Psilocybin-assisted therapy for reducing alcohol intake in patients with alcohol use disorder: protocol for a randomised, double-blinded, placebo-controlled 12-week clinical trial... by Claus Thorn Ekstrøm, Patrick MacDonald Fisher, Gitte Moos Knudsen, Dea Siggaard Stenbæk, Anders Fink-Jensen, Mathias Ebbesen Jensen, Tobias Søgaard Juul

“…Preliminary findings suggest that psilocybin, a psychedelic compound, can safely and reliably occasion highly meaningful experiences that may spur a positive change in drinking behaviour when administered in a therapeutic context. However, the efficacy of a single psilocybin administration and its potential neurobiological underpinnings still remain unknown.Methods and analysis To establish efficacy, we will investigate the effects of psilocybin-assisted therapy versus placebo in a randomised, double-blinded, placebo-controlled 12-week clinical trial. …”
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IL-13 Augments Histone Demethylase JMJD2B/KDM4B Expression Levels, Activity, and Nuclear Translocation in Airway Fibroblasts in Asthma by Khuloud Bajbouj, Mahmood Y. Hachim, Rakhee K. Ramakrishnan, Huwaida Fazel, Jumana Mustafa, Shahed Alzaghari, Mahmoud Eladl, Jasmin Shafarin, Ronald Olivenstein, Qutayba Hamid

“…Given that there is no single therapeutic medicine to effectively treat the various subtypes of asthma, this study provides promising insights into JMJD2B as a new therapeutic target that could potentially improve the treatment and management of asthma.…”
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Understanding trends in osteoporosis drug prescribing: implications for reducing futile biomedical research by Jonathan R. Guillemot, Jonathan R. Guillemot, John W. Abraham, Anthea Tinker

“…Reimbursable therapeutic indications in France showed fluctuating availability, reflecting changes in policy priorities and patient demographics. …”
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Single-cell RNA sequencing revealed PPARG promoted osteosarcoma progression: based on osteoclast proliferation by Lei Sun, Jinhao Zhang, Zhikai Xiahou, Zhenzhen Zhao, Yanchen Liang

“…Given the pivotal role of osteoclasts in OS progression, we speculated that these signaling pathways and transcription factors could emerge as novel therapeutic targets, offering innovative strategies for OS treatment.ConclusionThis study enhanced our understanding of OS and osteoclasts through scRNA-seq. …”
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Mediating Mendelian randomization in the proteome identified potential drug targets for obesity-related allergic asthma by Jiannan Lin, Shuwen Lu, Xiaoyu Zhao

“…However, further research is needed to explore their therapeutic potential and the mechanisms underlying their effects. …”
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Insights Into the Role of Bmi‐1 Deregulation in Promoting Stemness and Therapy Resistance in Glioblastoma: A Narrative Review by Fatima Shaalan, Nissrine Ballout, Wafaa Takash Chamoun

“…Targeting Bmi‐1 could be a promising novel therapeutic strategy for GBM treatment.…”
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Evaluation of the effectiveness of combination therapy for post-occlusive retinal changes by A.G. Shchuko, S.I. Zhukova, M.V. Akulenko

“…To evaluate the volume of therapeutic measures necessary for the relief of macular edema in patients with Branch Retinal Vein Occlusion (BRVO) depending on the initial macular ischemia. …”
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Efficacy of pegylated interferon alfa-2b «Algeron» in the treatment of chronic hepatitis C by M. V. Mayevskaya, O. O. Znoyko, E. A. Klimova, S. L. Maximov, S. N. Kizhlo, N. A. Petrochenkova, F. I. Nagimova, R. A. Ivanov, Yu. N. Linkova, T. V. Chernovskaya

“…The complex assessment of the efficacy and safety allowed to make the conclusion about the optimal therapeutic dose of Algeron, equal to 1.5 μg/kg/week.Conclusions. …”
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Latest Advancements in Transcutaneous Electrical Nerve Stimulation (TENS) and Electronic Muscle Stimulation (EMS): Revisiting an Established Therapy with New Possibilities by Patel P, Green M, Tram J, Wang E, Murphy M, Abd-Elsayed AA, Chakravarthy K

“…Additionally, TENS may influence autonomic functions, such as micro-perfusion and sympathetic tone, further broadening its therapeutic potential. EMS, on the other hand, enhances muscle strength and neuromuscular function, particularly in rehabilitation settings, by recruiting additional muscle fibers and improving neuromuscular efficiency. …”
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Refining prognostic assessment of diffuse large B-cell lymphoma: insights from multi-omics and single-cell analysis unveil SRM as a key target for regulating immunotherapy by Xiaojie Liang, Jia Guo, Baiwei Luo, Weixiang Lu, Qiumin Chen, Yeling Deng, Yunong Yang, Liang Wang

