A Case Report and Genetic Characterization of a Massive Acinic Cell Carcinoma of the Parotid with Delayed Distant Metastases by Anthony C. Nichols, Michelle Chan-Seng-Yue, John Yoo, Sumit K. Agrawal, Maud H. W. Starmans, Daryl Waggott, Nicholas J. Harding, Samuel A. Dowthwaite, David A. Palma, Kevin Fung, Bret Wehrli, S. Danielle MacNeil, Philippe Lambin, Eric Winquist, James Koropatnick, Joe S. Mymryk, Paul C. Boutros, John W. Barrett

“…Future large-scale efforts will be necessary to define the mutational landscape of salivary gland malignancies to identify therapeutic targets and biomarkers of treatment failure.…”
Get full text

Inflammation as a Driver of Clonal Evolution in Myeloproliferative Neoplasm by Angela G. Fleischman

“…Because inflammation plays a central role in MPN inflammation is a logical therapeutic target in MPN.…”
Get full text

Spontaneous-Idiopathic Left Anterior Descending Artery Dissection: Is Watchful Waiting Better Than Immediate Stenting? by A. Arrivi, M. Bazzucchi, M. De Paolis, A. Placanica, C. Bock, C. Milici, E. Boschetti, M. Dominici

“…The lack of firm recommendations about this issue is a great limitation which makes any therapeutic decision controversial. The case described is that of a young, otherwise healthy woman, who presented with an ostial dissection of the left anterior descending (LAD) artery. …”
Get full text

Role of Radiotherapy in Modern Treatment of Hodgkin's Lymphoma by Kheng-Wei Yeoh, N. George Mikhaeel

“…Hodgkin's Lymphoma was incurable until the advent of effective therapeutic radiation around the first half of the 20th century. …”
Get full text

Review of Current First-Line Pharmacotherapy Strategies for Thyroid Eye Disease by Julia Ryniecka, Maciej Wojszczyk, Damian Zys, Piotr Pasek, Julia Kulbacka, Michalina Wójcikiewicz, Marta Chuncia-Ileczko, Julia Kacperczyk, Filip Arczewski, Karol Dziedzic

“… Thyroid eye disease (TED) is a challenging autoimmune disorder that often requires therapeutic intervention. Glucocorticoids (GCs), particularly in intravenous (IV) regimens, remain the first-line treatment due to their strong anti-inflammatory and immunosuppressive effects. …”
Get full text

Refractory Epistaxis due to Severe Factor V Deficiency with Inhibitor by Elizabeth S. John, Minesh D. Patel, Julio Hajdenberg

“…Given that there are no consensus guidelines on treatment, this case offers important insight into the therapeutic approaches that can be used to treat such patients.…”
Get full text

Neurofibroma of bladder: A case report and literature review by Zhipeng Yan, Baoqun Xu, Maokun Sun, Heng Zhang, Xiaolu Sun, Lihua Li, Yulan Gao, Yunji Sun

“…The successful diagnostic and therapeutic experience of this case can be referenced for clinical practice.…”
Get full text

Small Extracellular Vesicles from Young Healthy Human Plasma Inhibit Cardiac Fibrosis After Myocardial Infarction via miR-664a-3p Targeting SMAD4 by Wang W, Li Y, Zhang C, Zhou H, Li C, Cheng R, Chen X, Pu Y, Chen Y

“…Considering the ease of obtaining plasma-derived sEVs, our study offers a promising therapeutic strategy for heart failure, with the potential for rapid clinical translation in the near future. …”
Get full text

Evaluation of in-vitro and in-silico antidiabetic potential, glucose metabolism, antioxidant, cytotoxicity and phytochemical content of Ipomoea bolusiana Schinz and Ipomoea crassip... by Garland Kgosi More, Nolitha Nkobole, Charmy Twala, Sechaba Machedi, Tebogo Amos Moswetsa, Ramakwala Christinah Chokwe

“…The results documented in this study will be valuable leads in the development of therapeutic candidates for diabetes and oxidative stress.…”
Get full text

Creating stimulating environments for young people in residential care: the Israeli youth village 'ecological' model by Emmanuel Grupper

“…In addition, the ever-increasing cost of treating a child in a residential care therapeutic programme is encouraging policy makers to look for less expensive solutions, even though their effectiveness has not always been proven (Grupper, 2002).…”

