A Case of Large Perianal Mucinous Adenocarcinoma Arising from Recurrent Abscess and Complex Fistulae by Fahmi Pramaditto Azmi, Nur Afdzillah Abdul Rahman, Luqman Mazlan, Normala Basiron, Farrah-Hani Imran

“…Mucinous adenocarcinoma of the perianal region is an oncologic rarity posing a diagnostic and therapeutic dilemma for treating oncologists. This is due to the low number of reported cases, compounded by the lack of definitive therapeutic guidelines. …”
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The gut microbiota predicts and time-restricted feeding delays experimental colitis by Hannah K. Ruple, Eva Haasis, Anna Bettenburg, Carina Maier, Carolin Fritz, Laura Schüle, Sarah Löcker, Yvonne Soltow, Lynn Schintgen, Nina S. Schmidt, Celine Schneider, Axel Lorentz, W. Florian Fricke

“…Our findings provide perspectives for new diagnostic and TRF-based, therapeutic applications in IBD that should be further explored.…”
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Low power laser radiation treatment in patients with recurrent aphthous stomatitis by Yety Isabel Rosado Fernández, Edel Alejandro Fonte Vigo, Gilberto Salas Contreras, Nancy Díaz Canedo, Maricelys de la Caridad Hernández Cabeza, Gloria Barroso de Mazarredo

“…<br /><strong>Objective</strong>: to determine the therapeutic effect of treatment with low-power laser radiation in patients diagnosed with recurrent aphthous stomatitis.…”
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Employing the Oncolytic Vesicular Stomatitis Virus in Cancer Virotherapy: Resistance and Clinical Considerations by Alaa A. Abdelmageed, Stephen Dewhurst, Maureen C. Ferran

“…Several VSV-based phase I/II clinical trials show promise; however, addressing resistance and developing novel strategies to enhance therapeutic efficacy are essential for realizing the full potential of VSV oncolytic virotherapy. …”
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Neuroprotective Effects of Myrtle Berry By-Product Extracts on 6-OHDA-Induced Cytotoxicity in PC12 Cells by Debora Dessì, Giacomo Fais, Paolo Follesa, Giorgia Sarais

“…These results highlight the therapeutic promise of Myrtus extracts in mitigating neurodegenerative processes, paving the way for future interventions.…”
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Mechanistic relationship between obesity-induced inflammation triggering endothelial dysfunction and the initiation of atherosclerosis development by Richard L. Jayaraj, Elhadi H Aburawi

“…In addition, we are also exploring new therapeutic strategies to reverse ED to prevent CVD and MD. …”
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YTHDF2 in peritumoral hepatocytes mediates chemotherapy-induced antitumor immune responses through CX3CL1-mediated CD8+ T cell recruitment by Zhenyun Yang, Xin Wang, Yizhen Fu, Weijie Wu, Zili Hu, Qingyang Lin, Wei Peng, Yangxun Pan, Juncheng Wang, Jinbin Chen, Dandan Hu, Zhongguo Zhou, Li Xu, Yaojun Zhang, Jiajie Hou, Minshan Chen

“…The findings of this study provide valuable insights into the mechanism underlying the therapeutic benefits of targeting YTHDF2.…”
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First Clinical Nutrition Outpatient Consultation: A Review of Basic Principles in Nutritional Care of Adults with Hematologic Disease by Julia da Silva Goncalves dos Santos, Barbara de Farias Meirelles, Isabela de Souza da Costa Brum, Mariana Zanchetta, Bruna Xerem, Lucas Braga, Marcia Haiut, Renata Lanziani, Taha Hussein Musa, Karen Cordovil

“…The first nutrition consultation may represent investigative steps that help the clinical nutritionist in the management, allowing a longitudinal and specific nutritional therapeutic planning for patients assisted in large reference centers for hematological disease.…”
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MicroRNAs as Immunotherapy Targets for Treating Gastroenterological Cancers by Yixin Yang, Christopher Alderman, Ayoub Sehlaoui, Yuan Xiao, Wei Wang

“…Since the current targeted therapies provide limited benefit to the overall response and survival, there is an urgent need for developing novel therapeutic strategy to improve the outcome of gastroenterological cancers. …”
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Genetically modified chickens as bioreactors for protein-based drugs by Shujuan Meng, Aijun Miao, Sen Wu, Sen Wu, Xuguang Du, Xuguang Du, Fei Gao

“…This has paved the way for enhanced production of recombinant therapeutic proteins with desired glycosylation patterns and reduced immunogenic responses.…”
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Unraveling the Role of Ubiquitin-Conjugating Enzyme UBE2T in Tumorigenesis: A Comprehensive Review by Chang Gao, Yan-Jun Liu, Jing Yu, Ran Wang, Jin-Jin Shi, Ru-Yi Chen, Guan-Jun Yang, Jiong Chen

