USP39 phase separates into the nucleolus and drives lung adenocarcinoma progression by promoting GLI1 expression by Shaoxuan Cheng, Zhiyuan Qiu, Ziyi Zhang, Yuxuan Li, Yue Zhu, Yuxin Zhou, Yinghui Yang, Yaowen Zhang, Dian Yang, Yingqiu Zhang, Han Liu, Zhaoxia Dai, Shu-Lan Sun, Shuyan Liu

“…Downregulation of USP39 effectively suppressed lung cancer growth, and therefore targeting USP39 provides novel therapeutic strategy to treat lung cancer.…”
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Suberoylanilide Hydroxamic Acid Attenuates Autoimmune Arthritis by Suppressing Th17 Cells through NR1D1 Inhibition by Da Som Kim, Hong-Ki Min, Eun Kyung Kim, Seung Cheon Yang, Hyun Sik Na, Seon-Yeong Lee, Jeong-Won Choi, Kyung-Ah Jung, Seung-Ki Kwok, Sung-Hwan Park, Mi-La Cho

“…Therefore, SAHA is a potential therapeutic candidate for RA.…”
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Helicobacter mastomyrinus infection induces autoimmune hepatitis in mice by Liqi Zhu, Yuanyuan Liang, Linghan Yang, Qihui Yang, Jun Yin, Tao Wang, Xiangming Xu, Quan Zhang

“…This model may serve as a novel animal model for the study of the pathogenesis and potential therapeutic strategies for human AIH.…”
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Immunotherapeutic Potential of Mollusk Hemocyanins in Combination with Human Vaccine Adjuvants in Murine Models of Oral Cancer by Juan José Mora Román, Miguel Del Campo, Javiera Villar, Francesca Paolini, Gianfranca Curzio, Aldo Venuti, Lilian Jara, Jorge Ferreira, Paola Murgas, Alvaro Lladser, Augusto Manubens, María Inés Becker

“…Here, we analyzed the preclinical therapeutic potential of the traditional keyhole limpet hemocyanin (KLH) and two new hemocyanins from Concholepas concholepas (CCH) and Fissurella latimarginata (FLH) in mouse models of oral squamous cell carcinoma. …”
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Cobalt oxide nanoparticles induce cytotoxicity and excessive ROS mediated mitochondrial dysfunction and p53-independent apoptosis in melanoma cells by Hanan R. H. Mohamed, Basma A. Mohamed, George M. Hakeem, Shahd H. Elnawasani, Maria Nagy, Rawan Essam, Ayman Diab, Gehan Safwat

“…Abstract Nanotherapy has emerged as a promising strategy for the targeted and efficient treatment of melanoma, the most aggressive and lethal form of skin cancer, with minimized systemic toxicity. However, the therapeutic efficacy of cobalt oxide nanoparticles (Co3O4NPs) in melanoma treatment remains unexplored. …”
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Antimony Resistance in Leishmania, Focusing on Experimental Research by Fakhri Jeddi, Renaud Piarroux, Charles Mary

“…There are few available treatments and antimonials are still of major importance in the therapeutic strategies used in most endemic regions. …”
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Portrait of WWP1: the current state in human cancer by Jiaming Lei, Jun Chen, Wenwen Yu, Qing Wu, Shuang Jing, Yuanguang Tang, Li Lin, Meichun Hu

“…This review summarizes WWP1’s biological roles, therapeutic potential in oncology, upstream regulatory factors, and downstream substrates. …”
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Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators by Lulu Yao, Qiang Zhou

“…Past efforts in targeting NMDARs for therapeutic intervention have largely been on inhibitors of NMDARs. …”
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The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology by Winder Mateusz, Bulska-Będkowska Weronika, Chudek Jerzy

“…Substances available in nature with potential therapeutic effects are the subject of research that raises tremendous hopes for new challenges in medicine. …”
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Generation of human induced pluripotent stem cell lines from three different male XLRS patients carrying RS1 gene mutation by Sang-Yun Kim, Yong-Min Choi, Yunho Park, Seung-Hyun Kim, Hyun Beom Song, Jeong Hun Kim, Ok-Seon Kwon, Kyung-Sook Chung

“…These iPSC lines demonstrated pluripotency, in vitro differentiation potential, and a normal karyotype, making them valuable resource for investigating XLRS pathogenesis and for advancing therapeutic development.…”
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Tracing the Spectrum of Inborn Errors of Immunity from Past to Present by Safa Barış, Talal A. Chatila

