Targeting Adult Neurogenesis for Poststroke Therapy by Jianfei Lu, Anatol Manaenko, Qin Hu

“…Thus, enhancing the endogenous neurogenesis driven by ischemia and promoting the survival of newborn neurons can be promising therapeutic interventions for stroke. Here, we present an overview of the process of adult neurogenesis and the potential of stroke-induced neurogenesis on brain repair.…”
Get full text

Oncological principles in the management of ocular surface squamous neoplasia - A Review by Rolika Bansal, Santosh G Honavar

“…It also provides a foundation for the oncologic principles of managing OSSN while offering insights into future therapeutic approaches.…”
Get full text

New perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseases by Yan-rui Sun, Qian-Kun Lv, Jun-Yi Liu, Fen Wang, Chun-Feng Liu

“…It discusses the potential roles of the glymphatic system in ND, including Alzheimer's disease (AD), Parkinson's disease (PD), and multiple system atrophy (MSA), and proposes the glymphatic system as a novel therapeutic target for these conditions.…”
Get full text

Into the clinic: Talimogene laherparepvec (T-VEC), a first-in-class intratumoral oncolytic viral therapy by Ann W. Silk, Howard L. Kaufman, Hasan Rehman, Michael P. Kane

“…Limiting factors include the intratumoral route of administration, which is unfamiliar to medical oncologists, biosafety concerns related to the use of a live virus in the clinic, and the explosion of other therapeutic strategies now available for the treatment of advanced melanoma. …”
Get full text

A Case of Rosai-Dorfman Disease Successfully Treated by Corticotherapy by Alioune Badara Diallo, Moustapha Ndiaye, Moussa Seck, Mohamed Keita, Elimane Seydi Bousso, Sokhna Aissatou Touré, Blaise Félix Faye, Saliou Diop

“…It is a rare disease, with fewer than 1,000 cases reported in the literature, which explains its lack of knowledge by physicians and the lack of codified therapeutic strategies. We report the case of an 8-year-old girl who presented a rapidly progressive cervical lymph node mass; the diagnosis of RDD was made based on histology and immunohistochemistry. …”
Get full text

Granulocyte Colony-Stimulating Factor and Its Potential Application for Skeletal Muscle Repair and Regeneration by Craig R. Wright, Alister C. Ward, Aaron P. Russell

“…This has been supported by preclinical studies and clinical trials investigating G-CSF as a potential therapeutic agent in relevant disease states. This review focuses on the growing literature associated with G-CSF and G-CSFR in skeletal muscle under healthy and disease conditions and highlights the current controversies.…”
Get full text

Treatment of Advanced Parkinson's Disease by Sara Varanese, Zoe Birnbaum, Roger Rossi, Alessandro Di Rocco

“…These complications include motor fluctuations, dyskinesia, unpredictable or absent response to medications, falls, dysautonomia, dementia, hallucinations, sleep disorders, depression, and psychosis. The therapeutic management should be driven by the attempt to create a balance between benefit and side effects of the pharmacological treatments available. …”
Get full text

The regulation of glutamatergic nervous system in sleep-wake states and general anesthesia by Wei Luo, Meiyi Duan, Enpeng Liang, Siwei Wang, Jie Yuan

“…Understanding these mechanisms can lead to improved therapeutic strategies for sleep disorders and more precise anesthetic practices, providing new avenues for clinical intervention.…”
Get full text

Polymer and nanocomposite fillers as advanced materials in biomedical applications by Angeline Julius, Suresh Malakondaiah, Raghu Babu Pothireddy

“…This review underscores the need for focused research on biocompatibility, functional predictability, and the integration of polymer nanocomposites into clinical diagnostics and therapeutic applications to bridge current limitations and unlock their full potential in the field of biomedicine.…”
Get full text

Rodent Models for Investigating the Dysregulation of Immune Responses in Type 1 Diabetes by Feng-Cheng Chou, Heng-Yi Chen, Shyi-Jou Chen, Mei-Cho Fang, Huey-Kang Sytwu

“…This paper will focus on the use of genetically manipulated NOD mice to explore the pathogenesis of T1D and to develop potential therapeutic approaches.…”
Get full text

Brugada syndrome update by Tingting Xu, Shaokun Wang, Jiawen Wang, Jihong Xing

“…This review elaborates on the current insights into BrS, focusing on recent diagnostic techniques, risk assessment strategies, and therapeutic advancements. It also critically examines ongoing controversies in the field.…”
Get full text