“…Such insights may pave the way for novel strategies in cancer diagnosis and treatment, enhancing our understanding of UBE2T’s role in cancer biology and supporting the development of innovative therapeutic approaches.…”
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Inhibition of MEK1 Signaling Pathway in the Liver Ameliorates Insulin Resistance by Atsunori Ueyama, Nobuhiro Ban, Masanori Fukazawa, Tohru Hirayama, Minako Takeda, Tatsuo Yata, Hiroyasu Muramatsu, Masaki Hoshino, Marii Yamamoto, Masao Matsuo, Yuka Kawashima, Tatsuhiko Iwase, Takehisa Kitazawa, Youichi Kushima, Yuichiro Yamada, Yoshiki Kawabe

“…Taken together, these results suggested that the MEK signaling pathway could be a novel therapeutic target for novel antidiabetic agents.…”
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Gene Expression Profiling in Lungs of Chronic Asthmatic Mice Treated with Galectin-3: Downregulation of Inflammatory and Regulatory Genes by Esther López, M. Paz Zafra, Beatriz Sastre, Cristina Gámez, Carlos Lahoz, Victoria del Pozo

“…These results suggest that negative regulation of SOCS1 and 3 following Gal-3 treatment could be a valuable therapeutic approach in allergic disease.…”
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Protective effect of compound K against podocyte injury in chronic kidney disease by maintaining mitochondrial homeostasis by Fugang Huang, Shuo Huang, Ke Sun, Yanhao Chen, Guanqun Xie, Jie Bao, Yongsheng Fan

“…Here, we unveil the profound therapeutic potential of CK in a folic acid (FA)-induced CKD mouse model, demonstrating its ability to restore renal function and mitigate podocyte injury. …”
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Exploring the Potential of SGLT-2 Inhibitors in Cancer Treatment: Mechanisms, Preclinical Findings, and Clinical Implications by Aldona Sokołowska, Klaudia Fikas, Kamil Chwaliszewski, Sebastian Samuła, Michał Mazur, Dorota Waz, Jakub Szarłowicz, Zofia Goliszek, Karolina Łucja Sobek, Wiktoria Tabin-Barczak

“…Conclusions SGLT-2 inhibitors represent a novel therapeutic strategy in oncology, with potential to improve outcomes in combination with traditional therapies. …”
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Impact of the −174 G > C IL-6 Polymorphism on Bioelectrical Parameters in Obese Subjects after Laparoscopic Adjustable Gastric Banding by Laura Di Renzo, Maria Grazia Carbonelli, Alessia Bianchi, Emidio Domino, Maria Rita Migliore, Guido Rillo, Leonardo Iacopino, Nicola Di Daniele, Antonino De Lorenzo

“…Recent data demonstrated that the −174 G>C IL-6 polymorphism may account for differences in the therapeutic response to laparoscopic adjustable gastric banding (LAGB) surgery. …”
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Metronomic Cyclophosphamide and Methotrexate Chemotherapy Combined with 1E10 Anti-Idiotype Vaccine in Metastatic Breast Cancer by Jorge L. Soriano, Noyde Batista, Eduardo Santiesteban, Mayté Lima, Joaquín González, Robin García, Yohanka Zarza, María V. López, Myriam Rodríguez, Jorge L. Loys, Narciso Montejo, Frank Aguirre, Amparo Macías, Ana M. Vázquez

“…The combination of metronomic chemotherapy with therapeutic vaccines might increase the efficacy of the treatment. …”
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7,8-Dihydroxyflavone Protects Nigrostriatal Dopaminergic Neurons from Rotenone-Induced Neurotoxicity in Rodents by Shuke Nie, Kai Ma, Mingkuan Sun, Matthew Lee, Yang Tan, Guiqin Chen, Zhentao Zhang, Zhaohui Zhang, Xuebing Cao

“…7,8-Dihydroxyflavone (7,8-DHF) is thought to be a promising therapeutic agent for various neurodegenerative diseases. …”
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Local Overexpression of Interleukin-11 in the Central Nervous System Limits Demyelination and Enhances Remyelination by Anurag Maheshwari, Kris Janssens, Jeroen Bogie, Chris Van Den Haute, Tom Struys, Ivo Lambrichts, Veerle Baekelandt, Piet Stinissen, Jerome J. A. Hendriks, Helena Slaets, Niels Hellings

“…Overall, we demonstrate that IL-11 is of therapeutic interest for MS and other demyelinating diseases by limiting demyelination and promoting remyelination.…”
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Advances in cardiac organoid research: implications for cardiovascular disease treatment by Ziteng Huang, Keran Jia, Yadan Tan, Yang Yu, Wudian Xiao, Xiangyu Zhou, Jingyan Yi, Chunxiang Zhang

“…Consequently, the development of accurate models that simulate cardiac function holds significant scientific and clinical value for both disease research and therapeutic interventions. Cardiac organoids, which are three-dimensional structures derived from the induced differentiation of stem cells, are particularly promising. …”
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