“…Furthermore, these endeavors have synergized with innovative therapeutic modalities, forging a trajectory toward enhanced patient care. …”
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Posaconazole: A New Agent for the Prevention and Management of Severe, Refractory or Invasive Fungal Infections by Andrea V Page, W Conrad Liles

“…As the incidence of both common and uncommon fungal infections increases commensurate with the growing population of immunocompromised individuals, posaconazole may ultimately become an important therapeutic option. The present article reviews the in vitro and in vivo data describing its activity, and focuses on both the proven and the potential clinical applications of this new triazole agent.…”
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Exercise and Physical Activity in the Therapy of Substance Use Disorders by Elisabeth Zschucke, Andreas Heinz, Andreas Ströhle

“…The present work reviews studies addressing the therapeutic effects of exercise in alcohol abuse/dependence, nicotine abuse/dependence, and illicit drug abuse/dependence. …”
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High-Frequency and Low-Intensity Patterned Transcranial Magnetic Stimulation over Left Dorsolateral Prefrontal Cortex as Treatment for Major Depressive Disorder: A Report of 3 Case... by Lizbeth Castillo-Aguilar, Alma E. Ríos-Ponce, Edson Albano de Mendonca, Gabriel Villafuerte

“…Nevertheless, different studies have shown that very small magnetic fields, at higher frequencies (50-1000 Hz.), produce therapeutic effects in major depressive disorder. We report the application of high-frequency and low-intensity patterned magnetic pulses over the left prefrontal dorsolateral cortex in three subjects diagnosed with clinical major depressive disorder. …”
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The Role of MicroRNAs in Diabetic Nephropathy by Hao Wu, Lili Kong, Shanshan Zhou, Wenpeng Cui, Feng Xu, Manyu Luo, Xiangqi Li, Yi Tan, Lining Miao

“…The aim of this review is to summarize DN-related miRNAs and provide potential targets for diagnostic strategies and therapeutic intervention.…”
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Donor Specific Anti-HLA Antibody and Risk of Graft Failure in Haploidentical Stem Cell Transplantation by Piyanuch Kongtim, Kai Cao, Stefan O. Ciurea

“…The recognition of the role of humoral rejection in the development of primary graft failure in this setting has broadened our understanding about causes of engraftment failure in these patients, helped us better select donors for patients in need of AHSCT, and developed rational therapeutic measures for HLA sensitized patients to prevent this unfortunate event, which is usually associated with a very high mortality rate. …”
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Biliothoracic Fistula after Microwave Ablation of Liver Metastasis : Literature Review by Valentina Tassi, Claudia Mosillo, Massimiliano Mutignani, Roberto Cirocchi, Mark Ragusa, Sergio Bracarda, Giovanni Passalacqua, Gabriele Marinozzi, Massimiliano Allegritti

“…We reviewed aetiology, pathogenesis, clinical picture, diagnostic possibilities, and therapeutic options for biliothoracic fistula developed after microwave ablation of liver metastasis. …”
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Asymmetric Dimethyl Arginine as a Biomarker of Atherosclerosis in Rheumatoid Arthritis by Manuela Di Franco, Bruno Lucchino, Fabrizio Conti, Guido Valesini, Francesca Romana Spinelli

“…Moreover, the metabolic pathway of methylarginines offers possible targets for therapeutic interventions to decrease the cardiovascular risk. …”
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Stem cells in gastroenterology: prospects and problems by A. O. Buyeverov, V. T. Ivashkin

“…Cell-based treatment is rather new and, probably, promising trend in treatment of many severe diseases in which traditional methods fail to achieve due results. In therapeutic aspect of gastrointestinal and liver diseases inflammatory bowel diseases, colorectal cancer and decompensated liver cirrhosis seem to be most perspective at the present stage. …”
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Dry and neovascular “wet” age-related macular degeneration: Upcoming therapies by Audrey Yan, Nasiq Hasan, Jay Chhablani

“…The age-related macular degeneration (AMD) field is witnessing promising advancements in therapeutic options. Breakthrough drugs such as pegcetacoplan and avacincaptad have been FDA-approved for dry AMD, marking a significant development as there were no treatment options until August 2023. …”
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