Extracorporeal Cardiac Shock Wave Therapy Ameliorates Clinical Symptoms and Improves Regional Myocardial Blood Flow in a Patient with Severe Coronary Artery Disease and Refractory... by Christian Prinz, Oliver Lindner, Thomas Bitter, Detlef Hering, Wolfgang Burchert, Dieter Horstkotte, Lothar Faber

“…Different therapeutic options are being used for chronic coronary artery disease (CAD). …”
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Hydroxyurea Treatment for Sickle Cell Disease by Martin H. Steinberg

“…Pharmacologic agents that can reverse the switch from γ- to β-chain synthesis — γ-globin chains characterize HbF, and sickle β-globin chains are present in HbS — or selectively increase the proportion of adult erythroid precursors that maintain the ability to produce HbF are therapeutically useful. Hydroxyurea promotes HbF production by perturbing the maturation of erythroid precursors. …”
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Severe Clostridial Pyomyoma following an Abortion Does Not Always Require Surgical Intervention by Daphna Stroumsa, Eliel Ben-David, Nurith Hiller, Drorith Hochner-Celnikier

“…In selected cases of infected myoma complicated by clostridial sepsis, refraining from surgical intervention is a possible therapeutic approach.…”
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Endoscopic Alcohol Injection Therapy of Giant Gastric Leiomyomas: An Alternative Method to Surgery by Burhan Ozdil, Hikmet Akkiz, Can Kece, Macit Sandikci

“…The treatment of esophageal leiomyoma has been enhanced by improvements in diagnostic and therapeutic endoscopic techniques; however, the same cannot be said for gastric leiomyoma management. …”
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Advances and current concepts on Eph receptors and ephrins in upper digestive tract cancers by Luccas Lavareze, Luccas Lavareze, Talita de Carvalho Kimura, Talita de Carvalho Kimura, João Figueira Scarini, João Figueira Scarini, Reydson Alcides de Lima-Souza, Reydson Alcides de Lima-Souza, Moisés Willian Aparecido Gonçalves, Moisés Willian Aparecido Gonçalves, Raisa Sales de Sá, Raisa Sales de Sá, Iara Gonçalves Aquino, Iara Gonçalves Aquino, Patricia Maria Fernandes, Fernanda Cristina Poscai Ribeiro, Albina Altemani, Fernanda Viviane Mariano, Gary Chris Fillmore, Erika Said Abu Egal, Erika Said Abu Egal

“…In addition, we discuss molecular findings that represent promising therapeutic targets for these cancers.…”
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Smoking associated metabolites from gut microbiota on health: Nicotine degradation brings hopes by Guangyi Zeng, Wanwan Guo, Bo Chen, Yanli Pang, Lulu Sun

“…Gut microbiota-mediated nicotine degradation has emerged as a promising therapeutic approach for smoking-related metabolic disorders associated with smoking. …”
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Mesenchymal Stem Cells Isolated from Adipose and Other Tissues: Basic Biological Properties and Clinical Applications by Hakan Orbay, Morikuni Tobita, Hiroshi Mizuno

“…Isolation and induction of these cells could provide a new therapeutic tool for replacing damaged or lost adult tissues. …”
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Achalasia complicated with bilateral pneumonia and sepsis by Jelena Isaković, Ivana Spasojević, Stanislava Petrović, Ivan Ergelašev, Branislava Jorović, Dajana Lendak

“…The case study highlights the importance of a multidisciplinary approach, choosing the right therapeutic approach, and objective assessment of the situation, when we decide on one option while another option arises as the only one that is sustainable. …”
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Questions from the fourth son: A clinician reflects on immunomonitoring, surrogate markers and systems biology by Charles Wiseman, M.D.

