Nanostructured lipid carriers co-encapsulating Apigenin and Melatonin: An innovative strategy against cancer by Lorena Bonilla-Vidal, Marta Świtalska, Marta Espina, Joanna Wietrzyk, María Luisa García, Eliana B Souto, Anna Gliszczyńska, Elena Sánchez-López

“…This novel and natural treatment could open a new therapeutical window in cancer treatment.…”
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Production of Prodigiosin Using Tannery Fleshing and Evaluating Its Pharmacological Effects by C. Sumathi, D. MohanaPriya, S. Swarnalatha, M. G. Dinesh, G. Sekaran

“…The secondary metabolite was analyzed using ESI-MS, FTIR, and NMR. Therapeutic efficacy was assessed by in vitro anticancer studies. …”
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Epigenetic Properties of Compounds Contained in Functional Foods Against Cancer by Giulia Casari, Brenda Romaldi, Andrea Scirè, Cristina Minnelli, Daniela Marzioni, Gianna Ferretti, Tatiana Armeni

“…Therefore, to develop innovative therapeutic strategies, research for compounds able to modulate the complex epigenetic landscape of cancer is rapidly surging. …”
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Adipocytokines in Rheumatoid Arthritis: The Hidden Link between Inflammation and Cardiometabolic Comorbidities by Piero Ruscitti, Paola Di Benedetto, Onorina Berardicurti, Vasiliki Liakouli, Francesco Carubbi, Paola Cipriani, Roberto Giacomelli

“…Despite better recent therapeutic strategies improving long-term outcomes, RA is associated with a high rate of comorbidities, infections, malignancies, and cardiovascular disease (CVD). …”
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Silk-engineered bioactive nanoparticles for targeted alleviation of acute inflammatory disease via macrophage reprogramming by Renfeng Liu, Erkang Zhao, Yejing Wang, Hua Zuo, Lanlan Li, Qingyou Xia, Huawei He

“…Consequently, TPSN, characterized by its favorable protective effects and excellent biocompatibility, exhibits considerable promise as a therapeutic intervention for inflammation-related diseases. …”
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Development and Treatments of Inflammatory Cells and Cytokines in Spinal Cord Ischemia-Reperfusion Injury by Ping Zhu, Jia-xin Li, Masayuki Fujino, Jian Zhuang, Xiao-Kang Li

“…Hence, there is great potential of anti-inflammatory cytokine antagonist for therapeutic use of spinal cord IRI. We here review the mediators and several possibilities of treatment in spinal cord IRI.…”
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Islet organoids: a new hope for islet transplantation in diabetes by Xuemei Yu, Chengkong Liu, Zheng Kuang, Siyuan Song, Limin Tian, Yi Wang, Yi Wang

“…Islet transplantation offers a promising therapeutic strategy. However, it is limited by organ shortage globally and other risk factors. …”
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The structural basis of protective and nonprotective human monoclonal antibodies targeting the parainfluenza virus type 3 hemagglutinin-neuraminidase by Rose J. Miller, Ian A. Durie, Aaron D. Gingerich, Mohamed A. Elbehairy, Abigail G. Branch, Riley G. Davis, Nada Abbadi, Melinda A. Brindley, Jarrod J. Mousa

“…The potent Site 2-directed mAb demonstrated clinical efficacy in hamsters, reducing viral replication prophylactically and therapeutically. These findings advance our understanding of PIV3 immunity and underscore the significance of targeting HN for clinical therapeutic development against PIV3.…”
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Central amygdala neuroimmune signaling in alcohol use disorder by Mariam Melkumyan, Patrick A. Randall, Yuval Silberman

“…Current treatments for AUD, including FDA-approved medications such as naltrexone and acamprosate, have limited efficacy and compliance, underscoring the need for novel therapeutic approaches. The central amygdala (CeA) plays a crucial role in the development and maintenance of AUD, particularly aspects associated with stress and binge behaviors. …”
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Detection of The TNFSF Members BAFF, APRIL, TWEAK and Their Receptors in Normal Kidney and Renal Cell Carcinomas by Vassiliki Pelekanou, George Notas, Katerina Theodoropoulou, Marilena Kampa, Dimitrios Takos, Vassilia-Ismini Alexaki, Jelena Radojicic, Frank Sofras, Andreas Tsapis, Efstathios N. Stathopoulos, Elias Castanas

“…Therapeutic approaches targeting TNF-alpha have shown limited efficacy, while anti-TRAIL (TNFSF10) antibodies have shown enhanced activity. …”
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New therapies in pulmonary arterial hypertension: Recent insights by Giulia Guglielmi, Konstantinos Dimopoulos, S. John Wort

