Aurora kinase A promotes hepatic stellate cell activation and liver fibrosis through the Wnt/β-catenin pathway by Guanqi Dai, Guanqi Dai, Junhao Lin, Yuchuan Jiang, Yuchuan Jiang, Xinhui Liu, Peng Chen, Yixiao Zhang, Zhenghui Song, Xuefen Zhuang, Jinge Cong, Yingchun Li, Xuanjia Hong, Yun Liu, Dong Xiao, Dong Xiao, Aimin Li, Yue Luo

“…Pharmacological inhibition of AURKA phosphorylation also resulted in reduced liver fibrosis in vivo.ConclusionIn conclusion, AURKA may promote HSC activation and liver fibrosis through the Wnt/β-catenin pathway, suggesting its potential as a therapeutic target for liver fibrosis.…”
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Effect of Chromatin-Remodeling Agents in Hepatic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells In Vitro and In Vivo by Danna Ye, Tong Li, Philip Heraud, Rangsun Parnpai

“…TSA and/or 5-aza-dC derived hepatocytes-like cells failed to improve the therapeutic potential in liver damage. We conclude that HDACis enhance hepatic differentiation in a time-dependent manner, while DNMTis do not induce the hepatic differentiation of rBM-MSCs in vitro. …”
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Irritable Bowel Syndrome: Gut Microbiota Dysbiosis and Psychological Co-morbidities by Bijita Bhowmick, Sharmistha Banerjee, Sanchaita Gayen, Supriya Samanta, Nilotpal Banerjee

“…The socio-economic burden is reflected in increased rates of absenteeism, presenteeism and healthcare costs. Current therapeutic interventions, including probiotics, prebiotics, Faecal Microbiota Transplantation (FMT) and targeted medications, hold promise but require further research to establish their long-term efficacy and safety. …”
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Local delivery of TGF-β1-mRNA decreases fibrosis in osteochondral defects by Gianluca Fontana, Brett Nemke, Yan Lu, Connie Chamberlain, Jae-Sung Lee, Joshua A. Choe, Hongli Jiao, Michael Nelson, Margot Amitrano, Wan-Ju Li, Mark Markel, William L. Murphy

“…We used mineral-coated microparticles to deliver TGF-β1 mRNA to autologous BMAC. mRNA-activated BMAC was suspended in peripheral blood to generate therapeutic BMAC clots, which were then implanted in rabbit osteochondral defects. …”
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Helicobacter pylori Eradication in Idiopathic Thrombocytopenic Purpura: A Meta-Analysis of Randomized Trials by Bum Jun Kim, Hyeong Su Kim, Hyun Joo Jang, Jung Han Kim

“…This meta-analysis indicates that H. pylori eradication has a significant therapeutic effect in patients with ITP. Considering the intrinsic limits in the design and sample size of the included studies, however, large randomized controlled trials are warranted to validate the therapeutic impact of H. pylori eradication in adults as well as children with ITP.…”
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PARP Inhibitors in the Treatment of Ovarian Cancer by Andrzej Paweł Zuzak, Magdalena Cieślik-Porębska, Krzysztof Kułak, Jagoda Niewiadomska

“…Combination therapies, such as olaparib with bevacizumab, further enhance therapeutic outcomes, showcasing the potential for synergistic effects. …”
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Medical Interns’ Self-Evaluation of Clinical Skills Training in the Emergency Department at Babol University of Medical Sciences by Zahra Rostamtabar, Sobhan Rahimi Esbo, Mehdi Mohammadian Amiri, Hemmatollah Gholinia Ahangar, Maryam Ghaemi-Amiri

“…Participants completed demographic questionnaires and satisfaction surveys assessing their acquisition of clinical skills in managing emergency patients, performing essential therapeutic procedures, and their education in the emergency department. …”
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Cellular heterogeneity and communication networks in gastric cancer: Single-cell analysis reveals β-hydroxybutyrylation-associated genes and immune infiltration characteristics by You Hu, Jun Xu, Jian Lv, Yan Qin, Yongda Lu, Fan Cen, Hongbao Yang, Kai Chen, Suhua Xia

“…These findings underscore the prognostic value of Kbhb-associated genes and their potential as therapeutic targets. This study not only provides insights into the molecular underpinnings of gastric cancer but also offers potential biomarkers for patient stratification and targets for therapeutic intervention.…”
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Metabolites derived from medicinal plants modulating voltage-gated sodium channel activity: A systematic review by José Luis Estela-Zape, Mayra Liliana Pizarro-Loaiza, Gabriel Arteaga, Santiago Castaño, Leonardo Fierro

“…These compounds exhibited analgesic, antiarrhythmic, and neuroprotective properties, suggesting their therapeutic potential for disorders linked to Nav channel dysfunction. …”
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Molecular Detection of EMT Markers in Circulating Tumor Cells from Metastatic Non-Small Cell Lung Cancer Patients: Potential Role in Clinical Practice by Annalisa Milano, Francesca Mazzetta, Sabatino Valente, Danilo Ranieri, Laura Leone, Andrea Botticelli, Concetta Elisa Onesti, Salvatore Lauro, Salvatore Raffa, Maria Rosaria Torrisi, Paolo Marchetti

