Developing a Machine Learning–Based Automated Patient Engagement Estimator for Telehealth: Algorithm Development and Validation Study by Pooja Guhan, Naman Awasthi, Kathryn McDonald, Kristin Bussell, Gloria Reeves, Dinesh Manocha, Aniket Bera

“…This can assist psychotherapists in the development of a therapeutic relationship with the patient and enhance patient engagement in the treatment of mental health conditions during tele–mental health sessions. …”
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Rhein Mitigates Lung Injury in Severe Acute Pancreatitis Through the Inhibition of MARK4-Mediated Microtubule Destabilization by Sun Z, Liu J, Ge P, Cao Y, Liu J, Wen H, Luo X, Pei B, Jin Z, Li H, Xun L, Luo Y, Yang Q, Chen H

“…The potential therapeutic effects and appropriate dosages of rhein on SAP-ALI and PMVEC were investigated in both in vivo and in vitro experiments. …”
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Longitudinal MRI evaluation of the efficacy of non-enhanced lung cancer brain metastases by Xian Zhang, Jun Yang, Hong Hu, Yong Wang, Zhenfeng Zhang, Jinhao lv, Junping Li

“…Therefore, the aim of this study is to conduct a longitudinal MRI evaluation of the therapeutic effect of non-enhanced lung cancer BM, thereby enabling improved efficacy prediction and more personalized treatment plans. …”
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Human Umbilical Cord-Derived Mesenchymal Stem Cell Therapy Ameliorates Nonalcoholic Fatty Liver Disease in Obese Type 2 Diabetic Mice by Bing Li, Yu Cheng, Songyan Yu, Li Zang, Yaqi Yin, Jiejie Liu, Lin Zhang, Yiming Mu

“…The two conditions can act synergistically to produce adverse outcomes. However, the therapeutic options for patients with NAFLD and T2DM are currently limited. …”
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Elocalcitol, a fluorinated vitamin D derivative, prevents high-fat diet-induced obesity via SCAP downregulation and miR-146a-associated mechanisms by Monika Jürgenson, Keerthana Chithanathan, Aivar Orav, Külli Jaako, Janeli Viil, Mithu Guha, Kalev Kask, Alexander Zharkovsky

“…BackgroundObesity is an emerging health problem worldwide as it is associated with increased risk of cardiovascular, metabolic, mental disorders, and cancer. Therapeutic weight management remains one of the options for the treatment of excess weight and associated comorbidities. …”
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Systemic Resolvin E1 (RvE1) Treatment Does Not Ameliorate the Severity of Collagen-Induced Arthritis (CIA) in Mice: A Randomized, Prospective, and Controlled Proof of Concept Study by Rafael Scaf de Molon, Rogier M. Thurlings, Birgitte Walgreen, Monique M. Helsen, Peter M. van der Kraan, Joni Augusto Cirelli, Marije I. Koenders

“…CIA triggered significant inflammation in the synovial cavity, proteoglycan loss, and cartilage and bone destruction in the ankle joints of mice. Prophylactic and therapeutic RvE1 regimens did not ameliorate CIA incidence and severity. …”
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New bitongling regulates gut microbiota to predict angiogenesis in rheumatoid arthritis via the gut-joint axis: a deep neural network approach by Yin Guan, Xiaoqian Zhao, Yun Lu, Yue Zhang, Yan Lu, Yue Wang

“…Recent research indicates that gut microbiota might be pivotal in RA development through the “gut-joint axis,” presenting novel therapeutic possibilities.PurposeThis study seeks to explore the therapeutic potential of the traditional Chinese medicine (TCM) compound new bitongling (NBTL) for RA, with an emphasis on its capacity to regulate gut microbiota and suppress angiogenesis via the vascular endothelial growth factor (VEGF) signaling pathway.MethodsWe utilized a collagen-induced arthritis (CIA) rat model to assess the impact of NBTL. …”
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Association of Serum Phosphate and Related Factors in ESRD-Related Vascular Calcification by Cai-Mei Zheng, Kuo-Cheng Lu, Chia-Chao Wu, Yung-Ho Hsu, Yuh-Feng Lin