“…Collectively, these therapeutic approaches can be valuable in treating PAH by targeting multiple aspects of its pathogenesis, potentially resulting in improved clinical outcomes for patients affected by this debilitating, life-limiting condition.…”
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Insights into the molecular mechanisms and nanoparticle-based therapies for gastric cancer: A review by Smarika Chauhan, Eswar Marcharla, Sneha Hariharan, Saranya Vinayagam, Thanigaivel Sundaram, Priya SD, Swamynathan Ganesan, Maximilian Lackner

“…Nanoparticles enhance drug delivery in gastric cancer by enabling precise delivery to tumor sites, improving therapeutic precision, and reducing side effects. They also boost therapy outcomes by overcoming chemotherapy resistance and enabling co-delivery of multiple drugs. …”
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Metformin-induced mitophagy suppresses auditory hair cell apoptosis via AMPK pathway by Yifan Lai, Jiawei Qiu, Kuang Zheng, Xiang Li, Yinuo Lin, Zhengzheng Li, Haiqiu Sun

“…Overall, our results suggest that metformin may represent a promising and innovative therapeutic strategy for mitigating the onset of hearing loss.…”
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mRNA vaccines as cancer therapies by Shaoxiong Huang, Haiying Que, Manni Wang, Xiawei Wei, Yanjie Yin

“…This review provides an in-depth analysis of messenger RNA (mRNA) vaccines as a therapeutic approach for cancer immunotherapy, focusing on their molecular biology, classification, mechanisms, and clinical studies. …”
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Metal-organic framework (MOF)-bioactive glass (BG) systems for biomedical applications - A review by Andrada-Ioana Damian-Buda, Nariman Alipanah, Faina Bider, Orhan Sisman, Zuzana Neščáková, Aldo R. Boccaccini

“…Overall, this review highlights the current research directions and emerging trends in the synergistic use of MOFs and BGs for biomedical applications, which represents a novel strategy for developing a new family of advanced therapeutic materials.…”
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α-methyltryptophan-mediated protection against diabetic nephropathy in db/db mice as studied with a metabolomics approach by Aimin Cai, Dingchao Shen, Qiushuang Xiong, Jie Ding, Yang Ding, Xinlu Lin, Lijia Chen, Qing Yao, Qing Yao, Guangyong Lin, Ruijie Chen, Vadivel Ganapathy, Vadivel Ganapathy, Longfa Kou

“…These findings highlight the potential of α-MT as a promising therapeutic agent for diabetic nephropathy.…”
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Cupric Doping Hollow Prussian Blue Nanoplatform for Enhanced Cholesterol Depletion: a Promising Strategy for Breast Cancer Therapy and Metastasis Inhibition by Shuangqian Yan, Panpan Xue, Ying Sun, Tingjie Bai, Sijie Shao, Xuemei Zeng

“…Demonstrating therapeutic efficacy in both 4T1 tumor subcutaneous and metastasis mouse models, the study presents a direct and effective strategy for tumor therapy and metastasis inhibition through enhanced cholesterol depletion.…”
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Natural product virtual-interact-phenotypic target characterization: A novel approach demonstrated with Salvia miltiorrhiza extract by Rui Xu, Hengyuan Yu, Yichen Wang, Boyu Li, Yong Chen, Xuesong Liu, Tengfei Xu

“…Salvia miltiorrhiza (SM), a herb with recognized therapeutic potential against ischemic stroke (IS), was used to illustrate the workflow. …”
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Biological evaluation of novel 5-((1H-indol-3-yl) methyl)-2-(4-chlorobenzyl)-6-phenyl-imidazo[2,1-b][13,4]thiadiazole derivatives as novel BCL-2 specific inhibitors by Shivangi Sharma, Sadashivamurthy Shamanth, Humaira Siddiqua, Laijau Goyary, Kunigal S. Sagar, Susmita Kumari, Divya Sathees, Gudapureddy Radha, Bibha Choudhary, Sathees C. Raghavan, Kempegowda Mantelingu

“…Taken together, our results suggest that Disarib derivatives may have the potential to be developed as cancer therapeutic.…”
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Transcutaneous Electrical Acupoint Stimulation in Early Life Changes Synaptic Plasticity and Improves Symptoms in a Valproic Acid-Induced Rat Model of Autism by Xiaoxi Wang, Rui Ding, Yayue Song, Juan Wang, Chen Zhang, Songping Han, Jisheng Han, Rong Zhang

“…The therapeutic efficacy of TEAS was evaluated in the VPA model of ASD in the present study. …”
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