Invariant NKT Cells as Novel Targets for Immunotherapy in Solid Tumors by Karsten A. Pilones, Joseph Aryankalayil, Sandra Demaria

“…Therefore, they represent promising therapeutic targets. In cancer, NKT cells are attributed a role in immunosurveillance. …”
Get full text

Synchronous Leydig Cell Tumor and Seminoma in the Ipsilateral Testis by Ifeyinwa E. Obiorah, Alexandra Kyrillos, Metin Ozdemirli

“…Increased awareness of the entity is important in order to distinguish Leydig cell tumor and seminomas from other malignancies due to difference in therapeutic management.…”
Get full text

Unraveling the AMPK-SIRT1-FOXO Pathway: The In-Depth Analysis and Breakthrough Prospects of Oxidative Stress-Induced Diseases by Guangqi Guan, Yaoxing Chen, Yulan Dong

“…This review provides a comprehensive analysis of the biological roles, regulatory mechanisms, and functions of the AMPK-SIRT1-FOXO pathway in diseases influenced by OS, offering new insights and methods for understanding OS pathogenesis and its therapeutic approaches.…”
Get full text

Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy by Ji-Yoon Noh, Suk Ran Yoon, Tae-Don Kim, Inpyo Choi, Haiyoung Jung

“…In this review, we will discuss the expression and cellular function of TLRs in NK cells and also introduce some therapeutic applications of TLR agonists for NK cell-mediated immunotherapy.…”
Get full text

Cancer in a polyp of the large intestine – an interdisciplinary decision problem by Przemysław Stefaniak, Hanna Majewska, Dariusz Zadrożny, Janusz Godlewski

“…A correct interpretation of the pathomorphological protocol is crucial for the therapeutic decision, which should be consistent with the actual recommendations of gastroenterological societies. …”
Get full text

Advances in Gene Therapy for Neurologic Disorders: An Overview by Pallavi Chand, K. Trideva Sastri, Ashish Singh Chauhan, Souvik Chakraborty, Vikash Jakhmola

“…Gene therapy has progressed to a compelling therapeutic approach for various neurodegenerative disorders. …”
Get full text

Extracellular vesicular microRNAs and cardiac hypertrophy by Hai Hu, Hai Hu, Xiulian Wang, Hui Yu, Hui Yu, Zhanli Wang

“…Understanding the molecular events that inhibit or repress cardiac hypertrophy may help identify novel therapeutic strategies. Increasing evidence has indicated that extracellular vesicle (EV)-derived microRNAs (miRNAs) play a significant role in the development and progression of cardiac hypertrophy. …”
Get full text

Current Development of Mesenchymal Stem Cell-Derived Extracellular Vesicles by Bingyi Zheng, Xueting Wang, Meizhai Guo, Chi-Meng Tzeng

“…Recent studies suggest that one of the key therapeutic mechanisms of MSCs seems to derive from their paracrine product, called extracellular vesicles (EVs). …”
Get full text

Management of Maxillary Incisors With Middle-Third Root Perforation: A Case Report by Daysi Morocho-Monteros, María José Masson-Palacios, Juan Marcos Parise-Vasco

“…These perforations typically occur during root canal preparation or endodontic post placement, presenting significant therapeutic challenges. The main objective in the management of such complications is to seal the perforation, thus preventing bacterial invasion and tooth loss. …”
Get full text

Hyperoxia-activated Nrf2 regulates ferroptosis in intestinal epithelial cells and intervenes in inflammatory reaction through COX-2/PGE2/EP2 pathway by Yanping Liu, Tianming Li, Changping Niu, Zhengwei Yuan, Siyu Sun, Dongyan Liu

“…These findings have important implications for future clinical prevention and therapeutic approaches to neonatal organ injury caused by hyperoxia treatment.…”
Get full text

Esophageal Electrical Cardioversion of Atrial Fibrillation: When Esophagus Gives a Help to Cardiologists by Luca Santini, Giovanni B. Forleo, Francesco Romeo

“…Electrical cardioversion is the first choice therapeutic approach for patients in which sinus rhythm could improve the quality of life and where the maintenance of sinus rhythm is considered likely. …”
Get full text

Case Report of Probable DRESS Syndrome Associated with Ribociclib by Florian Carneiro, Marine Bove, Frédérique Beau-Salinas, Tevy San, Pierre Combe

“…Another CDK4/6 inhibitor, palbociclib, was introduced later without any cross-toxicity and with an excellent therapeutic response for more than 3 years.…”
Get full text

Diagnostic Consideration for Sinonasal Wegener’s Granulomatosis Clinically Mistaken for Carcinoma by Cristina La Rosa, Carmela Emmanuele, Maria Grazia Tranchina, Massimo Ippolito, Sebastiano Cosentino, Vincenzo Saita, Giuseppina Improta, Filippo Fraggetta

“…Clinical findings and image studies suggested an erroneous diagnosis of malignancy whereas a definitive diagnosis of Wegener’s granulomatosis was achieved only after repeated biopsies thus leading to a correct therapeutic approach. The Wegener granulomatosis must be added to the list of the differential diagnoses of the masses of the nasopharynx associated with or without enlarged laterocervical nodes.…”
Get full text

The Cardiorenal Syndrome: Making the Connection by Gautham Viswanathan, Scott Gilbert

“…We will examine the scope and impact of this problem, the pathophysiology associated with this relationship, including underperfuson and venous congestion, diagnostic tools for earlier detection, and therapeutic interventions to prevent and treat this complication.…”
Get full text

Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases by Junio Dort, Paul Fabre, Thomas Molina, Nicolas A. Dumont

“…Considering the key roles of macrophages in skeletal muscle, they represent an attractive target for new therapeutic approaches aiming at mitigating various muscle disorders. …”
Get full text

Automatic Cardioversor-desfibrillator Implantable to a Patient with Recovered Sudden Death by Magdiel Echazabal Leal, Ernesto Pérez Martínez, Raiko Cruz Sosa

“…The implantable automatic cardio-desfibrillator has been one of the therapeutic modalities highly effective in the treatment of malignant arrhythmia. …”
Get full text

The diagnostic and prognostic significance of HOXC13-AS and its molecular regulatory mechanism in human cancer by Xiaosi Gu, Xin Hu, Sijia Zhang, Xiaoyu Zhang, Yong Wang, Lianlian Li, Lianlian Li

“…Overall, this review emphasizes the potential of HOXC13-AS as a human tumor predictive biomarker and therapeutic target, paving the way for its clinical application.…”
Get full text

Deep Endometriosis Induced Spontaneous Colon Rectal Perforation in Pregnancy: Laparoscopy Is Advanced Tool to Confirm Diagnosis by Aurelio Costa, Annalisa Sartini, Silvia Garibaldi, Marco Cencini

“…Laparoscopy can be a useful means of diagnosis and in addition a therapeutic tool in selected pregnant patients with abdominal pain. …”
Get full text

Dental Erosion from an Excess of Vitamin C by Priya Bahal, Serpil Djemal

“…This demonstrates the importance of the manufacturer’s instructions and the clinician’s role in advising patients with regard to the correct therapeutic doses.…”
Get full text

The Transcribed-Ultraconserved Regions: A Novel Class of Long Noncoding RNAs Involved in Cancer Susceptibility by Paola Scaruffi

“…Most recent studies show that they are significantly altered in adult chronic lymphocytic leukemias, carcinomas, and pediatric neuroblastomas, leading to the hypothesis that UCRs may play a role in tumorigenesis and promising innovative future T-UCR—based therapeutic approaches.…”
Get full text