“…Abstract Purposes Previous studies have demonstrated that proliferation, stroma or immunity strongly influence the prognosis and therapeutic resistance of diffuse large B-cell lymphoma (DLBCL). …”
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Phytochemical and toxicological evaluation of aqueous leaf extract of Premna integrifolia L. in male balb/c mice by Suman, Pratibha Gaurav, Rajesh Saini, Kavindra Nath Tiwari, Gautam Geeta Jiwatram

“…Conclusion: Based on the findings from both the acute and subacute toxicity studies, it is evident that the ALEPI does not actuate adverse effects of toxicological significance at the tested doses and hence can be used at appropriate concentrations in therapeutic application.…”
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Comparative and Correlational Evaluation of the Phytochemical Constituents and Antioxidant Activity of Musa sinensis L. and Musa paradisiaca L. Fruit Compartments (Musaceae) by Barnabas Oluwatomide Oyeyinka, Anthony Jide Afolayan

“…Secondary metabolites and their biological activity have pharmacological relevance in the prevention and therapeutic management of disease, including the facilitation of normal physiological processes through biochemical mechanisms. …”
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Factors influencing osteoradionecrosis progression during hyperbaric oxygen therapy: A case study [version 2; peer review: 1 approved, 2 approved with reservations] by Khadija Bahrini, Chaima Zitouni, Sameh Mezri, Hedi Gharsallah, Wiem Boughzala, Mounir Haggui

“…Introduction Although relatively uncommon, osteoradionecrosis (ORN) remains a serious complication following radiotherapy. Various therapeutic approaches, including hyperbaric oxygen therapy (HBOT), are utilized in managing ORN. …”
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S100A8-CAMKK2-AMPK axis confers the protective effects of mild hypothermia against cerebral ischemia-reperfusion injury in rats by Dandan Zhang, Yuting Dai, Xiaoyan Xu, Fuguo Ma, Mingshan Wang, Weiwei Qin

“…By targeting the S100A8-initiated CAMKK2/AMPK signaling pathway, we may unlock a novel therapeutic intervention or develop a refined MH therapeutic strategy against cerebral IR injury.…”
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Self-administered active versus sham acupressure for diarrhea predominant irritable bowel syndrome: a nurse-led randomized clinical trial by Maha Gamal Ramadan Asal, Ahmed Abdelwahab Ibrahim El-Sayed, Samira Ahmed Alsenany, Zahraa Hassan Ramzy, Rasha Fathy Ahmed Dawood

“…The active group applied pressure to specific therapeutic acupoints, while the sham group used non-therapeutic points. …”
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Host Epithelial Interactions with Helicobacter Pylori: A Role for Disrupted Gastric Barrier Function in the Clinical Outcome of Infection? by Andre G Buret, Jason P Fedwick, Andrew N Flynn

“…These mechanisms and the associated signalling events may represent novel therapeutic targets to control disease processes induced by H pylori, a microbial pathogen that colonizes the stomach of over 50% of the human population.…”
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Pertussis Reinfection in an Adult: A Cause of Persistent Cough Not to Be Ignored by Theocharis Koufakis, Anastasia Paschala, Dimitrios Siapardanis

“…In this article, we report a case of pertussis reinfection 30 years after natural infection, which was complicated by pneumonia, and we discuss our diagnostic and therapeutic approach, aiming to raise clinicians’ degree of suspicion regarding pertussis diagnosis in adults. …”
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Die betekenis en funksie van die himnes in Openbaring 4-11 by F. P. Viljoen

“…The hymns are thus therapeutic throughout. They revolve around the theme of the sovereignity of God and the Lamb, his coming in judgement and the establishment of the kingdom of the saints. …”
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Distinct Functions of Specialized Dendritic Cell Subsets in Atherosclerosis and the Road Ahead by Alma Zernecke

“…Furthermore, an outlook on future challenges faced when studying DCs in this detrimental disease are provided, and hurdles that will need to be overcome in order to enable a better understanding of the contribution of DCs to atherogenesis are discussed, a prerequisite for their therapeutic targeting in atherosclerosis.…”
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Role of B-Cell Lymphoma/Leukemia 11A in Normal and Malignant Hematopoiesis by Haihang Zhang, Junhao Zeng, Fangling Zhang, Jing Liu, Long Liang

“…This review provides a comprehensive overview of the role of BCL11A in normal and malignant hematopoiesis, details the hematological disorders associated with its dysregulation and explores the current therapeutic strategies targeting this transcription factor.…”
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