Paracrine activity of Smurf1-silenced mesenchymal stem cells enhances bone regeneration and reduces bone loss in postmenopausal osteoporosis by Alberto González-González, Itziar Álvarez-Iglesias, Daniel García-Sánchez, Monica Dotta, Ricardo Reyes, Ana Alfonso-Fernández, Alfonso Bolado-Carrancio, Patricia Díaz-Rodríguez, María Isabel Pérez-Núñez, José Carlos Rodríguez-Rey, Jesús Delgado-Calle, Flor M. Pérez-Campo

“…These findings warrant further in vivo studies and clinical trials to validate its therapeutic efficacy and safety.…”
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CPEB4 modulates liver cancer progression by translationally regulating hepcidin expression and sensitivity to ferroptosis by M. Eugenia Delgado, Salvador Naranjo-Suarez, Marta Ramírez-Pedraza, Beatriz I. Cárdenas, Carmen Gallardo-Martínez, Alexandra Balvey, Eulalia Belloc, Judit Martín, Mark Boyle, Raúl Méndez, Mercedes Fernandez

“…Background & Aims: Liver cancer is a significant global health issue, with its incidence rising in parallel with the obesity epidemic. The limited therapeutic options available emphasize the need for a better understanding of the molecular pathways involved in its pathogenesis. …”
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Impact of donor CYP3A5 genotype on pharmacokinetics of tacrolimus in South African paediatric liver transplant patients by C Wheeler, C Masimirembwa, B Mthembu, J Botha, J Scholefield, J Fabian

“…It is characterised by a narrow therapeutic index and wide interpatient variability, necessitating therapeutic drug monitoring of whole-blood concentrations. …”
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miR124a-3p inhibitor alleviates AFB1-induced hepatoxicity via targeting chicken glucocorticoid receptor mRNA by Mindie Zhao, Liang Chen, Yulan Zhao, Jie Liu, Huimin Chen, Ruqian Zhao

“…This study highlights GR and its miRNA as potential therapeutic targets for AFB1-induced liver disease, providing new insights into therapeutic strategies to mitigate the harmful effects of AFB1 exposure in poultry.…”
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Chaihu Shugan San and Zuogui Yin synergistically improve premature ovarian failure in a rat model via the PI3K/Akt/mTOR pathway by Fei Zhang, RuiFang Liu, ZhenLing Xu, WenJie Chen, XiYa Lu, Yang Wang

“…This study aims to evaluate the therapeutic effects of Chaihu Shugan San, Zuogui Yin, and their combination on POI in a rat model and to elucidate the underlying mechanisms involving the PI3K/Akt/mTOR signaling pathway. …”
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Disruption of tumor-intrinsic PGAM5 increases anti-PD-1 efficacy through the CCL2 signaling pathway by Yan Li, Hong Wang, Xiaoyang Li, Yuan He, Huiquan Liu, Dong Han, Ting Mei, Yixuan Li, Zilong Xu, Xiaoying Wei, Jianguo Wang, Peijie Zhou, Yuwen Wang, Ziye Li, Junhao Ning, Anlin Wang, Jingjing Cheng, Dong Qian

“…Tumor-intrinsic PGAM5 can be a therapeutic target to improve immunotherapy efficacy in patients with HCC.…”
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RECQL4 affects MHC class II‐mediated signalling and favours an immune‐evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melan... by Sara Egea‐Rodriguez, Renáta Váraljai, Thierry M. Nordmann, Restuan Lubis, Manuel Philip, Florian Rambow, Alexander Roesch, Michael Flaig, Susanne Horn, Raphael Stoll, Fang Zhao, Annette Paschen, Bert Klebl, Ian D. Hickson, Dirk Schadendorf, Matthias Mann, Iris Helfrich

“…Abstract Background Cancer immunotherapy has transformed metastatic cancer treatment, yet challenges persist regarding therapeutic efficacy. RECQL4, a RecQ‐like helicase, plays a central role in DNA replication and repair as part of the DNA damage response, a pathway implicated in enhancing efficacy of immune checkpoint inhibitor (ICI) therapies. …”
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Advances in the Treatment of Desseminated Mycobacterium avium Complex in Adults with AIDS by Carol A Kemper

“…Though our understanding of this infection has been rapidly advanced in the past three years. much remains to be learned about its optimal therapeutic management.…”
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Guidelines for the management of patients with Crohn’s disease. Recommendations of the Polish Society of Gastroenterology and the Polish National Consultant in Gastroenterology by Michał Łodyga, Piotr Eder, Magdalena Gawron-Kiszka, Agnieszka Dobrowolska, Maciej Gonciarz, Marek Hartleb, Maria Kłopocka, Ewa Małecka-Wojciesko, Piotr Radwan, Jarosław Reguła, Edyta Zagórowicz, Grażyna Rydzewska

