Predicting, Treating and Preventing Postoperative Recurrence of Crohn’s Disease: The State of the Field by Anna M Borowiec, Richard N Fedorak

“…Furthermore, the postoperative prophylaxis profiles of available Crohn’s disease therapeutic agents such as 5-aminosalicylates, immunomodulators, steroids and probiotics have been disappointing. …”
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Rituximab Efficacy during a Refractory Polyarteritis Nodosa Flare by Emmanuel Ribeiro, Thomas Cressend, Pierre Duffau, Marieke Grenouillet-Delacre, Marie Rouanet-Larivière, Anne Vital, Maïté Longy-Boursier, Patrick Mercié

“…On the other hand, therapeutic trials are needed to determine the real efficacy and place of rituximab in the treatment of polyarteritis nodosa.…”
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Widening the histopathological tool kit in clear cell odontogenic carcinoma for precision diagnostics by Ramya Ramadoss, Abigail Viola E, Chitra Shivalingam

“…Precise additional diagnostic tools like FTIR for effective ionic characterization are crucial to derive precision diagnostic and therapeutic strategies in lesions with enigmatic features.…”
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Erythropoietin: from erythropoiesis to cardioprotection by Liermis Michael Dita Salabert, Ivis Mendoza Hernández, Rafael Alejandro Gómez Baute, Elena García López, Lázaro E. de la Cruz Avilés, Aramis Núñez Quintana

“…Although many agents have been evaluated as potential cardioprotective therapeutic, clinical data are limited and does not suggest that the use of these agents promotes the survival of patients undergoing cardiotoxic treatments. …”
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The Role of the Microbiome and Intestinal Mucosal Barrier in the Development and Progression of Non-Alcoholic Fatty Liver Disease by T. S. Krolevets, M. A. Livzan, S. I. Mozgovoy

“…The results of modern studies confirm the formation of a new concept in the pathophysiology of NAFLD, which encourages the development of new therapeutic strategies.…”
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Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer by Isabel López de Silanes, María Paz Quesada, Manel Esteller

“…A thorough understanding of these alterations and their impact upon 3′UTR-directed posttranscriptional gene regulation will uncover promising new targets for therapeutic intervention.…”
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Epidermal Growth Factor Receptor Gene in Non-Small-Cell Lung Cancer: The Importance of Promoter Polymorphism Investigation by Vladimir Jurišić, Jasmina Obradovic, Sonja Pavlović, Nataša Djordjevic

“…Recently, epidermal growth factor receptor (EGFR) was a key molecule in investigation of lung cancer, and it was a target for a new therapeutic strategy, based on molecular analyses. In this review, we have summarized some issues considering the role of EGFR in lung cancer, its coding gene, and its promoter gene polymorphisms (SNPs) -216G/T and -191C/A in non-small-cell lung cancer (NSCLC). …”
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Unleashing the potential of extracellular vesicles for ulcerative colitis and Crohn's disease therapy by George Chigozie Njoku, Cathal Patrick Forkan, Fumie Mitani Soltysik, Peter Lindberg Nejsum, Flemming Pociot, Reza Yarani

“…EVs are nano-sized vesicles that are non-replicating and carry bioactive molecules that modulate immune responses, promote tissue repair, can facilitate drug delivery and, therefore, hold great therapeutic promise. This review summarizes the role of EVs as a cell-free therapy for IBD, highlighting opportunities for further investigation and potential clinical applications.…”
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Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targets by Claire Vinel, James Boot, Weiwei Jin, Nicola Pomella, Alexandra Hadaway, Charles Mein, Nicolae Radu Zabet, Silvia Marino

“…The heterogeneous nature of the tumour, to which epigenetic dysregulation significantly contributes, is among the main therapeutic challenges of the disease. Results We have leveraged SYNGN, an experimental pipeline enabling the syngeneic comparison of glioblastoma stem cells and expanded potential stem cell (EPSC)-derived neural stem cells to identify regulatory features driven by chromatin remodelling specifically in glioblastoma stem cells. …”
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Traditional Chinese Medicine Protects against Cytokine Production as the Potential Immunosuppressive Agents in Atherosclerosis by Yan Ren, Wei Qiao, Dongliang Fu, Zhiwei Han, Wei Liu, Weijie Ye, Zunjing Liu