“…Risk factors for calcification are nowadays focused for the therapeutic prevention of vascular calcification with the hope of reducing cardiovascular complications.…”
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Foreword—Breaking barriers in chemical biology: the innovative tour de force of the ChemBio GDR by Lopez, Marie, Mileo, Elisabetta, Defrancq, Eric, Delmas, Agnès,  Vauzeilles, Boris, Guianvarc’h, Dominique, Biot, Christophe

“…Therefore, Chemical Biology has strong interactions with the design of therapeutic strategies, diagnosis, agrochemicals or Ecology.…”
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Misdiagnosed Uterine Rupture of an Advanced Cornual Pregnancy by Christian Linus Hastrup Sant, Poul Erik Andersen

“…Cornual pregnancy is a diagnostic and therapeutic challenge with potential severe consequences if uterine rupture occurs with following massive intraabdominal bleeding. …”
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A Novel Case of Symptomatic BK Viraemia in a Patient Undergoing Treatment for Hodgkin Lymphoma by Jacinta Perram, Jane Estell

“…This case highlights the importance of casting a wide diagnostic net for adverse events encountered with novel therapeutic agents or regimens.…”
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Colonoscopic Splenic Injury: A Simplified Radiologic Approach by Tara Chen, Qiu Tong, Alexander Kurchin

“…We discuss the diagnostic and therapeutic approach to colonoscopic splenic injury.…”
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Utilization of Liposuction for Delayed Morel-Lavallée Lesion: A Case Report and Review by Preston Gardner, Diana Flis, Kongkrit Chaiyasate

“…The objective in this review was to discuss the delayed presentation of a Morel-Lavallée lesion and operative utility of liposuction in the patient’s treatment and review literature with particular focus on diagnosis and therapeutic interventions. The reviewed case demonstrates the presentation and successful therapy of a young female presenting with a MLL and contour deformity.…”
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CD44: From diagnosis to therapy in the journey of oral cancer by Selvaraj Jayaraman, Vishnu Priya Veeraraghavan

“…. • Studying CD44's role in OSCC is vital for validating its potential as a prognostic marker and therapeutic target.…”
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Challenges and opportunities for digital twins in precision medicine from a complex systems perspective by Manlio De Domenico, Luca Allegri, Guido Caldarelli, Valeria d’Andrea, Barbara Di Camillo, Luis M. Rocha, Jordan Rozum, Riccardo Sbarbati, Francesco Zambelli

“…It enables the exploration of diverse therapeutic strategies and supports dynamic clinical decision-making through insights from network science, quantitative biology, and digital medicine.…”
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Targeting Acinetobacter baumannii resistance-nodulation-division efflux pump transcriptional regulators to combat antimicrobial resistance by Ruwani L. Wimalasekara, Dawn White, Ayush Kumar

“…This review explores the current understanding of these regulators, aiming to inspire strategies to combat bacterial resistance and improve therapeutic outcomes.…”
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Recombinant human erythropoietin, and myocardial and cerebral acute ischemia: implications for clinical use. by Rafael Alejandro Gómez Baute, Liermis Dita Salabert, Yaney González Yglesias, Tamara Guerra Alfonso, Maritza Cabrera Zamora

“…In the present review is rife with detail about these new features in the light of new discoveries and explores the therapeutic opportunities offered by these new scientific evidence.…”
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Diagnosis and behavior in autonomic trigeminal headaches by Erélido Hernández Valero, María Octavina Rodríguez Roque

“…In this paper we propose the most likely diagnosis and therapeutic to this nosologic entity…”
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Transfusion-Dependent Anemia in a Simultaneous Pancreas and Kidney Transplant Recipient by Jeevan Prakash Gopal, David Taube, John Martin, Simona Deplano, Saral Desai, Vassilios Papalois, Anand Sivaprakash Rathnasamy Muthusamy

“…We discuss the diagnostic difficulties and the therapeutic dilemma, along with the pitfalls in ascertaining the final diagnosis.…”
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Un exemple de créativité ordinaire au bénéfice d’une dynamique inclusive by Olivier Kheroufi-Andriot

“…A young child boarding in a Therapeutic, Educational and Pedagogical Institute (ITEP) is again enrolled in an elementary school class in the so-called "ordinary" school environment, and the purpose of this article is to highlight "little things » deployed by the actors registered in this situation of inclusion. …”
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