Emerging Strategies for Revascularization: Use of Cell-Derived Extracellular Vesicles and Artificial Nanovesicles in Critical Limb Ischemia by Vijay Murali Ravi Mythili, Ramya Lakshmi Rajendran, Raksa Arun, Vasanth Kanth Thasma Loganathbabu, Danyal Reyaz, ArulJothi Kandasamy Nagarajan, Byeong-Cheol Ahn, Prakash Gangadaran

“…Critical limb ischemia (CLI) poses a substantial and intricate challenge in vascular medicine, necessitating the development of innovative therapeutic strategies to address its multifaceted pathophysiology. …”
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Mesenchymal stromal cell-derived extracellular vesicles as nanotherapeutics for concanavalin a-induced hepatitis: modulating the gut‒liver axis by Fan Yang, Beibei Ni, Xiaoqi Liang, Yizhan He, Chao Yuan, Jiajie Chu, Yiju Huang, Hongyu Zhong, Li Yang, Jianxi Lu, Yan Xu, Qi Zhang, Wenjie Chen

“…Abstract Background As cell-free nanotherapeutics, extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) have shown potential therapeutic action against liver diseases. However, their effects on autoimmune hepatitis (AIH) are not yet well understood. …”
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Treatment with the CCR5 antagonist OB-002 reduces lung pathology, but does not prevent disease in a Syrian hamster model of SARS-CoV-2 infection. by Bryce M Warner, Robert Vendramelli, Amrit S Boese, Jonathan Audet, Nikesh Tailor, Courtney Meilleur, Nathan Glowach, Marnie Willman, Thang Truong, Estella Moffat, Kevin Tierney, Beata Kosak, Irfan Dhanidina, Jarret Engstrom, Bozena Korczak, Ian McGowan, Carissa Embury-Hyatt, Darwyn Kobasa

“…Here we evaluated whether OB-002, an analog of human CCL5 and a potent antagonist of CCR5, provides therapeutic benefit in SARS-CoV-2 infected Syrian hamsters. …”
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A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma by Josefina Navarrete-Solís, Juan Pablo Castanedo-Cázares, Bertha Torres-µlvarez, Cuauhtemoc Oros-Ovalle, Cornelia Fuentes-Ahumada, Francisco Javier González, Juan David Martínez-Ramírez, Benjamin Moncada

“…Objective. To evaluate the therapeutic effect of topical niacinamide versus hydroquinone (HQ) in melasma patients. …”
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A multifunctional mesoporous silica drug delivery nanosystem that ameliorates tumor hypoxia and increases radiotherapy efficacy by Yanhong Chu, LiFeng Wang, Yaohua Ke, Xiaoyu Feng, Wenmei Rao, Wei Ren, Kai Xin, Yan Wang, Lixia Yu, Baorui Liu, Qin Liu

“…These attributes collectively augmented the therapeutic efficacy of RT by alleviating hypoxia and immunosuppression. …”
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Effects of natural products on macrophage immunometabolism: A new frontier in the treatment of metabolic diseases by Jiani Li, Chen Guo, Xiaofei Yang, Weinan Xie, Wenjing Mi, Chenglong Hua, Cheng Tang, Han Wang

“…This review aims to elucidate the metabolic regulation of the immune system, analyze metabolic alterations in macrophage associated with metabolic diseases, and summarize the beneficial roles of natural products in immunometabolism, providing novel insights for the prevention and therapeutic management of metabolic diseases.…”
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The Role of Interferon Regulatory Factor-1 (IRF1) in Overcoming Antiestrogen Resistance in the Treatment of Breast Cancer by J. L. Schwartz, A. N. Shajahan, R. Clarke

“…By understanding IRF1 signaling in the context of endocrine responsiveness, we may be able to develop novel therapeutic strategies and better predict how patients will respond to endocrine therapy.…”
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Molecular mechanisms of mTOR-mediated cisplatin response in tumor cells by Amirhosein Maharati, Yasamin Rajabloo, Meysam Moghbeli

“…However, CDDP resistance is a frequent therapeutic challenge that reduces prognosis in cancer patients. …”
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Colon-targeted engineered postbiotics nanoparticles alleviate osteoporosis through the gut-bone axis by Tingting Yu, Rushui Bai, Zeming Wang, Yuting Qin, Jingwei Wang, Yaohua Wei, Ruifang Zhao, Guangjun Nie, Bing Han

“…Specifically, the treatment of engineered postbiotics nanoparticles can also improve the quality and quantity of bone with restoration of deteriorative mechanical properties, which indicating a therapeutic potential on fracture prevention. This study provides valuable insights into the gut-bone axis and establishes a promising and safe therapeutic strategy for osteoporosis.…”
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Efficacy of Rituximab in a Systemic Lupus Erythematosus Patient Presenting with Diffuse Alveolar Hemorrhage by Gabriela Montes-Rivera, Grissel Ríos, Luis M. Vilá

