Unlocking the multifaceted roles of GLP-1: Physiological functions and therapeutic potential by Tohada M. AL-Noshokaty, Rehab Abdelhamid, Nourhan M. Abdelmaksoud, Aya Khaled, Mariam Hossam, Razan Ahmed, Toka Saber, Shahd Khaled, Shereen Saeid Elshaer, Ahmed I. Abulsoud

“…Glucagon (GCG) like peptide 1 (GLP-1) has emerged as a powerful player in regulating metabolism and a promising therapeutic target for various chronic diseases. This review delves into the physiological roles of GLP-1, exploring its impact on glucose homeostasis, insulin secretion, and satiety. …”
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Therapeutic Outcomes of Patients with Multifocal Papillary Thyroid Microcarcinomas and Larger Tumors by Soh-Ching Ng, Sheng-Fong Kuo, Szu-Tah Chen, Chuen Hsueh, Bie-Yu Huang, Jen-Der Lin

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Merging metabolic modeling and imaging for screening therapeutic targets in colorectal cancer by Niki Tavakoli, Emma J. Fong, Abigail Coleman, Yu-Kai Huang, Mathias Bigger, Michael E. Doche, Seungil Kim, Heinz-Josef Lenz, Nicholas A. Graham, Paul Macklin, Stacey D. Finley, Shannon M. Mumenthaler

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Immunobiologics in juvenile dermatomyositis: a systematic review of promising therapeutic advances by Aline Maria de Oliveira Rocha, Gabriel Fidelis Ribeiro, Juliana Capecce Silva

“…Conclusions For severe or refractory disease, biologics tend to be the medication with the best therapeutic response.…”
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Management of Severe Hypertriglyceridemia in Pregnancy With Niacin: Reevaluating Safety and Therapeutic Benefits by Nisha Suda, Daisy Leon-Martinez, Patricia R. Peter, Clare A. Flannery, Roxanna A. Irani

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Intervention program through therapeutic physical exercise in patients with lung cancer by Onesio Esteban de León Gutierrez, Israel Triana Pérez, Iván Castillo Ledo

“…<br /><strong>Objective</strong>: to describe the results of a therapeutic intervention program in patients with lung cancer.…”
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Elucidating the role of pyrimidine metabolism in prostate cancer and its therapeutic implications by Liang Huang, Yu Xie, Shusuan Jiang, Kan Liu, Zhihao Ming, Hong Shan

“…Targeting this metabolic pathway offers a promising strategy for the development of new therapeutic approaches, particularly for overcoming drug resistance and improving outcomes in patients with advanced prostate cancer.…”
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Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunity by Brian M Ortmann

“…Cancer remains one of the most formidable challenges in modern medicine, due to its complex and dynamic nature, which demands innovative therapeutic approaches. One major challenge to cancer treatment is the tumour microenvironment and in particular tumour hypoxia (low oxygen levels), which contributes to tumour progression and immune evasion. …”
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The Enteric Nervous System and Its Emerging Role as a Therapeutic Target by Mark A. Fleming, Lubaina Ehsan, Sean R. Moore, Daniel E. Levin

“…Exciting opportunities in which the ENS could be used as a therapeutic target for common GI diseases will also be highlighted, as the further unlocking of such mechanisms could open the door to more therapy-related advances and ultimately change our treatment approach.…”
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Emerging Lung Cancer Therapeutic Targets Based on the Pathogenesis of Bone Metastases by Moses O. Oyewumi, Adnan Alazizi, Daniel Wehrung, Rami Manochakian, Fayez F. Safadi

“…We strongly believe that molecular targets (tumor-related and bone microenvironment based) that have been implicated in lung cancer bone metastases hold great promise in lung cancer therapeutics. Thus, this paper discusses some of the emerging molecular targets that have provided insights into the cascade of metastases in lung cancer with the focus on bone invasion. …”
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Understanding Rett Syndrome: Genetic, clinical and therapeutic perspectives - literature review by Sylwia Urbańska, Aleksandra Witas, Martyna Borowska-Łygan, Justyna Pięta

“…The aim of this article is to bring together the latest information and clinical, genetic and therapeutic perspectives on RTT. Review Methods: The review was based on publicly available PubMed and Google Scholar, Web of Science and Scopus databases from 2019 to 2024 using the following phrases: rett syndrome, rett syndrome treatment, rett syndrome rehabilitation, MECP2. …”
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The Arve Valley and Environmental Health: From Therapeutic Imagination to Eco-anxiety by Alexandre Savioz

“…Though this contrasts sharply with past therapeutic representations of the mountains as mentioned above, current fears around air quality in the Arve Valley find themselves echoed in broader societal debates around environmental health and eco-anxiety.…”
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Identification of glutamine as a potential therapeutic target in dry eye disease by Xiaoniao Chen, Chuyue Zhang, Fei Peng, Lingling Wu, Deyi Zhuo, Liqiang Wang, Min Zhang, Zhaohui Li, Lei Tian, Ying Jie, Yifei Huang, Xinji Yang, Xiaoqi Li, Fengyang Lei, Yu Cheng

“…Our study demonstrated that co-treatment with mesenchymal stem cells (MSCs) and thymosin beta-4 (Tβ4) yielded the best therapeutic outcome against dry eye, surpassing monotherapy outcomes. …”
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Topical Timolol as a Therapeutic Modality in Severe Disfiguring Infantile Haemangioma by Mohita Mahajan, Bharat Bhushan Mahajan

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Insights into the mechanisms, regulation, and therapeutic implications of extracellular matrix stiffness in cancer by Ximo Zhang, Abdullah Al‐Danakh, Xinqing Zhu, Dan Feng, Linlin Yang, Haotian Wu, Yingying Li, Shujing Wang, Qiwei Chen, Deyong Yang

“…Abstract The tumor microenvironment (TME) is critical for cancer initiation, growth, metastasis, and therapeutic resistance. The extracellular matrix (ECM) is a significant tumor component that serves various functions, including mechanical support, TME regulation, and signal molecule generation. …”
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MicroRNAs in pancreatic cancer drug resistance: mechanisms and therapeutic potential by Fangying Dong, Jing Zhou, Yijie Wu, Zhaofeng Gao, Weiwei Li, Zhengwei Song

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Mitochondrial Dysfunction as a Therapeutic Target in Diabetic Cardiomyopathy: Progress and Prospects by Feng Zhang, Zhuqing Li, Yanxin Wang, Chao Li, Chengzhi Lu

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A Case of the Serotonin Syndrome Secondary to Phenelzine Monotherapy at Therapeutic Dosing by A. Malik, N. Junglee

“…To the best of our knowledge, this is the first reported case to associate the condition with phenelzine alone at therapeutic dose.…”
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Therapeutic Effect of Conductive Education Rehabilitation Training on Children with Cerebral Palsy by Yifang CAI, Haiyan HUANG, Xiaofeng QIU

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Expansion of Gammadelta T Cells from Cord Blood: A Therapeutical Possibility by Sofia Berglund, Ahmed Gaballa, Piamsiri Sawaisorn, Berit Sundberg, Michael Uhlin

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