Acid-Sensing Ion Channels as Potential Therapeutic Targets in Neurodegeneration and Neuroinflammation by Audrey Ortega-Ramírez, Rosario Vega, Enrique Soto

“…Over the years, different studies have shown that activation of these channels is linked to various physiological and pathological processes, such as memory, learning, fear, anxiety, ischemia, and multiple sclerosis to name a few, so their potential as therapeutic targets is increasing. This review focuses on recent advances that have helped us to better understand the role played by ASICs in different pathologies related to neurodegenerative diseases, inflammatory processes, and pain.…”
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Optimizing therapeutic outcomes: preconditioning strategies for MSC-derived extracellular vesicles by Yuqi Song, Fengrui Liang, Weikun Tian, Erin Rayhill, Liping Ye, Xinghan Tian

“…Mesenchymal stem cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) are increasingly recognized for their therapeutic potential in regenerative medicine, driven by their capabilities in immunomodulation and tissue repair. …”
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Emerging Therapeutic Strategies for Targeting Chronic Myeloid Leukemia Stem Cells by Ahmad Hamad, Zeyad Sahli, Maya El Sabban, Maha Mouteirik, Rihab Nasr

“…This highlights the need to develop new therapeutic strategies for CML to achieve a permanent cure, and to allow TKI interruption. …”
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Therapeutic target genes and regulatory networks of gallic acid in cervical cancer by Zhixi You, Ye Lei, Yongkang Yang, Zhihui Zhou, Xu Chao, Keyi Ju, Songyi Wang, Yuanyuan Li, Yuanyuan Li

“…IntroductionThis study aims to identify the therapeutic targets and regulatory mechanisms of the antitumor drug gallic acid (GA) in cervical cancer (CC).MethodsHeLa cells were treated with GA and subjected to RNA-sequencing using the DNBSEQ platform. …”
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Modulation of Toll-Like Receptor Signalling as a New Therapeutic Principle by Philipp M. Lepper, Martha Triantafilou, Luke A. O'Neill, Natalija Novak, Hermann Wagner, Andrew E. Parker, Kathy Triantafilou

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Characteristics, pathogenic and therapeutic role of gut microbiota in immunoglobulin A nephropathy by Kaijin Yao, Lingqian Zheng, Wenmin Chen, Yina Xie, Chunling Liao, Tianbiao Zhou

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Classifications of triple-negative breast cancer: insights and current therapeutic approaches by Ziqi Chen, Yumeng Liu, Minchuan Lyu, Chi Ho Chan, Meiheng Sun, Xin Yang, Shuangying Qiao, Zheng Chen, Sifan Yu, Meishen Ren, Aiping Lu, Ge Zhang, Fangfei Li, Yuanyuan Yu

“…We also address the limitations of conventional therapeutic approaches and explore innovative biological strategies, all aimed at advancing the development of targeted and effective therapeutic strategies for TNBC.…”
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Therapeutic potential of 4-hexylresorcinol in reducing sarcopenia in diabetic masseter muscle by Dhouha Gaida, Young-Wook Park, Yei-Jin Kang, Seong-Gon Kim

“…These findings suggest that 4HR holds potential as a therapeutic agent for combating muscle wasting in diabetes.…”
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Grave’s Disease with Severe Hepatic Dysfunction: A Diagnostic and Therapeutic Challenge by Ashok Krishna Bhuyan, Dipti Sarma, Uma Kaimal Saikia, Bipul Kumar Choudhury

“…Hepatic dysfunction in a patient with thyrotoxicosis may result from hyperthyroidism per se, as a side effect of antithyroid drugs, and causes unrelated to hyperthyroidism which sometimes causes diagnostic and therapeutic difficulties. A young female patient was admitted to our hospital with symptoms of thyrotoxicosis, diffuse goiter and ophthalmopathy along with cholestatic pattern of jaundice, and proximal muscle weakness. …”
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Neratinib as a Potential Therapeutic for Mutant RAS and Osimertinib-Resistant Tumours by Paul Dent, Laurence Booth, Andrew Poklepovic, John F. Hancock

“…Collectively, these findings argue that the possibilities for the further development of neratinib as cancer therapeutic in malignancies that do not express or over-express members of the ERBB receptor family are potentially wide-ranging.…”
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Chitosan Micro/Nanocapsules in Action: Linking Design, Production, and Therapeutic Application by Yaride Pérez-Pacheco, Bartosz Tylkowski, Ricard García-Valls

“…The potential to customize chitosan for different environments and therapeutic uses introduces opportunities for drug encapsulation and release. …”
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Obesity and inflammatory arthritis: impact on occurrence, disease characteristics and therapeutic response by Jérémie Sellam, Claire I Daien

“…This article first reviews the epidemiological and clinical data available on obesity in inflammatory rheumatic diseases, that is, its impact on incident disease, disease characteristics and the therapeutic response. The second part of this review gives an overview of the factors potentially involved in the specifics of inflammatory arthritis in patients with obesity, such as limitations in the clinical assessment, diet, microbiota and adipokines.…”
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Insufficient Sleep and Alzheimer’s Disease: Potential Approach for Therapeutic Treatment Methods by Dieu Quynh Trinh, Nhu Huynh Mai, Toan Duc Pham

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Regulation of Posttranscriptional Modification as a Possible Therapeutic Approach for Retinal Neuroprotection by Yoko Ozawa, Toshihide Kurihara, Kazuo Tsubota, Hideyuki Okano

“…Finally, we review the therapeutic potential of regulating the UPS to protect tissue function, citing examples from clinical applications in other medical fields.…”
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The Effect of Irisin as a Metabolic Regulator and Its Therapeutic Potential for Obesity by Hui Li, Fang Wang, Mu Yang, Jiao Sun, Yi Zhao, Dongqi Tang

“…Irisin, a newly identified exercise-responsive myokine, which is produced by the proteolytic cleavage of fibronectin type III domain-containing protein 5 (FNDC5), has emerged as a promising therapeutic strategy to combat obesity and obesity-related complications. …”
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Bioinformatic analysis of ferroptosis related biomarkers and potential therapeutic targets in vitiligo by Linli Liu, Lingli Deng, Li Guan, Yuan Hu, Qianying Li, Chunshui Yu

“…Collectively, our findings provide novel insights into the molecular mechanisms underpinning vitiligo and suggest new avenues for diagnostic and therapeutic development.…”
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Therapeutic rigid bronchoscopy for endobronchial glomus tumors: a case series by Rong Lih Ho, Byeong-Ho Jeong, Joungho Han, Hojoong Kim

“…Little is known about the therapeutic outcomes of rigid bronchoscopy for endobronchial GT. …”
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Enhancing the Therapeutic Potential of Peptide Antibiotics Using Bacteriophage Mimicry Strategies by Hongping Wan, Xinyi Zhong, Shinong Yang, Jiarong Deng, Xu Song, Yong Liu, Yuanfeng Li, Zhongqiong Yin, Xinghong Zhao

“…Consequently, there is an urgent need for novel therapeutics targeting antibiotic‐resistant pathogens. …”
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Network Pharmacology Analysis of the Therapeutic Potential of Colchicine in Acute Lung Injury by Fei Sun, Lijuan Zhang, Lulu Shen, Chunman Wang

“…ALI-related genes were curated using databases such as DisGeNET, Therapeutic Target, and Comparative Toxicogenomics Database to curate ALI-related genes. …”
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Therapeutic Approaches in COVID-19 Patients: The Role of the Renin-Angiotensin System by Farzaneh Ketabchi, Sina Jamzad

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