Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics by Haisong Li, Can Li, Cong Fu, Yizhuo Wang, Tingting Liang, Haitao Wu, Chenxi Wu, Chang Wang, Tianmeng Sun, Shuhan Liu

“…This review explores the biological mechanisms of NET formation, their interactions with NPs, and the therapeutic applications of NP-based drug delivery systems for modulating NETs. …”
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Implications of intratumoral microbiota in tumor metastasis: a special perspective of microorganisms in tumorigenesis and clinical therapeutics by Lei Zhang, Xichu Duan, Yanhua Zhao, Dejiu Zhang, Yuan Zhang

“…Tumor metastasis is the main cause of therapeutic failure and mortality in cancer patients. …”
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The burden of Alagille syndrome: uncovering the potential of emerging therapeutics – a comprehensive systematic literature review by Philip Bufler, Robin Howard, Lucia Quadrado, Guy Lacey, Jolan Terner-Rosenthal, Andrea Goldstein, Pamela Vig, Deirdre Kelly

Evolution of Alzheimer’s Disease Therapeutics: From Conventional Drugs to Medicinal Plants, Immunotherapy, Microbiotherapy and Nanotherapy by Emma Ortiz-Islas, Pedro Montes, Citlali Ekaterina Rodríguez-Pérez, Elizabeth Ruiz-Sánchez, Talía Sánchez-Barbosa, Diego Pichardo-Rojas, Cecilia Zavala-Tecuapetla, Karla Carvajal-Aguilera, Victoria Campos-Peña

“…Among the therapeutic alternatives, immunotherapy stands out, employing monoclonal antibodies to specifically target and eliminate toxic proteins implicated in AD. …”
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Advancing CNS Therapeutics: Enhancing Neurological Disorders with Nanoparticle-Based Gene and Enzyme Replacement Therapies by Liu S, Li H, Xi S, Zhang Y, Sun T

“…A major obstacle in treating these conditions is the blood-brain barrier (BBB), which restricts the passage of therapeutic agents to the brain. Nanotechnology, particularly the use of nanoparticles (NPs), offers a promising solution to this challenge. …”
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The emergence of cell-based protein arrays to test for polyspecific off-target binding of antibody therapeutics by Diana M. Norden, Carmen T. Navia, Jonathan T. Sullivan, Benjamin J. Doranz

“…Moreover, about 20% of therapeutic mAbs in clinical development and currently on the market display off-target binding. …”
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Structure-guided identification of mitogen-activated protein kinase-1 inhibitors towards anticancer therapeutics. by Md Nayab Sulaimani, Shazia Ahmed, Farah Anjum, Taj Mohammad, Anas Shamsi, Ravins Dohare, Md Imtaiyaz Hassan

“…The study highlights that these compounds could be explored further in preclinical and clinical investigations to develop anticancer therapeutics.…”
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L’imaginaire thérapeutique des chocs à l’insuline by Coline Fournout

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Diagnosis, treatment, and management of Mpox in urban Informal Settlements in Southwestern Nigeria: an ethnographic approach by Olufunke Adegoke, Megan Schmidt-Sane, Michael Kunnuji, Syed Abbas, Akanni Lawanson, Ayodele Jegede, Hayley MacGregor

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In vitro evaluation of hypochlorous acid-silver nanoparticle waterline disinfectant for dental unit waterline disinfection by Tingting Yin, Qiaowen Li, Huan Sun, Jin Zheng, Yuanyuan Wang, Yi Luo, Li Wang

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Research progress of femoral head necrosis in HIV-infected patients by Youhan Yang, Futao Ke, Zhengqi Pan, Liaobin Chen

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A screening setup to streamline in vitro engineered living material cultures with the host by Krupansh Desai, Shrikrishnan Sankaran, Aránzazu del Campo, Sara Trujillo

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Development of an algorithm impacting COPD care through personalized nutrition and IoT-based monitoring by Prachi Sharma, Mihir Gharia, Devina Aswal, Vishva Trivedi, Bhavnita Soni, Prerna Soni, Devesh Joshi, Dhvni Lalan, Vrushali Athavale, Irfan Shaikh, Koshy Jacob

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Tofacitinib Efficacy/Safety in Patients with Ankylosing Spondylitis by Baseline Body Mass Index: A Post Hoc Analysis of Phase 2/3 Trials by Hillary Norton, Paula Sliwinska-Stanczyk, Tomas Hala, Bassel El-Zorkany, Lori Stockert, Rajiv Mundayat, Lisy Wang, Christopher T. Ritchlin

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Neurological sequelae of long COVID: a comprehensive review of diagnostic imaging, underlying mechanisms, and potential therapeutics by Grant McGee Talkington, Grant McGee Talkington, Paresh Kolluru, Timothy E. Gressett, Timothy E. Gressett, Saifudeen Ismael, Umar Meenakshi, Mariana Acquarone, Rebecca J. Solch-Ottaiano, Amanda White, Blake Ouvrier, Blake Ouvrier, Kristina Paré, Nicholas Parker, Amanda Watters, Nabeela Siddeeque, Brooke Sullivan, Nilesh Ganguli, Victor Calero-Hernandez, Gregory Hall, Michele Longo, Gregory J. Bix, Gregory J. Bix, Gregory J. Bix, Gregory J. Bix

“…We lastly evaluate the clinical treatment landscape, scrutinizing the efficacy of various therapeutic strategies ranging from antivirals to anti-inflammatory agents in mitigating the multifaceted symptoms of LC.…”
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Anticonvulsant valproic acid and other short-chain fatty acids as novel anticancer therapeutics: Possibilities and challenges by Lipska Katarzyna, Gumieniczek Anna, Filip Agata A.

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Reducing off-target expression of mRNA therapeutics and vaccines in the liver with microRNA binding sites by Brian J. Parrett, Satoko Yamaoka, Michael A. Barry

“…Lipid nanoparticles (LNPs) are often liver tropic, presenting challenges for LNP-delivered mRNA therapeutics intended for other tissues, as off-target expression in the liver may increase side effects and modulate immune responses. …”
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ACE2 : S1 RBD Interaction-Targeted Peptides and Small Molecules as Potential COVID-19 Therapeutics by Lennox Chitsike, John Krstenansky, Penelope J. Duerksen-Hughes

“…The ACE2 and S1 RBD interaction, therefore, represents an attractive therapeutic intervention to prevent viral entry and spread. …”
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Cancer theragnostics: closing the loop for advanced personalized cancer treatment through the platform integration of therapeutics and diagnostics by Olga V. Sergeeva, Liang Luo, Anthony Guiseppi-Elie, Anthony Guiseppi-Elie, Anthony Guiseppi-Elie

“…Theragnostics, an integration of diagnostic and therapeutic capabilities into a single hybrid platform system, has the potential to address these challenges by enabling real-time monitoring of treatment response while allowing endogenously controlled personalized treatment adjustments. …”
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Advancements in Antioxidant-Based Therapeutics for Spinal Cord Injury: A Critical Review of Strategies and Combination Approaches by Yang-Jin Shen, Yin-Cheng Huang, Yi-Chuan Cheng

“…This review provides a comprehensive and critical evaluation of recent advancements in antioxidant-based therapeutic strategies for SCI, including natural compounds, RNA-based therapies, stem cell interventions, and biomaterial applications. …”
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