Real-Life Data on the Efficacy of Canakinumab in Patients with Adult-Onset Still’s Disease by Antonio Vitale, Virginia Berlengiero, Jurgen Sota, Luisa Ciarcia, Nicola Ricco, Sara Barneschi, Mariam Mourabi, Giuseppe Lopalco, Chiara Marzo, Francesca Bellisai, Florenzo Iannone, Bruno Frediani, Luca Cantarini

“…Their clinical and therapeutic data were retrospectively collected and statistically analysed to assess the role of CAN as a therapeutic opportunity in AOSD patients in terms of clinical and laboratory disease control along with corticosteroid-sparing effect. …”
Get full text

CSF3 promotes colorectal cancer progression by activating p65/NF-κB signaling pathway and inducing an immunosuppressive microenvironment by Junfeng Xu, Na Li, Hui Xie, Changwei Duan, Xingchen Liao, Ruoran Li, Heng Zhang, Yuanming Pan, Xianzong Ma, Shuwen Du, Jianqiu Sheng, Xin Wang, Lang Yang, Peng Jin

“…Conclusion: CSF3 modulated the NF-κB signaling pathway through a distinct mechanism involving p65 phosphorylation and the activation of NF-κB by enhancing IκBα ubiquitination, thereby effectively promoting CRC development, and CSF3 may serve as a potential therapeutic target for repressing CRC advance and metastasis.…”
Get full text

Baicalin Liposome Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Inhibiting TLR4/JNK/ERK/NF-κB Pathway by Yu Long, Yan Xiang, Songyu Liu, Yulu Zhang, Jinyan Wan, Qiyue Yang, Mingquan Cui, Zhimin Ci, Nan Li, Wei Peng

“…These results suggest that BA-LP could be a valuable therapeutic candidate in the treatment of ALI.…”
Get full text

Liposomal encapsulation of cholecalciferol mitigates in vivo toxicity and delays tumor growth by Miriam Ezcurra-Hualde, Miriam Ezcurra-Hualde, Sara Zalba, Sara Zalba, Ángela Bella, Ángela Bella, Leire Arrizabalaga, Leire Arrizabalaga, Aline Risson, Aline Risson, Román García-Fuentes, Román García-Fuentes, Celia Gomar, Celia Gomar, Nuria Ardaiz, Nuria Ardaiz, Virginia Belsue, Virginia Belsue, David Ruiz-Guillamon, David Ruiz-Guillamon, Alejandro Serrano-Alcaide, Alejandro Serrano-Alcaide, Ainara Salgado, Ainara Salgado, Fernando Aranda, Fernando Aranda, Maria J. Garrido, Maria J. Garrido, Pedro Berraondo, Pedro Berraondo, Pedro Berraondo

“…VD-LP shows potential for enhanced therapeutic applications with reduced adverse effects, warranting further clinical exploration.…”
Get full text

The Emerging Role of Nanomedicine in the Management of Nonalcoholic Fatty Liver Disease: A State-of-the-Art Review by Seyedeh Alia Moosavian, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar

“…In this review, we cover the current therapeutic approaches to manage NAFLD and provide a review of recent up-to-date advances in the uses of nanoparticles for the treatment of NAFLD.…”
Get full text

Toward spatial glycomics and glycoproteomics: Innovations and applications by Patcharaporn Boottanun, Sayaka Fuseya, Atsushi Kuno

“…An agile development approach enables unraveling aberrant glycosylations, glycobiomarkers, and glycotargets for spatial imaging, diagnosis, and therapeutic purposes. We discuss glycopathology and tissue glycomic profiling using highly sensitive lectin-based analyses and introduce deep visual proteomics for glycomic/glycoproteomic sample preparation. …”
Get full text

Stem cell therapy for the treatment of psychiatric disorders: a real hope for the next decades by Rosa Villanueva

“…Therefore, the development of stem cell-based regenerative medicine and its possible combination with emerging therapeutic approaches that promote neural plasticity are expected to advance neuropsychiatry in the next few decades.…”
Get full text

Four Cases of Chylous Ascites following Robotic Gynecologic Oncological Surgery by Ahmet Göçmen, Muhittin Eftal Avcı, Fatih Şanlıkan, Mustafa Gazi Uçar

“…The most common causes of chylous ascites are therapeutic interventions and trauma. In this report, we present four cases of chylous ascites following robot-assisted surgery for endometrial staging and the treatment strategies that we used. …”
Get full text

Management of High Blood Pressure in Those without Overt Cardiovascular Disease Utilising Absolute Risk Scores by Mark R. Nelson

