Arachidonic Acid Derivatives and Their Role in Peripheral Nerve Degeneration and Regeneration by Carlos Rodrigo Camara-Lemarroy, Emmanuel Irineo Gonzalez-Moreno, Francisco Javier Guzman-de la Garza, Nancy Esthela Fernandez-Garza

“…In this paper, we discuss the role that AA derivatives might play during WD and nerve regeneration, and the therapeutic possibilities that arise.…”
Get full text

A Modified Reverse Remplissage Procedure for Management of a Locked Posterior Shoulder Dislocation by Xavier Zwiebel, Stéphane Pelet, Alexandre Leclerc

“…Posterior shoulder dislocation is rare and often represents a diagnostic and therapeutic challenge. An impaction fracture of the anteroinferior aspect of the humeral head (called a reverse Hill-Sachs (RHS) fracture) is always present in case of chronic locked posterior dislocation. …”
Get full text

Application of adoptive cell therapy in malignant melanoma by Qianrong Hu, Jiangying Xuan, Lu Wang, Kangjie Shen, Zixu Gao, Yuhong Zhou, Chuanyuan Wei, Jianying Gu

“…Thus, adoptive cell therapy (ACT), employing immune cells with specific tumor-recognizing receptors, has emerged as a promising therapeutic approach to display on-tumor toxicity. This review discusses the application, efficacy, limitations, as well as future prospects of four commonly utilized approaches -including tumor-infiltrating lymphocytes, chimeric antigen receptor (CAR) T cell, engineered T-cell receptor T cells, and chimeric antigen receptor NK cells- in the context of malignant melanoma.…”
Get full text

Hypovitaminosis and its association with recurrent aphthous stomatitis: a comprehensive review of clinical correlations and diagnostic considerations by Alessio Rosa, Giovanni Cianconi, Riccardo De Angelis, Alberto Maria Pujia, Claudio Arcuri

“…BackgroundHypovitaminosis, or vitamin deficiency, has been increasingly recognized as a potential contributing factor in the development of recurrent aphthous stomatitis (RAS), a condition characterized by the periodic formation of painful ulcers in the oral mucosa.Materials and methodsThis mini review includes a literature search on PubMed, Web of Science, and Scopus databases using keywords “hypovitaminosis AND aphthous ulcers.”ResultsThere is a growing body of evidence supporting the link between various vitamin deficiencies—particularly vitamins B12, C, and folate—and the prevalence of RAS, with implications for both diagnosis and management.ConclusionThis review aims to outline the clinical and biochemical findings associated with hypovitaminosis in individuals presenting with RAS, emphasizing the diagnostic importance of recognizing vitamin deficiencies in these patients and exploring possible therapeutic approaches.…”
Get full text

Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related Lymphomagenesis by Adrianos Nezos, Clio P. Mavragani

“…Appreciating the functional implications of SS-related genetic variants could provide further insights into our understanding of SS heterogeneity, allowing the design of tailored therapeutic interventions.…”
Get full text

Targeted drug delivery in neurodegenerative diseases: the role of nanotechnology by Rupal Dhariwal, Rupal Dhariwal, Mukul Jain, Mukul Jain, Yaser Rafiq Mir, Abhayveer Singh, Bhavik Jain, Pankaj Kumar, Mohd Tariq, Mohd Tariq, Devvret Verma, Khemraj Deshmukh, Virendra Kumar Yadav, Tabarak Malik, Tabarak Malik

“…The findings underscore the importance of advancing nanomedicine applications to develop effective therapeutic strategies that can alleviate the burden of neurodegenerative diseases on individuals and healthcare systems.…”
Get full text

The Anticancer Perspective of Tangeretin: A Small Review by Yuan Xu, Xi Yan, Junpeng Zhuang, Haijun Hao

“…Tangeretin can also work with other chemotherapy drugs, such as cisplatin, to reduce the drug resistance of cancer cells and improve the therapeutic effect of chemotherapy drugs. This review summarizes the effects of tangeretin on various cancers.…”
Get full text

Targeted intervention of tumor microenvironment with HDAC inhibitors and their combination therapy strategies by Wanli Zhang, Luqi Ge, Yiwen Zhang, Zhentao Zhang, Wen Zhang, Feifeng Song, Ping Huang, Tong Xu

“…Overexpression of histone deacetylases (HDACs) is prevalent across various cancer types, positioning HDAC inhibitors as broadly applicable therapeutic agents. These inhibitors are known to enhance tumor immune antigenicity, potentially slowing tumor progression. …”
Get full text

Telling Ghost Stories Around a Bonfire—A Literature Review of Acute Bleeding Secondary to Pancreatitis by Gabriele Bellio, Silvia Fattori, Andrea Sozzi, Matteo Maria Cimino, Hayato Kurihara

