Psychopathology and Continuous Subcutaneous Insulin Infusion in Type 1 Diabetes by Francesco Rotella, Caterina Lamanna, Ilaria Dicembrini, Carlo Faravelli, Caterina Calasso, Edoardo Mannucci

“…Higher levels of psychopathology could represent a limit for the attainment and maintenance of therapeutic goals with CSII.…”
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Iodine-131 Metaiodobenzylguanidine Therapy for Neuroblastoma: Reports So Far and Future Perspective by Daiki Kayano, Seigo Kinuya

“…The combination therapy with I-131 MIBG and other modalities such as nonmyeloablative chemotherapy and myeloablative chemotherapy with HCT improved the therapeutic response in patients with refractory or relapsed neuroblastoma. …”
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Pan-inhibition of super-enhancer-driven oncogenic transcription by next-generation synthetic ecteinascidins yields potent anti-cancer activity by Max Cigrang, Julian Obid, Maguelone Nogaret, Léane Seno, Tao Ye, Guillaume Davidson, Philippe Catez, Pietro Berico, Clara Capelli, Clara Marechal, Amélie Zachayus, Clémence Elly, Marie Jose Guillen Navarro, Marta Martinez Diez, Gema Santamaria Nunez, Tsai-Kun Li, Emmanuel Compe, Pablo Avilés, Irwin Davidson, Jean-Marc Egly, Carmen Cuevas, Frédéric Coin

“…Abstract The plasticity of cancer cells facilitates their ability to adopt heterogeneous differentiation states, posing a significant challenge to therapeutic interventions. Specific gene expression programs, driven in part by super-enhancers (SEs), underlie cancer cell states. …”
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Hyaluronidase-responsive hydrogel loaded with magnetic nanoparticles combined with external magnetic stimulation for spinal cord injury repair by Zhiyi Fan, Guofu Zhang, Wanda Zhan, Juehan Wang, Chaoyong Wang, QianYing Yue, Zhangheng Huang, Yongxiang Wang

“…These results underscore the therapeutic potential of hydrogel.…”
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Gold nanorod-based engineered nanogels for cascade-amplifying photothermo-enzymatic synergistic therapy by Ling Ding, Xiaoshan Wang, Qing Wu, Xia Wang, Qigang Wang

“…Among these, cooperative physical and biochemical activation strategies have attracted increasing attention because of their spatiotemporal controllability, low toxicity, and high therapeutic efficacy. Herein, we demonstrate a nanogel complex as a multilevel ROS-producing system by integrating chloroperoxidase (CPO) into gold nanorod (AuNR)-based nanogels (ANGs) for cascade-amplifying photothermal-enzymatic synergistic tumor therapy. …”
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RGD-HSA-TAC nanoparticles targeted delivery of tacrolimus and attenuation of podocyte injury in diabetic kidney disease by Zhaochen Guo, Shaohui Gao, Feng Xu, Zige Chen, Qinger Wang, Zhaojie Liu, Ziyue Wang, Weisong Qin, Caihong Zeng, Zhihong Liu, Hao Bao

“…Importantly, compared to tacrolimus alone, both SANPs and CNPs demonstrated superior therapeutic efficacy, with CNPs exhibiting a greater advantage over SANPs. …”
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Potential impact of coronaviruses upon cardiovascular system under COVID-19 pandemic by L.O. Tkachenko, O.A. Yepanchintseva, B.M. Todurov

“…The review reflects the main trends of the general approach in understanding organizational and therapeutic procedures in the care of patients with cardiovascular disease during the pandemic COVID-19.…”
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Decoding NAD+ Metabolism in COVID-19: Implications for Immune Modulation and Therapy by Shixu Song, Jialing Gan, Qiuyue Long, Zhancheng Gao, Yali Zheng

“…The persistent threat of COVID-19, particularly with the emergence of new variants, underscores the urgency for innovative therapeutic strategies beyond conventional antiviral treatments. …”
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Molecular Mechanisms of Phthalate-Induced Hepatic Injury and Amelioration by Plant-Based Principles by Lalit Kumar Singh, Rashmi Pandey, Nikhat Jamal Siddiqi, Bechan Sharma

“…This review presents a comprehensive and updated account of the chemical, biochemical, immunological, and toxicological properties of phthalates, along with novel plant-based therapeutic strategies to mitigate the phthalate-induced adverse effects on living systems.…”
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Allogeneic CD33-directed CAR-NKT cells for the treatment of bone marrow-resident myeloid malignancies by Yan-Ruide Li, Ying Fang, Siyue Niu, Yichen Zhu, Yuning Chen, Zibai Lyu, Enbo Zhu, Yanxin Tian, Jie Huang, Valerie Rezek, Scott Kitchen, Tzung Hsiai, Jin J. Zhou, Pin Wang, Wanxing Chai-Ho, Sunmin Park, Christopher S. Seet, Caspian Oliai, Lili Yang

