BRAF V600E-Negative Hairy Cell Leukaemia by Stephen E. Langabeer, David O'Brien, Anthony M. McElligott, Michelle Lavin, Paul V. Browne

“…The diagnostic and therapeutic implications are discussed.…”
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The Pharmacology of Acute Lung Injury in Sepsis by Brian Michael Varisco

“…In this paper, we discuss the epidemiology and pathophysiology of ALI, commonly employed pharmacologic and nonpharmacologic treatments, and innovative therapeutic modalities that will likely be the focus of future trials.…”
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Wrong-route drug administration errors: A review of the literature by J Taylor, M Blockman

“…This narrative review aims to explore the pathophysiological mechanisms underlying such errors and investigate preventive strategies and potential therapeutic options. …”
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Novel t(5;19) Translocation in a Patient with PDGFRB Associated Chronic Leukemia: Implications for Treatment Strategy by Joel D. Provenzano, J. Phillip Kuebler

“…This case demonstrates the possibility for lower therapeutic doses of imatinib mesylate than previously reported, in order to control leukocyte counts and reverse the genetic mutation.…”
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Eighth Joint National Committee: Other Controversial Issues by Alberto Morales Salinas, Marcelina González García, Belkis Hernández Mesa, Kenia Rivera Jiménez

“…Now, we will briefly present some considerations on other controversial issues of the Eighth Joint National Committee, such as the methodology used and the increased therapeutic goal in patients over 60 years old.…”
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Treatment Dilemmas in a Young Man Presenting with Narcolepsy and Psychotic Symptoms by Victoria Fernandez, Sharon Davies, Nicola Walters

“…Our report illustrates the relevance of a thorough differential diagnosis as well as the need to explore treatment avenues based on the evidence available for both narcolepsy and psychosis symptoms to try and maximise the therapeutic impact.…”
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Characteristics of tongue coating microbiota in diabetic and non-diabetic kidney patients receiving hemodialysis by Qiang Luo, Siyuan Chu, Yongqun Wu, Lingling Jin, Rui Liu, Yulin Xu, Yina Yu, Yawei Jin, Luckress Ornelle Edouarda Phyfamin Houndekon, Heshen Hu, Yvchen Zou, Hao Huang, Haimin Chen

“…Abstract Background Tongue-coating microbiota, especially known as the tongue microbiome, holds significant value as both a prospective clinical diagnostic biomarker and therapeutic target, which plays a crucial role in the oral microecological health. …”
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Safety and efficacy of mesenchymal stromal cells mitochondria transplantation as a cell-free therapy for osteoarthritis by Ana Maria Vega-Letter, Cynthia García-Guerrero, Liliana Yantén-Fuentes, Carolina Pradenas, Yeimi Herrera-Luna, Eliana Lara-Barba, Felipe A. Bustamante-Barrientos, Masyelly Rojas, María Jesús Araya, Nicole Jeraldo, Constanza Aros, Francisca Troncoso, Daniela Poblete, Angela Court, Alexander Ortloff, Jose Barraza, Francesca Velarde, Carlos Farkas, Claudio Carril, Noymar Luque-Campos, Gonzalo Almarza, Maximiliano Barahona, Jose Matas, Lucas Cereceda, Rocío Lorca, Jorge Toledo, Karina Oyarce, Rolando Vernal, Andrés Caicedo, Andrea del Campo, Yessia Hidalgo, Roberto Elizondo-Vega, Farida Djouad, Maroun Khoury, Fernando E. Figueroa, Patricia Luz-Crawford

“…Furthermore, the transcriptional changes following mitochondrial uptake by chondrocytes were evaluated using an Affymetrix analysis, Lastly, the dose dependence therapeutic efficacy, biodistribution and immunogenicity of Mito-MSC were assessed in vivo, through an intra-articular injection in male C57BL6 mice in a collagenase-induced OA (CIOA) model. …”
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Metabolic Profiling by UPLC–Orbitrap–MS/MS of Liver from C57BL/6 Mice with DSS-Induced Inflammatory Bowel Disease by Zhongquan Xin, Zhenya Zhai, Hongrong Long, Fan Zhang, Xiaojun Ni, Jinping Deng, Lunzhao Yi, Baichuan Deng

“…Liver disorder often occurs in patients with inflammatory bowel disease (IBD); however, the changes in IBD-induced liver disorder at the intrinsic molecular level (chiefly metabolites) and therapeutic targets are still poorly characterized. …”
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Mechanical and Pharmacological Revascularization Strategies for Prevention of Microvascular Dysfunction in ST-Segment Elevation Myocardial Infarction: Analysis from Index of Microc... by Ji-Hun Jang, Man-Jong Lee, Kyu-Yong Ko, Jin-Hee Park, Yong-Soo Baek, Kwon Sung-Woo, Sung-Hee Shin, Seong-Ill Woo, Dae-Hyeok Kim, Young Ju Suh, Jun Kwan, Sang-Don Park

