Book review: Residential child care: prospects and challenges Andrew Kendrick, Editor by Irene Stevens

“…The fourth section deals with children's rights, training and recruitment of staff, leadership and therapeutic approaches.…”

Frontostriatal Cognitive Staging in Parkinson's Disease by Raúl de la Fuente-Fernández

“…Although the model admittedly needs further refinements, it provides a framework for hypothesis testing and may help clinicians optimize therapeutic strategies.…”
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Nanotechnology and Tumor Imaging: Seizing an Opportunity by Daniel C. Sullivan, Mauro Ferrari

“…Similarly, many copies of targeted ligands can be attached to nanoparticles to markedly inrease specific binding. Drugs or therapeutic isotopes can be added to create multifunctional nanoparticles. …”
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"Accompagner" des sujets malades en appartement de coordination thérapeutique : regards croisés des professionnels by Martha Isabel Arciniegas Cardoso

“…This association proposes an accommodation and a global support by means of a plan named -apartment of therapeutic coordination-. This support is implemented by a multidisciplinary team. …”
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Qinggan Yipi capsule ameliorates hepatic fibrosis in rats by down-regulating the TGF-β1/Smad2/3 signaling pathway and improving gut microbiota imbalance by Wenjing Xue, Haiqing Liu, Ziheng Su, Siqi Wang, Junping Cheng, Yunzhi Pan, Lurong Zhang

“…The therapeutic mechanism of QgYp for HF was predicted through network pharmacology. …”
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Single-cell RNA sequencing and AlphaFold 3 insights into cytokine signaling and its role in uveal melanoma by Hongyan Sun, Cunzi Li, Zuhui Pu, Zuhui Pu, Ying Lu, Ying Lu, Zijing Wu, Zijing Wu, Lan Zhou, Lan Zhou, Hongzhan Lin, Yumo Wang, Tao Zi, Lisha Mou, Lisha Mou, Ming-ming Yang

“…The insights into cytokine signaling and T-cell dynamics within the UVM microenvironment provide a foundation for developing personalized therapeutic strategies to improve patient outcomes.…”
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Neuregulin1 ameliorates metabolic dysfunction-associated fatty liver disease via the ERK/SIRT1 signaling pathways by Chengan Xu, Shouhao Wang, Di Meng, Mingshan Wang, Rong Yan, Yining Dai

“…This study might indicate a new therapeutic strategy for MAFLD.…”
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Molecular Alterations of KIT Oncogene in Gliomas by Ana L. Gomes, Jorge S. Reis-Filho, José M. Lopes, Olga Martinho, Maryou B. K. Lambros, Albino Martins, Fernando Schmitt, Fernando Pardal, Rui M. Reis

“…Gliomas are the most common and devastating primary brain tumours. Despite therapeutic advances, the majority of gliomas do not respond either to chemo or radiotherapy. …”
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Efficacy of wearable transcutaneous electrical acupoint stimulation bracelet on moderate-to-severe postoperative nausea and vomiting in patients after general anesthesia: a study p... by Peng Ding, Dong-yu Zheng, Hong-wei Zhu, Ming Gong, Yong-qiang Wang, Ling-yan Jin, Guang-li Ren, Hui-jing Shi, Yong-hua Li

“…Discussion This multi-center randomized controlled trial aims to reveal the therapeutic effect of the wearable TEAS bracelet on PONV. …”
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Cellular heterogeneity and cytokine signatures in acute myeloid leukemia: A novel prognostic model by Jinxia Cao, Bin Hu, Tianqi Li, Dan Fang, ling Jiang, Jun Wang

“…This diversity complicates the development of effective, universally applicable therapeutic strategies and highlights the necessity for personalized approaches to treatment. …”
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Comparative-effectiveness research of COVID-19 treatment: a rapid scoping review by Sharon E Straus, Jesmin Antony, Andrea C Tricco, Rachel Warren, Erin Macdonald, Ba Pham, Milan Patel, Fatemeh Yazdi, Amruta Radhakrishnan, Marco Ghassemi, Patricia Rios, Chantal Williams, Naveeta Ramkissoon, Matthew P Muller, Nazia Darvesh, Gordon V Cormack, Maura R Grossman, Melissa Kampman, Reid Robson

“…The most common therapeutic categories involving multiple drugs were antimalarials/antibiotics (16%), steroids/non-steroidal immunosuppressants (9%) and antimalarials/antivirals/antivirals (7%). …”
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Effects on impulsivity and delay discounting of intermittent theta burst stimulation add-on to dialectical behavioral therapy in borderline personality disorder: a randomized, sham... by Milenko Kujovic, Christian Bahr, Mathias Riesbeck, Daniel Benz, Martina Deiß, Zsofia Margittai, Sebastian Henges, Dirk Reinermann, Christian Plewnia, Eva Meisenzahl

