The role of the C5a-C5aR pathway in iron metabolism and gastric cancer progression by Qinxue Ni, Hong Yang, Hang Rao, Liyong Zhang, Mengyuan Xiong, Xiao Han, Boshao Deng, Lulu Wang, Jian Chen, Yan Shi

“…Gastric cancer continues to be a leading global health concern, with current therapeutic approaches requiring significant improvement. …”
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Single-nucleus RNA sequencing reveals distinct pathophysiological trophoblast signatures in spontaneous preterm birth subtypes by Cherilyn Uhm, Jianlei Gu, Weina Ju, Stephanie Pizzella, Hande Oktay, Joyce Yao-Chun Peng, Sararose Guariglia, Yong Liu, Hongyu Zhao, Yong Wang, Ramkumar Menon, Nanbert Zhong

“…Our study highlights the critical need to distinguish sPTB subtypes to improve diagnostic precision and therapeutic targeting. The molecular insights gained provide a foundation for future investigations aimed at functional validation of key pathways and exploration of trophoblasts on the development of sPTB. …”
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Tumour heterogeneity and personalized treatment screening based on single-cell transcriptomics by Xinying Zhang, Jiajie Xie, Zixin Yang, Carisa Kwok Wai Yu, Yaohua Hu, Jing Qin

“…By integrating multiple bioinformatics analyses, we explored the biological differences underlying tumour cell heterogeneity at the single-cell level and identified tumour cell subcluster-specific biomarkers and potential therapeutic drugs for each subcluster. Interestingly, although tumour cell subpopulations exhibit dramatic differences within the same cancer type and between different cancers at both the genomic and transcriptomic levels, some demonstrate similar oncogenic pathway activities and phenotypes. …”
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Levistolide A and periplogenin inhibit the growth of gastric cancer cells in vitro and in vivo by Jia Li Guo, Hong Mei Hu, Shao Chin Lee, Ji Zhong Zhao

“…Conclusions: LA and PPG could inhibit the growth of the cancer cells, alone or in combination with 5-FU, in vitro and in vivo, suggesting that they are promising investigational drugs for therapeutic development.…”
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All-Cause Mortality Prediction in Subjects with Diabetes Mellitus Using a Machine Learning Model and Shapley Values by Oana Mirea, Mostafa Ghelich Oghli, Oana Neagoe, Mihaela Berceanu, Eugen Țieranu, Liviu Moraru, Victor Raicea, Ionuț Donoiu

“…Identifying risk factors for mortality in these patients is crucial, as early recognition can facilitate prompt therapeutic intervention. Machine learning (ML) models have proved to be valuable tools in different scenarios of healthcare decision making. …”
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Transcriptomic and proteomic profiling identifies feline fibrosarcoma as clinically amenable model for aggressive sarcoma subtypes by Mikiyo Weber, Daniel Fuchs, Amiskwia Pöschel, Erin Beebe, Zuzana Garajova, Armin Jarosch, Laura Kunz, Witold Wolski, Lennart Opitz, Franco Guscetti, Mirja C. Nolff, Enni Markkanen

“…In conclusion, this detailed landscape provides a rich resource to identify target candidates and therapeutic vulnerabilities within and across species and supports feline FSA as relevant models for the human disease.…”
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TNF Superfamily: A Growing Saga of Kidney Injury Modulators by Maria D. Sanchez-Niño, Alberto Benito-Martin, Sara Gonçalves, Ana B. Sanz, Alvaro C. Ucero, Maria C. Izquierdo, Adrian M. Ramos, Sergio Berzal, Rafael Selgas, Marta Ruiz-Ortega, Jesus Egido, Alberto Ortiz

“…Tumor necrosis factor (TNF) and Fas ligand regulate renal cell survival and inflammation, and therapeutic targeting improves the outcome of experimental renal injury. …”
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New drugs for acute kidney injury by Geoffroy Hariri, Matthieu Legrand

“…Several ongoing clinical trials are evaluating the efficacy of these different strategies and we are facing an exiting time with multiple therapeutic interventions being tested to prevent or treat AKI. …”
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INVESTIGATING THE BIOCHEMICAL PROFILE AND NUTRITIONAL COMPOSITION OF VERNONIA AMYGDALINA LEAVES: A STUDY ON ANTIOXIDANT PROPERTIES, PHYTOCHEMICAL COMPOSITION, ENZYME INHIBITION, AN... by Olugbenga D. Oloruntola, Fehintoluwa S. Oladebeye, Samuel A. Adeyeye, Simeon O. Ayodele, Ojurereoluwa A. Ayodele, Olufemi E. Adeniji

“…These findings collectively emphasize the multifaceted health-promoting properties and nutritional value of Vernonia amygdalina leaves, advocating their utilization in various dietary and therapeutic applications.…”
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Critical factors influencing live birth rates in fresh embryo transfer for IVF: insights from cluster ensemble algorithms by Zheng Yu, Xiaoyan Zheng, Jiaqi Sun, Pengfei Zhang, Ying Zhong, Xingyu Lv, Hongwen Yuan, Fanrong Liang, Dexian Wang, Jie Yang

“…The NMFE analysis highlights the significant influence of therapeutic interventions, Embryo transfer outcomes, and ovarian response assessment on live births of IVF-ET. …”
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Advancing the understanding of Naegleria fowleri: Global epidemiology, phylogenetic analysis, and strategies to combat a deadly pathogen by Awadh Alanazi, Sonia Younas, Hasan Ejaz, Muharib Alruwaili, Yasir Alruwaili, Bi Bi Zainab Mazhari, Muhammad Atif, Kashaf Junaid

