Management of restrictive and obstructive lung disease in intensive care unit: a review by Dian Ayu Listiarini, Akhmad Yun Jufan, Calcarina Fitriani Retno Wisudarti

“…It is essential to differentiate between RLD and OLD because they have different therapeutic management. This review aims to discuss the management of restrictive and obstructive lung disease in intensive care unit It is drawn upon various sources, including case reports, literature reviews, systematic reviews, and meta-analyses, to provide an overview of the difference between RLD and OLD to help clinicians differentiate between RLD and OLD and provide appropriate therapeutic management. …”
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Metabolite-Sensing Receptors: Emerging Targets for Modulating Chronic Pain Pathways by Ciprian Pușcașu, Corina Andrei, Octavian Tudorel Olaru, Anca Zanfirescu

“…This review explores the molecular mechanisms of metabolite-sensing receptors in chronic pain, their therapeutic potential, and challenges in clinical application. …”
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Rehabilomics Strategies Enabled by Cloud-Based Rehabilitation: Scoping Review by Sejun Oh, SangHeon Lee

“…The use of cloud platforms is expected to strengthen patient-centered data management and collaboration, contributing to the advancement of innovative strategies and therapeutic developments in rehabilomics.…”
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Medical cannabis in the management of musculoskeletal pain: a systematic review of clinical trials by Przemysław Płatek, Laura Piejko

“…Aims: The aim of this study was to summarize the current state of knowledge regarding the therapeutic potential of medical cannabis in the management of musculoskeletal pain. …”
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Comparing the Efficacy of Triamcinolone Acetonide Iontophoresis versus Topical Calcipotriol/Betamethasone Dipropionate in Treating Nail Psoriasis: A Bilateral Controlled Clinical T... by Nasrin Saki, Shahla Hosseinpoor, Alireza Heiran, Ali Mohammadi, Mehdi Zeraatpishe

“…We aimed to compare the therapeutic effects of triamcinolone acetonide iontophoresis (TI) and topical calcipotriol/betamethasone dipropionate in the nail bed and nail matrix involvements of psoriasis using Nail Psoriasis Severity Index (NAPSI). …”
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To describe the subsets of malignant epithelial cells in gastric cancer, their developmental trajectories and drug resistance characteristics by Tingting Xu, Tianying Zhang, Yan Sun, Sijia Wu

“…Developmental trajectory analysis revealed potential stem-like characteristics in certain clusters, suggesting their involvement in therapeutic resistance and disease recurrence. Cell–cell communication analysis uncovered a dynamic network of interactions within the tumor microenvironment, potentially influencing tumor growth and metastasis. …”
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The impact of gut microbiome on neuro-autoimmune demyelinating diseases by Pouria Abolfazli, Cristina Nkene Apue Nchama, Brandon Lucke-Wold

“…Understanding these relationships provides potential therapeutic approaches targeting gut microbiota to more effectively manage and alleviate demyelinating diseases.…”
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The Impact of Epigenetics on the Pathophysiology of Type 2 Diabetes and Associated Nephropathic Complications by Amit Mukherjee, Tanusree Debbarman, Basu D. Banerjee, Sheelu S. Siddiqi

“…More extensive research is needed to identify specific epigenetic mechanisms involved in DKD to further refine predictive models and therapeutic strategies. This unified exploration of significant epigenetic modifications offers a focused analysis of how these alterations influence the trajectory of disease and presents new avenues for therapeutic intervention.…”
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The role of glucagon-like peptide-1 receptor (GLP-1R) agonists in enhancing endothelial function: a potential avenue for improving heart failure with preserved ejection fraction (H... by Darshan Hullon, Ghasaq K. Subeh, Yelizaveta Volkova, Karolina Janiec, Adam Trach, Ruslan Mnevets

“…GLP-1R agonists present a promising therapeutic option for HFpEF by targeting endothelial dysfunction and other pathophysiological mechanisms. …”
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Deep learning-based malaria parasite detection: convolutional neural networks model for accurate species identification of Plasmodium falciparum and Plasmodium vivax by Diego A. Ramos-Briceño, Alessandro Flammia-D’Aleo, Gerardo Fernández-López, Fhabián S. Carrión-Nessi, David A. Forero-Peña

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Optimal Dose and Concentration of Hypertonic Saline in Traumatic Brain Injury: A Systematic Review by Martin SUSANTO, Ika RIANTRI

