Why natural drugs being attracted to treat oral cancer? – Highlights from “Oral oncology reports” by Vinothini Gunasekaran, Palanivel Sathishkumar

“…Natural products derived from plants and microorganisms have been extensively studied for their anticancer potential, over half-century. Herein, the therapeutic efficacy, feasibility, and limitations of various natural drugs for the oral cancer treatment approaches published in “Oral Oncology Reports” from the past two years are discussed in detail. …”
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Glial cells improve Parkinson’s disease by modulating neuronal function and regulating neuronal ferroptosis by Mengzhu Li, Mengxuan Chen, Haiyan Li, Da Gao, Lijun Zhao, Meiling Zhu

“…This opens up a new pathway for basic research and therapeutic strategies in Parkinson’s disease.…”
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Protocol to develop A 3D tumor model for drug testing applications by Prasiddha Guragain, Sunil Singh, Hossein Tavana

“…Compatible with robotic automation, our protocol significantly enhances reproducibility and scalability of creating a tumor model to study tumor-stromal interactions and test therapeutic compounds…”
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Melatonin in Hypoxic-Ischemic Brain Injury in Term and Preterm Babies by Justyna Paprocka, Marek Kijonka, Beata Rzepka, Maria Sokół

“…Melatonin may serve as a potential therapeutic free radical scavenger and broad-spectrum antioxidant. …”
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Real-world studies of crizotinib in patients with ROS1-positive non-small-cell lung cancer: experience from China by Hua Zhong, Jun Lu, Mengzhao Wang, Baohui Han

“…As one of the leading countries of real-world research on crizotinib, China has contributed significantly to data on standardization of the therapeutic use of crizotinib, including its clinical treatment patterns, the timing and duration of treatment and drug resistance monitoring and management.…”

Low Tidal Volume Ventilation in Patients without Acute Respiratory Distress Syndrome: A Paradigm Shift in Mechanical Ventilation by Jed Lipes, Azadeh Bojmehrani, Francois Lellouche

“…Low tidal volume ventilation is associated with particular clinical challenges and is therefore often underutilized as a therapeutic option in clinical practice. Despite some potential difficulties, data have been published examining the application of protective ventilation in patients without lung injury. …”
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Utility of Plasmapheresis in Autoimmune-Mediated Encephalopathy in Children: Potentials and Challenges by Abdulhafeez M. Khair

“…Autoimmune-mediated encephalopathy in children continues to constitute a diagnostic and therapeutic challenge in pediatric population. Utility and usefulness in this clinical setting of plasmapheresis have seldom been evaluated in current pediatric literature. …”
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Sodium butyrate is incorporated into central metabolism in fly head while inducing oxygen consumption increase. by Annika Müller-Eigner, Benedikt Gille, Frederik Dethloff, Chen Meng, Christina Ludwig, John T Heiker, Patrick Giavalisco, Shahaf Peleg

“…Collectively our data supports the notion that the therapeutic benefits of acute butyrate treatment may be also mediated by improving metabolic rates, rather than solely targeting the epigenome or acetylome.…”
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Auditory Neural Plasticity in Tinnitus Mechanisms and Management by Kunkun Wang, Dongmei Tang, Jiaoyao Ma, Shan Sun

“…The conclusion drawn from the available evidence is that there is no specific medication for tinnitus treatment at present, and tinnitus management might provide better solutions. Therapeutic interventions for tinnitus should be based on a comprehensive understanding of the etiology and features of individual cases of tinnitus, and more high quality and large-scale research studies are urgently needed to develop more efficacious medications.…”
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Diagnosis and treatment of cerebral vasospasm after subarachnoid hemorrhage by Youssef Fardos, Daniel Mattimore, Wesam Andraous, Sofia Geralemou, Sergio Bergese, Ana Costa