“…Accordingly, strategies to inhibit immune activation and impede immune responses towards anti-inflammatory activity are an alternative therapeutic strategy to conventional chemotherapy on cardiocerebrovascular outcomes. …”
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Diagnostic Musculoskeletal Ultrasound for the Evaluation of the Lateral Elbow: Implications for Rehabilitation Providers by Robert C. Manske, Chris Wolfe, Phil Page, Michael Voight

“…This article reviews the utility of MSKUS for rehabilitation providers, focusing on its role in accurately identifying pathoanatomical changes, guiding treatment strategies, and monitoring therapeutic outcomes. Specific emphasis is placed on the integration of diagnostic ultrasound in clinical practice, imaging techniques, and its advantages compared to other modalities. …”
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Protocol for isolation of human bone marrow stromal cells and characterization of cellular metabolism by Martina Dzubanova, Michaela Ferencakova, Andrea Benova, Dalia Ali, Michaela Tencerova

“…These assays provide information on hBMSC metabolic status valuable to regenerative medicine and therapeutic applications.For complete details on the use and execution of this protocol, please refer to Tencerova et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.…”
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QUALITY ASSESSMENT OF LEARNERS PROFICIENCY IN TERMS OF THE COMPETENCE APPROACH TO EDUCATION (ON THE EXAMPLE OF DISCIPLINE "PHYSICAL THERAPY AND MASSAGE") by Anton V. Reva

“…The development of such tasks has become the fundamental in creating the base of didactic materials and methodologies for monitoring the students’ progress in the discipline "Therapeutic physical culture" and "Massage" that included in the curricula of the majority areas of athletic training education. …”
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Understanding the tumor microenvironment for personalized immunotherapy in early-onset head and neck squamous cell carcinoma by Yidan Shan, Di He, Fengguo Yan, Weijia Huang

“…Consequently, tailored immunotherapy may offer a promising therapeutic strategy for this distinct patient population.…”
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Repetitive Transcranial Magnetic Stimulation, Cognition, and Multiple Sclerosis: An Overview by Grigorios Nasios, Lambros Messinis, Efthimios Dardiotis, Panagiotis Papathanasopoulos

“…In this overview, we focus on the brain’s functional reorganization in MS, theoretical and practical aspects of rTMS utilization in humans, and its potential therapeutic role in treating cognitively impaired MS patients.…”
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Supporting the cognitive development of individuals with intellectual disabilities through a video game for emotional regulation by Marisela Hernández-Lara, Karina Caro, Ana Isabel Martínez-García

“…However, these individuals often face significant challenges in this area. Therapeutic interventions have been designed to improve emotional regulation. …”
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The Bone Marrow Microenvironment as Niche Retreats for Hematopoietic and Leukemic Stem Cells by Felix Nwajei, Marina Konopleva

“…Leukemia poses a serious challenge to current therapeutic strategies. This has been attributed to leukemia stem cells (LSCs), which occupy endosteal and sinusoidal niches in the bone marrow similar to those of hematopoietic stem cells (HSCs). …”
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Pulmonary Limited MPO-ANCA Microscopic Polyangiitis and Idiopathic Lung Fibrosis in a Patient with a Diagnosis of IgA Nephropathy by Alwin Tilanus, Patricia Van der Niepen, Caroline Geers, Karl Martin Wissing

“…This unique case illustrates the diagnostic and therapeutic challenges of an unusual presentation of microscopic polyangiitis presenting first as isolated kidney disease with recurrence in the form of pneumonitis without renal involvement, in association with renal IgA deposits and ITP as coexisting autoimmune conditions.…”
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Treatment of HIV-1 Infection with Combination Therapy: Antiretroviral Agents and Biological Response Modifiers by Steven M Schnittman

“…In particular, since HIV infection dysregulates and destroys the immune system. it is logical to develop therapeutic approaches that would both restore the immune response and have direct antiviral activity. …”
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What Roles Do Probiotics Play in the Eradication of Helicobacter pylori? Current Knowledge and Ongoing Research by Han-Yi Song, Long Zhou, Dong-yan Liu, Xin-Jie Yao, Yan Li

“…However, inconsistent test results have prevented conclusions about the therapeutic prowess of probiotics for HP. The mechanisms of actions of probiotics include the production of substances that inhibit or kill HP or compete with HP for the adhesion site on gastric epithelial cells. …”
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