MicroRNAs in atrial fibrillation – have we discovered the Holy Grail or opened a Pandora’s box? by Alkora Ioana Balan, Alina Scridon

“…In clinical studies, miRNA changes have been associated with AF, whereas in experimental studies miRNA manipulation has emerged as a potential therapeutic approach. It would appear that, with the advent of miRNAs, we may have found the Holy Grail, and that efficient and personalized AF therapy may be one step away. …”
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Multi-target regulatory effects of rhaponticin in a rat model of hepatic fibrosis revealed by non-targeted metabolomics by Min Yang, Dihua Jiang, Longfei Huang, Tao Zhang, Wenfen Guo, Wenyan Lin, Jiali Zhao, Yunsheng Wei, Lang Peng, Yong-Jia Hao, Ying Zhou

“…The lack of preventive and therapeutic strategies has created an urgent need for effective anti-fibrosis agents. …”
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Dual-Modality Monitoring of Tumor Response to Cyclophosphamide Therapy in Mice with Bioluminescence Imaging and Small-Animal Positron Emission Tomography by Xibo Ma, Zhaofei Liu, Xin Yang, Qiujuan Gao, Shouping Zhu, Chenghu Qin, Kai Liu, Bo Zhang, Dong Han, Fan Wang, Jie Tian

“…The purpose of this study was to noninvasively monitor the therapeutic efficacy of cyclophosphamide (CTX) in a mouse model by dual-modality molecular imaging: positron emission tomography (PET) and bioluminescence imaging (BLI). …”
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Droplet microfluidic screening to engineer angiotensin-converting enzyme 2 (ACE2) catalytic activity by Evelyn F Okal, Philip A. Romero, Pete Heinzelman

“…This study leverages protein engineering to enhance ACE2’s therapeutic potential for treating conditions such as respiratory viral infections, acute respiratory distress syndrome, and diabetes. …”
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CONDITIONS OF SKIN AND INTESTINE MICROBIOTES IN PATIENTS WITH PSORIASIS by Ya.O. Yemchenko, K.E. Ishcheikin, I.P. Kaidashev, G.Yu. Morokhovets

“…Disorders in the regulation of skin microbiota may become a new therapeutic target in patients with psoriasis, and the restoration of symbiosis may increase the effectiveness of existing treatments. …”
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Discrepancies Between Bayesian Vancomycin Models Can Affect Clinical Decisions in the Critically Ill by Asad E. Patanwala, Danijela Spremo, Minji Jeon, Yann Thoma, Jan-Willem C. Alffenaar, Sophie Stocker

“…Overall, 52%, 42%, and 47% of the AUC24 values were therapeutic for the Goti, Colin, and Thomson models, respectively. …”
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New Insights in Genetic Cholestasis: From Molecular Mechanisms to Clinical Implications by Eva Sticova, Milan Jirsa, Joanna Pawłowska

“…This review summarises the current knowledge of the clinical manifestations, genetics, and molecular mechanisms of these diseases and briefly outlines the therapeutic options, both conservative and invasive, with an outlook for future personalised therapeutic strategies.…”
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Cannabis oil in treating Parkinson’s disease: improvement of motor and non-motor symptoms: a case report by C. T. M. I. Issa, R. D. Castro, K. L. G. D. Albuquerque

“…These compelling results suggest that cannabis oil may offer a valuable and effective therapeutic option for individuals with Parkinson's disease.…”
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The Pivotal Immunomodulatory and Anti-Inflammatory Effect of Histone-Lysine N-Methyltransferase in the Glioma Microenvironment: Its Biomarker and Therapy Potentials by Seidu A. Richard, Kuugbee D. Eugene

“…EZH2 is a promising therapeutic as well as prognostic biomarker for the treatment of glioma.…”
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A systematic review of progenitor survival and maturation in Parkinsonian models by Giulia Comini, Eilís Dowd

“…This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell–derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.…”
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Clinical Holistic Medicine: Avoiding the Freudian Trap of Sexual Transference and Countertransference in Psychodynamic Therapy by Søren Ventegodt, Isack Kandel, Joav Merrick

“…Sexual transference and countertransference can make therapy slow and inefficient when libidinous gratification becomes more important for both the patient and the therapist than real therapeutic progress. Sexual transference is normal when working with a patient's repressed sexuality, but the therapeutic rule of not touching often hinders the integration of sexual traumas, as this needs physical holding. …”
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Liver Fibrosis and Altered Matrix Synthesis by Katrin Neubauer, Bernhard Saile, Giuliano Ramadori