Production of Lipid Microparticles Magnetically Active by a Supercritical Fluid-Based Process by Keti Vezzù, Chiara Campolmi, Alberto Bertucco

“…Magnetite nanoparticles (MNPs) were encapsulated into triestearin and phosphatidylcholine mixtures to increase their biocompatibility for future applications in the fields of biomedical diagnostics and therapeutic medications. The lipid particles produced were characterized to determine size and size distribution, and to confirm the encapsulation of MNP. …”
Get full text

Dynamic Multidrug Therapies for HIV: Optimal and STI Control Approaches by B. M. Adams, H. T. Banks, Hee-Dae Kwon, Hien T. Tran

“…We formulate a dynamic mathematical model that describes theinteraction of the immune system with the human immunodeficiencyvirus (HIV) and that permits drug ''cocktail'' therapies. Wederive HIV therapeutic strategies by formulating and analyzing anoptimal control problem using two types of dynamic treatmentsrepresenting reverse transcriptase (RT) inhibitors and proteaseinhibitors (PIs). …”
Get full text

Dysphagia in patients with cerebrovascular disease. Update. by Amarilis Barbié Rubiera, Ligia María Marcos Plasencia, Yolanda Aguilera Martínez

“…A wide review of the subject was performed including experts´ opinions, from the above mentioned institutions, in order to gather an updated report related with the significance of early diagnosis of dysphagia in patients with ictus and the opportune and correct use of therapeutic measures to reduce complication risk.…”
Get full text

Antibody-Drug Conjugates in the Treatment of Metastatic Breast Cancer: The Emerging Questions of Sequence and Resistance by Allan Relecom, Francesco Sciotto, Mathieu Chevallier, José Luis Sandoval

“…Metastatic breast cancer continues to present significant therapeutic challenges, necessitating ongoing exploration of innovative treatments. …”
Get full text

Biclonal IgD and IgM Plasma Cell Myeloma: A Report of Two Cases and a Literature Review by Zhongchuan W. Chen, Ioanna Kotsikogianni, Jay S. Raval, Christine G. Roth, Marian A. Rollins-Raval

“…Biclonal plasma cell myelomas, while currently not well characterized in terms of their clinical behavior, should be distinguished from B-cell lymphoma with plasmacytic differentiation, given the different therapeutic implications. Both cases reported herein demonstrated chemotherapy-resistant clinical courses.…”
Get full text

Hypoxic-Ischemic Injury in the Developing Brain: The Role of Reactive Oxygen Species Originating in Mitochondria by Vadim S. Ten, Anatoly Starkov

“…This paper focuses on current data that support a pathogenic role of ROS originating from mitochondrial respiratory chain in the promotion of secondary energy failure and proposes potential therapeutic strategy against reperfusion-driven oxidative stress following hypoxia-ischemia-reperfusion injury of the developing brain.…”
Get full text

Guidelines of the Polish Society of Pediatric Endocrinology and Diabetology and Pediatric Section of Diabetes Poland on insulin therapy using hybrid closed-loop systems in childr... by Agnieszka Szadkowska, Agata Chobot, Barbara Głowińska-Olszewska, Przemysława Jarosz-Chobot, Beata Mianowska, Małgorzata Myśliwiec, Agnieszka Szypowska, Agnieszka Zubkiewicz-Kucharska, Mieczysław Walczak

“…Currently, hybrid closed loop (HCL) systems represent the most advantageous therapeutic option for people with diabetes requiring intensive insulin therapy. …”
Get full text

Research Progress on the Interaction between Taurine Metabolism and the Gut Microbiota by YANG Xinyu, WU Qingjie, MI Shengquan, ZHANG Yanzhen, GUO Junxia

“…The aim is to provide a scientific basis for the development of preventive and therapeutic measures for diseases related to gut microbiota imbalance.…”
Get full text

Mitochondrial Disorder Aggravated by Metoprolol by Cheryl Samuels, Mary Kay Koenig, Mariana Hernandez, Aravind Yadav, Ricardo A. Mosquera

“…Beta-adrenergic blocking agents or beta-blockers are a class of medications used to treat cardiac arrhythmias and systemic hypertension. In therapeutic dosages, they have known adverse outcomes that can include muscular fatigue and cramping, dizziness, and dyspnea. …”
Get full text