The polarity of high-definition transcranial direct current stimulation affects the planning and execution of movement sequences by Jake J. Son, Tara D. Erker, Thomas W. Ward, Yasra Arif, Peihan J. Huang, Jason A. John, Kellen M. McDonald, Nathan M. Petro, Grant M. Garrison, Hannah J. Okelberry, Kennedy A. Kress, Giorgia Picci, Elizabeth Heinrichs-Graham, Tony W. Wilson

“…Noninvasive brain stimulation of the primary motor cortex has been shown to alter therapeutic outcomes in stroke and other neurological conditions, but the precise mechanisms remain poorly understood. …”
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Co-Localized in Amyloid Plaques Cathepsin B as a Source of Peptide Analogs Potential Drug Candidates for Alzheimer’s Disease by Marilena K. Theodoropoulou, Konstantina D. Vraila, Nikos C. Papandreou, Georgia I. Nasi, Vassiliki A. Iconomidou

“…., a crucial consideration for therapeutic safety. These findings point out the potential of APR-derived peptide analogs from co-localized proteins as innovative agents against AD, paving the way for further exploration in peptide-based therapeutic development.…”
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Olivetol’s Effects on Metabolic State and Gut Microbiota Functionality in Mouse Models of Alimentary Obesity, Diabetes Mellitus Type 1 and 2, and Hypercholesterolemia by Anastasia A. Zabolotneva, Katerina E. Popruga, Valentin V. Makarov, Sergei M. Yudin, Andrei M. Gaponov, Sergei A. Roumiantsev, Aleksandr V. Shestopalov

“…Olivetol, a natural compound, could be proposed as a promising therapeutic agent for preventing, treating, or alleviating metabolic complications of such pathological conditions. …”
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Urinary Proteomic Shifts over Time and Their Associations with eGFR Decline in Chronic Kidney Disease by Zhalaliddin Makhammajanov, Kamila Nurlybayeva, Zikrillo Artikov, Pavel Tarlykov, Mohamad Aljofan, Rostislav Bukasov, Duman Turebekov, Syed Hani Abidi, Mehmet Kanbay, Abduzhappar Gaipov

“…These findings highlight VTDB, FBN1, and CD44 as potential prognostic biomarkers, providing insights into CKD progression and therapeutic targets.…”
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Polysaccharide-based biomaterials for regenerative therapy in intervertebral disc degeneration by Xin Wang, Yixue Huang, Yilin Yang, Xin Tian, Yesheng Jin, Weimin Jiang, Hanliang He, Yong Xu, Yijie Liu

“…Intervertebral disc (IVD) degeneration represents a significant cause of chronic back pain and disability, with a substantial impact on the quality of life. Conventional therapeutic modalities frequently address the symptoms rather than the underlying etiology, underscoring the necessity for regenerative therapies that restore disc function. …”
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Evaluating wound-healing effect of silicon-zinc-boron-containing glycerohydrogel and its effect on mammary glands of high producing dairy cows by L. I. Drozdova, A. S. Barkova, M. N. Isakova, L. P. Larionov, V. V. Permikin, N. M. Starikov, T. G. Khonina

“…Cow’s milk quality, which may deteriorate due to inflammatory processes in the mammary glands, remains one of the important problems of dairy farming and requires effective, safe and affordable therapeutic agents. Nanocomposite silicon-zinc-boron-containing glycerohydrogel (Si-Zn-B-gel) may become a very good solution to the issue. …”
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Management of adult patients with alcoholic liver disease: clinical guidelines of the Russian Scientific Liver Society by V. T. Ivashkin, M. V. Mayevskaya, Ch. S. Pavlov, Yu. P. Sivolap, V. D. Lunkov, M. S. Zharkova, R. V. Maslennikov

“…Abstinence from alcohol is the first line and the basic therapeutic procedure for any form and stage of ALD. …”
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Exploring the prognostic role of microbial and genetic markers in lung squamous cell carcinoma by Fan Yang, Xiaodong Jia, Zihuan Ma, Siyao Liu, Chunzi Liu, Dan Chen, Xiuju Wang, Niansong Qian, Hui Ma

“…Abstract Despite advances in diagnostic and therapeutic strategies, the prognosis of lung squamous cell carcinoma (LUSC) patients remains poor, and the potential of microbiome-based prognostic biomarkers and therapeutic targets remains largely unexplored. …”
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The Effect of Serine Protease Inhibitors on Airway Inflammation in a Chronic Allergen-Induced Asthma Mouse Model by Chih-Che Lin, Li-Jen Lin, Shulhn-Der Wang, Chung-Jen Chiang, Yun-Peng Chao, Joseph Lin, Shung-Te Kao

“…The serine protease inhibitors FUT, FOY, and UTI have potential therapeutic benefits for treating asthma by downregulating Th2 cytokines and Th17 cell function and inhibiting NF-κB activation in lung tissue.…”
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CB-MNCs@ CS/HEC/GP promote wound healing in aged murine pressure ulcer model by Zhi-cheng Yang, He Lin, Guo-jun Liu, Hui Pan, Jun-lu Zhu, Xiao-hong Zhang, Feng Gao, Zhong Wang, Zhi-hao Wang

“…Thus, CB-MNCs@CS/HEC/GP represents a novel therapeutic approach for skin regeneration of chronic wounds.…”
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Hydrogen‐Generating Magnesium Alloy Seed Strand Sensitizes Solid Tumors to Iodine‐125 Brachytherapy by Pan Hu, Letao Lin, Guanyu Chen, Dengyao Liu, Huanqing Guo, Meigui Xiao, Zhihui Zhong, Guang Yang, Bingchen Xu, Dongcun Huang, Sheng Peng, Yong Li, Yanling Zhang, Tao Huang, Fujun Zhang