“…This review highlights the global impact of N. fowleri, future surveillance strategies, prompt diagnosis, potential therapeutic options, and vaccine development to prevent PAM outbreaks. …”
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Altered NKp30, NKp46, NKG2D, and DNAM-1 Expression on Circulating NK Cells Is Associated with Tumor Progression in Human Gastric Cancer by Bin Han, Fang-yuan Mao, Yong-liang Zhao, Yi-pin Lv, Yong-sheng Teng, Mubing Duan, Weisan Chen, Ping Cheng, Ting-ting Wang, Zhong-yuan Liang, Jin-yu Zhang, Yu-gang Liu, Gang Guo, Quan-ming Zou, Yuan Zhuang, Liu-sheng Peng

“…Altogether, our data suggest that the decreased expression of activating receptors NKp30, NKp46, NKG2D, and DNAM-1 on peripheral blood NK cells is positively associated with GC progression, and that TGF-β1-mediated NK cell suppression may be a therapeutically targetable characteristic of GC.…”
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Integrated analysis of proteomics and metabolomics in infantile epileptic spasms syndrome by Jun Chen, Xiaoqian Wang, Xueyi Rao, Huan Luo, Yajun Shen, Jing Gan

“…Additionally, these findings also assist in identifying new therapeutic targets and developing more effective treatment strategies.…”
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Sustained release of miR-21 carried by mesenchymal stem cell-derived exosomes from GelMA microspheres inhibits ovarian granulosa cell apoptosis in premature ovarian insufficiency by Xiaofei Zhang, Linzi Ma, Xiaotong Liu, Xingyu Zhou, Ao Wang, Yunhui Lai, Jun Zhang, Ying Li, Shiling Chen

“…Mesenchymal stem cell-derived exosomes (MSC-Exo) exhibit promising potential as a therapeutic approach for POI. However, their clinical application is hindered by their instability and low long-term retention rate in vivo. …”
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Feasibility study of emotion mimicry analysis in human–machine interaction by Herag Arabian, Tamer Abdulbaki Alshirbaji, Ashish Bhave, Verena Wagner-Hartl, Marcel Igel, J. Geoffrey Chase, Knut Moeller

“…This system is part of a research intervention aimed at therapeutic applications for individuals with autism spectrum disorder. …”
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PRAF2 as a novel biomarker for breast cancer with machine learning and experimentation validation by Zheng Wang, Zilin Bi, Hongguang Bo, Junyi Xu, Rui Sha, Zhaocai Yin, Changsheng Yu, Yufa Xu, Xiaomeng Shi, Wenbo Song, Bin Chen, Yabing Wang, Qian Zhang, Jianping Chen

“…Abstract Background Breast cancer (BC) is the most prevalent malignancy in women. Potential therapeutic targets for BC are of great significance. …”
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Mesenchymal Stem/Stromal Cells Derived from Induced Pluripotent Stem Cells Support CD34pos Hematopoietic Stem Cell Propagation and Suppress Inflammatory Reaction by Mohsen Moslem, Irina Eberle, Iuliia Weber, Reinhard Henschler, Tobias Cantz

“…Mesenchymal stem/stromal cells (MSCs) represent a promising cell source for research and therapeutic applications, but their restricted ex vivo propagation capabilities limit putative applications. …”
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Pretreatment with serine protease inhibitors impairs Leishmania amazonensis survival on macrophages by Patrícia de Almeida Machado, Pollyanna Stephanie Gomes, Elaine Soares Coimbra, Herbert Leonel de Matos Guedes

“…The discovery of new therapeutic alternatives is extremely essential, and the discovery of cellular targets is a tool that helps in the development of new drugs. …”
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Small Intestinal Bacterial Overgrowth in Various Specialties of Medical Practice (Literature Review and Expert Council Resolution) by V. T. Ivashkin, V. V. Fomin, O. N. Tkacheva, O. S. Medvedev, E. A. Poluektova, D. I. Abdulganieva, S. R. Abdulkhakov, O. P. Alexeeva, S. A. Alekseenko, D. N. Andreev, A. Yu. Baranovsky, M. S. Zharkova, O. Yu. Zolnikova, K. V. Ivashkin, I. L. Kliaritskaia, N. V. Korochanskaya, S. N. Mammaev, R. V. Maslennikov, R. G. Myazin, M. V. Perekalina, A. V. Povtoreyko, A. I. Ulyanin, M. V. Fadeeva, I. B. Khlynov, V. V. Tsukanov, O. S. Shifrin

“…Rifaximin is the first-line treatment due to the highest therapeutic efficacy. One of the ways to increase the efficacy of SIBO treatment is to include strain-specific probiotics in the treatment regimen. …”
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Comparative drug release kinetics of Terminalia arjuna mediated SeNPs NanoGel and ZnONPs NanoGel – An in-vitro study by R. Vijayalakshmi, N. Ambalavanan, S. Rajeshkumar, Jaideep Mahendra, Uma Sudhakar, Devi Parameswari

“…The sustained release profiles of both formulations suggest effective control over drug release, maintaining therapeutic drug levels over an extended period. The near-complete release of the drug at 500 min highlights the potential for prolonged therapeutic efficacy, reducing the need for frequent dosing and enhancing patient compliance. …”
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