Generation and characterization of novel induced pluripotent stem cell (iPSC) lines derived from three symptomatic carriers of a pathogenic MYH11 variant and two non-carrier relati... by Aria Atash, Maarten Jan Cramer, Barend Mees, Pieter A. Doevendans, Joost P.G. Sluijter, Francesca Stillitano

“…These cell lines offer a platform for in vitro investigation of the unknown fTAAD pathophysiology and testing of therapeutical agents for aneurysm growth attenuation.…”
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MICRO RNA: A PROSPECTIVE DIAGNOSTICBIOMARKER IN ALZHEIMER’S DISEASE by Syeda Uroosa Hashmi, Ameer Haider Ali

“…This research explores the mechanisms and roles of miRNAs in gene regulation related to AD and highlights their potential as therapeutic agents for neurodegenerative diseases. …”
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Association between Nonalcoholic Fatty Liver Disease and Endocrinopathies: Clinical Implications by Ana-Maria Singeap, Carol Stanciu, Laura Huiban, Cristina Maria Muzica, Tudor Cuciureanu, Irina Girleanu, Stefan Chiriac, Sebastian Zenovia, Robert Nastasa, Catalin Sfarti, Camelia Cojocariu, Anca Trifan

“…Definite correlations are supported by clear evidence so far, but further studies are needed in order to completely clarify the pathogenic mechanisms and, especially, to identify therapeutic implications. In this review, we present the main relationships between NAFLD and endocrinopathies, emphasizing the reciprocal causality, evolutive interconnections, and current clinical scenarios of presentations of which the clinicians should be aware.…”
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Genomic Profiling of Liver Cancer by Ju-Seog Lee

“…Novel approaches combining multiple datasets from patient tissues have created an unparalleled opportunity to uncover potential new therapeutic targets and prognostic/predictive biomarkers for personalized therapy that can improve clinical outcomes of the patients with liver cancer.…”
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Spinal muscular atrophy type 1 in the Caribbean: the first case report from the Dominican Republic by María Belén Martín-Sanz, Delvis Lucas-Muñoz, Manuel Colomé-Hidalgo, Manuel Colomé-Hidalgo

“…Our study aims to illustrate, through a case report, the clinical analysis, therapeutic interventions, and progression until the patient’s demise. …”
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Roles of core fucosylation modification in immune system and diseases by Qiu Pan, Xiao-Lian Zhang

“…A deeper understanding of these mechanisms can provide insights into cellular biology and suggest new therapeutic approaches and targets for related diseases.…”
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Injection Therapy for Nonvariceal Gastrointestinal Bleeding by Paul Kortan

“…In patients with continuous or recurrent bleeding (20%), mortality and morbidity are high, and emergency surgery is often required, which has a higher mortality than the same operation performed electively. Successful therapeutic endoscopic intervention in this high risk group is necessary to improve outcome. …”
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Hemophagocytic lymphohistiocytosis secondary to refractory acute myeloid leukemia resolved after second line treatment with azacitidine plus venetoclax by Claudio Fozza

“…Herein we report for the first time a case of HLH secondary to refractory/relapsed AML resolved after a second line treatment with azacitidine plus venetoclax, thus offering a new potential therapeutic perspective in the context of a life-threatening clinical scenario. …”
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Neurobiology of Major Depressive Disorder by Rosa Villanueva

“…We highlight data of potential diagnostic significance and the relevance of this information to develop new therapeutic approaches. Controversial issues, such as whether neurogenesis is the basis of the disease or whether it is a response induced by antidepressant treatments, are also discussed.…”
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Interactions between the tumor microbiota and breast cancer by Hua Guo

“…We also explore the potential function of the microbiota as biomarkers for prognosis and therapeutic response, highlighting the need for further research to clarify the causal relationship between the microbiota and breast cancer. …”
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Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant by Alexander Augustyn, Mona Lisa Alattar, Harris Naina

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Use of Diagnostic Musculoskeletal Ultrasound in the Evaluation of Piriformis Syndrome: A Review for Rehabilitation Providers by Robert C. Manske, Chris Wolfe, Phil Page, Michael Voight, Beth Bardowski

“…We discuss the technical aspects of ultrasound use, interpretation of findings, and integration into clinical practice, aiming to enhance the diagnostic accuracy and therapeutic outcomes for patients with suspected PS.…”
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Application of Computer-aided Rehabilitation by Zhuoming CHEN

“…The second, the ability of data storage, data analysis and judgment of computer could be applied to the rehabilitation training and evaluation of rehabilitation therapeutic effect with rehabilitation measures to get a more precise determination before and after rehabilitation. …”
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Small Bowel Enteroscopy by Christopher W Teshima, Gary May

“…The small bowel is no longer out of reach, and has fallen within the diagnostic and therapeutic realm of the gastrointestinal endoscopist. …”
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Experience and Interpretation: Emotion as Revealed in Narration by Annikki Kaivola-Bregenhøj

“…In retrospect I have thought about the therapeutic effect of speaking, forgetting and remaining silent.…”
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The History of Cystinosis: Lessons for Clinical Management by Paul Goodyer

“…This paper focuses on the importance management lessons from these milestones and the potential new therapeutic strategies which may be looming in the near future.…”
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Interleukin-33 in cutaneous wound healing by Bei Liu

“…This overview aids in elucidating the mechanisms through which IL-33 contributes to wound healing, thereby offering insights into potential therapeutic strategies for treating chronic wounds.…”
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Hilar Tumours by Guido Costamagna, Andrea Tringali, Lucio Petruzziello, Cristiano Spada

“…Tumours that involve the confluence of the bile ducts in the liver hilum provide a major therapeutic challenge. Adequate palliation requires relief of jaundice. …”
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CANDLE syndrome – a narrative review by Aleksandra Snopkowska, Joanna Gołda, Julia Mężyk, Piotr Gacka, Marcin Dołęga

“…The diagnostic criteria remain undefined, necessitating a multidisciplinary approach for accurate diagnosis and management. Despite therapeutic complexities, recent advancements in genetic testing and targeted therapies, notably Janus kinase inhibitors, offer promising avenues for improved patient outcomes. …”
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Endometriosis, Angiogenesis and Tissue Factor by Graciela Krikun

“…Our findings suggest that TF might be an ideal target for therapeutic intervention in endometriosis. We have employed a novel immunoconjugate molecule known as Icon and were able to eradicate endometrial lesions in a mouse model of endometriosis without affecting fertility. …”
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