Connections and Unmet Needs: Severe Asthma Biologics and Osteoporosis by Fabiana Furci, Marco Umberto Scaramozzino, Giuseppe Rocco Talesa, Corrado Pelaia

“…With the use of new, available biologic therapies for asthma, perhaps even anticipating the times of their use in therapeutic management, in the current guidelines and with targeted strategies of prevention it may be possible to improve asthma management, preventing some comorbidities, such as osteoporosis.…”
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Levosimendan for sepsis-induced myocardial dysfunction: friend or foe? by Xinxin Du, Xinxin Du, Fang Xiong, Yafei Hou, Xiangyou Yu, Pengfei Pan

“…In this review, we summarized the therapeutic mechanisms of levosimendan in SIMD and considered recent research on how to improve the efficacy of levosimendan in SIMD. …”
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The Role of PPARγ in Helicobacter pylori Infection and Gastric Carcinogenesis by Jong-Min Lee, Sung Soo Kim, Young-Seok Cho

“…As H. pylori infection is the main etiologic factor in chronic gastritis and gastric cancer, understanding of the potential roles of PPARγ in H. pylori infection may lead to the development of a therapeutic target. In this paper, the authors discuss the current knowledge on the role of PPARγ in H. pylori infection and its related gastric carcinogenesis.…”
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GLP-1 and SGLT2 Therapies in Type 2 Diabetes Mellitus. Cutting-Edge Approaches to Advancing Diabetes Care by Agnieszka Parfianowicz, Alicja Surma

“…GLP-1 receptor agonists (GLP-1 RAs) and SGLT2 inhibitors represent two novel classes of antidiabetic agents that have transformed the therapeutic landscape. This paper explores their mechanisms of action, clinical benefits, and potential synergistic effects, emphasizing their impact on cardiovascular and renal outcomes. …”
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Sirtuins and Their Implications in the Physiopathology of Gestational Diabetes Mellitus by Katarzyna Zgutka, Marta Tkacz, Marta Grabowska, Wioletta Mikołajek-Bedner, Maciej Tarnowski

“…Gestational diabetes mellitus (GDM) imposes serious short- and long-term health problems for the mother and her child. An effective therapeutic that can reduce the incidence of GDM and improve long-term outcomes is a major research priority and is very important for public health. …”
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Spatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle Exocytosis by Xiaoxu Zhou, Ping Shentu, Yingke Xu

“…Understanding the interaction between insulin signaling molecules and key regulatory proteins that are involved in spatiotemporal regulation of GLUT4 vesicle exocytosis is of great importance to explain the pathogenesis of diabetes and may provide new potential therapeutic targets.…”
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“Navigating growth challenges: A case study of radiation-induced growth retardation” by Ramya Selvam, Manjit Kour Mehta, Sivakumar N, Abhisek Bhattacharjee, Heena Agrawal, Shaleen Chandra

“…However, with the current therapeutic modules, the adverse effects can be reduced significantly. …”
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Potential of radiological methods in gastroenterology by Z. A. Lemeshko

“…Significant input of radiological methods to assessment of treatment approach at therapeutic and surgical pathology of digestive system, necessity of utilization of radiological methods at noninvasive medical manipulations, classical surgical interventions, long-term monitoring by patients is shown.Conclusion. …”
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5-ASA Suppositories in Hemorrhoidal Disease by P Gionchetti, M Campieri, A Belluzzi, C Brignola, M Miglioli, L Barbara

“…There were no adverse events reported related to the use of suppositories. 5-ASA suppositories are a valid therapeutic approach for hemorrhoidal disease as it reduces the intensity of all symptoms and significantly decreases congestion of the hemorrhoidal plexus.…”
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Real-Time fMRI Neurofeedback Modulation of Dopaminergic Midbrain Activity in Young Adults With Elevated Internet Gaming Disorder Risk: Randomized Controlled Trial by Anqi Gu, Cheng Lam Chan, Xiaolei Xu, Joseph P Dexter, Benjamin Becker, Zhiying Zhao

“…We show that, after 2 sessions of neurofeedback training, participants successfully downregulated their brain responses to gaming cues, suggesting the therapeutic potential of rt-fMRI NF for IGD (Trial Registration: ClinicalTrials.gov NCT06063642; https://clinicaltrials.gov/study/NCT06063642).…”
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The role of peroxisome proliferator-activated receptor in the treatment of non-alcoholic fatty liver disease by Sun Xin, Zhang Yan, Xie Meilin

