Nature’s magic: how natural products work hand in hand with mitochondria to treat stroke by Lin Cheng, Shangbin Lv, Chengkai Wei, Sucheng Li, Hao Liu, Yong Chen, Zhaoliang Luo, Hongyan Cui

“…Future research should further investigate the effectiveness and safety of these natural products in clinical applications, advancing their development as a new therapeutic strategy for stroke.…”
Get full text

Neurobiological Mechanisms Underlying Psychological Dysfunction After Brain Injuries by Prashin Unadkat, Tania Rebeiz, Erum Ajmal, Vincent De Souza, Angela Xia, Julia Jinu, Keren Powell, Chunyan Li

“…The review highlights promising therapeutic avenues for addressing injury-associated psychological dysfunction, emphasizing Nrf2, neuropeptides, and nonpharmacological therapies as multi-mechanistic interventions capable of modulating upstream mediators to address the complex interplay of factors underlying psychological dysfunction in brain injury. …”
Get full text

Role of physical activity in cardiovascular disease prevention: impact of epigenetic modifications by Yi Sun, Zuoying Peng, Hua Liang

“…This information may help guide future research efforts and improve our understanding of epigenetics as a therapeutic, prognostic, and diagnostic biomarker for CVD.…”
Get full text

Wharton’s Jelly Mesenchymal Stem Cell Administration Improves Quality of Life and Self-Sufficiency in Children with Cerebral Palsy: Results from a Retrospective Study by Dariusz Boruczkowski, Izabela Zdolińska-Malinowska

“…The aim of this paper was to describe the outcome of the therapeutic administration of allogenic mesenchymal stem cells obtained from Wharton’s jelly (WJ-MSCs) in children with cerebral palsy (CP) during a medical therapeutic experiment. …”
Get full text

Curcumin-enhanced NIR-II-responsive gold nanobipyramids for targeted HSP 90 inhibition by Zhenying Diao, Youcheng Liang, Yong Liu, Dou Zhang, Long Qiu, Jianbo Sun, Qiaoyou Lu, Yanlei Liu, Daxiang Cui, Ting Yin

“…Overall, this work provides a new therapeutic modality paradigm for potential NSCLC treatment on the basis of synergistic therapies.…”
Get full text

MicroRNA Deregulation in Anaplastic Thyroid Cancer Biology by Cesar Seigi Fuziwara, Edna Teruko Kimura

“…Therefore, molecular interference to restore the expression of tumor suppressor miRNAs, or to blunt overexpressed oncogenic miRNAs, is a promising therapeutic approach to ameliorate the treatment of ATC. …”
Get full text

Calpain 2 regulates IL-1α secretion and inhibits tumor development via modulating calpain 1 expression in the tumor microenvironment by Zuhairah Binte Hanafi, Yu Mei, Huey Yee Teo, Ying Zhu, Chew Chin Yong Lionel, Jing Wen Chiu, Jinhua Lu, Haiyan Liu

“…Tumor-promoting inflammation significantly impacts cancer progression, and targeting inflammatory cytokines has emerged as a promising therapeutic approach in clinical trials. Interleukin (IL)-1α, a member of the IL-1 cytokine family, plays a crucial role in both inflammation and carcinogenesis. …”
Get full text

Stem cell-derived exosome delivery systems for treating atherosclerosis: The new frontier of stem cell therapy by Hassan Tariq, Syeda Zunaira Bukhari, Ruibing An, Jian Dong, Ayesha Ihsan, Muhammad Rizwan Younis

“…In the end, a comparative and balanced viewpoint has been given regarding the current challenges and potential solutions to advance exosome engineering for cardiovascular therapeutic applications.…”
Get full text

Combined drug delivery and treatment monitoring using a single high frequency ultrasound system by Yesna O. Yildiz, Jia-Ling Ruan, Michael D. Gray, Luca Bau, Richard J. Browning, Christophoros Mannaris, Anne E. Kiltie, Borivoj Vojnovic, Eleanor Stride

“…Therefore, delivery and monitoring of therapeutic ultrasound typically requires two transducers to enable both treatment and imaging. …”
Get full text

Modulation of Adipose-Derived Mesenchymal Stem/Stromal Cell Transcriptome by G-CSF Stimulation by Luz M. Avila-Portillo, Fabio Aristizabal, Angela Riveros, Martin C. Abba, Diego Correa

“…Collectively, these data suggest a direct modulatory effect of G-CSF on ADSC function, potentially altering their therapeutic capacity and thus the design of future clinical protocols.…”
Get full text

Exploiting Cancer Dormancy Signaling Mechanisms in Epithelial Ovarian Cancer Through Spheroid and Organoid Analysis by Emily J. Tomas, Yudith Ramos Valdes, Jennifer Davis, Bart Kolendowski, Adrian Buensuceso, Gabriel E. DiMattia, Trevor G. Shepherd

