Upregulated FoxO1 promotes arrhythmogenesis in mice with heart failure and preserved ejection fraction by Thassio Mesquita, Rodrigo Miguel-dos-Santos, Weixin Liu, Mario Fournier, Russell G. Rogers, Jocelyn Alfaro, Asma Nawaz, Lizbeth Sanchez, Xaviar M. Jones, Liang Li, Eduardo Marbán, Eugenio Cingolani

“…These results not only implicate FoxO1 in arrhythmogenesis and lusitropy but also demonstrate that pro-fibrotic remodeling and cardiomyocyte-fibroblast communication can be corrected, constituting an alternative therapeutic strategy for HFpEF.…”
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Exosomes as Mediators of Cell-to-Cell Communication in Thyroid Disease by Yi Wang, Feng Xu, Jia-Yu Zhong, Xiao Lin, Su-Kang Shan, Bei Guo, Ming-Hui Zheng, Ling-Qing Yuan

“…These studies suggest that exosomes are involved in thyroid disease and appear as impressive potentials in thyroid therapeutic areas.…”
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Chondrosternal Arthritis in Infant: An Unusual Entity by Athina Nikolarakou, Dana Dumitriu, Pierre-Louis Docquier

“…A wait-and-see approach with close follow-up in the first weeks is the best therapeutic option.…”
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Changes in the organ of vision in neurofibromatosis type 1 in the developmental age by Mirosława Grałek, Katarzyna Piasecka, Katarzyna Wasyliszyn-Sieroszewska, Anna Niwald

“…There is no causal treatment. The therapeutic management depends on each patient’s specific needs. …”
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Effects of Calcium Ion, Calpains, and Calcium Channel Blockers on Retinitis Pigmentosa by Mitsuru Nakazawa

“…Apoptosis is known to be a final common pathway in RP and, therefore, a possible therapeutic target for photoreceptor rescue. However, apoptosis is not a single molecular cascade, but consists of many different reactions such as caspase-dependent and caspase-independent pathways commonly leading to DNA fractionation and cell death. …”
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Recent Advances in Methamphetamine Neurotoxicity Mechanisms and Its Molecular Pathophysiology by Shaobin Yu, Ling Zhu, Qiang Shen, Xue Bai, Xuhui Di

“…In addition, the feasible therapeutic strategies according to recent studies were also summarized ranging from drug and protein to gene level.…”
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Gut Microbiota in HIV Infection: Implication for Disease Progression and Management by Felix Chinweije Nwosu, Ekaterina Avershina, Robert Wilson, Knut Rudi

“…We provide perspective for discussing potential future therapeutic strategies focused on modulating the gut microbiota to abate HIV disease progression.…”
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Microbiota modifications in prehabilitation – the next step towards comprehensive preparation for surgery. The scoping review by Igor Łoniewski, Tomasz Banasiewicz, Jerzy Sieńko, Karolina Skonieczna-Zydecka, Ewa Stachowska

“…However, it also notes the need for further research to standardise therapeutic regimens and confirm the safety and efficacy of these interventions in clinical practice.…”
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Initial validation of the clinical significance of the NETest in Japanese gastroenteropancreatic neuroendocrine tumor patients by Hao Zhang, Takahiro Tsuchikawa, Satoshi Takeuchi, Kenji Hirata, Kimitaka Tanaka, Aya Matsui, Yoshitsugu Nakanishi, Toshimichi Asano, Takehiro Noji, Toru Nakamura, Shintaro Takeuchi, Masataka Wada, Satoshi Hirano

“…The NETest demonstrated high diagnostic efficacy and accurate therapeutic monitoring capabilities in a Japanese population.…”
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A Review of Injectable and Implantable Biomaterials for Treatment and Repair of Soft Tissues in Wound Healing by Shih-Feng Chou, Simi Gunaseelan, Mhd Hussam Hijazi Kiellani, Venkata Vamsi Krishna Thottempudi, Pierre Neuenschwander, Huarong Nie

“…., nanoparticles and nanofibers) and their therapeutic function in wound healing as dressing materials. …”
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Cardiovascular Effects Mediated by HMMR and CD44 by Kinga Jaskuła, Mariusz Sacharczuk, Zbigniew Gaciong, Dominik S. Skiba

