Cannabinoid receptor 2 selective agonist ameliorates adjuvant-induced arthritis by modulating the balance between Treg and Th17 cells by Na Tian, Cui Yang, Yu Du, Miao Chen, Bin Li, Bin Li, Bin Li, Bin Li, Bin Li, Dan Li, Sheng-Ming Dai

“…This study explores the therapeutic efficacy of HU-308, a CB2 receptor-specific agonist, on inflammation and immune balance in AIA.MethodsAIA was induced in mice by CFA injection. …”
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Proteomic profiling of bronchoalveolar lavage fluid uncovers protein clusters linked to survival in idiopathic forms of interstitial lung disease by Linh T. Ngo, Michaella J. Rekowski, Devin C. Koestler, Takafumi Yorozuya, Atsushi Saito, Imaan Azeem, Alexis Harrison, M. Kristen Demoruelle, Jonathan Boomer, Bryant R. England, Paul Wolters, Philip L. Molyneaux, Mario Castro, Joyce S. Lee, Joshua J. Solomon, Koji Koronuma, Michael P. Washburn, Scott M. Matson

“…Background Idiopathic interstitial pneumonias (IIPs), such as idiopathic pulmonary fibrosis and interstitial pneumonia with autoimmune features, present diagnostic and therapeutic challenges due to their heterogeneous nature. …”
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The Effect of Repetitive Transcranial Magnetic Stimulation on Motor Symptoms in Hereditary Spastic Paraplegia by J. Antczak, J. Pera, M. Dąbroś, W. Koźmiński, M. Czyżycki, K. Wężyk, M. Dwojak, M. Banach, A. Slowik

“…Repetitive transcranial magnetic stimulation (rTMS) has been previously investigated as a therapeutic tool for similar motor deficits in a number of neurologic conditions. …”
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The Transcription Factor SOX18 Inhibitor Small Molecule 4 Is a Potential Treatment of Cancer‐Induced Lymphatic Metastasis and Lymphangiosarcoma by Katja K. Koll, Martin M. Zimmermann, Patrick A. Will, Ulrich Kneser, Christoph Hirche

“…Aims In this in vitro study, we investigated the potential therapeutic effect of a small molecule called Sm4, which inhibits SOX18, on lymphatic endothelial and lymphangiosarcoma cells in vitro. …”
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CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models by Felipe Saceanu Leser, Flavio de Souza Júnyor, Iohanna Bianca Pagnoncelli, Anna Beatriz Delgado, Isabelle Medeiros, Ana Clara Campanelli Nóbrega, Brenda da Silva Andrade, Maiara Nascimento de Lima, Nícolas Emanoel da Silva, Laurent Jacob, Kevin Boyé, Luiz Henrique Medeiros Geraldo, Alessandra Mendonça Teles de Souza, Tatiana Maron-Gutierrez, Hugo Castro-Faria-Neto, Cristian Follmer, Carolina Braga, Gilda Angela Neves, Anne Eichmann, Luciana Ferreira Romão, Flavia Regina Souza Lima

“…Altogether, our data indicate that navarixin blocks CCL21/CCR7-mediated neuron-microglia communication and could be used as a therapeutic strategy against PD. Graphical Abstract…”
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McKenzie’s method effectiveness in patients with cervical vertebral pain. Chambas, Ciego de Ávila, 2022-2023 by Onesio Esteban de León Gutierrez, Israel Triana Pérez, Tania Alemán Martínez, Aray Pérez Pino, Félix Jorge Jiménez Cantero, Iván Castillo Ledo

“…<br /><strong>Objective:</strong> to determine the McKenzie’s method physical exercises therapeutic effectiveness in patients with cervical vertebral pain. …”
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Preventive treatment with guarana powder (Paullinia cupana) mitigates acute paracetamol-induced hepatotoxicity by modulating oxidative stress by Clécia Dias Teixeira, Priscila Oliveira Barbosa, Wanderson Geraldo Lima, Gustavo Silveira Breguez, Miliane Martins de Andrade Fagundes, Daniela Caldeira Costa, Cintia Lopes de Brito Magalhães, Joana Ferreira Amaral, Melina Oliveira de Souza

“…Liver damage caused by high doses of paracetamol is a global public health concern. Consequently, therapeutic strategies are being explored to prevent this damage. …”
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Elucidating the role of carrier proteins in cytokine stabilization within double emulsion‐based polymeric nanoparticles by Emily R. Rhodes, Nicole B. Day, Emma C. Aldrich, C. Wyatt Shields IV, Kayla G. Sprenger

“…Findings from this work have implications in establishing design principles to enhance the stability of cytokines and other unstable proteins in particles formed by double emulsification for improved stability and therapeutic efficacy.…”
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Acanthopanax versus 3-Methyladenine Ameliorates Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting the Autophagic Pathway in Rats by Xiaohong Wang, Guoxiong Zhou, Chun Liu, Ronglong Wei, Shunxing Zhu, Yuefen Xu, Mengjie Wu, Qing Miao