“…This paper is an update of the diagnostic and therapeutic recommendations of the National Consultant for Gastroenterology and the Polish Society of Gastroenterology from 2012. …”
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Radiologic Evaluation of Small Renal Masses (II): Posttreatment Management by J. Santos, C. Deltoro, M. I. Martín, A. Marhuenda

“…The increase in the detection of small renal masses (SRMs) and their best knowledge leads to a change in the therapeutic management of these lesions. The use of a less aggressive surgical technique or even an expectant attitude is the current tendency, in order to preserve as much renal function as possible. …”
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Manipulation of the Complement System for Benefit in Sepsis by Peter A. Ward, Ren-Feng Guo, Niels C. Riedemann

“…Based on these data, it seems reasonable to consider therapeutic blockade of C5a in humans entering into sepsis and septic shock. …”
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Diffuse Alveolar Hemorrhage Caused by Warfarin after Rifampicin Discontinuation by Takashige Kiyota, Seiji Shiota, Ryosuke Hamanaka, Daisuke Tsutsumi, Takeshi Takakura, Eishi Miyazaki

“…Rifampicin suppresses the anticoagulant activity of warfarin, which can lead to a need for increased doses of warfarin to achieve and maintain a therapeutic INR. More frequent INR monitoring is needed even after discontinuing rifampicin.…”
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The Off-Label Use of a Lumen-Apposing Metal Stent (LAMS) for a Benign Colon Anastomotic Stricture Causing Recurrent Bowel Obstruction in a Patient with Keloids by Michael Coles, Pearl Uy, Victoria Madray, John Erikson Yap, Subbaramiah Sridhar

“…Lumen-apposing metal stents (LAMSs) have recently emerged as a potentially superior therapeutic option. We herein report a patient with a past medical history of pT3, N0 adenocarcinoma of the colon with anastomotic stricture recurrence who underwent successful placement of an LAMS. …”
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Neovascular age-related macular degeneration: disease pathogenesis and current state of molecular biomarkers predicting treatment response—a scoping review by Nikolaos Dervenis, Eleftherios Agorogiannis, Panagiotis Dervenis

“…At the same time, new challenges and unmet needs arose due to the limitations of the current therapeutic options. Neovascularisation development during the course of the disease has a complex pathogenetic mechanism, and several biomarkers and their association with treatment outcomes have been investigated. …”
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Advances in engineered T cell immunotherapy for autoimmune and other non-oncological diseases by Qiaolin Huang, Xiaojian Zhu, Yicheng Zhang

“…However, realizing broader therapeutic applications of engineered T cells in other diseases requires further exploration in clinical investigations. …”
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The molecular mechanisms of cuproptosis and its relevance to atherosclerosis by Jiankang Wang, Zhian Chen, Hang Shang, Jiajuan Guo

“…The goal is to propose novel diagnostic and therapeutic strategies for atherosclerosis through the lens of cuproptosis.  …”
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A Case of Transcatheter Aortic Valve Implantation in a Centenarian Patient by Salem Badr, Daniel O. Johnsrud, Charnai D. Sherry, Suhail Q. Allaqaband, Eric S. Weiss, Tanvir K. Bajwa

“…In recent years, transcatheter aortic valve implantation (TAVI) has emerged as a therapeutic option for severe aortic stenosis. However, there is a paucity of data regarding the outcomes of TAVI in patients older than 100 years. …”
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From Inflammation to Current and Alternative Therapies Involved in Wound Healing by Mariana Barreto Serra, Wermerson Assunção Barroso, Neemias Neves da Silva, Selma do Nascimento Silva, Antonio Carlos Romão Borges, Iracelle Carvalho Abreu, Marilene Oliveira da Rocha Borges

“…Finally, we will discuss the current therapeutic interventions in the wounds treatment, and the alternative therapies used as promising results in the development of new products with healing potential.…”
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Postmenopausal Deep Infiltrating Endometriosis of the Colon: Rare Location and Novel Medical Therapy by Benjamin M. Snyder, Joseph W. Beets, Bruce A. Lessey, Samuel R. W. Horton, Gary A. Abrams

“…Instead of surgery, we prescribed a novel medical therapeutic approach using conjugated estrogen-bazedoxifene to antagonize the proliferative effects of estrogen on endometrial tissue. …”
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Fecal microbiota transplantation: lights and shadows of a new weapon against inflammatory bowel disease by Andrea Piccioni, Federico Rosa, Federica Manca, Davide Antonio Della Polla, Martina Petrucci, Benedetta Simeoni, Marcello Covino

“…For this reason, similar to what happened for Clostridium difficile, fecal microbiota transplantation is making its way as a possible new therapeutic weapon in the treatment of this disease. …”
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