“…Impulsivity and impaired decision-making are prominent features of BPD, and therapeutic interventions targeting these symptoms could lead to significant improvements. …”
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Transcutaneous vagus nerve stimulation for Parkinson’s disease: a systematic review and meta-analysis by Jiatong Shan, Jiatong Shan, Jiatong Shan, Zehong Li, Minxiu Ji, Miao Zhang, Caidi Zhang, Yikang Zhu, Zhen Feng

“…It has small to moderate therapeutic effects on motor functions and may negatively impact on a few other outcomes. …”
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Recent trends in research on the role of cholesterol in leukemia: a bibliometric and visualization study by Huijuan Lv, Ke Lu, Ximing Wang, Yanfang Zhang, Mengqi Zhuang, Jing Li, Keli Su, Wen Gao

“…These insights suggest crucial areas for further research.DiscussionOur findings emphasize cholesterol’s significance in leukemia, indicating its potential as a therapeutic target. Further exploration at the intersection of cholesterol metabolism and leukemia requires multidisciplinary collaboration.ConclusionThis bibliometric study delineates the evolving research landscape on cholesterol’s role in leukemia, pinpointing emerging trends and future research directions to inform effective therapeutic strategies.…”
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Low-exhaustion peripheral circulating γδ T cells serve as a biomarker for predicting the clinical benefit rate of non-small cell lung cancer (NSCLC) patients to chemotherapy or tar... by Dongdong Zhang, Guichao Liu, Jinhui Ye, Ke Li, Guojun Zhang, Qiang Quan, Xinhai Zhu, Peng Li

“…However, the association between the immunophenotype of circulating γδ T cells and the therapeutic response in NSCLC patients undergoing chemotherapy or targeted therapy remains unclear. …”
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Investigating the antioxidant and anti-inflammatory potential of Nypa fruticans: a multifaceted approach to skin protection and aging by Seul Ki Kim, Sang-Back Kim, Seul Bi Lee, Kang sub Kim, So-Ri Son, En Jin Choi, Byung Chul Park, Eunyoung Hong, You Ah Kim, Byoung Seok Moon, Sullim Lee

“…Future investigations should aim to further elucidate the clinical applications of NF in dermatology to maximize its therapeutic benefits.…”
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Exploring ketogenic diet resistance in glucose transporter type 1 deficiency syndrome: A comprehensive review and critical appraisal by Raffaele Falsaperla, Vincenzo Sortino, Gerhard Josef Kluger, Thomas Herberhold, Andrea Rüegger, Pasquale Striano, Martino Ruggieri, Joerg Klepper, Georgia Ramantani

“…In cases of KDT ineffectiveness for seizure control in GLUT1DS patients, exploring alternative therapeutic strategies becomes imperative to managing symptoms while maintaining quality of life. …”
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Genome-wide transcriptome analysis and drug target discovery reveal key genes and pathways in thyroid cancer metastasis by Minjing Zou, Amal Qattan, Monther Al-Alwan, Hazem Ghebeh, Naif Binjumah, Latifa Al-Haj, Khalid S. A. Khabar, Abdulmohsen Altaweel, Falah Almohanna, Abdullah M. Assiri, Abdelilah Aboussekhra, Ali S. Alzahrani, Ali S. Alzahrani, Yufei Shi

“…Braf-mutant Met cells developed resistance to BRAFV600E inhibitor PLX4720, but remained sensitive to β-catenin inhibitor PKF118-310.ConclusionWe have identified several overexpressed genes/pathways in thyroid cancer metastasis, making them attractive therapeutic targets. Given the complexity of metastasis involving multiple pathways (PD-L1, Mertk, IL6, COX-1/Tbxas1-TXA2), simultaneously targeting more than one of these pathways may be warranted to achieve better therapeutic effect for metastatic thyroid cancer.…”
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Quinazolinone Derivative MR2938 Protects DSS-Induced Barrier Dysfunction in Mice Through Regulating Gut Microbiota by Ling Lv, Mireguli Maimaitiming, Jichen Yang, Shuli Xia, Xin Li, Pingyuan Wang, Zhiqing Liu, Chang-Yun Wang

“…<b>Conclusions</b>: These findings suggest that intestinal flora play a crucial role in MR2938’s therapeutic mechanism for alleviating colitis.…”
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Extracellular vimentin is a damage-associated molecular pattern protein serving as an agonist of TLR4 in human neutrophils by Łukasz Suprewicz, Krzysztof Fiedoruk, Karol Skłodowski, Evan Hutt, Magdalena Zakrzewska, Alicja Walewska, Piotr Deptuła, Agata Lesiak, Sławomir Okła, Peter A. Galie, Alison E. Patteson, Paul A. Janmey, Robert Bucki

“…This, in turn, opens new windows of therapeutic intervention in inflammatory and immunological diseases characterized by immune system dysfunction, in which eVim and CitVim play a key role.…”
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