Mini review of spatially fractionated radiation therapy for cancer management by Shrikant B. Mali

“…Hypoxic subvolumes, a subpopulation of cancer stem cells, and inherent or acquired radioresistance define tumour aggressiveness and metastatic potential, which remain a therapeutic challenge. Non-conventional irradiation techniques, such as SFRT, have been developed to tackle some of these challenges and offer a high therapeutic index when treating radioresistant tumors. …”
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Luteolin ameliorates rat model of metabolic syndrome-induced cardiac injury by apoptosis suppression and autophagy promotion via NR4A2/p53 regulation by Xiyan Dai, Bo Liang, Yaolin Sun

“…The aim of this investigation was to assess the therapeutic potential of luteolin, with documented beneficial properties, against MetS-associated cardiac injury. …”
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Exploring Developmental Care in Neonatal Jaundice Management: A Case Report with Supporting Literature Synthesis by Esther Aduramo, Deborah T. Esan, Emmanuel Adesuyi, Opeoluwa Olabode, Elizabeth Awoniyi, Blessed Oyama, Oluwadamilare Akingbade

“…This report highlights the benefits of developmental care in care in reducing stress, promoting bonding and optimizing neurodevelopment in preterm neonates, underscoring its importance in improving therapeutic outcomes in neonatal jaundice. Conclusions: The components of developmental care are effective and should therefore be incorporated into the management of neonatal jaundice, for improved therapeutic outcomes.…”
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Biomarkers in Nasopharyngeal Carcinoma (NPC): Clinical relevance and prognostic potential by Madhan Krishnan, Shyamaladevi Babu

“…The integration of these biomarkers into routine clinical practice could facilitate early diagnosis, predict therapeutic responses, and identify patients at higher risk of recurrence. …”
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Evaluating Curative Effects of Different Moxibustion Temperatures on Patients with Spastic Hemiplegia after Stroke by Liu YANG, Haili MA, Li GE, Qiaojing LIAO, Qiong HAN, Ling YE

“…Objective:To evaluate therapeutic effects of different moxibustion temperatures on stroke patients with spastic hemiplegia, in order to provid suitable and objective moxibustion temperature for such patients with abnormal perceptual abnormalities.Methods:A total of 80 patients were randomly divided into thermal burning group and temperature-sensing group, with 40 cases in each group. …”
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D-2-hydroxyglutarate impairs DNA repair through epigenetic reprogramming by Fengchao Lang, Karambir Kaur, Haiqing Fu, Javeria Zaheer, Diego Luis Ribeiro, Mirit I. Aladjem, Chunzhang Yang

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Comparison between cortical and subcortical diaphragmatic motor stimulation by transcranial magnetic stimulation on patients with chronic obstructive pulmonary disease by Hanan Mohamed Ibrahim Elshoura, Ahmed Adel Ahmed Ghareeb Nofal, Hossam Salaheldin Labib

“…These advancements allowed TMS to be considered as a therapeutic tool in the COPD rehabilitation program.…”
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« Even the most ignorant among the insane are not beyond the reach of instruction » : l’école à l’Asile de Hanwell ou le pari controversé d’un aliéniste engagé (1839-1853)... by Laurence Dubois

“…In doing so, not only did he experiment an innovative therapeutic approach, but he also took part in the broader debate over popular education, one of the most widely debated issues of the Victorian era. …”
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Restoration of Genetic Code in Macular Mouse Fibroblasts via APOBEC1-Mediated RNA Editing by Sonali Bhakta, Hiroko Kodama, Masakazu Mimaki, Toshifumi Tsukahara

“…Around 35% of the mutated C nucleotide (nt) was restored to U, demonstrating that our RNA editing system is reliable and has potential for therapeutic clinical application. RNA base editing via human RNA-guided cytidine deaminases is a potentially attractive approach for in vivo therapeutic application and provides opportunities for new developments in this field.…”
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Acceptance and commitment therapy reduces perceived ostracism in suicidal patients by Emilie Olié, Manon Malestroit, Véronique Brand-Arpon, Philippe Courtet, Deborah Ducasse

“…Reduced social pain was correlated with improved therapeutic processes and decreased suicidal ideation, highlighting the therapeutic potential of ACT for managing ostracism and suicide risk.…”
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Biochemical Behaviours of Salmeterol/Fluticasone Propionate in Treating Asthma and Chronic Obstructive Pulmonary Diseases (COPD) by Hilla Mills, Ronald Acquah, Nova Tang, Luke Cheung, Susanne Klenk, Ronald Glassen, Magali Pirson, Alain Albert, Duong Trinh Hoang, Thang Nguyen Van

“…The drugs used for the treatment of asthma and COPD are metabolised once in the body system and at the same time exerting the therapeutic effect provided the concentration of the drug is within the therapeutic window. …”
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The efficacy of an allosteric modulator of the alpha 7 nicotinic acetylcholine receptor in a murine model of stroke by Katherine Hernandez, Nathan Jones, Sterling B. Ortega

