Pulmonary Hydatidosis in Children. A Case Presentation by Gladys Esther Escalante, Ivonne Espinosa Gómez, Yaquelin González Ricardo

“…With clinical, epidemiological, radiological and therapeutic diagnostic methods, hydatid disease was found. …”
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Adalimumab induced psoriasis in Crohn’s disease and treatment with ustekinumab: case report and special histopathological findings by Fang Qiu, Weiquan Chen, Ying Zhou

“…The patient’s condition significantly improved following the transition from adalimumab to ustekinumab, which highlights the importance of alternative therapeutic strategies for patients who exhibit paradoxical reactions to TNF-α inhibitors.…”
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Nitric oxide as a mediator of inflammation?—You had better believe it by Mark J. S. Miller, Matthew B. Grisham

“…We contend that there is ample evidence to consider nitric oxide as a molecular aggressor in inflammation, particularly chronic inflammation. Therapeutic benefit can be achieved by inhibition of inducible nitric oxide synthase and not the donation of additional nitric oxide. …”
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Diffuse Pancreatic Carcinoma with Hepatic Metastases by Hoang Quan Nguyen, Ngoc Trinh Thi Pham, Van Trung Hoang, Hoang Anh Thi Van, Chinh Huynh, Duc Thanh Hoang

“…Therefore, timely diagnosis and therapeutic management are desirable goals for this disease. …”
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Oral submucous fibrosis: a contemporary narrative review with a proposed inter-professional approach for an early diagnosis and clinical management by Naman R. Rao, Alessandro Villa, Chandramani B. More, Ruwan D. Jayasinghe, Alexander Ross Kerr, Newell W. Johnson

“…This expert opinion paper updates the literature and provides a critique of diagnostic and therapeutic pitfalls common in developing countries and of deficiencies in management. …”
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Colocolic Intussusception in an Adult Patient Secondary to Caecal Adenocarcinoma by Hicham Elmajdoubi, Marouane Baiss, Mohamed El Absi, El Hassan El Faricha El Alami, Mohamed El Ouanani, El Mahjoub Echarrab, Mohamed El Amraoui, Abdelkader Errougani

“…By review of literature, we discuss diagnostic and therapeutic procedures in emergency.…”
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Generation of a BEST1 Pr-EGFP reporter human embryonic stem cell line via CRISPR/Cas9 editing by Shuaiyan Lu, Ming Chen, Xiaoyu Liu, Jiahang Li, Hui Liu, Shasha Li

“…The resulting gene-edited line, WAe009-A-2 M, maintained a normal karyotype, expressed pluripotency markers, and demonstrated differentiation potential, making it invaluable for RPE development and therapeutic research.…”
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An Overview of Alkylresorcinols Biological Properties and Effects by Anastasia A. Zabolotneva, Olga P. Shatova, Anastasia A. Sadova, Aleksandr V. Shestopalov, Sergei A. Roumiantsev

“…Besides, ARs are considered as promising bioregulators of metabolic and immune processes, as well as adjuvant therapeutic agents for antimicrobial and anticancer treatment. …”
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Treatment of an ankle fracture-dislocation using RALCA external fixation. Five-year monitoring by Yaniel Truffin Rodriguez, Osmany Pérez Martínez, Annia L. López Hernández

“…The association of a dislocation in ankle fractures modifies its therapeutic approach since the joint should not remain for more than six hours in this situation and therefore emergency surgical treatment will be required. …”
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The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy by Qinglong Ma, Wenyang Zhang, Kongming Wu, Lei Shi

“…Given that cancer cells rely on these metabolic changes to sustain cell growth and survival, targeting these processes may represent a promising therapeutic strategy for KRAS-driven cancers.…”
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Ribosomal Alteration-Derived Signals for Cytokine Induction in Mucosal and Systemic Inflammation: Noncanonical Pathways by Ribosomal Inactivation by Yuseok Moon

“…In the present study, ribosomal inactivation-related modulation of cytokine production was reviewed in leukocyte and epithelial pathogenesis models to characterize mechanistic evidence of ribosome-derived cytokine induction and its implications for potent therapeutic targets of mucosal and systemic inflammatory illness, particularly those triggered by organellar dysfunctions.…”
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Minimally invasive treatment of the cyst of the canal of Nuck with the laparoscopic total extraperitoneal approach by Ülkü Mete Ural, Neriman Şengül, Elif Betül Esmer, Elif Aydın, Selma Erdoğan Düzcü

