Phytocannabinoids: a new frontier in Alzheimer’s disease management by Jagadeesh S. Rao

“…Individuals have utilized therapeutic cannabis-derived remedies for medicinal purposes. …”
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Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer by Daniela Trisciuoglio, Marta Di Martile, Donatella Del Bufalo

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Responsive afatinib treatment in high-grade salivary gland ductal carcinoma and NSCLC with uncommon EGFR mutations: Treatment outcomes by Sivakamavalli Jeyachandran

“…Ongoing research aims to optimize afatinib use in these contexts, refining treatment protocols and maximizing therapeutic efficacy.…”
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Quadriceps Activation After Anterior Cruciate Ligament Reconstruction: The Early Bird Gets the Worm! by Ayrton MOIROUX--SAHRAOUI, Florian FORELLI, Jean MAZEAS, Alexandre JM RAMBAUD, Andreas BJERREGAARD, Jérôme RIERA

“…These alterations contribute to the development of AMI. Therapeutic interventions aimed at addressing AMI encompass a multidimensional approach targeting pain reduction, inflammation management, proprioceptive training, and quadriceps activation. …”
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Endoscopic Band Ligation for Nonvariceal Bleeding: A Review by Sergio Zepeda-Gómez, Norman E Marcon

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Targeting NANOS1 in triple-negative breast cancer: synergistic effects of digoxin and PD-1 inhibitors in modulating the tumor immune microenvironment by Tangyi Wang, Yadian Lei, Jingwei Sun, Li Wang, Yuxin Lin, Zhijing Wu, Shoude Zhang, Chengzhu Cao, Chengzhu Cao, Chengzhu Cao, Haiyan Wang, Haiyan Wang, Haiyan Wang

“…Researchers may explore FDA-approved drugs targeting the potential target NANOS1 for TOE (Taraxacum officinale extract) treatment to develop innovative therapeutic strategies. In this context, Dig (Digoxin) and AA (Algestone acetophenide) have been identified as potential drug candidates for further exploration of their therapeutic effects and application potential in targeting NANOS1.MethodsRNA sequencing (RNA-seq) was employed to identify potential targets for triple-negative breast cancer (TNBC) from TOE. …”
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Study of anti-inflammatory, antioxidant, antimicrobial and mineralizing effects of an N-isopropenylimidazole zinc metal complex derivative in experimental endodontic-periodontal le... by Pavel A. Galenko-Yaroshevsky, Ivan I. Pavlyuchenko, Olga V. Shelemekh, Boris A. Trofimov, Lidiya N. Parshina, Viktor L. Popkov, Svetlana A. Demyanenko, Oleg V. Tsymbalov, Andrey V. Zadorozhniy, Anait V. Zelenskaya, Irina B. Nektarevskaya, Alina V. Sergeeva, Nikolay E. Korovaykin, Svetlana A. Lebedeva

“…Conclusion: The presented results of studying Pilim-1 and its combination with M-D indicate their high therapeutic efficiency, especially when using the latter in the experimental EPL in rats, which makes it possible to consider Pilim-1 and Pilim-1 + M-D as potential therapeutic agents to treat EPL.…”
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Role of laparoscopic surgery in blunt abdominal trauma; retrospective analysis in a tertiary trauma center by Rifan Alyami, Ahad E. Alotaibi, Leen Almohayya, Ajyad Al Jawad, Raghad Almukhayzim, Abeer Alhoumedan, Rakan S. Aldusari

“…Following surgery, 78.4% of the patients underwent therapeutic procedures after laparotomy, while 37.8% received therapeutic interventions post-laparoscopy. …”
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A bibliometric analysis of the top 100 most cited articles on corticospinal tract regeneration from 2004 to 2024 by Saijilafu, Saijilafu, Ling-Chen Ye, Huanyi Li, Haokun Li, Xinyi Lin, Kehui Hu, Zekai Huang, Chimedragchaa Chimedtseren, Linjun Fang, Saijilahu, Ren-Jie Xu

“…The implementation of these strategies promises to enhance therapeutic outcomes and the quality of life of patients with spinal cord injury (SCI).…”
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Neuromodulatory Effects of Transcranial Direct Current Stimulation on Motor Excitability in Rats by Hui-Hua Liu, Xiao-Kuo He, Hsin-Yung Chen, Chih-Wei Peng, Alexander Rotenberg, Chi-Hung Juan, Yu-Cheng Pei, Hao-Li Liu, Yung-Hsiao Chiang, Jia-Yi Wang, Xiao-Jun Feng, Ying-Zu Huang, Tsung-Hsun Hsieh