“…While advances in diagnostic and therapeutic techniques have improved outcomes, bleeding in pancreatitis remains a challenging clinical problem requiring a multidisciplinary approach. …”
Get full text

Non-motor Disorders and their Neuro-anatomical Substrate in Parkinson's Disease by Julio López Argüelles, Leydi María Sosa Águila

“…New studies are necessary to clarify the pathophysiological bases of Parkinson's disease that allow establishing future therapeutic strategies for the follow-up of patients with these disorders.…”
Get full text

HSV-1 Encephalitis in an Elderly Man Receiving Ibrutinib for Waldenstrom’s Macroglobulinemia by Mark R. Wallace

“…Ibrutinib is a major new addition to the therapeutic armamentarium for chronic lymphocytic leukemia, mantle cell lymphoma, Waldenstrom’s macroglobulinemia, and chronic graft versus host disease. …”
Get full text

Entre deux eaux : courants thérapeutiques franco-brésiliens dans le processus de balnéarisation de Rio de Janeiro by Antoine Huerta

“…They encouraged the practice of therapeutic bathing in their works which were widely read within the educated population. …”
Get full text

MicroRNAs in Human Pituitary Adenomas by Xu-Hui Li, Elaine Lu Wang, Hai-Meng Zhou, Katsuhiko Yoshimoto, Zhi Rong Qian

“…To provide an overview of miRNAs dysregulation and functions of these miRNAs in pituitary adenoma progression, we summarize the deregulated miRNAs and their targets to shed more light on their potential as therapeutic targets and novel biomarkers.…”
Get full text

Castleman disease misdiagnosed as immunoglobulin G4-related disease: a case report by Na Li, LiFen Xu, Xiaoxia Liu, Pengjia Wu, Jun Liu, Jiashun Zeng

“…Comprehensive evaluation, including clinical presentation, organ involvement, serological and pathological findings, as well as therapeutic response, is essential to ensure accurate diagnosis and timely management.…”
Get full text

Pharmaceutical hemostasis at peptic ulcer bleeding: state-of-the-art and perspectives by A. A. Schegolev, O. A. Al Sabunchi, S. A. Valetov, A. V. Pavlychev, Ye. A. Klochneva

“…In the first group no relapses of bleeding or mortality was detected, in the second group in 4 (10%) patients there was relapse of bleeding, that allows to assume higher efficacy of therapeutic hemostasis by the parenteral form of proton pump inhibitors within complex therapy.Conclusions. …”
Get full text

Diagnostic Musculoskeletal Ultrasound of the Achilles Tendon by Phil Page, Robert C. Manske, Michael Voight, Chris Wolfe

“…Its ability to provide real-time, high-resolution imaging facilitates accurate diagnosis, dynamic assessment, and precise therapeutic interventions. The Achilles tendon, the largest and strongest tendon in the body, is critical for lower limb function and prone to a variety of pathologies, particularly in athletes and active individuals. …”
Get full text

Multimodal MRI Neuroimaging Biomarkers for Cognitive Normal Adults, Amnestic Mild Cognitive Impairment, and Alzheimer's Disease by Ai-Ling Lin, Angela R. Laird, Peter T. Fox, Jia-Hong Gao

“…Further developments of these techniques and the establishment of promising neuroimaging biomarkers will enhance our ability to diagnose aMCI and AD in their early stages and improve the assessment of therapeutic efficacy in these diseases in future clinical trials.…”
Get full text

Leukotrienes as Modifiers of Preclinical Atherosclerosis? by Graziano Riccioni, Magnus Bäck

“…Recently, leukotrienes have been implicated as mediators, biomarkers, and possible therapeutic targets in the context of subclinical atherosclerosis. …”
Get full text

Beyond bronchial thermoplasty – where to now? by Peter B. Noble, David Langton, Chuan T. Foo, Bruce R. Thompson, Alvenia Cairncross, Michael J. Hackmann, Francis Thien, Graham M. Donovan

“…This viewpoint discusses initial controversy surrounding BT (lack of an effect on forced expiratory volume in 1 s), its underutilisation, and importantly how non-standard diagnostics successfully demonstrated therapeutic response which escaped traditional lung function metrics. …”
Get full text

Schistosoma Tegument Proteins in Vaccine and Diagnosis Development: An Update by Cristina Toscano Fonseca, Gardênia Braz Figueiredo Carvalho, Clarice Carvalho Alves, Tatiane Teixeira de Melo

“…Bioinformatics tools, together with the access to parasite genome, published recently, should help generate new knowledge on parasite biology and search for new vaccines or therapeutic targets and antigens to be used in the disease diagnosis. …”
Get full text