STUDY OF THE EFFECT OF METHIONINE HYPERHOMOCYSTEINEMIA AND ITS CORRECTION WITH CHOLINE AND VITAMIN D ON THE CONDITION OF THE PERIODONTIUM, SMALL INTESTINE, AND LIVER OF RATS by Oleh Kutelmakh, Yulia Chumakova, Lina Kovalchuk, Yulia Odnorih, Olexandra Kutelmakh, Anastasiya Spodaruk

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Golgi scaffold protein PAQR11 in pan-cancer landscape: A comprehensive bioinformatics exploration of expression patterns, prognostic significance, and potential immunological funct... by Zhu Liu, Zhi-Qiang Ling

“…By elucidating these aspects, the research seeks to assess PAQR11's potential as a biomarker and therapeutic target in oncology. Methods: We conducted a comprehensive bioinformatics analysis using publicly available pan-cancer datasets from TCGA, GEO, UALCAN, TIMER, GEPIA2, KM plotter, and TISIDB. …”
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Prediction of outcomes after chemoradiotherapy for cervical cancer by neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio by Jing Yu, Longzhang Huang, Ting Dong, Lihua Cao

“…Receiver operating characteristic (ROC) curves were plotted to analyse the optimal cut-off values of NLR and PLR for predicting the therapeutic effects of concurrent chemoradiotherapy. …”
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Usefulness of Measuring Thiopurine Metabolites in Children with Inflammatory Bowel Disease and Autoimmunological Hepatitis, Treated with Azathioprine by Katarzyna Bąk-Drabik, Piotr Adamczyk, Justyna Duda-Wrońska, Dominika Dąbrowska-Piechota, Anna Jarzumbek, Jarosław Kwiecień

“…Only twenty-five (41%) children had therapeutic 6-TGN concentrations, ten (16%) subjects had suboptimal 6-TGN concentrations, and twenty-six subjects (43%) had 6-TGN concentrations above the recommended therapeutic range. 6-MMP was not above the therapeutic range in any case. …”
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Astrocyte-Derived Interleukin 11 Modulates Astrocyte–Microglia Crosstalk via Nuclear Factor-κB Signaling Pathway in Sepsis-Associated Encephalopathy by Dandan Zhu, Peng Wang, Xiyue Chen, Kaituo Wang, Yunsong Wu, Min Zhang, Jianhua Qin

“…In addition, the SAE mouse model was utilized to determine the state of glial cells and evaluate the therapeutic effect of drugs targeting the astrocyte–microglia crosstalk in vivo. …”
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Efficacy of Acupuncture Treatment for Postprandial Distress Syndrome: A Systematic Review and Meta-Analysis by Jihang Du, Yinhao Feng, Qiang Yuan, Haiping Gong, Jie An, Liu Wu, Qian Dai, Bojun Xu, Haozhong Wang, Jian Luo

“…Acupuncture had a significant effect on the total therapeutic effect (OTE) at week 4 (OR 4.74, 95% CI 02.88-7.83, Z=6.10, P=0<0.05). …”
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Epithelial cell diversity and immune remodeling in bladder cancer progression: insights from single-cell transcriptomics by Jianpeng Li, Yunzhong Jiang, Minghai Ma, Lu Wang, Minxuan Jing, Zezhong Yang, Mengzhao Zhang, Ke Chen, Jinhai Fan

“…This highlights glycolysis as a potential therapeutic target for disrupting tumor progression. …”
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Antimicrobial use in animal farms in Egypt: rates, patterns, and determinants by Nada ElSayed, Amira Amine, Laila El-Attar, Mohamed E. K. Amin

“…All surveyed personnel reported using antimicrobials, and almost two-thirds (65%) reported using them for non-therapeutic purposes. Non-therapeutic use of antimicrobials, however, had no impact on FCR across all farm types (poultry, cattle, and mixed). …”
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Integrated Analysis and Validation of Ferroptosis-Related Genes Associated with Ischemia/Reperfusion Injury in Lung Transplantation by Li Q, Yin J, Lin Q, He J, Shi X, Nie H

“…These findings offer promising therapeutic targets for preventing LIRI and improving outcomes in lung transplantation.Keywords: lung ischemia/reperfusion injury, ferroptosis, biomarkers, immune cell infiltration…”
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Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy by Wenjun Li, Wenjun Li, Junjiang Sun, Susi Feng, Ariana La Rosa, Panli Zhang, Eveline Y. Wu, Richard Loeser, Chengwen Li, Chengwen Li, Chengwen Li

“…Finally, we investigated the therapeutic effect of AAV/shPD-L1 via intramuscular injection. …”
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The Combined Effect of Multisensory Stimulation and Therapist Support on Physical and Mental Health of Older Adults Living in Nursing Homes: Pilot Randomized Controlled Trial by Sewar Khatib, Yuval Palgi, Yoni K Ashar, Natalya Polyvyannaya, Pavel Goldstein