The Functions of PPARs in Aging and Longevity by Adnan Erol

“…Drugs targeting PPARs activity are already in widespread clinical use; however, based on these concepts, this review highlights the understanding of the role of PPARs in aging and indicates the necessary particular attention for the potential therapeutic uses of current PPAR agonists in age-associated diseases.…”
Get full text

Inflammation of the Dental Pulp by Sang Hyuk Park, Ling Ye, Robert M. Love, Jean-Christophe Farges, Hiromichi Yumoto

Get full text

Imaging Reactive Oxygen Species in Arthritis by Wei-Tsung Chen, Ching-Hsuan Tung, Ralph Weissleder

“…In vivo chemiluminescence imaging is expected to become a useful modality to elucidate the role of ROS in the pathogenesis of arthritides and in determining therapeutic efficacy of protective therapies.…”
Get full text

Treatment of inoperable pancreatic adenocarcinoma with focused ultrasound and microbubbles in patients receiving chemotherapy by Margrete Haram, Rune Hansen, Ola Finneng Myhre, Stian Solberg, Naseh Amini, Bjørn Atle Angelsen, Catharina de Lange Davies, Eva Hofsli

“…Objective: Preclinical trials have demonstrated promising results for increased tumor uptake and therapeutic effect of drugs combined with focused ultrasound (FUS) and microbubbles (MBs). …”
Get full text

Magnesium in pain control - mechanisms of action in perioperative pain, neuropathic pain and migraine by Anna Konarska, Artur Fabijański, Adriana Dukacz, Wojciech Firlej, Joanna Rychlewska-Duda, Justyna Lisiecka, Michał Nowak, Mateusz Janik, Barbara Ufnalska, Anna Machowiak

“…This article provides an overview of magnesium's therapeutic applications in neuropathic pain, migraine, and perioperative pain, drawing on research from PubMed and Google Scholar published between 1988 and 2025. …”
Get full text

[18F]Tetrafluoroborate, a new NIS PET/CT radiopharmaceutical: an overview focused on differentiated thyroid cancer by Arnoldo Piccardo, Francesco Fiz, Sergio Righi, Stefano Raffa, Mattia Riondato, Gianluca Bottoni, Matteo Bauckneht, Michela Massollo, Alessio Rizzo, Mehrdad Shoushtari Zadeh Naseri, Pierpaolo Trimboli, Giorgio Treglia

“…Background: In relapsing differentiated thyroid cancer (DTC), the in vivo evaluation of natrium–iodide symporter (NIS) expression is pivotal in the therapeutic planning and is achieved by 131/123Iodine (131/123I) whole body scan. …”
Get full text

Identifying Multiomic Signatures of X‐Linked Retinoschisis‐Derived Retinal Organoids and Mice Harboring Patient‐Specific Mutation Using Spatiotemporal Single‐Cell Transcriptomics... by Yueh Chien, You‐Ren Wu, Chih‐Ying Chen, Yi‐Ping Yang, Lo‐Jei Ching, Bo‐Xuan Wang, Wei‐Chao Chang, I‐Hsun Chiang, Pong Su, Shih‐Yu Chen, Wen‐Chang Lin, I‐Chieh Wang, Tai‐Chi Lin, Shih‐Jen Chen, Shih‐Hwa Chiou

“…Collectively, the complex transcriptomic signatures obtained from Rs1emR209C mice and patient‐derived retinal organoids using the multiomics approach provide opportunities to unravel potential therapeutic targets for incurable retinal diseases, such as XLRS.…”
Get full text

Evaluation of the cardiotoxicity of Echinochrome A using human induced pluripotent stem cell-derived cardiac organoids by Su-Jin Lee, Eunji Kim, Yeeun Jeong, Jae Boum Youm, Hyoung Kyu Kim, Jin Han, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Sung Joon Kim, Hyang-Ae Lee

“…This study fills a critical gap and highlights the translational relevance of hCOs for cardiotoxicity assessment, demonstrating EchA's cardiac safety and supporting its potential therapeutic and environmental applications.…”
Get full text

(−)-Epigallocatechin-3-Gallate and Quercetin Inhibit Quiescin Sulfhydryl Oxidase 1 Secretion from Hepatocellular Carcinoma Cells by Lumin Yang, Yuying Fang, Yufeng He, Jinsong Zhang

“…Liver cancer is one of the most prevalent cancers worldwide. The first-line therapeutic drug sorafenib offers only a moderate improvement in patients’ conditions. …”
Get full text