Is narrow band imaging accurate to differentiate between high-risk and low-risk vocal fold leukoplakia? A systematic review and meta-analysis by Mina Sarabi Jamab, Arezoo Aghakouchakzadeh, Seied Omid Keyhan, Hosein Rafiemanesh, Ahmadreza Mirzaei, Mina Teimouri Badeleh Dareh

“…Vocal fold leukoplakia (VFL) is a pre-cancerous lesion that its management is still a therapeutic dilemma due to the need for timely diagnosis of its nature. …”
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Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency by Nadia Charfi, Mahdi Kamoun, Mouna Feki Mnif, Neila Mseddi, Fatma Mnif, Nozha Kallel, Basma Ben Naceur, Nabila Rekik, Hela Fourati, Emna Daoud, Zainab Mnif, Mourad Hadj Sliman, Tahia Sellami-Boudawara, Mohamed Abid

“…This distinction is interesting because LCTs and TARTs require different therapeutic approaches. Hereby, we present an unusual case of a 19-year-old patient with CAH due to 11β-hydroxylase deficiency, who presented with TARTs and an epididymal Leydig cell tumor.…”
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Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease by V. Conti, G. Corbi, V. Manzo, G. Pelaia, A. Filippelli, A. Vatrella

“…Thus, there is an urgent need to clarify the molecular mechanisms responsible for this condition in order to identify new biomarkers and therapeutic targets. Processes including oxidant/antioxidant, protease/antiprotease, and proliferative/antiproliferative balance and control of inflammatory response become dysfunctional during aging as well as in COPD. …”
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Rare Abdominal Wall Metastasis following Curative Resection of Gastric Cancer: What Can Be Learned from the Use of Percutaneous Catheters? by Arthur A. Parsee, Kerry L. Thomas, Masoumeh Ghayouri, Rutika Mehta, Kujtim Latifi, Jennifer Sweeney, Daniel Jeong, Abraham Ahmed

“…The oncologic patient provides many challenges and may require multiple catheters for drainage and at times infusion of nutrition or therapeutic agents. These foreign bodies should be scrutinized both clinically and radiographically, as they may create vulnerabilities in keeping malignant diseases contained and controlled. …”
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From actinic keratosis to cutaneous squamous cell carcinoma: the key pathogenesis and treatments by Zhenlin Li, Zhenlin Li, Zhenlin Li, Zhenlin Li, Fangqi Lu, Fangqi Lu, Fangqi Lu, Fangqi Lu, Fujin Zhou, Fujin Zhou, Fujin Zhou, Dekun Song, Dekun Song, Dekun Song, Lunhui Chang, Lunhui Chang, Lunhui Chang, Lunhui Chang, Weiying Liu, Guorong Yan, Guorong Yan, Guorong Yan, Guolong Zhang, Guolong Zhang, Guolong Zhang, Guolong Zhang

“…It is of great significance to uncover the progression mechanisms from AK to cSCC, which will facilitate the early therapeutic intervention of AK before malignant transformation. …”
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RETRACTED ARTICLE: Emerging insights into the role of IL-1 inhibitors and colchicine for inflammation control in type 2 diabetes by Jianbin Guan, Haimiti Abudouaini, Kaiyuan Lin, Kaitan Yang

“…This review provides a comprehensive examination of the inflammatory mechanisms underlying T2DM, focusing on the role of the NLRP3 inflammasome and interleukin-1β (IL-1β) in mediating inflammatory responses. We discuss the therapeutic potential of IL-1 inhibitors and colchicine, highlighting their mechanisms in inhibiting the NLRP3 inflammasome and reducing IL-1β production. …”
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Circulating T Cell Subsets in Type 1 Diabetes by Aldo Ferreira-Hermosillo, Paola Santana-Sánchez, Ricardo Vaquero-García, Manuel R. García-Sáenz, Angélica Castro-Ríos, Adriana K. Chávez-Rueda, Rita A. Gómez-Díaz, Luis Chávez-Sánchez, María V. Legorreta-Haquet

“…By employing flow cytometry to compare the characteristics of T cells, we can pinpoint potential indicators of treatment response or therapeutic inefficacy. Our study reveals elevated prolactin (PRL) levels in T1D patients, along with a decreased production of key cytokines. …”
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Elevated CA-125 as Humoral Biomarker of Congestive Heart Failure: Illustrative Cases and a Short Review of Literature by Attila Frigy, Boglárka Belényi, Ádám Kirchmaier, Nándor Fekete, István Adorján Szabó

“…Humoral biomarkers in HF are capable to reflect different aspects of the cardiac morpho-functional changes and the related pathophysiological processes and could have important diagnostic, prognostic, and therapeutical roles. CA-125 is a well-known tumor marker (mainly for ovarian cancer), and also a useful, but less applied cardiac biomarker. …”
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Mathematical modeling and treating tumors in a fuzzy environment by Aadil Sheergojri, Pervaiz Iqbal