“…ConclusionsThe combined intervention of SS and TS showed therapeutic benefits for pain management and physical and mental health of older adults living in nursing homes, relative to each therapeutic component in isolation. …”
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NT5E Mediates Cisplatin Resistance in NSCLC Through the PI3K-AKT Signaling Pathway by Liangfeng Zheng, Jian Liu, Feiyue Ji, Chunxiang Li, Ye Qian, Lili Shao, Xiaomin Lu

“…This finding provides important insights for a deeper understanding of the mechanism of drug resistance in lung cancer and serves as a theoretical basis for the development of new therapeutic strategies and drugs.…”
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Real-world tafamidis experience in hereditary transthyretin amyloidosis with peripheral neuropathy in Brazil by Luiz Felipe Pinto, Marcus V. Pinto, Paula Accioli, Gabriela Amorim, Renata Gervais de Santa Rosa, Moises Dias, Mariana Guedes, Carlos P. Gomez, Roberto C. Pedrosa, Marcia Waddington-Cruz

“…It is the only disease-modifying treatment for hereditary TTR amyloidosis with peripheral neuropathy (ATTRv-PN) available in the National Therapeutic Form (Formulário Terapêutico Nacional, FTN, in Portuguese) of the Brazilian Unified Health System (Sistema Único de Saúde, SUS, in Portuguese).…”
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Suppressive activity of macrolide antibiotics on nitric oxide production by lipopolysaccharide stimulation in mice by Hajime Terao, Kazuhito Asano, Ken-ichi Kanai, Yoshiyuki Kyo, So Watanabe, Tadashi Hisamitsu, Harumi Suzaki

“…Background and aim: Low-dose and long-term administration of macrolide antibiotics into patients with chronic airway inflammatory diseases could favorably modify their clinical conditions. However, the therapeutic mode of action of macrolides is not well understood. …”
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Life-Threatening Rupture of a False Aneurysm after Femoral Arterial Catheterization: Unexpected Delay after a Common Procedure by Julie Renner, Pierre Pasquier, Elisabeth Falzone, Faye Rozwadowski, Stéphane Mérat

“…If there is not spontaneous closure, ultrasound-guided compression repair, minimally invasive percutaneous treatments, and surgical repair are the three therapeutic options.…”
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Bilateral Obstructive Uropathy Secondary to Giant Periureteral Diverticulum by Alberto Hernando Arteche, Luis Alberto San Jose Manso, Carlos Olivier Gomez, Angel Nellyt Silmi Moyano

“…They are often asymptomatic, although they may lead to complications that require a surgical therapeutic approach. We report the case of a patient with bilateral obstructive uropathy secondary to a giant periureteral diverticulum that was treated by diverticulectomy and reimplantation of the left ureter in the bladder.…”
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Utilization of Colistin for Treatment of Multidrug-Resistant Pseudomonas aeruginosa by Deana M Sabuda, Kevin Laupland, Johann Pitout, Bruce Dalton, Harvey Rabin, Thomas Louie, John Conly

“…BACKGROUND: Colistin is uncommonly used in clinical practice; however, the emergence of multidrug-resistant organisms has rekindled interest in this potentially toxic therapeutic option. The present study describes the authors’ experience with colistin in the management of patients who were infected with metallo-beta-lactamase (MBL)-producing Pseudomonas aeruginosa within the Calgary Health Region (Calgary, Alberta).…”
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Anaplastic Sarcoma of the Kidney by Apostolos P. Labanaris, Vahudin Zugor, Robert Smiszek, Reinhold Nützel, Reinhard Kühn

“…Although of unknown origin and pathogenesis, treating such a tumor as if it was anaplastic Wilms' tumor seems to be the only therapeutic solution at the present time. Newer immunohistochemical staining and molecular probes should be applied to this neoplasm in order for us to understand it nature and maximize therapy.…”
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Inhibition of the Transforming Growth Factor-β Signaling Pathway Confers Neuroprotective Effects on Beta-Amyloid-Induced Direct Neurotoxicity and Microglia-Mediated Neuroinflammati... by Shao Qin Tiong, Raxshanaa N. Mohgan, Jia Yee Quek, Jennifer Yue Suan Liew, Grace Yee Seen Wong, Zi Qing Thang, Zhi Ling Chan, Sook Yee Gan, Elaine Wan Ling Chan

“…Hence, targeting the TGF-β signaling pathway in both neuronal and microglia cells could provide a promising therapeutic strategy in AD.…”
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Predictors of Successful Clinical and Laboratory Outcomes in Patients with Primary Sclerosing Cholangitis Undergoing Endoscopic Retrograde Cholangiopancreatography by R Enns, MA Eloubeidi, K Mergener, PS Jowell, MS Branch, J Baillie

“…Endoscopic retrograde cholangiopancreatography (ERCP) in patients with primary sclerosing cholangitis (PSC) can be a challenging and sometimes gratifying opportunity for therapeutic intervention. Although there often appears to be initial radiological improvement after ERCP, the benefit as measured by serial estimations of subsequent liver enzymes is questionable. …”
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