“…In this study, we characterize primary patient samples and identify a unique therapeutic opportunity for CAR-engineered invariant natural killer T (CAR-NKT) cells. …”
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The potential of Dayak tribal herbal leaves as an anti-breast cancer agent: In silico approach by Kellik Setiawan Volta, Affan Ali Murtadlo Ahmad, Nur Muhammad Ansori Arif, Dhea Kharisma Viol, Dayu Rahma Turista Dora

“…This work supports the potential of traditional Dayak herbal medicine as a natural therapeutic strategy against breast cancer.…”
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Advanced Magnetic Resonance Imaging for Early Diagnosis and Monitoring of Movement Disorders by Emmanuel Ortega-Robles, Benito de Celis Alonso, Jessica Cantillo-Negrete, Ruben I. Carino-Escobar, Oscar Arias-Carrión

“…Furthermore, MRI provides objective metrics for tracking disease progression and assessing therapeutic efficacy, making it an indispensable tool in clinical trials. …”
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Hydrogel-based nanoparticles: revolutionizing brain tumor treatment and paving the way for future innovations by Alireza Shadab, Simin Farokhi, Arshia Fakouri, Neda Mohagheghzadeh, Ali Noroozi, Zahra Sadat Razavi, Arian Karimi Rouzbahani, Hamidreza Zalpoor, Mohamad Mahjoor

“…Further investigations are encouraged by this review to investigate potential advancements in hydrogel-based nanoparticle therapeutic approaches for brain tumors. This includes investigating tailored hydrogels, hybrid systems, computational modeling, and the integration of gene therapy and immunotherapy techniques. …”
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Electroencephalogram biomarkers as predictors of mortality and functional recovery in patients with severe traumatic brain injury: Protocol study by Walter Gomes da Silva Filho, Layza Julhia do Nascimento Moura, Arthur Barcelos Massariol Nascimento, Gabrielle Cristina Tessmann, Fabricia Silva Miranda, Vitória Caroline Reinoso de Almeida, Bárbara Vargens Broedel, Miller Lucas de Faria, Fernando Zanela da Silva Arêas

“…Through continuous monitoring and analysis of abnormal brain activity patterns, the protocol aims to personalize therapeutic interventions and improve patient quality of life. …”
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Surgical Options for the Refractive Correction of Keratoconus: Myth or Reality by L. Fernández-Vega-Cueto, V. Romano, R. Zaldivar, C. H. Gordillo, F. Aiello, D. Madrid-Costa, J. F. Alfonso

“…The purpose of this review is to describe the evidence about the conservative surgical treatment for keratoconus aiming to therapeutic and refractive effect. The visual rehabilitation for keratoconic corneas requires addressing three concerns: halting the ectatic process, improving corneal shape, and minimizing the residual refractive error. …”
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Modulation of glymphatic system by visual circuit activation alleviates memory impairment and apathy in a mouse model of Alzheimer’s disease by Wen Wu, Yubai Zhao, Xin Cheng, Xiaoru Xie, Yixiu Zeng, Quan Tao, Yishuai Yang, Chuan Xiao, Zhan Zhang, Jiahui Pang, Jian Jin, Hongbo He, Yangyang Lin, Boxing Li, Junxian Ma, Xiaojing Ye, Wei-Jye Lin

“…Here we report the therapeutic potential of low-intensity 40 hertz blue light exposure in a 5xFAD mouse model of Alzheimer’s disease. …”
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Effect of Gegen Qinlian Decoction on Cardiac Gene Expression in Diabetic Mice by Jing Han, Zhenglin Wang, Wei Xing, Yueying Yuan, Yi Zhang, Tiantian Lv, Hongliang Wang, Yonggang Liu, Yan Wu

“…The aim of this research is to investigate the therapeutic effect of GGQL decoction on cardiac dysfunction and elucidate the pharmacological mechanisms. db/db mice were divided into DB group or GGQL group, and WT mice were used as control. …”
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Biomarker testing in lung cancer: from bench to bedside by Ullas Batra, Shrinidhi Nathany

“…With increased knowledge about biomarkers and the consequent improvement in survival rates, NSCLC has changed from being a therapeutic nihilistic disease to that characterized by therapeutic enthusiasm. …”
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Applications of cell penetrating peptide-based drug delivery system in immunotherapy by Jing-Jing Du, Ru-Yan Zhang, Shangchi Jiang, Shanshan Xiao, Yiting Liu, Yongheng Niu, Wen-Xiang Zhao, Dongyuan Wang, Dongyuan Wang, XianShi Ma

“…These properties have made them as efficient drug-delivery tools to deliver therapeutic molecules to cells and tissues in a nontoxic manner, including small molecules, DNA, siRNA, therapeutic proteins and other various nanoparticles. …”
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Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1 by Huizhen Fan, Chunyan Jiang, Baoyuan Zhong, Jianwen Sheng, Ting Chen, Qingqing Chen, Jingtao Li, Hongchuan Zhao

“…Matrine-related proteins and CRC-related genes and therapeutic targets of matrine in CRC were predicted using a network pharmacology approach. …”
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