“…Objectives. To observe the therapeutic effects of Acanthopanax and 3-methyladenine against severe acute pancreatitis (SAP). …”
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Tacrolimus- and Mycophenolate-Mediated Toxicity: Clinical Considerations and Options in Management of Post-Transplant Patients by Alan D. Kaye, Shivam S. Shah, Coplen D. Johnson, Adalyn S. De Witt, Austin S. Thomassen, Charles P. Daniel, Shahab Ahmadzadeh, Sridhar Tirumala, Kristin Nicole Bembenick, Adam M. Kaye, Sahar Shekoohi

“…TDM ensures tacrolimus trough levels are maintained within a therapeutic range, minimizing the risks of nephrotoxicity and rejection. …”
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Effect of Vitreous Reflux after Intravitreal Aflibercept Injection for Macular Edema with Branch Retinal Vein Occlusion: A Real-World Study by Tetsuya Muto, Masaaki Sakamoto, Shigeki Machida, Shinichiro Imaizumi, Tetsuju Sekiryu

“…This study aimed to evaluate the therapeutic effect of vitreous reflux (VR) after intravitreal aflibercept injection (IVAI) for macular edema (ME) following naïve branch retinal vein occlusion (BRVO). …”
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E6AP is essential for the proliferation of HPV-positive cancer cells by preventing senescence. by Alicia Avenhaus, Milica Velimirović, Julia Bulkescher, Martin Scheffner, Felix Hoppe-Seyler, Karin Hoppe-Seyler

“…Our results further indicate that interfering with E6AP expression or function could result in therapeutically desired effects in HPV-positive cancer cells by efficiently inducing an irreversible growth arrest. …”
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Psychiatric Symptoms in Acute Intermittent Porphyria - Case Report and Course of Treatment Using Placebo by Waldemar Kosiba, Dominika Prystacka-Szar, Jakub Siemko, Wojciech Kupczak

“…This case demonstrates that placebo can be one of the components of a diagnostic and therapeutic plan of acute intermittent porphyria. …”
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Psychological Intervention in Traumatic Brain Injury Patients by Lizzette Gómez-de-Regil, Damaris F. Estrella-Castillo, Julio Vega-Cauich

“…CBT outstands as the preferred therapeutic approach for treating behavioural and emotional disturbances. …”
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Emerging trends and new developments in global research on artemisinin and its derivatives by Yu Lai, Huize Zhang, Xi Chen

“…Although the advent of novel therapeutic approaches has partially mitigated drug resistance, further investigations into the underlying mechanisms are needed. …”
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ANTITUMOR EFFECT OF ELECTROMAGNETIC FIELDS AND THEIR EFFECT ON PAIN IN EXPERIMENTAL AND CLINICAL ONCOLOGY by E. M. Frantsiyants, E. A. Sheiko

“…Information is given on possible physicochemical effects, features, and mecha­nisms of therapeutic influence at various levels of a living organism. …”
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A review on phytogenic compounds inhibit coronaviruses associated with respiratory syndrome in human by Majid Gholami-Ahangaran, Maryam Karimi-Dehkordi

“…It is hoped that using the information provided in this study, researchers will use the derivatives of natural compounds in the process of producing safe and effective anti-coronavirus therapeutic agents.…”
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Defining pediatric polypharmacy: A scoping review. by Paul M Bakaki, Alexis Horace, Neal Dawson, Almut Winterstein, Jennifer Waldron, Jennifer Staley, Elia M Pestana Knight, Sharon B Meropol, Rujia Liu, Hannah Johnson, Negar Golchin, James A Feinstein, Shari D Bolen, Lawrence C Kleinman

“…We recommend that pediatric polypharmacy studies specify the number of medications or therapeutic classes, if they are concurrent or sequential, and the duration of medications. …”
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Mesenchymal Stem Cells May Alleviate the Intervertebral Disc Degeneration by Reducing the Oxidative Stress in Nucleus Pulposus Cells by Yongzhao Zhao, Qian Xiang, Yunzhong Cheng, Jialiang Lin, Shuai Jiang, Weishi Li

“…Stem cell therapy is a promising therapeutic modality for intervertebral disc degeneration (IDD). …”
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Development and Application of Physiologically-Based Pharmacokinetic Model to Predict Systemic and Organ Exposure of Colorectal Cancer Drugs by Sara Peribañez-Dominguez, Zinnia Parra-Guillen, Iñaki F. Troconiz

“…This bottom-up approach represents an opportunity to personalize treatment and minimize the therapeutic risk/benefit ratio through the understanding of drug distribution within colorectal tissue. …”
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