“…Based on this pathophysiological mechanism, therapeutic methods are developed to inhibit matrix synthesis or stimulate matrix degradation. …”
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Current smoking improves ulcerative colitis patients’ disease behaviour in the northwest of China by Huihong Zhai, Wenyu Huang, Aiqin Liu, Qianqian Li, Qian Hao, Ling Ma, Feng Yang, Shutian Zhang

“…Based on the Modified Mayo score, heavier smokers had lower scores than other smokers and non-smokers. For the therapeutic requirements, current smokers needed fewer corticosteroids than non-smokers (p = 0.048). …”
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Therapy with Interleukin-22 Alleviates Hepatic Injury and Hemostasis Dysregulation in Rat Model of Acute Liver Failure by Tariq Helal Ashour

“…The therapeutic efficacy of interleukin-22 (IL-22) on liver injury and hematological disturbances was studied in rat model of acute liver failure (ALF) induced by D-galactosamine/lipopolysaccharide (D-GalN/LPS). …”
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The possible effects of chili peppers on ADHD in relation to the gut microbiota by Yinyue Li, Jing Feng, GuangYao Ding, Lin Deng, Ying He, Qiongqiong Zhang, Jianhui Wang, Xia Chen

“…Among them, capsaicin (8-methyl N-vanillyl-6-noneamide, CAP), as a key active component of peppers, has been shown to have potential therapeutic effects on central nervous system (CNS) diseases such as Parkinson’s disease, epilepsy, and depression. …”
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[F]Fluoroethyltyrosine–Positron Emission Tomography-Based Therapy Monitoring after Stereotactic Iodine-125 Brachytherapy in Patients with Recurrent High-Grade Glioma by Nathalie L. Jansen, Bogdana Suchorska, Silke B. Schwarz, Sabina Eigenbrod, Juergen Lutz, Vera Graute, Peter Bartenstein, Claus Belka, Friedrich W. Kreth, Christian la Fougère

“…Serial FET-PET scans were performed prior to therapeutic intervention and at 3-month intervals during the first year after SBT. …”
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Morphometric evaluation of the anterior cranial fossa during the prenatal stage in humans and its clinical implications. by Wojciech Derkowski, Alicja Kędzia, Krzysztof Dudek, Michał Glonek

“…We hypothesized that the growth of the anterior cranial fossa is not uniform throughout fetal development and that changing geometric relationships are important for possible therapeutic interventions in cases of congenital defects. …”
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The usage of Bupivacaina as anesthetic agent in knee arthroscopy. by José Julio Ojeda González, Evangelina Dávila Cabo de Villa, Ana María Machado Consuegra, José Toledo Torres, Carlos M. Hernández

“…<strong>Introduction: </strong>Artroscopy of the knee is a procedure that is frequently developed as a diagnostic and therapeutic means in patients who suffer among other diseases, from chronic sinuvitis, lesions of the meniscus and adherence . …”
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Pair combinations of human monoclonal antibodies fully protected mice against bunyavirus SFTSV lethal challenge. by Bang Li, Xiang-Rong Qin, Jia-Chen Qu, Guan-du Wu, Wen-Kang Zhang, Ze-Zheng Jiang, Pan-Pan Liu, Ze-Min Li, Tian-Mei Yu, Chuan-Min Zhou, Yong-Jun Jiao, Xue-Jie Yu

“…In conclusion, our findings indicate that the pair combinations of hmAbs 1B2 and 4-5 or hmAbs 1B2 and 1F6 may serve as promising therapeutic drugs for treating SFTSV infection.…”
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Development of ¹¹¹In-Labeled Monoclonal Antibodies Targeting SFTSV Structural Proteins for Molecular Imaging of SFTS Infectious Diseases by SPECT by Takeshi Fuchigami, Mya Myat Ngwe Tun, Yusuke Tanahara, Kodai Nishi, Sakura Yoshida, Kazuma Ogawa, Morio Nakayama, Daisuke Hayasaka

“…Overall, [¹¹¹In]In-DTPA-N-mAb is a promising imaging agent for non-invasive visualization of SFTSV-infected sites and may aid in elucidating SFTS pathology and assessing therapeutic efficacy.…”
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