“…Unlike prophylactic vaccines for infectious disease, where the development of antibody is considered a satisfactory endpoint, no such endpoint exists for human therapeutic vaccines. Why is this? Despite an extensive roster of in vitro assays that correlate immune responses to favorable clinical outcomes, no assay is sufficiently reliable to be usefully predictive for vaccine therapy. …”
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Revisiting substance P in migraine: a methodological approach inspired by anti-CGRP and anti-PACAP success by Lanfranco Pellesi, Lars Edvinsson

“…Abstract Substance P, previously dismissed as a therapeutic target for migraine due to the failure of neurokinin-1 receptor antagonists, warrants renewed attention. …”
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The important practical results and modern lines in studying diseases of the stomach and duodenum (Review of the Seventeenth Russian Gastroenterological Week proceedings, October,... by I. V. Mayev, A. A. Samsonov, N. G. Andreyev, D. N. Andreyev

“…Elements of diagnostic concepts and therapeutic approaches for this group of diseases of gastro-intestinal tract (GIT) are modified. …”
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Alternative Splicing Programs in Prostate Cancer by Claudio Sette

“…This review illustrates some examples of genes whose alternative splicing regulation is relevant to PCa biology and discusses the possibility to exploit alternative splicing regulation as a novel tool for prognosis, diagnosis, and therapeutic approaches to PCa.…”
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Wernicke encephalopathy in a patient with drug-induced liver failure: a case report by Jiao-Jiao Cao, Jing Li, Yan Cheng, Li-Min Luo, Yang Chen, Chang-Xing Huang, Ye Zhang

“…The classic symmetric hyperintense signals on T2-weighted and diffusion-weighted images were reversible after intravenous vitamin B1 supplementation.ConclusionA high index of clinical suspicion is required for early diagnosis and appropriate preventive and therapeutic strategies by adequate and immediate vitamin B1 supplements in the reversible stage of Wernicke encephalopathy.…”
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Regulation of Skp2 Expression and Activity and Its Role in Cancer Progression by Chia-Hsin Chan, Szu-Wei Lee, Jing Wang, Hui-Kuan Lin

“…The notion is supported by various genetic mouse models that demonstrate an oncogenic activity of Skp2 and its requirement in cancer progression, suggesting that Skp2 may be a novel and attractive therapeutic target for cancers.…”
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Perils and Pitfalls Regarding Differential Diagnosis and Treatment of Primary Cutaneous Anaplastic Large-Cell Lymphoma by Michael D. Diamantidis, Athena D. Myrou

“…Given their rarity and heterogeneity, these entities represent diagnostic and therapeutic challenges, thus requiring a multidisciplinary approach and expertise to ensure appropriate diagnosis and management. …”
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Interdisciplinary study of alexithymia by E.A. Gorobets, R.G. Esin, Yu.A. Volskaya

“…A review of modern neurostudies on alexithymia seeking to further explore it and identify optimal therapeutic strategies is provided.…”
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Peritoneal dialysis in an end-stage renal disease patient with massive ascites and primary liver cancer by Lulu Sun, Chunmei Liang, Yuqin Wang, Hui Li, Lijun Yao, Huajun Jiang

“…PD can serve as an efficacious therapeutic approach for such late-stage patients afflicted together with severe cirrhosis, massive ascites and primary liver cancer.…”
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Food allergens and oral immunotherapy as indicators of eosinophilic oesophagitis by Andrzej Kuźmiński, Justyna Przybyszewska, Zbigniew Bartuzi

“…To date, the appearance of EoE in the course of OIT is an absolute indication for discontinuation of this procedure; however, other therapeutic options that do not require termination of this procedure are increasingly being advocated. …”
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Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials by Vittorio Unfer, John E. Nestler, Zdravko A. Kamenov, Nikos Prapas, Fabio Facchinetti

“…The purpose of this systematic review is the analysis of recent randomized clinical trials of inositol(s) in PCOS, in particular myo- and D-chiro-inositol, in order to better elucidate their physiological involvement in PCOS and potential therapeutic use, alone and in conjunction with assisted reproductive technologies, in the clinical treatment of women with PCOS.…”
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Cardiac Output Assessed by Invasive and Minimally Invasive Techniques by Allison J. Lee, Jennifer Hochman Cohn, J. Sudharma Ranasinghe

“…Cardiac output (CO) measurement has long been considered essential to the assessment and guidance of therapeutic decisions in critically ill patients and for patients undergoing certain high-risk surgeries. …”
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