“…To date, there is no consensus on the optimal therapeutic dose and concentration of hypertonic saline for treating increased intracranial pressure. …”
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SARS-CoV-2 Infection in Kidney Transplant Recipients: A Single-Centre Study of 20 Cases from India by Ravi Raju Tatapudi, Venkateswara Rao Kopparti, Anusha Poosapati, Srinivas Metta, Atchyutha Rao Gongada, Balakrishna Vedulla

“…We describe clinical features, role of HRCT, therapeutic protocols, and mortality rate of 20 KTRs with SARS-CoV-2 infection. …”
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Green Synthesis of Iron Oxide Nanoparticles and Their Antibacterial Efficacy against Carbapenem-resistant Klebsiella pneumoniae in Bloodstream Infections by Rahul Harikumar Lathakumari, Leela Kakithakara Vajravelu, Jayaprakash Thulukanam, Vishnupriya Panneerselvam, Poornima Baskar Vimala, Dakshina Manoj Nair, Sujith Sri Surya Ravi

“…The increasing resistance to carbapenems and other critical antibiotics highlights an urgent need for alternative therapeutic strategies. Methods: We analyzed 180 Gram-negative bacilli isolates from blood specimens, of which 30 were identified as CRKP. …”
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Epstein-Barr virus reactivation induces divergent abortive, reprogrammed, and host shutoff states by lytic progression. by Elliott D SoRelle, Lauren E Haynes, Katherine A Willard, Beth Chang, James Ch'ng, Heather Christofk, Micah A Luftig

“…Conversely, induction of lytic reactivation in latent EBV-positive tumors presents a novel therapeutic opportunity. Therefore, defining the dynamics and heterogeneity of EBV lytic reactivation is a high priority to better understand pathogenesis and therapeutic potential. …”
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Proteome-wide mendelian randomization identifies causal plasma proteins in interstitial lung disease by Kunrong Yu, Wanying Li, Wenjie Long, Yijia Li, Yanting Li, Huili Liao, Jianhong Liu

“…Among these, three proteins—CDH15 (Cadherin-15), LTBR (Lymphotoxin-beta receptor), and ADAM15 (A disintegrin and metalloproteinase 15)—emerged as priority biomarkers and potential therapeutic targets, demonstrating more reliable associations by passing a series of sensitivity analyses compared to the others. …”
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Deep-insights: Nanoengineered gel-based localized drug delivery for arthritis management by Anitha Sriram, Harshada Ithape, Pankaj Kumar Singh

“…This approach combines the benefits of gels and nanocarriers to enhance therapeutic effects and improve patient compliance. …”
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16S rRNA sequencing-based evaluation of the protective effects of key gut microbiota on inhaled allergen-induced allergic rhinitis by Yi Tang, Yongchuan She, Danping Chen, Yibo Zhou, Dan Xie, Zhai Liu

“…This research aims to characterize the gut microbiota of patients with AR who are sensitized via inhalation, utilizing 16S rRNA sequencing to shed light on the pathogenesis of AR and identify potential therapeutic targets.MethodsTo achieve the study’s objectives, we compared the microbiota profiles between patients with AR and healthy controls. …”
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GDF15-mediated enhancement of the Warburg effect sustains multiple myeloma growth via TGFβ signaling pathway by Wenjing Xue, Ying Li, Yanna Ma, Feng Zhang

“…Overall, our study provides insights into the molecular mechanisms underlying MM pathogenesis and highlights the potential of targeting GDF15-TGFβ signaling -glycolysis axis as a therapeutic approach for future therapeutic interventions in MM.…”
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Prostate-Specific Membrane Antigen as Target for Neuroimaging of Central Nervous System Tumors by Brittany M. Stopa, James Crowley, Csaba Juhász, Cara M. Rogers, Mark R. Witcher, Jackson W. Kiser

“…There is a potential application for PSMA-targeted PET in neuro-oncology as a combination of diagnostic and therapeutic use, as a theranostic modality for managing CNS tumors. …”
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Carvacrol Essential Oil as a Neuroprotective Agent: A Review of the Study Designs and Recent Advances by Fahad Khan Tareen, Laura Catenacci, Sara Perteghella, Milena Sorrenti, Maria Cristina Bonferoni

“…This review highlights the therapeutic potential of one such monoterpene phenolic EO, carvacrol (CV), that has the potential to be used as a main therapeutic intervention for neurodegenerative disorders. …”
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