“…This case, together with other reports, suggests that rituximab is an effective therapeutic option for DAH in SLE.…”
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Immunomodulatory Properties of HLA-G in Infectious Diseases by Laurence Amiot, Nicolas Vu, Michel Samson

“…We also discuss the cellular source of HLA-G, according to the type of infection and the potential role of HLA-G. New therapeutic approaches based on synthetic HLA-G-derived proteins or antibodies are emerging in mouse models of cancer or transplantation, and these new therapeutic tools may eventually prove useful for the treatment of infectious diseases.…”
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Muscle Satellite Cells: Exploring the Basic Biology to Rule Them by Camila F. Almeida, Stephanie A. Fernandes, Antonio F. Ribeiro Junior, Oswaldo Keith Okamoto, Mariz Vainzof

“…Every phase of satellite cell activity is highly regulated and orchestrated by many molecules and signaling pathways; the elucidation of players and mechanisms involved in satellite cell biology is of extreme importance, being the first step to expose the crucial points that could be modulated to extract the optimal response from these cells in therapeutic strategies. Here, we review the basic aspects about satellite cells biology and briefly discuss recent findings about therapeutic attempts, trying to raise questions about how basic biology could provide a solid scaffold to more successful use of these cells in clinics.…”
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A Case of Subacute Cutaneous Lupus Erythematosus in a Patient with Mixed Connective Tissue Disease: Successful Treatment with Plasmapheresis and Rituximab by M. Fantò, S. Salemi, F. Socciarelli, A. Bartolazzi, G. A. Natale, I. Casorelli, A. Pavan, S. Vaglio, R. Di Rosa, R. D'Amelio

“…Subsequently, the patient was treated with three cycles of therapeutic plasma exchange (TPE) followed, one month after the last TPE, by the anti-CD20 antibody Rituximab (RTX) (375 mg/m2 weekly for 4 weeks). …”
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Malignant Pleural Effusion: Diagnosis and Management by Lucía Ferreiro, Juan Suárez-Antelo, José Manuel Álvarez-Dobaño, María E. Toubes, Vanessa Riveiro, Luis Valdés

“…Studies are contributing evidence on an increasing number of therapeutic options (therapeutic thoracentesis, thoracoscopic pleurodesis or thoracic drainage, indwelling pleural catheter, surgery, or a combination of these therapies). …”
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Microbial boundaries in peri-implantitis: a review of pathogen-related advances by Ehab Qasim Talib, Ghada Ibrahim Taha, Dhuha Mahmood Ali, Sahar Hashim Al-Hindawi, Fadia Abd Almuhsin Al-Khayat, Israa Amer Hasan

“…It covers a range of therapeutic approaches including surgical and non-surgical techniques as well as strategies stressing host-modification and photodynamic treatment. …”
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Comparison of steroid and platelet-rich plasma (prp) applications in the treatment of collagenase induced tendinopathy in rabbit by Nuriza Zamirbekova, Nuri Yavru

“…Rabbits were euthanized 3, 6, and 8 weeks after the therapeutic injections. The degree of histopathological degeneration of the tendons was made according to the Modified Movin scoring.…”
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Ethnomedicinal understandings and pharmacognosy of Dischidia (Apocynaceae: Asclepiadoideae): A potential epiphytic genus by Gitartha Saikia, Nilakshee Devi

“…Till hitherto, 21 bioactive compounds have been isolated from four species of Dischidia. The therapeutic potentialities of the documented bioactive compounds are boon with 18 different kinds of healing activities with the discovery of novel chemical compounds makes Dischidia as a potential and promising epiphytic genus of the Plant Kingdom.…”
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QSAR modeling of benzoquinone derivatives as 5-lipoxygenase inhibitors by T.K. Shameera Ahamed, Vijisha K. Rajan, K. Muraleedharan

“…This has increased the search for efficient therapeutic agents for protein 5-LOX and this process is now primarily based on QSAR. …”
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Treatment Approaches to Speech Sound Disorders: A Scoping Review by Hafsa Noreen, Nazia Mumtaz, Ghulam Saqulain

“… Objective: The objective was to highlight and review different therapeutic approaches to cater to speech sound disorders in Pakistan. …”
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The chemistry of gut microbiome in health and diseases by Agnes Wei Yin Lau, Loh Teng-Hern Tan, Nurul-Syakima Ab Mutalib, Sunny Hei Wong, Vengadesh Letchumanan, Learn-Han Lee

“…With a better understanding of this relationship, we will investigate the potential methods to modify the gut flora as the background of developing therapeutic options. There are already some therapeutic options such as prebiotics, probiotics, and fecal transplantation, but their clinical use is limited and restricted. …”
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