“…However, estimating absolute risk rather than measurement of a single risk factor such as blood pressure is a superior method to identify who is most at risk of having an adverse cardiovascular event such as stroke or myocardial infarction, and therefore who would most likely benefit from therapeutic intervention. Cardiovascular disease (CVD) risk calculators must be used to estimate absolute risk in those without overt CVD as physician estimation is unreliable. …”
Get full text

A Simple Matter of Life and Death—The Trials of Postnatal Beta-Cell Mass Regulation by Elena Tarabra, Stella Pelengaris, Michael Khan

“…Thus, the identification of the molecular regulators of beta-cell mass and a better understanding of the processes of beta-cell differentiation and proliferation may provide further insight for the development of new therapeutic targets for diabetes. This review will focus on the principal hormones and nutrients, as well as downstream signalling pathways regulating beta-cell mass in the adult. …”
Get full text

PPAR-δ in Vascular Pathophysiology by Nanping Wang

“…Therefore, it is suggested that PPAR-δ may have critical roles in cardiovascular pathophysiology and is a potential target for therapeutic intervention of cardiovascular disorders such as atherosclerosis.…”
Get full text

Observing versus creating flowers: a review of relevance for art therapy by Ephrat Huss, Mitsue Nagamine, Michele Zaccai

“…While it is known that flowers arouse positive emotions, this more nuanced comparison has interesting implications for visual art therapy, and for the therapeutic effects of nature photos, as opposed to drawn interpretations of nature.…”
Get full text

High Altitude Pulmonary Edema. Case Report and Bibliography Review by Edgar Ernesto Romo Pinos, Yojan Guevara Pérez, Rina María Idrovo Avecillas, Vilma Silvana Vele Quito

“…The objective of this report is to know the pathophisiology, diagnostic and therapeutic approach of high altitute pulmonary edema since it is a frequent condition in children of the region and it is unknown by many health professionals. …”
Get full text

Simultaneous Laparoscopic Surgery for Bladder Diverticulum and Urachal Remnant: A Case Report by Masaki Murata, Kohei Inui, Moto Hasegawa, Yohei Ikeda, Yuki Nakagawa, Noboru Hara, Tsutomu Nishiyama

“…She was followed up closely without therapeutic intervention; however, the residual urine increased gradually and frequent bladder diverticulitis developed. …”
Get full text

Osteoid-osteoma and osteoblastoma with rare localization – presentation of 4 clinical cases by Kircho Patrikov, Yordan Ivanov

“…Although both tumors are well known to the orthopedic community in Bulgaria, there are several rare localizations that would present difficulties in the diagnostic and therapeutic process. The purpose of our report is to present 4 pediatric cases with rare localization of osteoid-osteoma and osteoblastoma, diagnosed and treated in our clinic in the period between 2020-2022. …”
Get full text

Generation of a USP9Y knockout human embryonic stem cell line with CRISPR-Cas9 technology by Sai Wei, Yuting Zhen, Chao Sun, Yanlin Ma, Qi Li, Luan Wen

“…This model provides a valuable platform for studying USP9Y’s role in human development and male infertility, offering insights into related disorders and therapeutic potential.…”
Get full text

Drug Advances in NAFLD: Individual and Combination Treatment Strategies of Natural Products and Small-Synthetic-Molecule Drugs by Xing Wan, Jingyuan Ma, He Bai, Xuyang Hu, Yanna Ma, Mingjian Zhao, Jifeng Liu, Zhijun Duan

“…In recent years, progress has been made in understanding the pathogenesis of NAFLD, identifying multiple therapeutic targets and providing new directions for drug development. …”
Get full text

Role and interactions of organelle stress in septic cardiomyopathy by Wei Wei, Zhang Jinbo, Zhang Zhaocai

“…In addition, we further discuss the interactions between different organelle stress responses in the disease progression, providing a valuable reference for advancing the understanding of SCM and developing corresponding therapeutic strategies.…”
Get full text

Review of Anti-Inflammatory Herbal Medicines by Mona Ghasemian, Sina Owlia, Mohammad Bagher Owlia

“…Since the treatment of inflammation is not a one-dimensional remedy, this review tries to reach a multidimensional therapeutic approach to inflammation with the help of herbal medicine and modification in lifestyle.…”
Get full text

P53 and PIK3CA Mutations in KRAS/HER2 Negative Ovarian Intestinal-Type Mucinous Carcinoma Associated with Mature Teratoma by Sarah Bouri, Philippe Simon, Nicky D’Haene, Xavier Catteau, Jean-Christophe Noël

“…Our data suggest that these mucinous carcinoma variants probably present an extremely complex molecular biology profile that should be known in the future to stratify therapeutic outcomes and potential targeted therapies, particularly in recurrent disease.…”
Get full text