“…Microvascular dysfunction (MVD) after STEMI is correlated with infarct size and poor long-term prognosis, and the IMR is a useful analytical method for the quantitative assessment of MVD. However, therapeutic strategies that can reliably reduce MVD remain uncertain. …”
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Chinese patent medicine tongxinluo capsule as a supplement to treat chronic coronary syndromes: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials by Shi-Bing Liang, Shi-Bing Liang, Shi-Bing Liang, Yi-Fei Wang, Yi-Fei Wang, Yi-Fei Wang, Zhen-Chao Niu, Zhen-Chao Niu, Yu-Fei Li, Hui-Min Zheng, Hui-Min Zheng, Jia-Ming Huan, Jie Yuan, Nicola Robinson, Nicola Robinson, Jian-Ping Liu, Yun-Lun Li, Yun-Lun Li, Yun-Lun Li

“…Tongxinluo capsules (TXL) are widely used in China for treating CCS.ObjectivesTo systematically evaluate the therapeutic effects and safety of adding TXL to Western medical treatment (WM) for CCS.MethodsWe searched PubMed, Cochrane Library, CNKI, VIP, and Wanfang databases up to August 2024 for randomized controlled trials (RCTs) investigating the therapeutic effects and safety of combining TXL with WM compared to WM alone for CCS. …”
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CSNK1E is involved in TGF-β1 induced epithelial mesenchymal transformationas and related to melanoma immune heterogeneity by Wangbing Hong, Xin Wang, Xinyu Huang, Pengfei Chen, Yifan Liu, Ziying Zheng, Xin You, Yinghua Chen, Zengxin Xie, Gongnan Zhan, Heping Huang

“…Identifying novel biomarkers and therapeutic targets is critical for improving the prognosis and treatment of MM.MethodsIn this study, we analyzed the expression patterns of WNT signaling pathway genes in MM and explored their potential mechanisms. …”
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Hydrogen Sulfide Promotes Functional Endometrium Recovery via Regulating Pyroptosis in Severe Endometrial Injury: A Prospective Laboratory Based Randomized Control Trial by Haiyan Shan, Mingyuan Xu, Jie Ni, Ling Zhou, Mengchun Xue, Jun Xue, Xiaohuan Yuan, Luyang Tao, Mingyang Zhang, Hong Zhang

“…Conclusions: This study confirms the therapeutic efficacy of H2S in facilitating the recovery of injured endometrium and revealed its potential therapeutic mechanism, offering a promising therapeutic avenue for patients with severe endometrial injury.…”
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A novel gene signature for predicting outcome in colorectal cancer patients based on tumor cell-endothelial cell interaction via single-cell sequencing and machine learning by Lina Pang, Qingxia Sun, Wenyue Wang, Mingjie Song, Ying Wu, Xin Shi, Xiaonan Shi

“…Moreover, our findings emphasize the importance of considering tumor-endothelial cell interactions in cancer prognosis, providing insights for future therapeutic interventions targeting these interactions.…”
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Predictors of direct oral anticoagulant concentrations in the trauma population by Laura Adams, Alan M Smith, Louis Perkins, Dmitri Lerner, Jarrett Santorelli, Leslie Kobayashi

“…In total, 39% of patients had therapeutic and 20% had supratherapeutic anti-Xa levels. …”
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Identification of promising SARS-CoV-2 main protease inhibitor through molecular docking, dynamics simulation, and ADMET analysis by Ganesh Sharma, Neeraj Kumar, Chandra Shekhar Sharma, Taha Alqahtani, Yewulsew Kebede Tiruneh, Sharifa Sultana, Gabriel Vinícius Rolim Silva, Gabriela de Lima Menezes, Magdi E. A. Zaki, Jonas Ivan Nobre Oliveira

“…These results support the further development of 4896 − 4038 as a promising therapeutic agent in the fight against COVID-19 that warrants experimental validation and clinical investigation.…”
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Cytomegalovirus Genetic Diversity and Evolution: Insights into Genotypes and Their Role in Viral Pathogenesis by Cristina Venturini, Judith Breuer

“…Understanding CMV’s genetic diversity and evolutionary dynamics is crucial for elucidating its pathogenesis and developing effective therapeutic interventions. This review provides a comprehensive examination of CMV’s genetic diversity and evolution, focussing on the role of different genotypes in viral pathogenesis.…”
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Primary Cutaneous Mantle Cell Lymphoma: A Case Report by L. D. Mazzuoccolo, G. A. Castro Perez, I. Sorin, A. I. Bravo

“…Overexpression of cyclin D1 is pathognomonic of this condition, and surgery and radiation therapy are the most common therapeutic options. In this case, we describe the clinical, histopathological, immunohistochemical, and molecular characteristics of a new case of primary cutaneous MCL.…”
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Clinical Practice Guidelines for Exogenous Poisoning. by Alexis Díaz Mesa, Eddy Pereira Valdés, Alba Enseñat Álvarez, Carlos Alberto Rodríguez Armada

“…It includes the classification of toxic substances, clinical diagnosis (main syndromes), and description of therapeutic variations (vital support, antidotes, absorption measurements and increase of elimination and depuration of the toxic substance). …”
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A Great Masquerader: Nasal Type, Extranodal Natural Killer/T-cell Lymphoma Presenting as Recalcitrant Bacterial Sinusitis and Periorbital Cellulitis by Zaw Min, Nitin Bhanot

“…A high index of clinical suspicion of nasal ENKL should be raised when there is inadequate clinical response despite appropriate therapeutic intervention of sinusitis. Biopsy would be warranted and crucial in those instances to make an accurate and timely diagnosis.…”
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