmoil and distress.…”
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Effects of Changes in Osmolarity on the Biological Activity of Human Normal Nucleus Pulposus Mesenchymal Stem Cells by Hua Zhang, Wei Li, YaoHong Wu, Shengquan Zhang, Jie Li, Letian Han, Haoyu Chen, Ziyu Wang, Cailiang Shen, Yinshun Zhang, Hui Tao

“…The expansion and maintenance of the NPMSC (nucleus pulposus mesenchymal stem cell) phenotype are considered as potential therapeutic tools for clinical applications in intervertebral disc tissue engineering and regenerative medicine. …”
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Preclinical evaluation of the immunogenicity and safety of an inactivated enterovirus 71 candidate vaccine. by Shi-Hsia Hwa, Yock Ann Lee, Joseph N Brewoo, Charalambos D Partidos, Jorge E Osorio, Joseph D Santangelo

“…Therefore, the development of therapeutic and preventive strategies against HFMD is of growing importance. …”
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Targeting gut microbiota to regulate the adaptive immune response in atherosclerosis by Despina Giakomidi, Despina Giakomidi, Ayoola Ishola, Meritxell Nus, Meritxell Nus

“…Building on these concepts and the pitfalls on the gut microbiota and adaptive immune response interaction, this review explores potential strategies to therapeutically target the microbiome, including the use of prebiotics and vaccinations, which could influence the adaptive immune response and consequently plaque composition and development.…”
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Proximal Humerus Reconstruction after Tumor Resection: An Overview of Surgical Management by Antonio D’Arienzo, Edoardo Ipponi, Alfio Damiano Ruinato, Silvia De Franco, Simone Colangeli, Lorenzo Andreani, Rodolfo Capanna

“…Alone or in association with adjuvant treatments, surgery represents the main therapeutic option to treat and eradicate these diseases. …”
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New developments in immunotherapy for SCLC by Zhonglin Hao, Tsering Dolkar, Christopher Gates, Reinhold Munker

“…While SCLC rarely harbors actionable mutations, the receptor DLL3 is extensively present in SCLC, making it a potential target for immunotherapy. Three emerging therapeutic options include bispecific T cell engagers targeting DLL3, chimeric antigen receptor T cells (CAR-T cells), and antibody–drug conjugates. …”
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Early prevention of carrageenan-induced peripheral/spinal inflammation suppresses microglial hyperreactivity in the trigeminal spinal subnucleus caudalis and alleviates chronic fac... by Toru Yamamoto, Mitsuhiro Yoshida, Yuhei Koyama, Yatendra Mulpuri, Eiji Imado, Kana Oue, Mitsuru Doi, Yoshitaka Shimizu, Naotaka Kishimoto, Hiroshi Hanamoto, Kenji Seo

“…In this study, we investigated the mechanisms underlying carrageenan-induced chronic pain and the therapeutic effect of the anti-inflammatory drug meloxicam. …”
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Fructose: A Key Factor in the Development of Metabolic Syndrome and Hypertension by Zeid Khitan, Dong Hyun Kim

“…We present possible mechanisms by which fructose causes insulin resistance and suggest actions based on this association that have therapeutic implications.…”
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AAV-based vectors for human diseases modeling in laboratory animals by Timur I. Aliev, Dmitry V. Yudkin

“…The development of therapeutic drugs and vaccines requires the availability of appropriate model animals that replicate the pathogenesis of human diseases. …”
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The role of platelet-rich plasma in biomedicine: A comprehensive overview by Zhixin Zhang, Peng Liu, Xinmiao Xue, Zhiyu Zhang, Li Wang, Yvke Jiang, Chi Zhang, Hanwen Zhou, Shuhan Lv, Weidong Shen, Shiming Yang, Fangyuan Wang

“…Despite its cost-effectiveness, safety, and therapeutic efficacy, the widespread clinical adoption of PRP has been hindered by the absence of consistent preparation standards and standardized treatment protocols. …”
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The Immunotherapeutic Effect of SIRPα-Silenced DCs against Cervical Cancer by Xiaojie Li, Wenying Zhou, Yanlan Liang, Changzhi Xu, Zhizhi Xie, Jiayin Liang, Bo Hu

“…Taken together, these results suggest that SIRPα-silenced DC vaccination presented potential therapeutic implications against cervical cancer.…”
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Probiotics in the prevention of dental caries by Johany Duque de Estrada Riverón, Ileana Hidalgo-Gato Fuentes, Yensi Díaz Martell

