Bile Acids: Key Regulators and Novel Treatment Targets for Type 2 Diabetes by Yingjie Wu, An Zhou, Li Tang, Yuanyuan Lei, Bo Tang, Linjing Zhang

“…Furthermore, increasing studies suggest that bile acids may regulate glucose tolerance, insulin sensitivity, and energy metabolism, suggesting that bile acids may represent a potential therapeutic target for T2DM. This study summarizes the metabolism of bile acids and, more importantly, changes in their concentrations, constitution, and receptors in diabetes. …”
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Sex/gender analysis in systematic reviews. Critical review and recommendations by Raúl Aguilera Eguía, Olga Patricia López Soto, Ángel Roco Videla, Brenda Herrera Serna, Héctor Fuentes Barria, Lorena Gerli Candia

“…Sex/gender analysis allows for the detection of subtle differences in therapeutic effects, thereby enriching clinical practice and promoting the design of personalized therapies. …”
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Proposal for a Stratification Tool for Emergency Department Diabetic Patients with Uncomplicated Acute Hyperglycemia by Luís Alberto Corona Martínez, Laydami Rodríguez Amador, Jannet Rodríguez Valdés

“…It is based on the analysis of clinical information complemented with blood glucose readings, specifically for decision making; each group has a defined context, actions to take and pillars of therapeutic management, primarily focusing on insulin therapy. …”
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Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect by Chunying Cui, Yuji Wang, Yaonan Wang, Ming Zhao, Shiqi Peng

“…Compared to controls, alsterpaullone effectively prevented HeLa cells from entering S-phase. These potential therapeutic efficacies could be correlated with the activation of caspase-3.…”
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Radioimmunotherapy: A Specific Treatment Protocol for Cancer by Cytotoxic Radioisotopes Conjugated to Antibodies by Hidekazu Kawashima

“…To date, in order to reduce the unnecessary exposure and to enhance the therapeutic efficacy, various biological, chemical, and treatment procedural improvements have been investigated in RIT. …”
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Immunotherapy of osteosarcoma based on immune microenvironment modulation by Heping Lian, Heping Lian, Jiakui Zhang, Shuna Hou, Shuang Ma, Jiachen Yu, Wei Zhao, Duoyi Zhao, Zhiyu Zhang

“…Osteosarcoma is a highly malignant tumor with unsatisfactory therapeutic outcomes achieved by chemotherapy, radiotherapy, and surgery. …”
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Didactic means of overcoming difficulties in the development process of students’ motivation for creative activity by Valentina G. Ryndak, Gulmira S. Saifutdinova, Margarita V. Kozyar

“…Preventive, diagnostic and therapeutic procedures ensuring the elimination of the above-mentioned causes are justified. …”
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Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment by Fabian Flores-Borja, Sheeba Irshad, Peter Gordon, Felix Wong, Ibrahim Sheriff, Andrew Tutt, Tony Ng

“…Defining the complex network of interactions and crosstalk of ILC with other immune cells and understanding the specific contributions of each type of ILC leading to tumor development will allow the manipulation of their function and will be important to develop new interventions and therapeutic strategies.…”
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New directions in the fight against antibiotic resistance by Mihai Folescu, Eugenia Dumitrescu, Florin Muselin, Alexandru Octavian Doma, Daiana Ionela Cocoș, Larisa Ardelean, Romeo Teodor Cristina

“…The development of antibiotic resistance renders standard treatments ineffective, putting patients' lives at risk and limiting available therapeutic options. In the face of this global crisis, recent research is opening new directions in combating antibiotic resistance, focusing on the discovery of innovative antibiotics, alternative solutions, and strategies to prevent the spread of resistance. …”
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Cell Therapy in Patients with Critical Limb Ischemia by Rita Compagna, Bruno Amato, Salvatore Massa, Maurizio Amato, Raffaele Grande, Lucia Butrico, Stefano de Franciscis, Raffaele Serra