“…Digital subtraction angiography remains the gold standard test for the diagnosis of cerebral vasospasm as it allows for a quantitative assessment of vasospasm in each intracranial artery as well as therapeutic interventions. Due to the delayed occurrence of vasospasm following subarachnoid hemorrhage, preventive therapies have drawn significant interest in addressing different stages of their development. …”
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Burkholderia cepacia Complex: Emerging Multihost Pathogens Equipped with a Wide Range of Virulence Factors and Determinants by Sílvia A. Sousa, Christian G. Ramos, Jorge H. Leitão

“…The identification and characterization of these virulence factors is expected to lead to the design of novel therapeutic strategies to fight the infections caused by these emergent multidrug resistant human pathogens.…”
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The Informed Consent in Allergology from a Scientific, Technological and Social Perspective by Marisela Luisa Pérez Pacaréu, Yanet Morejón del Rosario, Gloria Arlenys Suárez Rodríguez, Aleima Rodríguez Carbajal

“…This paper reviews the application of the informed consent within the specialty of allergology in procedures (skin tests), therapeutic interventions (immunotherapy) and research (clinical trials) from a scientific, technological and social perspective, based on the advances achieved in Cuba in recent years to obtain better allergenic extracts for testing, high-quality vaccines and new drugs to benefit the allergic patient. …”
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Exercise Stress Testing in Children with Metabolic or Neuromuscular Disorders by Tim Takken, Wim G. Groen, Erik H. Hulzebos, Cornelia G. Ernsting, Peter M. van Hasselt, Berthil H. Prinsen, Paul J. Helders, Gepke Visser

“…The role of exercise as a diagnostic or therapeutic tool in patients with a metabolic disease (MD) or neuromuscular disorder (NMD) is relatively underresearched. …”
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Gallstone Dislodgement in the Airway during ERCP: A Case Report and Review of the Literature by Hisham Hurreiz, Amira Babikir, Edward Black

“…Endoscopic retrograde cholangiopancreatography (ERCP) is a diagnostic and therapeutic procedure with many studied complications. …”
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Merkel Cell Carcinoma: The Past, the Present, and the Future by Inamaria Erovic, Boban M. Erovic

“…Moreover, we will highlight the beginning of adjuvant therapeutic regimens with radiotherapy and chemotherapy and discuss the diagnostic work-up including imaging and histology of patients with Merkel cell carcinoma. …”
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Clinical Effects of Topical Tacrolimus on Fox-Fordyce Disease by Hilal Kaya Erdoğan, Işıl Bulur, Zeliha Kaya

“…We report two patients diagnosed with FFD by clinical and histopathologic examination and discussed therapeutic effects of topical tacrolimus on FFD in the light of literature.…”
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Adherence with Drug Therapy in Pregnancy by Doreen Matsui

“…Not taking prescribed drugs may have potentially negative consequences as patients may not achieve their therapeutic goal. In addition to the many factors that may influence medication-taking behaviour in the general population, unique challenges are encountered in pregnant women as both maternal health and fetal well-being must be considered. …”
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Enhancing the effectiveness of immunotherapy in rheumatoid arthritis by delaying immunosenescence triggered by fibroblast-like synoviocytes by Li Zhang, Yang Luo, Hai-Li Shen

“…This review examines the molecular alterations in RA FLSs in the context of systemic immune aging, with a focus on thymic insufficiency-associated T cell senescence, and explores potential therapeutic avenues.…”
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Role of the Microenvironment in Mesenchymal Stem Cell-Based Strategies for Treating Human Liver Diseases by Shan-jing Xu, Li-ping Ye, Wei Wang, Ya-hong Chen, Jian Dong, Xin-li Mao, Shao-wei Li

“…We, therefore, summarized the mechanisms underlying the MSC immune response, especially the interaction between MSCs and the liver microenvironment, discussing how to achieve better therapeutic effects.…”
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Modern Endoscopic Imaging in Diagnosis and Surveillance of Inflammatory Bowel Disease Patients by Gheorghe Hundorfean, Stephen P. Pereira, John G. Karstensen, Peter Vilmann, Adrian Saftoiu

“…Additionally, we discuss future directions and techniques as candidates for a superior inflammation imaging in the diagnosis and prediction of therapeutic response.…”
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