“…Abstract Radioactive iodine‐125 (125I) seed implantation, a brachytherapy technique, effectively kills tumor cells via X‐rays and gamma rays, serving as an alternative therapeutic option following the failure of frontline treatments for various solid tumors. …”
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Parthenolide improves sepsis-induced coagulopathy by inhibiting mitochondrial-mediated apoptosis in vascular endothelial cells through BRD4/BCL-xL pathway by Jun Zhang, Xing Zhu, Yong Li, Yinyu Wu, Yunxia Du, Hai Yang, Zhengchao Liu, Haoyu Pei, Rui Li, Huan Luo, Deyu Zuo, Han She, Qingxiang Mao

“…Conclusions This study clarifies the therapeutic effects and mechanisms of PTL on SIC, offering new strategies and directions for the treatment of sepsis.…”
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Antioxidant and anti-diabetic potential of the green synthesized silver nanoparticles using Martynia annua L. root extract by Megha B. Abbigeri, Bothe Thokchom, Sapam Riches Singh, Santosh Mallikarjun Bhavi, B.P. Harini, Ramesh Babu Yarajarla

“…Moreover, the AgNPs enhanced glucose uptake by yeast cells, indicating their promising therapeutic role in managing diabetes mellitus. This study highlights the pharmacological importance of M.annua, particularly its aqueous root extract, in the eco-friendly synthesis of AgNPs with potential therapeutic implications. …”
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Liquid biopsy approaches to capture tumor evolution and clinical outcomes during cancer immunotherapy by Susan Scott, Mark Sausen, Valsamo Anagnostou, Jennifer Jackson, Vincent Lam, Joseph C Murray, Lavanya Sivapalan, Jenna Vanliere Canzoniero, Blair Landon, Benjamin P. Levy

“…These efforts highlight the emerging role of liquid biopsies in selecting patients for cancer immunotherapy, monitoring therapeutic efficacy, determining the optimal duration of treatment and ultimately guiding treatment selection and sequencing. …”
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Rheopheresis in treatment of idiopathic sensorineural sudden hearing loss by Milan Kostal, Jakub Drsata, Milan Bláha, Miriam Lánská, Viktor Chrobok

“…Abstract Backround Only few therapeutic options exist for patients with refractory sudden idiopathic sensorineural hearing loss (SISHL). …”
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Efficacy of human umbilical cord mesenchymal stem cell in the treatment of neuromyelitis optica spectrum disorders: an animal study by Chunran Xue, Haojun Yu, Xuzhong Pei, Xiaoying Yao, Jie Ding, Xiying Wang, Yi Chen, Yangtai Guan

“…Abstract Background Human umbilical cord mesenchymal stem cells (hUC-MSCs) have great potential for treating autoimmune diseases for their immunomodulatory and tissue-regenerative abilities; however, their therapeutic role in neuromyelitis optica spectrum disorder (NMOSD) remains uncertain. …”
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Orbital Desmoid-Type Fibromatosis: A Case Report and Literature Review by Alessandro Moro, Paolo De Angelis, Giulio Gasparini, Sandro Pelo, Gianluigi Petrone, Emanuela Lucci Cordisco, Umberto Garagiola, Giuseppe D’Amato, Gianmarco Saponaro

“…The aim of the article is to describe this unusual and rare location for the desmoid fibromatosis and outline the principle phases in the decision-making process and the therapeutic alternatives for a patient affected by desmoid fibromatosis. …”
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Low-Intensity Pulsed Ultrasound Modulates RhoA/ROCK Signaling of Rat Mandibular Bone Marrow Mesenchymal Stem Cells to Rescue Their Damaged Cytoskeletal Organization and Cell Biolog... by Rong Zhang, Zhaoling Wang, Guoxiong Zhu, Gaoyi Wu, Qingyuan Guo, Hongchen Liu, Lei Chen

“…Inhibition of RhoA/ROCK signaling remarkably aggravated the inhibitory effect of radiation and attenuated the therapeutic effect of LIPUS. In the light of these findings, the RhoA/ROCK signaling pathway might be a promising target for modifying the therapeutic effect of LIPUS on osteoradionecrosis.…”
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MicroRNA-208a Dysregulates Apoptosis Genes Expression and Promotes Cardiomyocyte Apoptosis during Ischemia and Its Silencing Improves Cardiac Function after Myocardial Infarction by Hasahya Tony, Kai Meng, Bangwei Wu, Aijia Yu, Qiutang Zeng, Kunwu Yu, Yucheng Zhong

“…We investigated if miR-208a has proapoptotic effects on ischemic cardiomyocytes and if its silencing has therapeutic benefits in MI. Methods and Results. The effect of miR-208a on apoptosis during ischemia was studied in cultured neonatal mice myocytes transfected with agomir or antagomir. …”
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Global research landscape and hotspots for ferroptosis in glioma: A comprehensive bibliometric and visual analysis by Xinyue Zheng, Mengyao Diao, Shan Tong, Shuo Yang, Jing Lin, Shenghua Zhuo, Ting Wang, Jian Dai, Shenbo Chen, Kai Wang

“…Studying ferroptosis is crucial for understanding the mechanisms underlying the onset and progression of glioblastoma, identifying therapeutic targets, and improving prognosis assessment and diagnostic methods. …”
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