Ipilimumab, a Promising Immunotherapy with Increased Overall Survival in Metastatic Melanoma? by Gérald E. Piérard, François Aubin, Philippe Humbert

“…Malignant melanoma (MM) is one of the most aggressive skin cancer. The therapeutic options remain limited for advanced MM, and those directed to the neoplastic cells have not brought major survival advantage so far. …”
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To PLEX or Not to PLEX for Amiodarone-Induced Thyrotoxicosis by Tania Ahuja, Olivia Nuti, Cameron Kemal, Darren Kang, Eugene Yuriditsky, James M. Horowitz, Raymond A. Pashun

“…There are two types of AIT with treatment including antithyroid medications and corticosteroids and treatment of ventricular arrhythmias. Therapeutic plasma exchange (TPE) also known as “PLEX” may help remove thyroid hormones and amiodarone. …”
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Ambulatory Blood Pressure Monitoring in Resistant Hypertension by Dimitrios Syrseloudis, Ioannis Andrikou, Eirini Andrikou, Kyriakos Dimitriadis, Christodoulos Stefanadis

“…Lastly, ABPM may indicate the need for implementation of specific therapeutic strategies, such as chronotherapy, that is, administration-time dependent therapy, and the evaluation of their efficacy.…”
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Ischaemia with no obstructive coronary arteries: a review with focus on the Asian population by Rodney Yu-Hang Soh, Ting-Ting Low, Ching-Hui Sia, William Kok-Fai Kong, Tiong-Cheng Yeo, Poay-Huan Loh, Kian-Keong Poh

“…Ischaemia with no obstructive coronary arteries (INOCA) has been a diagnostic and therapeutic challenge for decades. Several studies have demonstrated that INOCA is associated with an increased risk of death, adverse cardiovascular events, poor quality of life and high healthcare cost. …”
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Clinicopathological Study of Thyroid Swelling with High Resolution Ultrasonographic Correlation by Kumar Gaurav, Rajeev Kumar Ranjan, Gunjan, Zahid Mustafa Khan, Anima R. Xalxo, Nisha Rai

“…Conclusion: The findings provide a thorough understanding of thyroid pathology, paving the door for more effective diagnostic approaches and personalized therapeutic strategies in clinical practice.…”
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Cigarette Smoking and Asthma: A Dangerous Mix by Catherine Lemiere, Louis-Philippe Boulet

“…Available data that examine the influence of smoking on clinical, functional and inflammatory characteristics of asthma, as well as the influence of smoking on the therapeutic response to corticosteroids, were reviewed. …”
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Dual Mycobacterial Invasion: A Case Report on Coexisting Tuberculosis and Nontuberculous Mycobacterium Infection by P. Prem Ananth, S. Raghul Raj, R. Anand, N. Nagarajan

“…Coinfections with TB and NTM, though rare, present diagnostic and therapeutic challenges. Mycobacterium kansasii, an NTM species, can cause pulmonary disease similar to TB, requiring thorough diagnostic approaches for effective treatment. …”
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Histoplasma capsulatum Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient Receiving Voriconazole Prophylaxis by Vaibhav Agrawal, Bryan J. Brinda, Sherif S. Farag

“…We report a patient who developed Histoplasma pneumonia while receiving voriconazole prophylaxis at a therapeutic trough level. The patient experienced significant clinical improvement after initiation of itraconazole pharmacotherapy. …”
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Repetitive Complete Molar Pregnancy in a 54-Year-Old Patient in a Time Distance of Eighteen Years from the First Incident: Case Report and Mini Review by Polychronis Oikonomidis, Basileios Pergialiotis, Elina Pitsouni, Stavros Natsis, Antonios Lagkadas, Konstantinos Giannakopoulos

“…Our diagnostic approach was through measurement of serum beta-human chorionic gonadotropin (β-HCG) and pelvic ultrasound evaluation, and the chosen therapeutic approach was abdominal hysterectomy and bilateral salpingoophorectomy.…”
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Pathophysiology of Portal Hypertension and Esophageal Varices by Hitoshi Maruyama, Osamu Yokosuka

“…It is detected in about 50% of cirrhosis patients, and approximately 5–15% of cirrhosis patients show newly formed varices or worsening of varices each year. The major therapeutic strategy of esophageal varices consists of primary prevention, treatment for bleeding varices, and secondary prevention, which are provided by pharmacological, endoscopic, interventional and surgical treatments. …”
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Dry Needling and Its Application in Dentistry: A Review by Puja Saha, Susmita Choudhary, Samrangi Kar, Vishnuja V. R. Nair, Yajas Kumar, Anjali Sen, Pratik Surana

“…Dry needling is a technique increasingly being used across various medical and therapeutic fields, including dentistry. It involves the insertion of fine needles into specific points in muscles or tissues to alleviate pain and promote healing. …”
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Ocular myasthenia by J. Zakaravičiūtė, M. Šerelytė

