Vitamin A family suppresses periodontitis by restoring mitochondrial metabolic reprogramming in macrophages through JAK-STAT pathway by Zishuo Cheng, Shun Huang, Qiya Tang, Danlan Zhang, Lan Huang

“…Experimental data confirmed vitamin A’s effects on mitochondrial dynamics and metabolic reprogramming through the STAT3 pathway.ConclusionThe study demonstrates that vitamin A’s therapeutic effect on periodontitis is mediated through JAK-STAT pathway-guided mitochondrial metabolic reprogramming in macrophages. …”
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Identification of biomarkers associated with coronary artery disease and non-alcoholic fatty liver disease by bioinformatics analysis and machine learning by Chuan Lu, Mei Han, Qiqi Ma, Li Ying, Yue Zhang

“…Our study provided new insights for potential biomarkers, molecular mechanism and therapeutic targets for both diseases.…”
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Hypotony maculopathy after glaucoma surgery: pathogenic mechanisms, diagnostic tools, and treatment modalites by V.P. Erichev, S.Yu. Petrov, N.A. Orekhova, L.Kh. El’murzaeva

“…El’murzaeva</b><br> </p> <p> <b>Scientific Research Institute of Eye Diseases, Moscow, Russian Federation</b> </p> <p> <i>This article reviews risk factors, mechanisms of the development, key diagnostic tools, therapeutic and preventive modalities for hypotony maculopathy. …”
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Active Ingredients and Potential Mechanism of Additive Sishen Decoction in Treating Rheumatoid Arthritis with Network Pharmacology and Molecular Dynamics Simulation and Experimenta... by Ren J, Liu Z, Qi X, Meng X, Guo L, Yu Y, Dong T, Li Q

“…Additive Sishen decoction (ASSD) is a widely used traditional Chinese medicine for the treatment of RA; however, its active ingredients and the mechanism of its therapeutic effects remain unclear.Methods: To predict the ingredients and key targets of ASSD, we constructed “drug-ingredient-target-disease” and protein–protein interaction networks. …”
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Integrative Bioinformatics Analysis Unravel the Association between Intracerebral Hemorrhage and Cellular Apoptosis through Immune Infiltration by Pandi Chen, Gengfan Ye, Jia Li, Kuan Feng, Guangyao Zhu, Maosong Chen, Wei Chen

“…We employed bioinformatics methods to identify key apoptotic genes associated with ICH, thereby offering potential therapeutic targets and contributing to a deeper understanding of the pathogenic mechanisms of apoptosis in ICH. …”
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Microbial-based natural products as potential inhibitors targeting DNA gyrase B of Mycobacterium tuberculosis: an in silico study by Tilal Elsaman, Magdi Awadalla Mohamed, Malik Suliman Mohamed, Eyman Mohamed Eltayib, Abualgasim Elgaili Abdalla

“…These comprehensive computational findings strongly support the potential of 1-Hydroxy-D-788-7 as an effective anti-TB lead compound, warranting further experimental validation to confirm its therapeutic efficacy.…”
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Wnt/β-catenin signalling underpins juvenile Fasciola hepatica growth and development. by Rebecca Armstrong, Nikki J Marks, Timothy G Geary, John Harrington, Paul M Selzer, Aaron G Maule

“…The exploitation of this system as a therapeutic target is impeded by a lack of understanding of the molecular mechanisms underpinning F. hepatica growth and development. …”
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Qingfei Tongluo Mixture Attenuates Bleomycin-Induced Pulmonary Inflammation and Fibrosis through mTOR-Dependent Autophagy in Rats by Shuyu Ge, Zhenghong Guo, Ting Xiao, Pingping Sun, Bo Yang, Yin Ying

“…This study aims to confirm whether it has a therapeutic effect on bleomycin-induced IPF in rats and to elucidate its mechanism of action. …”
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Assessment of Zinc Alpha-2 Glycoprotein Level in Gestational Diabetes Woman in Respect to Glycemic Status with and without Treatment by Bara Nahdh Saleem, Manal Khalid Abdulridha, Hind Abdalkhaliq Showman, Manal Sabbar

“…Objectives: This study was designed to evaluate the ZAG level in GDM pregnant women on different therapeutic modalities and whether it could be used as a biomarker in the diagnosis of GDM. …”
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The Effect of Mesenchymal Stem Cell-Derived Exosomes and miR17-5p Inhibitor on Multicellular Liver Fibrosis Microtissues by Farnaz Sani, Mina Soufi Zomorrod, Negar Azarpira, Masoud Soleimani

