Management of the Uncommon Bladder Cancers: A Single-Center Experience over 10 Years by Youssef Kadouri, Salim Lachkar, Hamza Dergamoun, Hachem El Sayegh, Lounis Benslimane, Yassine Nouini

“…There is not a clear and consensual therapeutic management for these entities. Purpose. …”
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Precision Psychobiotics for Gut–Brain Axis Health: Advancing the Discovery Pipelines to Deliver Mechanistic Pathways and Proven Health Efficacy by Rebecca F. Slykerman, Naomi Davies, Klara Vlckova, Kenneth J. O'Riordan, Shalome A. Bassett, James Dekker, Harriët Schellekens, Niall P. Hyland, Gerard Clarke, Elaine Patterson

“…ABSTRACT Advancing microbiome–gut–brain axis science requires systematic, rational and translational approaches to bridge the critical knowledge gaps currently preventing full exploitation of the gut microbiome as a tractable therapeutic target for gastrointestinal, mental and brain health. …”
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Exploring the Underlying Mechanism of Weiling Decoction Alleviates Cold-Dampness Diarrhea Based on Network Pharmacology, Transcriptomics, Molecular Docking and Experimental Validat... by Yannan Zhang, Shuai Zhang, Yimeng Fan, Sijuan Huang, Shimin Wang, Zhihui Hao, Jianzhong Shen

“…Additionally, a rat model of CDD was established to assess the therapeutic effects of WLD through a comprehensive approach. …”
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Exploring genetic associations and drug targets for mitochondrial proteins and schizophrenia risk by Wenxi Sun, Ping Sun, Jin Li, Qun Yang, Qing Tian, Shiting Yuan, Xueying Zhang, Peng Chen, Chuanwei Li, Xiaobin Zhang

“…After conducting the gene-drug analysis, HRG, F12, GPLD1, C1R, BCHE, CFH, PON1, and CA5A were identified as promising therapeutic targets. This present study reveals a significant causal relationship between mitochondria-associated proteins and SCZ, offering valuable insights into the disease’s pathogenicity and identifying potential therapeutic targets for drug development.…”
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Inhibition of TFF3 synergizes with c-MET inhibitors to decrease the CSC-like phenotype and metastatic burden in ER+HER2+ mammary carcinoma by Chuyu He, Xuejuan Wang, Yi-Shiou Chiou, Basappa Basappa, Tao Zhu, Vijay Pandey, Peter E. Lobie

“…Therefore, proof of concept is provided herein that antagonizing of TFF3 is a promising therapeutic strategy in combination with c-MET inhibition for the treatment of ER+HER2+ MC.…”
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Methylprednisolone substituted lipid nanoparticles deliver C3 transferase mRNA for combined treatment of spinal cord injury by Haoru Dong, Zongxing He, Shiyi Cai, Haiqiang Ma, Lili Su, Jianfeng Li, Huiying Yang, Rong Xie

“…This strategy aims to enhance the localization and concentration of MP at the injury site, thereby amplifying its therapeutic efficacy while mitigating systemic side effects. …”
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The role of oxidized non-coding RNAs of the epigenome in the development of human diseases (literature review) by S.S. Ostrovska, Ye.N. Dychko, T.Ye. Shumna, G.I. Titov, O.S. Trushenko, P.G. Gerasymchuk, I.Y. Burega

“…Many studies are aimed at using microRNAs for therapeutic purposes. The complete expression profile of microRNAs in human atherosclerotic plaques was studied, and the mechanisms affecting their formation were identified. …”
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Exosomes Derived from Schistosoma japonicum Cystatin-Treated Macrophages Attenuated CLP-Induced Sepsis in Mice by Feifei Huang, Yayun Qian, Huihui Li, Liang Chu, Chen Wan, Qili Shen, Qianqian Li, Xiuxiu Li, Xinyue Wu, Bin Zhan, Rui Zhou, Xiaodi Yang

“…The therapeutic effect of exosomes is associated with macrophage polarization from M1 to M2 in the infected tissues via downregulating TRL2/MyD88 inflammatory pathway. …”
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Single-cell transcriptomics analysis reveals dynamic changes and prognostic signature in tumor microenvironment of PDAC by Yongsheng Li, Zhilong Ding, Tingxin Cheng, Yihuai Hu, Fei Zhong, Shiying Ren, Shiyan Wang

“…Furthermore, our analysis revealed significant interactions between cells at different stages of PDAC and identified three promising therapeutic agents (XR-11576, Ixabepilone, and AMONAFIDE) based on correlated genes. …”
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Glucose‐induced LINC01419 reprograms the glycolytic pathway by recruiting YBX1 to enhance PDK1 mRNA stability in hepatocellular carcinoma by Yanfang Liu, Junjiao Song, Qili Shi, Bing Chen, Wenying Qiu, Yizhe Liu, Shenglin Huang, Xianghuo He