“…Clinical manifestations, diagnostic approach, relevance, and therapeutic options are discussed in this article. …”
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α-Methyl-Tryptophan Inhibits SLC6A14 Expression and Exhibits Immunomodulatory Effects in Crohn’s Disease by Su Y, Li J, Chen Y, Bao J, Lei Z, Ma M, Zhang W, Liu Q, Xu B, Hu T, Hu Y

“…These findings underscore the role of SLC6A14 in regulating intestinal immune cell infiltration during CD progression.Discussion: Our findings suggest that SLC6A14 could serve as a potential diagnostic biomarker and therapeutic target for CD. Furthermore, α-MT offers a novel approach for the clinical diagnosis and treatment of CD by targeting SLC6A14 for therapeutic intervention. …”
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Formulation, characterization, and evaluation of curcumin-loaded ginger-derived nanovesicles for anti-colitis activity by Shengjie Huang, Min Zhang, Xiaoge Li, Jierong Pei, Zhirong Zhou, Peng Lei, Meng Wang, Peng Zhang, Heshui Yu, Guanwei Fan, Lifeng Han, Haiyang Yu, Yuefei Wang, Miaomiao Jiang

“…In summary, our study demonstrated that GDNV can be used for CUR delivery with enhanced therapeutic potential.…”
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Application of hierarchical management based on bleeding risk assessment in patients with catheter-directed thrombolysis for treatment of lower extremity deep venous thrombosis (出血... by LIU Jiaying (刘佳莺), ZHANG Ting (张婷)

“…The control group received routine nursing, while the observation group received hierarchical nursing management based on bleeding risk assessment. The therapeutic effectiveness outcomes (patency rate, relief of lower extremity edema and treatment effect) and therapeutic safety outcomes (incidences of mild bleeding and severe bleeding) were measured and compared between two groups. …”
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Experimental evidence-based construction of electroacupuncture for ischemic stroke: a meta-analysis and systematic review by Yaoguang Guo, Sihan Hu, Sihan Hu, Shiman Luo, Lang Tu, Yao Tang, Fang Zeng, Fang Zeng, Fang Zeng

“…ObjectiveIschemic stroke represents a leading cause of disability and mortality worldwide, necessitating effective and complementary therapeutic strategies. Electroacupuncture (EA), a modern extension of traditional acupuncture, has garnered attention for its potential neuroprotective effects in ischemic stroke rehabilitation. …”
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Advances in physiological and clinical relevance of hiPSC-derived brain models for precision medicine pipelines by Negin Imani Farahani, Negin Imani Farahani, Negin Imani Farahani, Lisa Lin, Lisa Lin, Lisa Lin, Shama Nazir, Shama Nazir, Shama Nazir, Alireza Naderi, Alireza Naderi, Alireza Naderi, Leanne Rokos, Leanne Rokos, Leanne Rokos, Anthony Randal McIntosh, Anthony Randal McIntosh, Lisa M. Julian, Lisa M. Julian, Lisa M. Julian, Lisa M. Julian

“…Continued advances in tissue engineering combined with innovations in genomics, high-throughput screening and imaging strengthen the physiological relevance of hiPSC models and thus their ability to uncover disease mechanisms, therapeutic vulnerabilities, and tissue and fluid-based biomarkers that will have real impact on neurological disease treatment. …”
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Targeting SLC4A4: A Novel Approach in Colorectal Cancer Drug Repurposing by Krunal Pawar, Pramodkumar P. Gupta, Pooran Singh Solanki, Ravi Ranjan Kumar Niraj, Shanker L. Kothari

“…This study aims to explore the role of the SLC4A4 transporter as a biomarker in CRC progression and its potential as a therapeutic target, particularly in relation to tumor acidity and immune response. …”
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“Sichuanvirus”, a novel bacteriophage viral genus, able to lyse carbapenem-resistant Klebsiella pneumoniae by Juan Li, Qingqing Fang, Huan Luo, Yan Feng, Yu Feng, Zhiyong Zong

“…Abstract Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a severe threat for human health and urgently needs new therapeutic approaches. Lytic bacteriophages (phages) are promising clinically viable therapeutic options against CRKP. …”
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Preschool and Me: Educational-clinical linkage to improve health equity for children with developmental delays and disabilities from historically marginalized communities by Tina L. Schuh, Kathleen R. Diviak, Sarai Coba-Rodriguez, Emily Pela, Raphael Kinney, Michael L. Berbaum, Amanda Klemas, Kruti Acharya, Molly Martin, Reshma Shah

“…Societal and structural inequities have resulted in longstanding health care disparities among Black, Latino/a/e, and low-income preschool children with developmental delays and disabilities (PCw/DD), depriving them of educational and therapeutic services that improve future academic, economic, and health outcomes. …”
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