“…However, these agents present challenges such as a limited therapeutic window, incomplete reperfusion rates, risk of transformation, reperfusion-induced inflammation, and a lack of promoting neuroprotection. …”
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The link between spreading depolarization and innate immunity in the central nervous system by Kadir Oguzhan Soylu, Muge Yemisci, Hulya Karatas

“…Overall, this body of work highlights the need for further exploration of the mechanisms underlying SD-induced inflammation and potential therapeutic targets to mitigate neuroinflammatory disorders. …”
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Gut Microbiome Profiles in Colorectal Cancer Patients in Iraq by Fatima J. Kadhim, Zahid S. Aziz, Khalid S. Ibrahim

“…Further research needs to focus on elucidating the causal relationships and therapeutic potential of these microbiome changes in CRC management.…”
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Ventricular Depolarization Abnormalities and Their Role in Cardiac Risk Stratification — A Narrative Review by Maarten Blondeel, Tomas Robyns, Rik Willems, Bert Vandenberk

“…This risk stratification aims to identify patients at high risk of adverse cardiac events, to tailor preventive or therapeutic interventions. In this review, we provide an oversight of different techniques for assessing abnormal ventricular depolarization and their value in diagnosing certain conditions, in risk stratification of adverse events, and in guiding therapeutic decisions. …”
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Combined Effects of 2-Methoxyestradiol (Hypoxia-Inducible Factor 1α Inhibitor) and Dasatinib (A Second-Generation Tyrosine Kinase Inhibitor) on Chronic Myelocytic Leukemia Cells by Yuexian Zhang, Heng Chen, Yunfeng Shen, Xin Zhou

“…The activation of this gene mostly marks a poor outlook for cancer patients. To clarify the therapeutic effect of inhibiting this gene on CML, the present study is aimed at exploring the treatment effects of 2-methoxyestradiol (2-ME2), dasatinib alone, and combined both on K-562 cells and the possible mechanism of 2-ME2 in treating the disorder. …”
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A Comparative Study on the Effectiveness of Unified Protocols for Transdiagnostic Treatment of Emotional Disorders and Modular Cognitive-Behavioral Therapy on Positive and Negative... by Maryam Hashemipoor Zavareh, Mansoureh Bahramipour Isfahani, Ilnaz Sajjadian

“…After the completion of the therapeutic sessions, all three groups responded to the research questionnaires in the post-test phase and after a two-month follow-up and were compared. …”
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The Rapidly Evolving Treatment Landscape in Newly Diagnosed Multiple Myeloma: Current Status and Future Directions by Yuxin Liu, Clifton Mo, Monique Hartley-Brown, Shonali Midha, Adam S. Sperling, Giada Bianchi, Omar Nadeem, Betsy O’Donnell, Jacob Laubach, Paul G. Richardson

“…Over the past two decades, significant progress has been made in the management of multiple myeloma (MM), leading to the development of novel therapeutic approaches and treatment regimens to improve patient outcomes. …”
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Golden Tandem of Photothermal Ablation and Simultaneous Anti-Inflammation in One Nanoparticle for Activated Macrophage-Targeted Atherosclerosis Treatment by Lu Y, Wang Y, Li Y, Li Y, Jiang YW, Li J

“…The preparation and characterization of GSNPD, their cellular toxicity, photothermal conversion and targeted ablation efficiency, anti-inflammation and ROS scavenging effect, as well as the inhibition of foam cell formation were studied in vitro.Results: The experimental results showed that the fabricated GSNPD NPs displayed positive effects on anti-atherosclerosis by pro-inflammatory macrophages ablation, NO production and ROS scavenging.Discussion: GSNPD NPs were designed to effectively and accurately ablate pro-inflammatory macrophages by recognizing and targeting to SR-A overexpressed on the activated macrophages of arterial plaques via PTT, and simultaneous inhibit the PTT-induced inflammation through the laser-activated NO release in situ. This match of therapeutic agents and inhibitors not only achieves good therapeutic effects but also minimizes side effects as much as possible, which may provide an effective way for PTT-based treatment of atherosclerosis.Keywords: gold nanorods, photothermal therapy, NO, activated macrophages, atherosclerosis…”
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Effect of Zhi Tune Music on Motor Function of Cerebral Ischemic Stroke Hemiplegic Patients with Qi Deficiency and Blood Stasis Syndrome by Xia LI, Feng DENG, Xiaoyu WU, Jinxiu CHEN

“…The TCM symptomatic therapeutic effect of Zhi tune group was better than that of conventional control group (<italic>P</italic>&lt;0.05).Conclusion:Zhi tune music could improve motor function of lower extremities, repair nervous functional deficiency, and improve TCM syndrome of CISH patients with Qi deficiency and blood stasis syndrome.…”
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