“…Hepatic‐specific delivery of GalNAc‐siLINC01419 presents a promising therapeutic strategy for HCC.…”
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Determining the mechanism of Shuxuening injection against liver cirrhosis through network pharmacology and animal experiments by Qiyao Liu, Tingyu Zhang, Yongan Ye, Xin Sun, Huan Xia, Xu Cao, Xiaoke Li, Wenying Qi, Yue Chen, Xiaobin Zao

“…Objective: To screen and identify the key active molecules, signaling pathways, and therapeutic targets of Shuxuening (SXN) injection for treating liver cirrhosis (LC) and to evaluate its therapeutic potential using a mouse model. …”
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Integrated bioinformatics analysis of the effects of chronic pain on patients with spinal cord injury by Jinlong Zhang, Jinlong Zhang, Longju Qi, Yuyu Sun, Yuyu Sun, Shiyuan Chen, Jinyi Liu, Jiaxi Chen, Fangsu Yan, Wenqi Wang, Qinghua Wang, Liang Chen

“…This analysis uncovered shared pathways, proteins, transcription factor networks, hub genes, and potential therapeutic drugs. Regression analysis on the hub genes facilitated the development of a prognostic risk model. …”
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The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases by Feifei Qiu, Jingru Lin, Xiaofei Huang, Bin Yang, Weihui Lu, Weihui Lu, Zhenhua Dai, Zhenhua Dai

“…Beyond its hepatoprotective effects, an expanding body of research has underscored the immunoregulatory properties of SCO, indicating its potential therapeutic benefits for autoimmune and other inflammatory diseases. …”
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Virtual screening assisted identification of a phytocompound as potent inhibitor against Candida lusitaniae; an in-silico study by Rimsha Timotheous, Habiba Naz, Usman Arif, Momna Toqeer Dar, Muhammad Farhan Sarwar, Mudassar Fareed Awan, Sajed Ali, Safia Obaidur Rab

“…Hence, there is a need to design those drugs which possess comparatively higher degree of therapeutic potential. Phytochemicals were selected in this regard because these compounds which satisfactorily follow this criteria as, their therapeutic index is comparatively larger than the synthetic drugs. …”
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Primary breast osteosarcoma: A case report highlighting the importance of radiologic-pathologic correlation by Bailee Lichter, MS, Madison Landon, MS, DesiRae Muirhead, MD, Daniel Fetzer, MD

“…This case report details the clinical presentation, imaging findings, histopathological features, and therapeutic approach that transpired to diagnose and treat this rare malignancy.…”
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Clinical Practice Guidelines for Auricular Fibrillation. by Jorge Luis Ulloa Capestany, Aleyda Hernández Lara, Aymara Marcia Hernández Cardoso, Francisco García Valdez, Carlos Jaime Geroy Gómez

“…It includes important aspects as aetiology and trigger aspects, diagnosis, classification and treatment with emphasis on therapeutic emergencies. It includes assessment guidelines focused on the most important aspects to be accomplished.…”
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Modeling shrimp biomass and viral infection for production of biological countermeasures by H. Thomas Banks, V. A. Bokil, Shuhua Hu, A. K. Dhar, R. A. Bullis, C. L. Browdy, F.C.T. Allnutt

“…In this paper we develop a mathematical model for the rapid productionof large quantities of therapeutic and preventive countermeasures. Wecouple equations for biomass production with those for vaccine production inshrimp that have been infected with a recombinant viral vector expressing aforeign antigen. …”
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A Practical Method for No-Reflow Treatment by Mustafa Cetin, Emrullah Kiziltunc, Zehra Güven Cetin, Harun Kundi, Birsen Gulkan, Hülya Cicekcioglu

“…Vasoactive drug administration at the distal part of the coronary artery is suggested as a therapeutic option for no-reflow treatment. Here, we represent two cases of successful no-reflow management with previously used monorail balloon at the same procedure as a hand-made distal infusion catheter.…”
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Clinical Practice Guidelines for Auricular Fibrillation. by Lázaro De la Cruz Avilés, Félix Rolando Jorrín Román, Francisco De Jesús Valladares Carvajal, Pablo Rodríguez Díaz

“…It includes important aspects as aetiology and trigger aspects, diagnosis, classification and treatment with emphasis on therapeutic emergencies. It includes assessment guidelines focused on the most important aspects to be accomplished.…”
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Synthesis, characterization, and in silico studies of substituted 2,3-dihydro-1,3,4-thiadiazole derivatives by Yasser H. Zaki, Sobhi M. Gomha, Basant Farag, Magdi E.A. Zaki, Ahmed M. Hussein

“…Molecular docking studies further revealed that compounds 5h and 5e achieved the highest docking scores, suggesting potential therapeutic applications. These results, supported by ADMET studies, indicate that substituted 2,3-dihydro-1,3,4-thiadiazole scaffolds hold promise for further development as therapeutic agents. …”
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