“…Our findings emphasize the importance of studying cellular adaptations of EOC cells, as there may be different therapeutic targets depending on the step of EOC disease progression.…”
Get full text

Label-free proteomic analysis of Duchenne and Becker muscular dystrophy showed decreased sarcomere proteins and increased ubiquitination-related proteins by Juliana Cristina Tobar da Silva, Mariângela Rangel Alves Nogueira, Yara Martins da Silva, Fábio César Sousa Nogueira, Nathalie Henriques Silva Canedo, Katia Carneiro, Denise de Abreu Pereira

“…Since MDs currently have no cure, research has focused on identifying potential therapeutic targets to improve patients’ quality of life. …”
Get full text

RNA-seq and In Vitro Experiments Reveal the Protective Effect of Curcumin against 5-Fluorouracil-Induced Intestinal Mucositis via IL-6/STAT3 Signaling Pathway by Xuan-ying Wang, Bo Zhang, Yi Lu, Lu Xu, Yi-jie Wang, Bi-yu Cai, Qing-hua Yao

“…Taken together, these findings suggested that curcumin may be provided as a therapeutic agent in prevention and treatment of chemotherapy-induced IM.…”
Get full text

Mesenchymal stem cells enchanced by salidroside to inhibit ferroptosis and improve premature ovarian insufficiency via Keap1/Nrf2/GPX4 signaling by Lixuan Chen, Yingnan Wu, Tiying Lv, Rui Tuo, Yang Xiao

“…However, the efficacy of MSCs is still limited.Purpose This study aims to explain whether salidroside and MSCs combination is a therapeutic strategy to POI and to explore salidroside-enhanced MSCs inhibiting ferroptosis via Keap1/Nrf2/GPX4 signaling.Methods The effect of salidroside and MSCs on ovarian granular cells (GCs) was analyzed. …”
Get full text

Interprofessional approach to personalized medication management and therapy optimization in IBD care by Daniel Fleischmann, Benedicta Binder, Muriel Huss, Tanja Elger, Claudia Wolf, Johanna Loibl, Hauke Christian Tews, Arne Kandulski, Stephan Schmid, Martina Müller, Alexander Kratzer

“…Employing an IBD-specific questionnaire alongside the patients’ documented medication regimens enabled the identification and subsequent discussion of current therapeutic concerns and potential medication-related risks during follow-up consultations. …”
Get full text

Benefits of Dance Therapy in Overweight and Obese Women by Katia Rodríguez Palacios, Isaac Rodríguez Palacios, Lázaro Dionisio Rojas Matsuda, Yarisel López Pérez, Ismaray Sacerio González, Ivis Triana Oquendo

“…<strong>Background:</strong> therapeutic physical culture programs accompanied by adequate nutritional advice in groups of obese people, is a common practice to reduce excess weight in people. …”
Get full text

NEIL3 and TOP2A as key drivers of esophageal cancer through WNT signaling by Hui Li, Panpan Wang, Huijuan Chen, Yanyan Shao, Hui Luo

“…Targeting these molecules may offer promising therapeutic strategies for EC. …”
Get full text

Intravenous Administration of Adipose-Derived Stem Cell Protein Extracts Improves Neurological Deficits in a Rat Model of Stroke by Kai Zhao, Rui Li, Changcong Gu, Long Liu, Yulong Jia, Xize Guo, Wanping Zhang, Chunying Pei, Linlu Tian, Bo Li, Jianrong Jia, Huakun Cheng, Hongwei Xu, Lixian Li

“…While the injection of ADSC leads to a relatively mild but prolonged therapeutic effect, the administration of ADSC-E results in a fast and pronounced clinical improvement which was associated with a unique change in the molecular signature suggesting that potential mechanisms underlying different therapeutic approach may be different. …”
Get full text

Use of Magnetic Nanoparticles as Targeted Therapy: Theranostic Approach to Treat and Diagnose Cancer by Arif Malik, Tariq Tahir Butt, Sara Zahid, Fatima Zahid, Sulayman Waquar, Mahmood Rasool, Mahmood Husain Qazi, Aamer Mahmood Qazi

“…The metastasis of cancer epitomizes the diagnostic and therapeutic challenge as a result of cancer heterogeneity. …”
Get full text

Terminalia arjuna in Chronic Stable Angina: Systematic Review and Meta-Analysis by Navjot Kaur, Nusrat Shafiq, Harish Negi, Avaneesh Pandey, Srinivas Reddy, Harpreet Kaur, Neelima Chadha, Samir Malhotra

“…A number of experimental and clinical studies have been conducted to explore therapeutic potential of Terminalia arjuna in cardiovascular ailments specially in patients of coronary heart disease. …”
Get full text