Epigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical Therapies by Silvia Consalvi, Martina Sandoná, Valentina Saccone

“…In the context of regenerative medicine, based on the potential of stem cells to restore diseased tissues, epigenetics is becoming a pivotal area of interest. Therapeutic interventions that promote tissue and organ regeneration have as primary objective the selective control of gene expression in adult stem cells. …”
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Capnography and the Bispectral Index—Their Role in Pediatric Sedation: A Brief Review by Maria Sammartino, Barbara Volpe, Fabio Sbaraglia, Rossella Garra, Alessandro D'Addessi

“…Sedation in children is increasingly emerging as a minimally invasive technique that may be associated with local anaesthesia or diagnostic and therapeutic procedures which do not necessarily require general anaesthesia. …”
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Hemophagocytic Lymphohistiocytosis (HLH) Following Immune Checkpoint Therapy (ICT) by Saivaroon Gajagowni, Emily Wang, Jianbo Wang, Matthew T. Campbell, Bilal A. Siddiqui

“…In the past decade, the use of immune checkpoint therapy (ICT) has increased across many malignancies, including metastatic renal cell carcinoma as an option for frontline and subsequent lines of therapy. Despite the many therapeutic benefits of ICT, its use is complicated by the potential risk of immune-related adverse events (irAEs). …”
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Modulation of Fibrosis in Systemic Sclerosis by Nitric Oxide and Antioxidants by Audrey Dooley, K. Richard Bruckdorfer, David J. Abraham

“…Hence, targeting EGCG may prove a possible candidate for therapeutic treatment aimed at reducing both oxidant stress and the fibrotic effects associated with SSc.…”
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HERVs Endophenotype in Autism Spectrum Disorder: Human Endogenous Retroviruses, Specific Immunoreactivity, and Disease Association in Different Family Members by Marco Bo, Alessandra Carta, Chiara Cipriani, Vanna Cavassa, Elena Rita Simula, Nguyen Thi Huyen, Giang Thi Hang Phan, Marta Noli, Claudia Matteucci, Stefano Sotgiu, Emanuela Balestrieri, Leonardo Antonio Sechi

“…Therefore, we propose that investigating their fundamental properties could not only improve existing therapies but also pave the way for new therapeutic strategies.…”
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Targeting the chemokines in acute graft-versus-host disease by Ziwei Xu, Huafang Wang

“…Allogeneic hematopoietic stem cell transplantation (allo-HSCT) constitutes a critical therapeutic approach for patients with malignant hematological disorders. …”
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Recent Advances in Hydroxyapatite Scaffolds Containing Mesenchymal Stem Cells by John Michel, Matthew Penna, Juan Kochen, Herman Cheung

“…These cells differentiate along the osteogenic lineage when seeded on hydroxyapatite containing scaffolds and can be used as a therapeutic option to regenerate various tissues. In recent years, the combination of hydroxyapatite and natural or synthetic polymers has been studied extensively. …”
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Investigating the role of intratumoral Streptococcus mitis in gastric cancer progression: insights into tumor microenvironment by Ping Yang, Gaoli Liang, Yangyue Ni, Xiaojie Chu, Xiaoshan Zhang, Zhongyu Wang, Adeel Khan, Fangfang Jin, Han Shen, Miao Li, Zhipeng Xu

“…In summary, our findings suggest that the intratumoral microbiota, exemplified by Streptococcus mites, may be involved in regulating the progression of gastric cancer, thereby emerging as potential therapeutic targets for this disease.…”
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Cervical mucus in linked human Cervix and Vagina Chips modulates vaginal dysbiosis by Ola Gutzeit, Aakanksha Gulati, Zohreh Izadifar, Anna Stejskalova, Hassan Rhbiny, Justin Cotton, Bogdan Budnik, Sanjid Shahriar, Girija Goyal, Abidemi Junaid, Donald E. Ingber

“…Proteomic analysis of the Vagina Chip, following exposure to mucus from the Cervix Chip, revealed differentially abundant proteins, suggesting potential biomarkers and therapeutic targets for BV management. Our findings highlight the essential function of cervical mucus in preserving vaginal health and underscore the value of organ chip models for studying complex interactions within the female reproductive tract. …”
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Current status and future directions of application of urine proteomics in neonatology by Dan Wu, Dan Wu, Lulu Zhang, Lulu Zhang, Fangrui Ding, Fangrui Ding