“…The causes of CVD are not entirely clear, and new therapeutic targets are still being sought. One of the factors involved in CVD development among vascular damage and oxidative stress is chronic inflammation. …”
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Icariin Promotes Survival, Proliferation, and Differentiation of Neural Stem Cells In Vitro and in a Rat Model of Alzheimer’s Disease by Denglei Ma, Lihong Zhao, Li Zhang, Yali Li, Lan Zhang, Lin Li

“…Neural stem cell (NSC) transplantation has emerged as a promising therapeutic approach for treating AD. Icariin (ICA) is the main active component in Epimedium, a traditional Chinese herb. …”
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Effect of Modified Roux-en-Y Gastric Bypass Surgery on GLP-1, GIP in Patients with Type 2 Diabetes Mellitus by Shao-Wei Xiong, Jing Cao, Xian-Ming Liu, Xing-Ming Deng, Zeng Liu, Fang-Ting Zhang

“…Modified gastric bypass surgery has been applied to the treatment of T2DM patients in the 1990s, but the therapeutic mechanism to this function is still unclear. …”
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Functionalized conductive polymer composites for tissue engineering and biomedical applications- a mini review by V. Gayathri, Tabrej Khan, M. Gowtham, R. Balan, Tamer A. Sebaey, Tamer A. Sebaey

“…Tissue engineering (TE) has emerged as a promising therapeutic strategy, employing artificial scaffolds to regenerate functional cardiac tissue and offering new hope for innovative treatment approaches. …”
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Response after Infection-Associated Rise in Clozapine Levels in Treatment-Resistant Schizoaffective Disorder by Nina H. Grootendorst-van Mil, Anna R. M. Huiskens, Sieds Dieleman, Tom K. Birkenhäger

“…Herein, we report on a patient with schizoaffective disorder that initially showed no response to treatment with clozapine and ECT and therefore reached a therapeutic dead end. After an unintentional exposure to supratherapeutic clozapine levels, related to a pneumonia, a significant and persistent reduction of psychotic symptoms occurred. …”
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Exploring nutraceutical approaches linking metabolic syndrome and cognitive impairment by Rebecca Sonnino, Gea Ciccarelli, Simona Moffa, Laura Soldovieri, Gianfranco Di Giuseppe, Michela Brunetti, Francesca Cinti, Eleonora Di Piazza, Antonio Gasbarrini, Enrico C. Nista, Alfredo Pontecorvi, Andrea Giaccari, Teresa Mezza

“…This highlights their mutual influence and potential overlapping therapeutic strategies. Although lifestyle modifications remain essential, nutraceutical supplementation has emerged as a promising adjunct for the prevention and management of these preclinical conditions. …”
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The Use of Natural Health Products Especially Papaya Leaf Extract and Dandelion Root Extract in Previously Untreated Chronic Myelomonocytic Leukemia by Leena T. Rahmat, Lloyd E. Damon

“…Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic disorder which shares clinical and morphological features of myelodysplastic syndrome and myeloproliferative neoplasms. Conventional therapeutic options include hydroxyurea, hypomethylating agents, and systemic chemotherapy, which are all palliative measures and are associated with potential side effects. …”
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Unveiling the potential: Patient-derived organoids in cancer research and treatment by Zhan Wang

“…Unlike traditional cell cultures, PDOs retain the heterogeneity and complexity of the tumor microenvironment, making them invaluable tools for studying cancer biology, disease progression, and therapeutic responses. Overall, PDOs represent a transformative technology in cancer research, offering unprecedented opportunities to unravel the complexities of the disease and develop more effective personalized treatment strategies. …”
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Investigating the role of exosomal long non-coding RNAs in drug resistance within female reproductive system cancers by Nooshafarin Shirani, Neda Abdi, Matin Chehelgerdi, Matin Chehelgerdi, Hajar Yaghoobi, Mohammad Chehelgerdi, Mohammad Chehelgerdi

“…Additionally, the review highlights potential therapeutic strategies targeting exosomal lncRNAs, proposing a new frontier in overcoming drug resistance. …”
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Characterization and Comparison of Mesoporous Silica Particles for Optimized Drug Delivery by Xinyue Huang, Neil P Young, Helen E Townley

“…With these parameters in mind, we investigated the loading/ unloading profile of a model therapeutic into the pore structure of the nanoparticles. …”
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