“…Our findings indicated that anti-miR17-5p and MSC-EXO might be promising therapeutic options for treating liver fibrosis. Furthermore, EXO + anti-miR had the best effects on boosting the fibrotic markers. …”
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Case report: Trauma-induced Klebsiella pneumoniae invasive syndrome presenting with liver abscess, lung abscess, endophthalmitis, and purulent meningitis by Hong-qiao Chen, Zhen-hua Mo, Wu-xiao Wei

“…Future research should further investigate the relationship between trauma and hvKp infections and develop more comprehensive diagnostic and therapeutic guidelines.…”
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Blood coagulation monitoring of patients with mechanical heart valve visiting Imam by Nafiseh Montazeri, Sajad Pourmehr, Arash Ziapour, Reza Heidari Moghadam

“…For this reason, the correct monitoring of INR via the Time in Therapeutic Range (TTR) is needed. The present study aimed to explore the blood coagulation monitoring of patients with mechanical heart valve in Imam Ali Hospital of Kermanshah in 2021. …”
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Bioinformatics and Deep Learning Approach to Discover Food-Derived Active Ingredients for Alzheimer’s Disease Therapy by Junyu Zhou, Chen Li, Yong Kwan Kim, Sunmin Park

“…Alzheimer’s disease (AD) prevention is a critical challenge for aging societies, necessitating the exploration of food ingredients and whole foods as potential therapeutic agents. This study aimed to identify natural compounds (NCs) with therapeutic potential in AD using an innovative bioinformatics-integrated deep neural analysis approach, combining computational predictions with molecular docking and in vitro experiments for comprehensive evaluation. …”
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Abuse and misuse of tramadol in patients with non-oncologic pain in a region of Southern Europe by M. Perelló, K. Rio-Aigé, G. Cereza, P. Rius, F. J. Pérez-Cano, M. Rabanal

“…Its use has increased recently, especially in patients with chronic pain, and although a growing body of literature identifies a non-therapeutic use, patterns of misuse of tramadol is so far limited.Methods Two-year observational and cross-sectional study (January 2020 - December 2021) was conducted in 75 community pharmacies from Catalonia. …”
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A case report of exacerbation of extrapyramidal symptoms following the switch from risperidone to paliperidone during valproate therapy by Emi Hata, Masatoshi Miyauchi, Nobuhiko Noguchi, Takeshi Asami

“…Abstract Background Paliperidone is a second-generation antipsychotic and the main active metabolite of risperidone, formulated to provide consistent therapeutic effects through an extended-release system, designed to provide consistent therapeutic effects through an extended-release formulation. …”
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Expression of some circulating microRNAs as predictive biomarkers for prognosis and treatment response in glioblastoma by Elham Ali, Marwa Adel Ahmed, May A. Shawki, Lobna R. Ezz El Arab, Mohamed K. Khalifa, Menha Swellam

“…In conclusion, circulating miRs revealed a significant role in predicting GBM patient treatment outcomes providing valuable insights for personalized therapeutic strategies.…”
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Unraveling the Beneficial Role of Resveratrol in Fructose-Induced Non-Alcoholic Steatohepatitis with a Focus on the AMPK/Nrf2 Signaling Axis by Soha S. Zakaria, Safaa M. Hanafy

“…These findings underscore the potential of resveratrol as a promising therapeutic agent that can support treatment alongside conventional medications in the management of non-alcoholic steatohepatitis (NASH).…”
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Copper homeostasis and neurodegenerative diseases by Yuanyuan Wang, Daidi Li, Kaifei Xu, Guoqing Wang, Feng Zhang

“…Potential clinically significant therapeutic targets, including superoxide dismutase 1, D-penicillamine, and 5,7-dichloro-2-[(dimethylamino)methyl]-8-hydroxyquinoline, along with their associated therapeutic agents, are further discussed. …”
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Assessing the inflammation in pediatric MOGAD: Significance of CSF HMGB1 and related biomarkers by Xin Wang, Ruibin Zhao, Jiayu Fan, Chong Liu, Li Zhang, Huafang Yang, Weiyi Wang

“…Evaluation and monitoring of biomarkers associated with its pathogenesis would provide vital information on disease progression and therapeutic assessment.MethodsWe assessed NLRP3, HMGB1, IL-6, and IL-33 levels in the cerebrospinal fluid (CSF) of pediatric patients with MOGAD at different time points and their association with the risk of disease. …”
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Predictive Factors of Mortality in Chronic Obstructive Pulmonary Disease Subjects: A Monocenter Prospective Observational Study in Algeria by Nadia Fettal, Nadjet Siali, Mahammed Chaker, Abdelbassat Ketfi

“…Conclusion: Mortality among COPD patients in stable condition remains high despite adequate therapeutic care. This mortality rate is very significantly linked to the frequency of exacerbations.…”
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