“…This article begins with an overview of mathematical models for tumor development and treatment, which consider stochastic perturbations a therapeutic remedy. Also, it has been demonstrated that fuzzy modeling approaches may be used to investigate the impacts of various components on tumor development estimation, minimize tumor uncertainty, and attain a degree of realism.…”
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Iron Chelation Therapy in Myelodysplastic Syndromes by Emanuela Messa, Daniela Cilloni, Giuseppe Saglio

“…Iron chelation therapy may be a therapeutic option for these patients, especially since the approval of oral iron chelators, which are easier to use and better accepted by the patients. …”
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2-Cys Peroxiredoxins: Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks by Jinah Park, Sunmi Lee, Sanghyuk Lee, Sang Won Kang

“…These discoveries help reveal the redox signaling landscape in mammalian cells and may further provide a new paradigm of therapeutic approaches based on redox signaling.…”
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Chylous Ascites: A Rare Adverse Effect of Methimazole Treatment for Grave’s Disease—A Case Report and Review of the Literature by Tawfik Khoury, Ronen Schneider

“…The patient later underwent therapeutic thyroidectomy, after which all features of thyrotoxicosis had improved.…”
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L’intervention féministe sous l’influence de l’intersectionnalité : enjeux organisationnels et communicationnels au sein des organismes féministes au Québec by Isabelle Marchand, Christine Corbeil, Carole Boulebsol

“…In Quebec, feminist intervention was spread significantly in the mid-1970s and presented itself as a therapeutic and political alternative to traditional therapies in the field of mental health and the fight against gender-based violence, to support women and defend their rights. …”
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Humanized Mouse Models for Immuno-Oncology Research: A Review and Implications in Lung Cancer Research by Cheol-Kyu Park, MD, PhD, Maryam Khalil, BSc, Nhu-An Pham, PhD, Stephanie Wong, BSc, Dalam Ly, PhD, Adrian Sacher, MD, FRCPC, Ming-Sound Tsao, MD, FRCPC

“…We highlight the various approaches to generate them, factors that are critical to successfully establishing such models, their respective limitations, and considerations in model selection for preclinical lung cancer immuno-oncology research and therapeutic studies.…”
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Biomarkers for Hepatocellular Carcinoma by Tara Behne, M. Sitki Copur

“…These markers not only help in prediction of prognosis or recurrence but may also assist in deciding appropriate modality of therapy and may represent novel potential targets for therapeutic interventions. In this paper, a summary of most relevant available data from published papers reporting various tissue and serum biomarkers involved in hepatocellular carcinoma was presented.…”
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The Role of Exosomes in Cancer Progression and Therapy by Shynggys Sergazy, Roza Seydahmetova, Alexandr Gulyayev, Zarina Shulgau, Mohamad Aljofan

“…Recent advances have shown the potential for exosomes to be used in early disease detection and in targeted drug therapy by delivering therapeutic agents specifically to tumor sites. Despite the promising applications, a number of challenges remain, including exosome isolation and characterization, as well as their inherent heterogeneity. …”
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Drug Therapy for Non-Alcoholic Steatohepatitis-Induced Liver Fibrosis by D. V. Garbuzenko

“…In current clinical recommendations, therapeutic measures in non-alcoholic fatty liver disease should include lifestyle change, body weight normalisation, NASH-associated liver fibrosis-specific drug therapy and treatment for metabolic syndrome-related diseases. …”
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Advancing allergy practice in India for respiratory physician by Shambo S. Samajdar, Saibal Moitra

“…The landscape of allergy practice in India is undergoing transformative changes, shifting from traditional symptom management to embracing advanced diagnostic and therapeutic modalities for disease modification. This evolution is propelled by the integration of subcutaneous immunotherapy, biologic treatments, and the exploration of probiotics, alongside advancements in diagnostic approaches such as component-resolved diagnostics (CRD) and basophil activation tests. …”
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GLP-1/GLP-1R Signaling Regulates Ovarian PCOS-Associated Granulosa Cells Proliferation and Antiapoptosis by Modification of Forkhead Box Protein O1 Phosphorylation Sites by Zhihua Sun, Peiyi Li, Xiao Wang, Shuchang Lai, Hong Qiu, Zhi Chen, Shidi Hu, Jie Yao, Jie Shen

“…Although glucagon-like peptide 1 receptor agonists (GLP-IRAs) show therapeutic effects for PCOS, its target and underlying mechanism remains elusive. …”
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In Vivo Molecular Imaging in Retinal Disease by Fang Xie, Wenting Luo, Zhongyu Zhang, Dawei Sun

“…In vivo molecular imaging has a great potential to impact medicine by detecting diseases or screening disease in early stages, identifying extent of disease, selecting disease and patient-specific therapeutic treatment, applying a directed or targeted therapy, and measuring molecular-specific effects of treatment. …”
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