Prehospital ultrasound from a neurological point of view by Lučić-Prokin Aleksandra, Ružička-Kaloci Svetlana, Živanović Željko, Popović Nemanja, Vlahović Dmitar

“…There is evidence that POCUS improves the accuracy of diagnosis, the initial therapeutic approach and the appropriate decision to transport the patient to the appropriate health facility. …”
Get full text

DRAM1 enhances the proliferation and metastasis of gastric cancer through the PI3K/AKT/mTOR signaling pathway and energy metabolism by Xinrong Wu, Yifan Li, Weiwei Wang, Jiale Xu, Bei Zhao, Wenqi Sun, Dan Ge, Longying Xiong, Xiaotan Dou, Xiaoping Zou, Lei Wang, Min Chen

“…Therefore, through metabolic reprogramming, DRAM1 may serve as a potential therapeutic target for GC prevention.…”
Get full text

Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives by Marina de Tommaso, Lars Arendt-Nielsen, Ruth Defrin, Miriam Kunz, Gisele Pickering, Massimiliano Valeriani

“…In AD, no data on pain features are available. No controlled therapeutic trials and guidelines are currently available. …”
Get full text

Nanoparticles in Hormonal Regulation of the Female Reproductive System by Vandhana Vijayakumar, Thirumalaikumaran Rathinam, Sakthi Sanjana Deenadhayalan, Elizabeth Rani Edwin, Preethi Harikrishnan, Prathiba Balaji

“…Owing to their small size and large surface area, NPs can interact with biological systems in ways that may lead to both therapeutic innovations and toxicological concerns. …”
Get full text

Influence of AGTR1 and ABCB1 Gene Polymorphism on the Curative Effect of Irbesartan by Qiao Wang, Lingsen You, Zeyu Li, Leiyi Zhang, Xueqi Li, Xuesong Yang

“…In this study, we investigated the new combinational influences of AGTR1 and ABCB1 gene polymorphism on the therapeutic effect of irbesartan among Chinese hypertensive patients. …”
Get full text

In Situ Transformable Nanoparticle Effectively Suppresses Bladder Cancer by Damaging Mitochondria and Blocking Mitochondrial Autophagy Flux by Yulin Lv, Benli Song, Guang Yang, Yuting Wang, Zeyu Wu, Minggui Si, Zongzheng Yang, Huilin Chen, Chen Liu, Min Li, Yinshi Zhang, Zengying Qiao, Lu Wang, Wanhai Xu

“…Abstract Tumor therapeutic strategies based on mitochondrial damage have become an emerging trend. …”
Get full text

Exploring the efficacy and constraints of platinum nanoparticles as adjuvant therapy in silicosis management by Ge Ban, Yuanjie Chen, Yingbing Liang, Xiaona Wang, Dan Ding, Rui Liu, Jingjing Jia, Ran Zhao, Chenxia Wang, Na Li

“…This discourse delineates the interplay between ROS and PtNPs, the pathogenesis of silicosis and its progression to pulmonary fibrosis, and critically evaluates the potential adjunct role of PtNPs in the therapeutic landscape of silicosis, alongside a contemplation of the inherent limitations associated with PtNPs application in this context.…”
Get full text

New Insights into Chemical Profiles and Health-Promoting Effects of Edible Mushroom <i>Dictyophora indusiate</i> (Vent ex. Pers.) Fischer: A Review by Yogesh Kumar, Baojun Xu

“…Their wide range of bioactive compounds makes <i>D. indusiata</i> mushrooms functional foods with significant therapeutic potential.…”
Get full text

Immunocompatibility of Bacteriophages as Nanomedicines by Tranum Kaur, Nafiseh Nafissi, Olla Wasfi, Katlyn Sheldon, Shawn Wettig, Roderick Slavcev

“…As phage applications to human therapeutic development grow at an exponential rate, it will become essential to evaluate host immune responses to initial and repetitive challenges by therapeutic phage in order to develop phage therapies that offer suitable utility. …”
Get full text

Dual AAV/IL-10 Plus STAT3 Anti-Inflammatory Gene Delivery Lowers Atherosclerosis in LDLR KO Mice, but without Increased Benefit by Maohua Cao, Junaid A. Khan, Bum-Yong Kang, Jawahar L. Mehta, Paul L. Hermonat

“…To investigate possible therapeutic synergism, we delivered both full-length wild-type human (h) STAT3 and hIL-10 genes by separate adenoassociated virus type 8 (AAV8) tail vein injection into LDLR KO on HCD. …”
Get full text