“… The cyst of the canal of Nuck (CCN) is an extremely rare pathology that occurs as a result of the inability to obliterate the processus vaginalis. No standard therapeutic procedure currently exists, and the condition remains unfamiliar to gynecologists. …”
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Development of Personalized Periodontal Treatment Approaches: Integration of Genetic, Environmental, and Clinical Factors by Rajneesh Maheshwari, Iman Baig, Sana Zeba, Mamta Singh, Shilpi Tyagi, Prashansa Sharma

“…This study explores the potential of personalized periodontal treatments that integrate genetic, environmental, and clinical data to optimize therapeutic outcomes. A cohort of 150 patients with various stages of periodontal disease underwent tailored treatments based on genetic screening, lifestyle factors, and clinical presentation. …”
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Emergent Management of Intracardiac Thrombosis during Liver Transplantation by Caroline Protin, Dmitri Bezinover, Zakiyah Kadry, Thomas Verbeek

“…Our case suggests that if an intracardiac thrombus is identified early (before hemodynamic instability occurs), the use of IV heparin may be a safe therapeutic option.…”
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Identification of Novel Causal FBN1 Mutations in Pedigrees of Marfan Syndrome by Yueli Wang, Xiaoyan Li, Rongjuan Li, Ya Yang, Jie Du

“…These novel mutations provide important diagnostic and therapeutic insights for precision medicine in MFS, especially regarding the lethal cardiovascular events.…”
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Final recommendations for the Latin America and Caribbean Periodontics Consensus 2024 by Cristina Cunha VILLAR, Paola CARVAJAL, Fernanda CARRER, Giuseppe Alexandre ROMITO, James Rudolph COLLINS, Marco Antonio ALARCÓN, Cassiano Kuchenbecker RÖSING, Juliano CAVAGNI, Andres Duque DUQUE, Gloria Inés LAFAURIE Villamil, Ricardo Guimarães FISCHER, Bernal STEWART, Zilson MALHEIROS, Carlos BENÍTEZ, Claudio Mendes PANNUTI

“…This comprehensive document presents holistic recommendations to standardize diagnostic methodologies, enhance public awareness, and integrate preventive and therapeutic practices into general healthcare. Key areas include understanding the prevalence and impact of periodontal diseases, identifying risk factors, and improving diagnostic, preventive, and treatment strategies. …”
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Microbial metabolites and immune modulation by Hassan Ghasemi

“…Microbial metabolites serve as molecular mediators, orchestrating immune homeostasis and modulating responses to pathogens, inflammation, and diseases.1,2 Understanding these interactions has opened new avenues for therapeutic interventions targeting immune-related disorders. …”
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FGF21 and APOA1 mRNA-based therapies for the treatment of experimental acute pancreatitis by Amaya Lopez-Pascual, Eva Santamaria, Nuria Ardaiz, Iker Uriarte, Tiffany Palmer, Anne-Renee Graham, Celia Gomar, Roberto C. Barbero, M. Ujue Latasa, Maria Arechederra, Jesus M. Urman, Carmen Berasain, Antonio Fontanellas, Carlos L. del Rio, Maite G. Fernandez-Barrena, Paolo G.V. Martini, Joshua R. Schultz, Pedro Berraondo, Matias A. Avila

“…Abstract Background Acute pancreatitis (AP) presents a significant clinical challenge with limited therapeutic options. The complex etiology and pathophysiology of AP emphasize the need for innovative treatments. …”
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The added value of coupling anti-dsDNA and anti-chromatin antibodies in follow-up monitoring of systemic lupus erythematosus patients by Caroline Carlé, Françoise Fortenfant, Chloé Bost, Julie Belliere, Stanislas Faguer, Dominique Chauveau, Antoine Huart, David Ribes, Laurent Alric, Gregory Pugnet, Laurent Sailler, Yves Renaudineau

“…Conclusion: coupling anti-dsDNA with anti-Chr Ab detection at disease initiation/flare allows definition of endotypes, which is useful to follow disease activity, predict lupus nephritis/serositis, and anticipate therapeutic response in the DP + group.…”
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Inhibition of RAC1 activator DOCK2 ameliorates cholestatic liver injury via regulating macrophage polarisation and hepatic stellate cell activation by Jianli Qiu, Yitong Qu, Yinli Li, Cancan Li, Junling Wang, Lu Meng, Xiaojin Jing, Jiangping Fu, Yan Xu, Yuna Chai

“…Abstract Background The Rho GTPase Rac family small GTPase 1 (RAC1) is considered a promising fibrotic therapeutic target, but the role of its activator, dedicator of cytokinesis 2 (DOCK2), in liver fibrosis is largely unknown. …”
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