“…Current studies are targeting new molecular mechanisms that underlie NAFLD and associated metabolic disorders. Many therapeutic targets have been found and used in clinical studies. …”
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Management of Primary Sclerosing Cholangitis: Conventions and Controversies by Natasha Chandok, Gideon M Hirschfield

“…Despite its rarity, there is an urgent need for collaborative research efforts to advance therapeutic options for PSC beyond liver transplantation.…”
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Research on mobile stroke unit based on 5G network technology by Yu SHENG, Zhiheng LIU, Liya SHAN, Yi FENG

“…,to connect and achieve healthy interaction with people,equipment,and resources related to health care,which can guarantee people's timely access to preven-tive and therapeutic medical services.The composition design,functional modules,implementation architecture,and innovative service models of 5G mobile stroke units were discussed.The combination of 5G network technology and mobile stroke units were analyzed,and the network requirements of 5G mobile stroke units was analyzed with spe-cific cases.…”
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Colouterine and Jejunouterine Fistula Secondary to Chronic Diverticulitis by Ilias Galanis, Georgios Floros, Christophoros Theodoropoulos, Myriam Metaxa, Panagiotis Theodoropoulos, Panagiotis Tsintavis, Dimitrios Bartziotas, Georgios Giannos, Georgios Stylianidis, Georgios Papadopoulos

“…This case represents an unusual type of diverticulitis complication and aims to point out the diagnostic and therapeutic issues of such a rare medical condition.…”
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ALTE and Feeding Intolerance as a Presentation of Double Aortic Arch by Rekha Krishnasarma, Liza Green Golan Mackintosh, Francine Bynum

“…This presents a diagnostic and therapeutic challenge. We describe a case of a six-month-old full-term female presenting with an ALTE and found to have a double aortic arch, a congenital anomaly that usually presents with a more progressive onset of symptoms such as chronic cough, positional stridor, and feeding difficulties. …”
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Advances in thyroid peroxidase (TPO) and thyroid stimulating hormone receptor (TSHR) biomarkers for autoimmune thyroid diseases by Aulanniam, Achmad Rudijanto, Andreas Budi Wijaya

“…This review explores the molecular basis of TPO and TSHR as biomarkers, highlighting their importance in diagnosing AITD and their potential to guide effective therapeutic strategies. Additionally, it discusses the development of lateral flow assay (LFA) kits developed by the authors, which show promise as rapid and reliable diagnostic tools for AITD. …”
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Primary Angioplasty for Cardiac Allograft Vasculopathy Presenting as ST-Elevation Acute Myocardial Infarction during Endomyocardial Biopsy by Bruno Ramos Nascimento, Thalles Oliveira Gomes, Júlio César Borges, Guilherme Rafael Sant’Anna Athayde, Sílvio Amadeu de Andrade, Maria da Consolação Vieira Moreira

“…Cardiac allograft vasculopathy is still a major issue, with significative mortality in heart transplant patients, and the best therapeutic options are not yet established. The progressively higher survival rates after transplantation have made it a major concern. …”
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The Clinical Cost of Delays in Switching Therapy by Sharon Walmsley

“…This is best achieved by using combinations of agents to which the virus is most likely to have some susceptibility and, where possible, by using agents within a new therapeutic class. The cases discussed demonstrate how the use of a potent regimen as salvage therapy can have good clinical, immunological and virological outcomes. …”
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Persistent Ureteric Dilatation due to Pelvic Actinomycosis Presenting as Pelvic Inflammatory Disease by Richard Khafagy, Omar Jundi, Karol Rogawski, Siva Namasiviyam

“…Intravenous penicillin is the most preferred therapeutic agent, and it requires hospitalization up to one month. …”
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Intrathecal Trastuzumab Treatment of the Neoplastic Meningitis due to Breast Cancer: A Case Report and Review of the Literature by Cristina Dumitrescu, Dominique Lossignol

“…There is evidence in the literature that breast cancer receptor status may change over time, and when it occurs, it may modify the therapeutical approach. We reviewed the pertinent literature and concluded that IT trastuzumab might be a promising treatment for patients with HER2-positive breast cancer leptomeningeal carcinomatosis.…”
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