“…With continuous advancements in mass spectrometry technology, researchers increasingly utilize this method to investigate the molecular mechanisms underlying various diseases, and to identify novel diagnostic and therapeutic strategies. Among proteomics applications, urinary proteomics stands out for its non-invasive nature, making it particularly suitable for vulnerable populations like neonates. …”
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The role of BATF in immune cell differentiation and autoimmune diseases by Xiaomeng Wang, Yue Hong, Jinmei Zou, Bo Zhu, Chao Jiang, Liwei Lu, Jie Tian, Jing Yang, Ke Rui

“…This review summarizes the roles of BATF in the development and function of innate and adaptive immune cells, as well as its immunoregulatory effects in the development of autoimmune diseases, which may enhance the current understanding of the pathogenesis of autoimmune diseases and facilitate the development of new therapeutic strategies.…”
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NLRP3 Inflammasome-Mediated Osteoarthritis: The Role of Epigenetics by Yuzhou Liu, Ying Wang, Ping Yan, Ning Cui, Kejin Xu, Da Liu, Yuan Tian, Lingling Cao

“…The most common clinical therapeutic drugs are painkillers, yet they cannot impede the deteriorating course of OA. …”
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Oxidative Stress and the NLRP3 Inflammasome: Focus on Female Fertility and Reproductive Health by Efthalia Moustakli, Sofoklis Stavros, Periklis Katopodis, Charikleia Skentou, Anastasios Potiris, Periklis Panagopoulos, Ekaterini Domali, Ioannis Arkoulis, Theodoros Karampitsakos, Eleftheria Sarafi, Theologos M. Michaelidis, Athanasios Zachariou, Athanasios Zikopoulos

“…The aims of this review are to examine these molecular mechanisms and to explore therapeutic strategies targeting oxidative stress and NLRP3 inflammasome activity, with the goal of enhancing female fertility and improving clinical outcomes in reproductive health.…”
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Functional Cereal Products in the Diet for Type 2 Diabetes Patients by Ada Krawęcka, Aldona Sobota, Emilia Sykut-Domańska

“…The diet can exert prophylactic and therapeutic effects; changes in the diet in advanced disease can improve the quality of life of diabetic patients and minimise the risk of complications, which are the direct cause of diabetes-related death. …”
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Neonatal Cholestasis: A Red Alert for the Jaundiced Newborn by Dinesh Pashankar, Richard A Schreiber

“…Unravelling the etiopathogenesis of these neonatal cholestatic disorders will allow the development of novel diagnostic and therapeutic interventions that ultimately will effectuate the prognosis for these young patients.…”
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Autoimmune Cytopenias in Chronic Lymphocytic Leukemia by Giovanni D'Arena, Roberto Guariglia, Francesco La Rocca, Stefania Trino, Valentina Condelli, Laura De Martino, Vincenzo De Feo, Pellegrino Musto

“…In general, excluding the specific treatment of underlying CLL, the managementof these complications is not different from that of idiopathic autoimmune cytopenias or of those associated to other causes. Among different therapeutic approaches, monoclonal antibody rituximab, given alone or in combination, has shown to be very effective.…”
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Reversing NK cell exhaustion: a novel strategy combining immune checkpoint blockade with drug sensitivity enhancement in the treatment of hepatocellular carcinoma by Yuxiang Huang, Hengjian Liao, Jiefu Luo, Huaning Wei, Anling Li, Yujie Lu, Bangde Xiang

“…This article explores the promise of these innovative strategies in HCC immunotherapy, providing new therapeutic directions for optimizing NK cell function and improving drug sensitivity.…”
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Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders by Keren Zhou, Ligen Shi, Yan Wang, Sheng Chen, Jianmin Zhang

“…In conclusion, the NLRP3 inflammasome may be a promising therapeutic target for these CNS diseases.…”
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Mechanical thrombextraction in patient with acute ischemic stroke on background of oral anticoagulant therapy by V.О. Yarosh, V.V. Babenko, O.E. Svyrydiuk, O.J. Zharinov, O.A. Yepanchintseva, B.M. Todurov

“…Mechanic thrombextraction is considered to be an alternative therapeutic strategy in case of inefficacy or contraindications to thrombolytic therapy. …”
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Multidisciplinary management of a patient with acute oesophageal necrosis and severe neurological symptoms with full recovery by Katrīna Terehova, Poļina Zaļizko, Krista Lazdovska, Raimonds Skumbiņš, Aldis Puķītis

“…It poses significant diagnostic and therapeutic challenges as it often presents with multiple comorbidities and a poor prognosis. …”
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