A General Overview of Mesenchymal Stem Cell Therapies in Drug- and Chemical-Induced Liver Injury Models by Müşerref Şeyma Ceyhan, Suna Ömeroğlu, Zeynep Yığman

“…Although MSC therapy leads to amelioration in liver function, researchers still try to improve therapeutic efficacy. To this end, different modifications and application modalities of MSCs were investigated in drug-induced liver injury models. …”
Get full text

Exploring the Role of Tranexamic Acid in Dermatology: A literature Review by Aleksandra Górska, Natalia Gniaź, Wiktor Grela, Jagoda Niewiadomska, Daria Furtak, Dawid Tulej, Natalia Marko, Alicja Dziedzic, Dominika Marciniuk, Paulina Głogowska

“…Conclusions Tranexamic acid shows promising therapeutic potential in dermatology, particularly for pigmentary and inflammatory disorders. …”
Get full text

The effects of mirror therapy with neuromuscular electrical stimulation on motor and sensory functions in patients with common peroneal nerve injury by Xiaolei Chu, Jiajia Liang, Mingwei Gao, Xiaoxuan Zhao, Jiaojiao Sun, Wenjie Liu, Donglin Zhao, Zheng Xing, Qi Li

“…The objective is to identify novel therapeutic strategies for lower limb peripheral nerve injuries.30 patients with Common peroneal nerve caused by pelvic fractures were selected from the Rehabilitation Medicine Department of Tianjin Hospital between July 2023 and July 2024. …”
Get full text

Hematopoietic Stem Cell Transplantation: A Bioethical Lens by Arcangelo Liso, Margherita Neri, Francesca Maglietta, Raffaele La Russa, Emanuela Turillazzi

“…Hematopoietic stem cell transplantation (HSCT) is one of a range of therapeutic options available to patients suffering from various diseases. …”
Get full text

Protease-activated receptors in vascular smooth muscle cells: a bridge between thrombo-inflammation and vascular remodelling by Anxhela Habibi, Wolfram Ruf, Leon Schurgers

“…Additionally, we discuss current therapeutic strategies targeting PAR signalling - indirectly or directly – in relation to cardiovascular disease.…”
Get full text

Pathophysiology and Treatment of Psoriasis: From Clinical Practice to Basic Research by Yujie Gao, Tianqi Xu, Yu Wang, Yanjinhui Hu, Shaoping Yin, Zhiguo Qin, Hua Yu

“…Psoriasis, a chronic inflammatory dermatosis, represents a significant clinical challenge due to its complex pathogenesis and the limitations of existing therapeutic strategies. Current psoriasis diagnoses are primarily clinician-dependent, with instrumental diagnostics serving as adjuncts. …”
Get full text

Evaluation of the role of unconventional prefoldin RPB5 interactor (URI1) in hepatitis B virus infection by Karolína Štaflová, Aleš Zábranský, Iva Pichová

“…This suggests that URI1 may be a viable therapeutic target for patients with HBV-associated HCC without increasing HBV-related complications.…”
Get full text

Nutritional Health Perspective of Natto: A Critical Review by Muhammad Afzaal, Farhan Saeed, Fakhar Islam, Huda Ateeq, Aasma Asghar, Yasir Abbas Shah, Chigozie E. Ofoedu, James S. Chacha

“…The present review highlights the production technology, microbiology, nutritional composition, and therapeutic potentials of natto.…”
Get full text

Phosphorylation of SIRT7 by ATM causes DNA mismatch repair downregulation and adaptive mutability during chemotherapy by Lianhui Sun, Guangjian Fan, Zhuqing Zhang, Dong Chang, Xiaoyu Zhang, Tongqing Zhang, Jichuan Geng, Xiaoxia Zhang, Menghan Lin, Chen Hu, Jiaqi Zhou, Mengxue Wang, Liu Cao, Mary Zhang, Baokun He, Shengping Zhang, Chuangui Wang

“…During DNA-damaging treatments, cancer cells transiently increase their adaptive mutability, also known as microsatellite instability (MSI), to evade therapeutic pressure through MMR downregulation, conferring drug resistance. …”
Get full text

Bio-primed machine learning to enhance discovery of relevant biomarkers by David M. Henke, Alexander Renwick, Joseph R. Zoeller, Jitendra K. Meena, Nicholas J. Neill, Elizabeth A. Bowling, Kristen L. Meerbrey, Thomas F. Westbrook, Lukas M. Simon

“…This method holds promise for advancing personalized medicine by uncovering novel therapeutic targets and understanding the complex interplay of genetic and molecular factors in disease.…”
Get full text