Neurosteroid Binding Sites on the GABAA Receptor Complex as Novel Targets for Therapeutics to Reduce Alcohol Abuse and Dependence by Mary W. Hulin, Russell J. Amato, Johnny R. Porter, Catalin M. Filipeanu, Peter J. Winsauer

“…The purpose of this paper is to present pertinent literature suggesting that both alcohol and the neurosteroids interact at the GABAA receptor complex and that the neurosteroid sites on this receptor complex could serve as new targets for the development of novel therapeutics for alcohol abuse. This paper will also present data collected by our laboratory showing that one neurosteroid in particular, dehydroepiandrosterone (DHEA), decreases ethanol intake in rats under a variety of conditions. …”
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Turn TRAIL Into Better Anticancer Therapeutic Through TRAIL Fusion Proteins by Yan Wang, Xin Qian, Yubo Wang, Caiyuan Yu, Li Feng, Xiaoyan Zheng, Yaya Wang, Qiuhong Gong

“…Conclusion This work focuses on the progress in recombinant TRAIL fusion proteins and aims to provide more rational and effective fusion strategies to enhance the efficacy of recombinant soluble TRAIL, facilitating its translation from bench to bedside as an effective anti‐cancer therapeutic.…”
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The Interplay of Aging and PANoptosis in Osteoarthritis Pathogenesis: Implications for Novel Therapeutic Strategies by Liu S, Zhang G, Li N, Wang Z, Lu L

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Targeting fucosyltransferase FUT8 as a prospective therapeutic approach for DLBCL by Hao Xu, Qi Li, Yuchen Zhang, Chuan He, Xinyun Zhang, Zhiming Wang, Meifang Zhao, Yali Chai, Wenzhuo Zhuang, Bingzong Li

“…Collectively, morusinol showcased substantial promise as an anti-tumor agent for potential clinical application in DLBCL management, potentially augmenting established therapeutic strategies. Moreover, our findings offered promising prospects for natural products to effectively leverage its therapeutic advantages. …”
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Microalgae: A Treasure Trove of Anticancer Nutraceuticals and Promising Therapeutic Mechanisms by Sajjad Masoumi, Maryam Zokaei, Ardavan Ahmadvand, Nogol Ghalamkarpour, Naghmeh Asadimanesh, Armin Azarimatin, Khashayar Fattah, Zahra Payandeh, Masoumeh Rostami, Afsaneh Farjami, Rajan Kumar Pandey, Mohsen Nabi-Afjadi

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Shared signaling pathways and comprehensive therapeutic approaches among diabetes complications by Moein Ebrahimi, Hamid Ahmadieh, Mozhgan Rezaei Kanavi, Sare Safi, Saeed Alipour-Parsa, Soroor Advani, Christine M. Sorenson, Nader Sheibani

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Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases by Jialian Lv, Xinyue Song, Zixin Luo, Duoqin Huang, Li Xiao, Kang Zou

“…Luteolin has therapeutic effects on chronic obstructive pulmonary disease (COPD), acute lung injury/acute respiratory distress syndrome (ALI/ARDS), pulmonary fibrosis, allergic asthma, and lung cancer. …”
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Immune and Inflammation in Acute Coronary Syndrome: Molecular Mechanisms and Therapeutic Implications by Haiming Wang, Zifan Liu, Junjie Shao, Lejian Lin, Min Jiang, Lin Wang, Xuechun Lu, Haomin Zhang, Yundai Chen, Ran Zhang

“…We also provide a “from bench to bedside” perspective of a novel and promising personalized strategy in RIR intervention and therapeutic approaches for the treatment of ACS.…”
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Neuroinflammation and ALS: Transcriptomic Insights into Molecular Disease Mechanisms and Therapeutic Targets by Giovanna Morello, Antonio Gianmaria Spampinato, Sebastiano Cavallaro

“…Besides providing promising insights into the intricate relationship between inflammation and ALS, this paper represents a starting point for the rationale design and development of novel and more effective diagnostic and therapeutic applications.…”
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Therapeutic effects of Salvadora persica (Miswak) on patients with mild to moderate gingivitis. by Kawa F. Dizaye, Zainab Yalman Othman

“…This study compares the therapeutic effects of miswak (S. persica), toothbrush, S. persica mouthwash, and chlorhexidine mouthwash on patients with mild to moderate gingivitis by estimating gingival index and (debris) plaque index. …”
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Costimulatory Pathways: Physiology and Potential Therapeutic Manipulation in Systemic Lupus Erythematosus by Nien Yee Kow, Anselm Mak

“…Attempts to target these costimulatory pathways therapeutically will pave more potential treatment avenues for patients with SLE. …”
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Comprehensive analysis of ceRNA Networks in UCEC: Prognostic and therapeutic implications. by Li Fan, Mengqiu Lan, Xiaohua Wei, Lili Wei, Liuhong Yang, Liuying Nong, Jiajia Wei, Jingjing Li, Wenjie Huang

“…These findings suggest that the CDKN2B-AS1-hsa-miR-497-5p-IGF2BP3 axis is a key regulatory element in UCEC and a potential therapeutic target.…”
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Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications by Bou-Yue Peng, Navneet Kumar Dubey, Viraj Krishna Mishra, Feng-Chou Tsai, Rajni Dubey, Win-Ping Deng, Hong-Jian Wei

“…Cell-based therapy such as stem cells is considered as a promising therapeutic agent against DM and diabetic complications owing to their multilineage differentiation and regeneration potential. …”
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Immunoglobulin Gamma-Like Therapeutic Bispecific Antibody Formats for Tumor Therapy by Shixue Chen, Lingling Li, Fan Zhang, Yu Wang, Yi Hu, Lei Zhao

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Reactive Oxygen Species, a Potential Therapeutic Target for Vascular Dementia by Amanda Louise White, Grant M. Talkington, Blake Ouvrier, Saifudeen Ismael, Rebecca J. Solch-Ottaiano, Gregory Bix

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Therapeutic potential of seaweeds and their biofabricated nanoparticles in treating urolithiasis: A review by Dhanya Raj C. T, Vivekanandan Palaninathan, Surabhi Kandaswamy, Vimal Kumar, Rathinam Arthur James

“…This review examines the therapeutic properties of seaweed bioactive compounds and their possible applications in treating urolithiasis. …”
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Mitochondrial DNA leakage: underlying mechanisms and therapeutic implications in neurological disorders by Guangming Zhang, Huayuan Wei, Anliu Zhao, Xu Yan, Xiaolu Zhang, Jiali Gan, Maojuan Guo, Jie Wang, Fayan Zhang, Yifang Jiang, Xinxing Liu, Zhen Yang, Xijuan Jiang

“…Advancing our understanding of the complex interplay between mtDNA leakage and neuroinflammation is imperative for developing precision therapeutic interventions for neurological disorders.…”
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Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases by Juan Shi, Shuhong Chi, Jing Xue, Jiali Yang, Feng Li, Xiaoming Liu

“…Despite the fact that therapeutic interventions are available for ameliorating disease manifestations, there is no curative therapy currently available for autoimmune disorders. …”
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THE EFFECT OF THERAPEUTIC GROUP THERAPY ON THE DEVELOPMENT OF ADOLESCENT SELF IDENTITY IN ORPHANAGE by Siti Kholifah, Hendy Muagiri Margono, Rizki Fitryasari, Ah Yusuf, Hanik Endang, Budiono Budiono

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The mycobiome in human cancer: analytical challenges, molecular mechanisms, and therapeutic implications by Ting Ding, Chang Liu, Zhengyu Li

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