“…Longitudinal monitoring of three patients showed that the CTCsEMT detection is related to poor therapeutic response. Conclusions. The RT-PCR-based approach for the evaluation of CTCsEMT phenotype could be a promising and inexpensive tool to predict the prognosis and the therapeutic response in NSCLC patients.…”
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Catheter-directed therapy for pulmonary embolism in pediatrics: a systematic review and meta-analysis by Basel F. Alqeeq, Dina Essam Abo-elnour, Mohamed Rifai, Luis L. Gamboa, Ibrahim Qattea, Mohammed Hamzah, Khaled M. Al-Farawi, Alaa Ahmed Elshanbary, Ibrahim Kamal, Mohammed Alsabri

“…In patients presenting with massive/submassive PE, catheter-directed Therapy (CDT) presents an emerging therapeutic modality by which PE can be managed. Methods Electronic databases were systematically searched through May 2024. …”
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Cangfudaotan Decoction Alleviates Insulin Resistance and Improves Follicular Development in Rats with Polycystic Ovary Syndrome via IGF-1-PI3K/Akt-Bax/Bcl-2 Pathway by Chenye Wang, Caifei Ding, Zhoujia Hua, Chunyue Chen, Jia Yu

“…Given that CFD sufficiently suppresses insulin resistance and improves follicular development in this study, exploring these mechanisms might help to optimize the therapeutic treatment of CFD in PCOS patients.…”
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Antiviral activity of natural compounds extracted from Mediterranean medicinal plants against SARS-CoV-2 by Stephanie Ghio, Jean-Pierre Brincat, Yuksel Cetin, Frederick Lia

“…This review highlights studies that have investigated the antiviral activities of spices and Mediterranean herbs, as well as their mechanism of action against SARS-CoV-2. Potential therapeutic target mechanisms addressed in this review comprise both host-directed and virus-directed therapies. …”
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Bilayer 3D co‐culture platform inducing the differentiation of normal fibroblasts into cancer‐associated fibroblast like cells: New in vitro source to obtain cancer‐associated fibr... by Yeon Ju Kim, Hyeon Song Lee, Dohyun Kim, Hwa Kyung Byun, Woong Sub Koom, Won‐Gun Koh

“…Survival rate of cancer cells post‐irradiation and gemcitabine resistance increased significantly in the co‐culture setting, highlighting the role of CAFs in promoting cancer cell survival and therapeutic resistance. These findings would contribute to understanding molecular and phenotypic changes associated with CAF activation and provide insights into potential therapeutic strategies targeting the tumor microenvironment.…”
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Upper Gastrointestinal Bleeding as a Debut Form of Groove Pancreatitis: A Diagnostic Challenge by Belén Matías-García, Camilo José Castellón-Pavón, Gustavo Díaz-García, Belén Manso-Abajo, Daniel Hernández-Aceituno, Antonio Hermosín-Peña, Luis Mejías-Sosa, Manuel Durán-Poveda

“…We report the first clinical case of GP whose debut with UGB presented a greater diagnostic and therapeutic challenge.…”
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Arctiin alleviates the progression of osteoarthritis by regulating the cholesterol metabolic pathway by Jiale Mai, Jiacong Xiao, Yanhuai Ma, Dawei Gong, Jianliang Li

“…Metabolic syndrome has recently been implicated in OA pathogenesis, underscoring the need for novel therapeutic strategies. Arctiin (ARC), a lignan known for its anti-inflammatory and anti-osteoporotic properties, has potential effects on OA that merit exploration. …”
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Norcantharidin induces G2/M arrest and apoptosis via activation of ERK and JNK, but not p38 signaling in human renal cell carcinoma ACHN cells by Huang Shuaishuai, Tuergong Gulimire, Zhu Hangjie, Wang Xue, Weng Guobin, Ren Yu

“…This study provided evidence that NCTD is a promising therapeutic drug for the treatment of RCC.…”
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Platycodon grandiflorum-derived extracellular vesicles suppress triple-negative breast cancer growth by reversing the immunosuppressive tumor microenvironment and modulating the gu... by Min Yang, Jia Guo, Jinxian Li, Shuyue Wang, Yuan Sun, Ying Liu, Yinghua Peng

“…Abstract Despite the approval of several artificial nanotherapeutics for the treatment of triple-negative breast cancer (TNBC), significant challenges, including unsatisfactory therapeutic outcomes, severe side effects, and the high cost of large-scale production, still restrict their long-term application. …”
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Nonoperative management of colon and mesocolon injuries caused by blunt trauma: three case reports by Naa Lee, Euisung Jeong, Hyunseok Jang, Yunchul Park, Younggoun Jo, Jungchul Kim

“…The therapeutic approach for colon injury has changed continuously with the evolution of management strategies for trauma patients. …”
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Melanocortin Peptide Therapy for the Treatment of Arthritic Pathologies by S. J. Getting, M. Kaneva, Y. Bhadresa, D. Renshaw, Giovanna Leoni, H. B. Patel, M. J. P. Kerrigan, I. C. Locke

“…This review highlights the therapeutic potential of naturally occurring hormones and their peptides, in both arthritic models of disease and patients. …”
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