“…Critical limb ischemia (CLI) represents the most advanced stage of peripheral arterial obstructive disease (PAOD) with a severe obstruction of the arteries which markedly reduces blood flow to the extremities and has progressed to the point of severe rest pain and/or even tissue loss. Recent therapeutic strategies have focused on restoring this balance in favor of tissue survival using exogenous molecular and cellular agents to promote regeneration of the vasculature. …”
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Management of Uveitis-Related Choroidal Neovascularization: From the Pathogenesis to the Therapy by Enzo D’Ambrosio, Paolo Tortorella, Ludovico Iannetti

“…Hereby a standardization of the therapeutic approach is proposed.…”
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Number of Patients per Cohort and Sample Size Considerations Using Dose Escalation with Overdose Control by Mourad Tighiouart, André Rogatko

“…We show through simulations that the number of patients per cohort does not impact the proportion of patients given therapeutic doses, safety of the trial, and efficiency of the estimate of the MTD. …”
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Behavioural and Cognitive-Behavioural Treatments of Parasomnias by Andrea Galbiati, Fabrizio Rinaldi, Enrico Giora, Luigi Ferini-Strambi, Sara Marelli

“…Nonpharmacological treatments therefore represent valid therapeutic choices. This paper reviews behavioural and cognitive-behavioural managements employed for parasomnias. …”
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Eltrombopag Improves Refractory Thrombocytopenia in a Patient with Systemic Lupus Erythematosus by Natsuki Shima, Keiichi Sumida, Masahiro Kawada, Akinari Sekine, Masayuki Yamanouchi, Rikako Hiramatsu, Noriko Hayami, Eiko Hasegawa, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Kenmei Takaichi, Kenichi Ohashi, Takeshi Fujii, Yoshifumi Ubara

“…Eltrombopag may be a therapeutic option for SLE patients with severe thrombocytopenia refractory to conventional therapy.…”
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Cancer-associated fibroblasts in carcinogenesis by Shufen Zhou, Zekun Zhao, Zhaojun Wang, Hanzheng Xu, Yijie Li, Ke Xu, Wei Li, Jiahua Yang

“…Ultimately, our aim is to contribute to the development of novel therapeutic strategies for cancer treatment.…”
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Immunosuppressive metabolites in tumoral immune evasion: redundancies, clinical efforts, and pathways forward by David Munn, Maria Rain Jennings, John Blazeck

“…We hypothesize that prior lukewarm results may be attributed to redundancies in each metabolites’ synthesis or signaling pathway and highlight routes for how therapeutic development and patient stratification might proceed in the future.…”
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The Importance of Neuropsychomotor Development Between 0-2 Years by I.M. Fintina, B.N. Stark

“…Following the application of the therapeutic techniques and methods, the objectives set either at the general level or at the level of each stage have been met to a satisfactory extent.…”
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Psychosis of Epilepsy: An Update on Clinical Classification and Mechanism by Zhiruo Qiu, Jiahui Guo, Bofei Chen, Jiajia Fang

“…The alterations in brain structure and function, neurotransmitters, neuroinflammatory mediators, and genetic factors discussed in this review may offer insights into the onset and progression of psychotic symptoms in epilepsy patients and are anticipated to inform the identification of novel therapeutic targets in the future.…”
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The Prorenin and (Pro)renin Receptor: New Players in the Brain Renin-Angiotensin System? by Wencheng Li, Hua Peng, Dale M. Seth, Yumei Feng

“…Some future perspectives in PRR research are heighted with respect to novel therapeutic target for the treatment of hypertension and other cardiovascular diseases.…”
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Exploring the current potential of immunotherapeutic-based treatment approaches for the management of oral cancer: An updated review by Abin V. Geevarghese, R. Gopika

“…However, the primary issues in clinical care are poor therapeutic outcomes and adverse reactions. The tumor microenvironment, or TME, plays a role in prediction in addition to diagnosis, treatment, and avoidance of tumors. …”
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