“…It is necessary to deepen in the therapeutic effects of probiotics strains already discovered in order to obtain from them an effective preventive agent against dental caries and so ensuring a better quality of life, especially in children.…”
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Wyburn-Mason disease: Management of a Spetzler-Martin grade 5 arteriovenous malformation with predominant thalamic involvement by Jovan Dhatt, BS, Karis Houser, Kathryn A Szymanski, BS, Kelly Halderman, BS, Michael Kuwabara, MD

“…This case emphasizes the potential therapeutic role and risks of MEK inhibitors in managing high-grade AVMs in WMD and highlights the need for individualized management and careful monitoring in such cases.…”
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The application of procyanidins in diabetes and its complications: a review of preclinical studies by Yongchuang Zhang, Mengna Li, Haoyuan Liu, Yongfu Fan, Huan Huan Liu

“…The comprehensive analysis underscores the promising therapeutic role of PCs in diabetes care, indicating the need for further clinical studies to confirm and leverage their potential in comprehensive diabetes management strategies.…”
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Combined Treatment with Antiviral Therapy and Rituximab in Patients with Mixed Cryoglobulinemia: Review of the Literature and Report of a Case Using Direct Antiviral Agents-Based A... by Teresa Urraro, Laura Gragnani, Alessia Piluso, Alessio Fabbrizzi, Monica Monti, Elisa Fognani, Barbara Boldrini, Jessica Ranieri, Anna Linda Zignego

“…In the last decade, antiviral treatment (AT) with pegylated interferon (Peg-IFN) plus ribavirin (RBV) was considered the first therapeutic option for HCV-MC. In MC patients ineligible or not responsive to antivirals, the anti-CD20 monoclonal antibody rituximab (RTX) is effective. …”
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Applications of hydrogels and nanoparticles in the treatment of traumatic brain injury by Jiaying Shi, Jiaying Shi, Jiaying Shi, Jiajia Tang, Jin Xu, Ning Jiang, Yuanwei Yang, Honglin Chen, Yuhan Han, Yuhan Han, Yuhan Han, Xianhua Fu

“…Hydrogels and nanoparticles demonstrate substantial promise in addressing secondary brain injury, providing a broad spectrum of future therapeutic opportunities.…”
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Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome by Rosalie Matico, Karolien Grauwen, Dhruv Chauhan, Xiaodi Yu, Irini Abdiaj, Suraj Adhikary, Ine Adriaensen, Garcia Molina Aranzazu, Jesus Alcázar, Michela Bassi, Ellen Brisse, Santiago Cañellas, Shubhra Chaudhuri, Francisca Delgado, Alejandro Diéguez-Vázquez, Marc Du Jardin, Victoria Eastham, Michael Finley, Tom Jacobs, Ken Keustermans, Robert Kuhn, Josep Llaveria, Jos Leenaerts, Maria Lourdes Linares, Maria Luz Martín, Rosa Martín-Pérez, Carlos Martínez, Robyn Miller, Frances M Muñoz, Michael E Muratore, Amber Nooyens, Laura Perez-Benito, Mathieu Perrier, Beth Pietrak, Jef Serré, Sujata Sharma, Marijke Somers, Javier Suarez, Gary Tresadern, Andres A Trabanco, Dries Van den Bulck, Michiel Van Gool, Filip Van Hauwermeiren, Teena Varghese, Juan Antonio Vega, Sameh A Youssef, Matthew J Edwards, Daniel Oehlrich, Nina Van Opdenbosch

“…Dysregulation of NLRP3 activity is associated with various human diseases, making it an attractive therapeutic target. Patients with NLRP3 mutations suffer from Cryopyrin-Associated Periodic Syndrome (CAPS) emphasizing the clinical significance of modulating NLRP3. …”
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Potential Antidepressant Effects of Omeprazole Introduced Through Network Analysis and Systems Biology Should Be Interpreted with Caution in the Clinical Environment by Seyed-Ali Mostafavi

“…The authors presented important findings about potential therapeutic candidates for Major Depressive Disorder (MDD) using Network Analysis and Systems Biology. …”
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Generalized Aggressive Periodontitis and Its Treatment Options: Case Reports and Review of the Literature by T. Roshna, K. Nandakumar

“…Successful management of the disease is challenging especially if diagnosed at advanced stages of the disease, but not impossible with the current therapeutic choices for the disease. A vast array of treatment modalities is available which can be employed in the treatment of generalized aggressive periodontitis with varying success rates, but a definite guideline for the management is yet to be formulated. …”
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