“…Transcranial direct current stimulation (tDCS) is a noninvasive technique for modulating neural plasticity and is considered to have therapeutic potential in neurological disorders. For the purpose of translational neuroscience research, a suitable animal model can be ideal for providing a stable condition for identifying mechanisms that can help to explore therapeutic strategies. …”
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Investigating intra‐tumoural heterogeneity and microenvironment diversity in primary cardiac angiosarcoma through single‐cell RNA sequencing by Jingyuan Huo, Zhen Wang, Wenting Zhao, Miao Chen, Haoyang Li, Fengpu He, Xiao Tian, Yaqi Ma, Firyuza Husanova, Liang Ma, Yiming Ni, Hongda Ding, Weidong Li, Hongfei Xu

“…These findings underscore the importance of a multifaceted therapeutic approach for addressing the challenges posed by PCAS's heterogeneity and immune evasion. …”
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Update on Myopia Risk Factors and Microenvironmental Changes by Valeria Coviltir, Miruna Burcel, Alina Popa Cherecheanu, Catalina Ionescu, Dana Dascalescu, Vasile Potop, Marian Burcea

“…The focus of this update is to emphasize the recent advances in the pathogenesis and various molecular key approaches associated with myopia in order to reveal new potential therapeutic targets. We review the current evidence for its complex genetics and evaluate the known or candidate genes and loci. …”
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Determinants of Antiviral Treatment Initiation in a Hepatitis C-infected Population Benefiting from Universal Health Care Coverage by Romain Moirand, Marc Bilodeau, Suzanne Brissette, Julie Bruneau

“…BACKGROUND AND AIMS: In view of increasing therapeutic efficacy, the delivery of hepatitis C virus (HCV) antiviral treatment is expected to increase. …”
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Endoscopic Transcolonic Catheter-Free Pelvic Abscess Drainage by Halil Alis, Aliye Soylu, Kemal Dolay, Ersan Aygun

“…Natural orifice transluminal endoscopic surgery is a novel therapeutic method in development that uses different routes of surgical approach. …”
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The oral-gut microbiota axis: a link in cardiometabolic diseases by Qian Xu, Wenting Wang, Yiwen Li, Jing Cui, Mengmeng Zhu, Yanfei Liu, Yue Liu

“…Understanding these interactions provides insights for innovative therapeutic strategies to prevent and manage cardiometabolic diseases.…”
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AZD8055 Is More Effective Than Rapamycin in Inhibiting Proliferation and Promoting Mitochondrial Clearance in Erythroid Differentiation by Qian Liu, Tao Hao, Ze Lin, Yipeng Fang, Lei Li, Daqi Huang, Jianbo Wu, Yanchao Zhao, Xin Zhang

“…Conclusion: AZD8055 is more effective than rapamycin in inhibiting proliferation and promoting mitochondrial clearance in erythroid differentiation, which might provide us one more therapeutic option other than rapamycin for ineffective erythropoiesis treatment in the future. …”
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The Controversial Role of Microglia in Malignant Gliomas by Jun Wei, Konrad Gabrusiewicz, Amy Heimberger

“…Here, we review and discuss this duality and the potential therapeutic strategies that may inhibit their glioma-supportive and propagating functions.…”
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Hearing Loss and Kidney Dysfunction: Finding a Unifying Diagnosis by Praveena Iruku, Puja Karanth, Hannah Tiu, Charity Kankam, Khaldoon Shaheen

“…We provide diagnostic, therapeutic, and prognostic keys to microscopic polyangiitis.…”
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Adenosine A2A Receptors Modulate Acute Injury and Neuroinflammation in Brain Ischemia by Felicita Pedata, Anna Maria Pugliese, Elisabetta Coppi, Ilaria Dettori, Giovanna Maraula, Lucrezia Cellai, Alessia Melani

“…Recently, adenosine A2A receptor emerged as a potential therapeutic attractive target in ischemia. Ischemia is a multifactorial pathology characterized by different events evolving in the time. …”
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San-Huang-Yi-Shen Capsule Ameliorates Diabetic Kidney Disease through Inducing PINK1/Parkin-Mediated Mitophagy and Inhibiting the Activation of NLRP3 Signaling Pathway by Hanzhou Li, Yuansong Wang, Xiuhai Su, Qinghai Wang, Shufang Zhang, Wenjuan Sun, Tianyu Zhang, Mengxue Dong, Zhaiyi Zhang, Shuquan Lv

“…In conclusion, our study demonstrated the therapeutic effects of SHYS on DKD. Additionally, our results indicated that SHYS promoted PINK1/Parkin-mediated mitophagy and inhibited NLRP3 inflammasome activation to improve mitochondrial injury and inflammatory responses.…”
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